| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karly P Garnock-Jones, Paul L McCormac. Escitalopram: a review of its use in the management of major depressive disorder in adults. CNS drugs. vol 24. issue 9. 2010-12-13. PMID:20806989. |
escitalopram (escitalopram oxalate; cipralex, lexapro), a selective serotonin reuptake inhibitor (ssri) indicated for the treatment of major depressive disorder (mdd), demonstrates a highly selective and potent, dose-dependent inhibition of the human serotonin transporter, inhibiting serotonin reuptake into presynaptic nerve terminals and thus increasing serotonergic activity in the cns. |
2010-12-13 |
2023-08-12 |
human |
| Ryuji Yajima, Kensaku Kasuga, Tomoe Sato, Takeshi Ikeuchi, Masatoyo Nishizaw. [A case of amyotrophic lateral sclerosis/frontotemporal lobar degeneration with apraxia of eyelid opening]. Rinsho shinkeigaku = Clinical neurology. vol 50. issue 9. 2010-12-13. PMID:20960930. |
because serotonin receptors are markedly reduced in the frontal and temporal cortexes of patients with ftld, we considered that dysfunction of the serotonergic system in the frontotemporal lobe caused aeo. |
2010-12-13 |
2023-08-12 |
Not clear |
| Karolina Rogozinska, Jolanta Skangiel-Kramsk. Effect of focal cerebral ischaemia on modulatory neurotransmitter receptors in the rat brain: an autoradiographic study. Journal of chemical neuroanatomy. vol 40. issue 3. 2010-12-10. PMID:20600826. |
in this study, muscarinic cholinergic, serotonergic 5-ht(2a/2c), dopaminergic d(1) and noradrenergic beta(1) receptors were examined after focal cerebral ischaemia in different brain regions, using quantitative in vitro autoradiography. |
2010-12-10 |
2023-08-12 |
rat |
| Karolina Rogozinska, Jolanta Skangiel-Kramsk. Effect of focal cerebral ischaemia on modulatory neurotransmitter receptors in the rat brain: an autoradiographic study. Journal of chemical neuroanatomy. vol 40. issue 3. 2010-12-10. PMID:20600826. |
in contrast, in remote brain regions, a bilateral increase of serotonergic 5-ht(2a/2c) receptor binding in the somatosensory cortex at the striatum level is observed after 4h and after 7 days post-stroke. |
2010-12-10 |
2023-08-12 |
rat |
| Mark J Millan, Anne Dekeyne, Alain Gobert, Clotilde Mannoury la Cour, Mauricette Brocco, Jean-Michel Rivet, Benjamin Di Cara, Françoise Lejeune, Thomas I Cremers, Gunnar Flik, Trynke R de Jong, Berend Olivier, Guillaume de Nanteui. S41744, a dual neurokinin (NK)1 receptor antagonist and serotonin (5-HT) reuptake inhibitor with potential antidepressant properties: a comparison to aprepitant (MK869) and paroxetine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 9. 2010-12-08. PMID:20483567. |
further, s41744 increased extracellular levels of 5-ht in frontal cortex and hippocampus of rats to a greater extent than paroxetine, and its inhibitory influence upon serotonergic perikarya was blunted relative to its affinity for 5-ht transporters. |
2010-12-08 |
2023-08-12 |
mouse |
| Cristiane Luchese, Marina Prigol, Carmine Inês Acker, Cristina Wayne Nogueir. Antinociceptive effect of butyl (2-phenylethynyl) selenide on formalin test in mice: Evidences for the involvement of serotonergic and adenosinergic systems. European journal of pharmacology. vol 644. issue 1-3. 2010-12-07. PMID:20621089. |
these results indicate that butyl (2-phenylethynyl) selenide produced antinociception in the formalin test through mechanisms that involve an interaction with serotonergic (5-ht(3)) and adenosinergic systems. |
2010-12-07 |
2023-08-12 |
mouse |
| Francis Rodriguez Bambico, Tommaso Cassano, Sergio Dominguez-Lopez, Noam Katz, Claire Dominique Walker, Daniele Piomelli, Gabriella Gobb. Genetic deletion of fatty acid amide hydrolase alters emotional behavior and serotonergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 10. 2010-12-06. PMID:20571484. |
using behavioral and electrophysiological approaches, we have characterized the emotional phenotype and serotonergic (5-ht) activity of mice lacking the faah gene in comparison to their wild type counterparts, and their response to a challenge of the cb(1)r antagonist, rimonabant. |
2010-12-06 |
2023-08-12 |
mouse |
| Jan C Beucke, Idun Uhl, Michail Plotkin, Christine Winter, Hans-Jörg Assion, Tanja Endrass, Holger Amthauer, Andreas Kupsch, Georg Jucke. Serotonergic neurotransmission in early Parkinson's disease: a pilot study to assess implications for depression in this disorder. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 11. issue 6. 2010-12-06. PMID:20586535. |
we aimed to investigate the interaction between serotonergic (5-ht) and dopaminergic activity in early pd. |
2010-12-06 |
2023-08-12 |
Not clear |
| M Wienberg, B Y Glenthoj, K S Jensen, B Oranj. A single high dose of escitalopram increases mismatch negativity without affecting processing negativity or P300 amplitude in healthy volunteers. Journal of psychopharmacology (Oxford, England). vol 24. issue 8. 2010-12-02. PMID:19304862. |
results support the view that a broad range of increased serotonergic activity enhances mmn, while the relationship between serotonin and pn seems more complex. |
2010-12-02 |
2023-08-12 |
human |
