| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Best, M Reed, H F Nijhou. Models of dopaminergic and serotonergic signaling. Pharmacopsychiatry. vol 43 Suppl 1. 2010-08-25. PMID:20480448. |
mathematical models of dopaminergic and serotonergic synapses have enabled the authors to study quantitative aspects of the synthesis, release and reuptake of dopamine and serotonin, to investigate the effects of autoreceptors, and to explore the influence of the neurochemistry on the firing patterns of cells known to be involved in the behavioral responses to dopaminergic and serotonergic signaling. |
2010-08-25 |
2023-08-12 |
Not clear |
| J Best, M Reed, H F Nijhou. Models of dopaminergic and serotonergic signaling. Pharmacopsychiatry. vol 43 Suppl 1. 2010-08-25. PMID:20480448. |
three results from recent in silico experiments with the dopaminergic and serotonergic synapse models are described: (1) influence of substrate inhibition on the stability of dopamine and serotonin synthesis; (2) a predicted connection between serotonin reuptake transporter (sert) density on terminals and tonic firing rates; (3) an explanation of data from autoreceptor knock-out experiments. |
2010-08-25 |
2023-08-12 |
Not clear |
| Christian P Jacob, Thuy Trang Nguyen, Astrid Dempfle, Monika Heine, Christine Windemuth-Kieselbach, Katarina Baumann, Florian Jacob, Julian Prechtl, Maike Wittlich, Martin J Herrmann, Silke Gross-Lesch, Klaus-Peter Lesch, Andreas Rei. A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder. European archives of psychiatry and clinical neuroscience. vol 260. issue 4. 2010-08-24. PMID:19894072. |
the present study therefore aimed to detect main effects as well as interactions of serotonergic candidate genes (coding for the serotonin transporter, 5-htt; the serotonin autoreceptor, htr1a; and the enzyme which synthesizes serotonin in the brain, tph2) with the burden of life events (#le) in two independent samples consisting of 183 patients suffering from personality disorders and 123 patients suffering from adult attention deficit/hyperactivity disorder (aadhd). |
2010-08-24 |
2023-08-12 |
human |
| Osahiko Tsuji, Kyoko Miura, Yohei Okada, Kanehiro Fujiyoshi, Masahiko Mukaino, Narihito Nagoshi, Kazuya Kitamura, Gentaro Kumagai, Makoto Nishino, Shuta Tomisato, Hisanobu Higashi, Toshihiro Nagai, Hiroyuki Katoh, Kazuhisa Kohda, Yumi Matsuzaki, Michisuke Yuzaki, Eiji Ikeda, Yoshiaki Toyama, Masaya Nakamura, Shinya Yamanaka, Hideyuki Okan. Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 28. 2010-08-19. PMID:20615974. |
they also participated in remyelination and induced the axonal regrowth of host 5ht(+) serotonergic fibers, promoting locomotor function recovery. |
2010-08-19 |
2023-08-12 |
mouse |
| Daniela Rüedi-Bettschen, James K Rowlett, Roger D Spealman, Donna M Plat. Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms. Psychopharmacology. vol 210. issue 2. 2010-08-17. PMID:19859697. |
the mechanisms underlying this effect have not been characterized fully but may have a serotonergic component as kappa agonists also increase the release of serotonin (5-hydroxytryptamine, 5-ht). |
2010-08-17 |
2023-08-12 |
monkey |
| Hanna Viisanen, Antti Pertovaar. Roles of the rostroventromedial medulla and the spinal 5-HT(1A) receptor in descending antinociception induced by motor cortex stimulation in the neuropathic rat. Neuroscience letters. vol 476. issue 3. 2010-08-12. PMID:20398735. |
the results indicate that the rvm and the descending serotonergic pathway acting on the spinal 5-ht(1a) receptor contribute to spinal antinociception induced by m1 stimulation in neuropathic animals. |
2010-08-12 |
2023-08-12 |
rat |
| Ulrike Moser, Wolfgang Wadsak, Christoph Spindelegger, Markus Mitterhauser, Leonhard-Key Mien, Christian Bieglmayer, Kurt Kletter, Siegfried Kasper, Rupert Lanzenberge. Hypothalamic serotonin-1A receptor binding measured by PET predicts the plasma level of dehydroepiandrosterone sulfate in healthy women. Neuroscience letters. vol 476. issue 3. 2010-08-12. PMID:20399839. |
in conclusion, the serotonergic system may influence the dheas plasma level by modulating crh and acth release via hypothalamic 5-ht(1a) receptors as reported for cortisol before. |
2010-08-12 |
2023-08-12 |
human |
| Michael Kellne. Drug treatment of obsessive-compulsive disorder. Dialogues in clinical neuroscience. vol 12. issue 2. 2010-08-12. PMID:20623923. |
serotonergic antidepressants, such as selective serotonin reuptake inhibitors (ssrls) and clomipramine, are the established pharmacologic first-line treatment of ocd. |
2010-08-12 |
2023-08-12 |
Not clear |
| Luciana Oliveira, Frederico G Graeff, Silvia R C Pereira, Ieda F Oliveira-Silva, Glaura C Franco, Angela Maria Ribeir. Correlations among central serotonergic parameters and age-related emotional and cognitive changes assessed through the elevated T-maze and the Morris water maze. Age (Dordrecht, Netherlands). vol 32. issue 2. 2010-08-09. PMID:20431986. |
both thalamic serotonin (5-ht) concentration and amygdala serotonergic activity (5-hiaa/5-ht) are significantly correlated, respectively, to escape latency and behavioural extinction in the mwm only for middle-aged rats. |
2010-08-09 |
2023-08-12 |
human |
| Sikha Saha, Filomena O Gamboa-Esteves, Trevor F C Batte. Differential distribution of 5-HT 1A and 5-HT 1B-like immunoreactivities in rat central nucleus of the amygdala neurones projecting to the caudal dorsomedial medulla oblongata. Brain research. vol 1330. 2010-08-02. PMID:20226766. |
the cea receives a dense serotonergic innervation from the raphé nuclei and expresses several serotonin (5-hydroxytryptamine, 5-ht) receptor subtypes, including the 5-ht(1a) and 5-ht(1b) subtypes. |
2010-08-02 |
2023-08-12 |
rat |
| Feng-Yu Liu, Xiao-Xiu Qu, Xu Ding, Jie Cai, Hong Jiang, You Wan, Ji-Sheng Han, Guo-Gang Xin. Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation. Brain research. vol 1330. 2010-08-02. PMID:20230801. |
the descending serotonergic (5-ht) system is shown to be plastically altered under pathological conditions such as inflammation or peripheral nerve lesion. |
2010-08-02 |
2023-08-12 |
rat |
| Cecilie Löe Licht, Gitte Moos Knudsen, Trevor Shar. Effects of the 5-HT(4) receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels. Neuroscience letters. vol 476. issue 2. 2010-07-30. PMID:20381585. |
the 5-ht(4) receptor modulates activity of serotonergic neurons and is a new potential target for antidepressant treatment. |
2010-07-30 |
2023-08-12 |
rat |
| Kieran Rea, Joost Folgering, Ben H C Westerink, Thomas I F H Cremer. Alpha1-adrenoceptors modulate citalopram-induced serotonin release. Neuropharmacology. vol 58. issue 7. 2010-07-19. PMID:20043931. |
previous studies suggest that noradrenaline may regulate serotonergic (5-ht) neurotransmission at the serotonin cell body and noradrenaline nerve terminal. |
2010-07-19 |
2023-08-12 |
Not clear |
| Pretty Mary Abraham, Jes Paul, C S Paulos. Down regulation of cerebellar serotonergic receptors in streptozotocin induced diabetic rats: Effect of pyridoxine and Aegle marmelose. Brain research bulletin. vol 82. issue 1-2. 2010-07-19. PMID:20170713. |