| Philippe Huot, Tom H Johnston, Tayyeba Darr, Lili-Naz Hazrati, Naomi P Visanji, Donna Pires, Jonathan M Brotchie, Susan H Fo. Increased 5-HT2A receptors in the temporal cortex of parkinsonian patients with visual hallucinations. Movement disorders : official journal of the Movement Disorder Society. vol 25. issue 10. 2010-12-02. PMID:20629135. |
serotonergic type 2a (5-ht(2a)) receptors have been linked to many psychiatric disorders, including psychosis. |
2010-12-02 |
2023-08-12 |
Not clear |
| Damanpreet Singh, Rajesh Kumar Goe. Proconvulsant potential of cyproheptadine in experimental animal models. Fundamental & clinical pharmacology. vol 24. issue 4. 2010-11-30. PMID:20002750. |
however, the study of serotonergic and histaminergic pathway shows that the decreased neurotransmission of serotonin and histamine in the brain reduces seizures threshold. |
2010-11-30 |
2023-08-12 |
mouse |
| Nicola Pavese, Vinod Metta, Subrata K Bose, Kallol Ray Chaudhuri, David J Brook. Fatigue in Parkinson's disease is linked to striatal and limbic serotonergic dysfunction. Brain : a journal of neurology. vol 133. issue 11. 2010-11-30. PMID:20884645. |
we used ¹⁸f-dopa and ¹¹c-dasb [n,n-dimethyl-2-(2-amino-4-cyanophenylthio) benzylamine] positron emission tomography, markers of dopamine storage capacity and serotonin transporter availability, to investigate whether fatigue in parkinson's disease is associated with dopaminergic and serotonergic dysfunction in basal ganglia and limbic circuits. |
2010-11-30 |
2023-08-12 |
Not clear |
| Andreas Hahn, Rupert Lanzenberger, Wolfgang Wadsak, Christoph Spindelegger, Uirike Moser, Leonhard-Key Mien, Markus Mitterhauser, Siegfried Kaspe. Escitalopram enhances the association of serotonin-1A autoreceptors to heteroreceptors in anxiety disorders. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 43. 2010-11-30. PMID:20980606. |
by blocking the serotonin transporter, ssris modulate serotonergic neurotransmission as well as the function of autoreceptors and heteroreceptors. |
2010-11-30 |
2023-08-12 |
human |
| Daniele Focosi, Tuccori Marco, Richard Eric Kast, Fabrizio Maggi, Luca Ceccherini-Nelli, Mario Petrin. Progressive multifocal leukoencephalopathy: what's new? The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 16. issue 3. 2010-11-29. PMID:20479473. |
pml is caused by reactivation of latent jc virus, and serotonergic 5-ht(2a) receptors have been identified as being critical for viral infection of glial cells. |
2010-11-29 |
2023-08-12 |
human |
| F J Gracia-Llanes, J M Blasco-Ibáñez, J Nácher, E Varea, T Liberia, P Martínez, F J Martínez-Guijarro, C Cresp. Synaptic connectivity of serotonergic axons in the olfactory glomeruli of the rat olfactory bulb. Neuroscience. vol 169. issue 2. 2010-11-23. PMID:20493930. |
although the major mode of transmission for serotonin in the brain is volume transmission, previous anatomical studies have demonstrated that serotonergic axons do form synaptic contacts. |
2010-11-23 |
2023-08-12 |
rat |
| Matthew L Banks, Kenner C Rice, S Stevens Negu. Antinociceptive interactions between Mu-opioid receptor agonists and the serotonin uptake inhibitor clomipramine in rhesus monkeys: role of Mu agonist efficacy. The Journal of pharmacology and experimental therapeutics. vol 335. issue 2. 2010-11-23. PMID:20675432. |
serotonergic systems also modulate nociception, and serotonin uptake inhibitors may be useful as adjuncts to enhance analgesic effects and/or attenuate undesirable effects of mu agonists. |
2010-11-23 |
2023-08-12 |
monkey |
| Theresa M Szabo, Jonathan S Caplan, Mark J Zora. Serotonin regulates electrical coupling via modulation of extrajunctional conductance: H-current. Brain research. vol 1349. 2010-11-22. PMID:20599836. |
serotonin (5-hydroxytryptomine; 5ht) and serotonergic signaling pathways are important regulators of animal behavior and are pharmacological targets in a wide range of neurological disorders. |
2010-11-22 |
2023-08-12 |
human |
| Nanna H Jensen, Thomas I Cremers, Florence Sott. Therapeutic potential of 5-HT2C receptor ligands. TheScientificWorldJournal. vol 10. 2010-11-16. PMID:20852829. |
a large body of evidence supports a critical role of serotonin 2c receptors in mediating the interaction between serotonergic and dopaminergic systems, which is at the basis of their proposed involvement in the regulation of mood, affective behavior, and memory. |
2010-11-16 |
2023-08-12 |
Not clear |
| Stefan Bollinger, Harald Hübner, Frank W Heinemann, Karsten Meyer, Peter Gmeine. Novel pyridylmethylamines as highly selective 5-HT(1A) superagonists. Journal of medicinal chemistry. vol 53. issue 19. 2010-11-09. PMID:20860381. |
to further improve the maximal serotonergic efficacy and better understand the configurational requirements for 5-ht(1a) binding and activation, we generated and biologically investigated structural variants of the lead structure befiradol. |
2010-11-09 |
2023-08-12 |
Not clear |
| Miguel Skirzewski, Luis Hernandez, Lee E Schechter, Pedro Rad. Acute lecozotan administration increases learning and memory in rats without affecting anxiety or behavioral depression. Pharmacology, biochemistry, and behavior. vol 95. issue 3. 2010-11-01. PMID:20170670. |
lecozotan is a selective serotonergic 5-ht(1a) receptor antagonist previously shown to enhance task performance efficiency in aged rhesus monkeys. |
2010-11-01 |
2023-08-12 |
rat |