our results suggest that pyridoxine treated alone and in combination with insulin and a. marmelose has a role in the regulation of insulin synthesis and release, normalizing diabetic related oxidative stress and neurodegeneration affecting the motor ability of an individual by serotonergic receptors through 5-ht(2a) function. |
2010-07-19 |
2023-08-12 |
rat |
| Feng Wei, Ronald Dubner, Shiping Zou, Ke Ren, Guang Bai, Dong Wei, Wei Gu. Molecular depletion of descending serotonin unmasks its novel facilitatory role in the development of persistent pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 25. 2010-07-15. PMID:20573908. |
although 5-ht-containing neurons in the rostral ventromedial medulla (rvm) provide the major descending serotonergic projection to the spinal cord, it is not clear whether the neurotransmitter 5-ht itself released from rvm-spinal neurons contributes to descending pain modulation. |
2010-07-15 |
2023-08-12 |
rat |
| C Javierre, R Segura, J L Ventura, A Suárez, J M Rosé. L-tryptophan supplementation can decrease fatigue perception during an aerobic exercise with supramaximal intercalated anaerobic bouts in young healthy men. The International journal of neuroscience. vol 120. issue 5. 2010-07-14. PMID:20402569. |
modifications in activity levels of the serotonergic system, induced by variations in the availability of l-tryptophan (a serotonin precursor) may alter neural drive. |
2010-07-14 |
2023-08-12 |
human |
| Eamonn J Dickson, Dante J Heredia, Terence K Smit. Critical role of 5-HT1A, 5-HT3, and 5-HT7 receptor subtypes in the initiation, generation, and propagation of the murine colonic migrating motor complex. American journal of physiology. Gastrointestinal and liver physiology. vol 299. issue 1. 2010-07-12. PMID:20413719. |
tonic inhibition of the cm appears to be driven by ongoing activity in descending serotonergic interneurons; by activating 5-ht(7) receptors on ah neurons these interneurons also contribute to the generation of the cmmc. |
2010-07-12 |
2023-08-12 |
Not clear |
| Eva L van Donkelaar, Paul A T Kelly, Neil Dawson, Arjan Blokland, Jos Prickaerts, Harry W M Steinbusch, Linda Ferringto. Acute tryptophan depletion potentiates 3,4-methylenedioxymethamphetamine-induced cerebrovascular hyperperfusion in adult male Wistar rats. Journal of neuroscience research. vol 88. issue 7. 2010-06-30. PMID:19998482. |
the serotonergic (5-hydroxytryptamine; 5-ht) dysfunction found in depression may affect not only brain function (mood) but also cerebrovascular control. |
2010-06-30 |
2023-08-12 |
rat |
| Rachel H Sharpe, John C Vori. Nefazodone in the treatment of patients with post-traumatic stress disorder. Expert review of neurotherapeutics. vol 2. issue 5. 2010-06-28. PMID:19810976. |
through its mechanism inhibiting neuronal uptake of serotonin and norepinephrine and as a potent postsynaptic serotonergic antagonist, nefazodone has proven to be effective in treating post-traumatic stress disorder in several open-label trials. |
2010-06-28 |
2023-08-12 |
Not clear |
| G E Jacobs, J van der Grond, W M Teeuwisse, T J C Langeveld, J van Pelt, J C M Verhagen, M L de Kam, A F Cohen, F G Zitman, J M A van Gerve. Hypothalamic glutamate levels following serotonergic stimulation: a pilot study using 7-Tesla magnetic resonance spectroscopy in healthy volunteers. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 3. 2010-06-24. PMID:20138102. |
the serotonin precursor 5-hydroxytryptophan (5-htp), administered together with carbidopa and granisetron to improve kinetics and reduce adverse effects, acutely enhances central serotonergic neurotransmission and induces hypothalamus-pituitary-adrenal-(hpa) axis activation. |
2010-06-24 |
2023-08-12 |
human |