| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eugene Oh, Takashi Maejima, Chen Liu, Evan Deneris, Stefan Herlitz. Substitution of 5-HT1A receptor signaling by a light-activated G protein-coupled receptor. The Journal of biological chemistry. vol 285. issue 40. 2010-10-26. PMID:20643652. |
understanding serotonergic (5-ht) signaling is critical for understanding human physiology, behavior, and neuropsychiatric disease. |
2010-10-26 |
2023-08-12 |
mouse |
| Daniel R Rosell, Judy L Thompson, Mark Slifstein, Xiaoyan Xu, W Gordon Frankle, Antonia S New, Marianne Goodman, Shauna R Weinstein, Marc Laruelle, Anissa Abi-Dargham, Larry J Sieve. Increased serotonin 2A receptor availability in the orbitofrontal cortex of physically aggressive personality disordered patients. Biological psychiatry. vol 67. issue 12. 2010-10-25. PMID:20434136. |
the serotonergic system is known to be involved in the pathophysiology of aggression, and multiple lines of evidence have implicated the serotonin 2a receptor (5-ht(2a)r). |
2010-10-25 |
2023-08-12 |
Not clear |
| Daniel R Rosell, Judy L Thompson, Mark Slifstein, Xiaoyan Xu, W Gordon Frankle, Antonia S New, Marianne Goodman, Shauna R Weinstein, Marc Laruelle, Anissa Abi-Dargham, Larry J Sieve. Increased serotonin 2A receptor availability in the orbitofrontal cortex of physically aggressive personality disordered patients. Biological psychiatry. vol 67. issue 12. 2010-10-25. PMID:20434136. |
we sought to examine the role of the 5-ht(2a)r in impulsive aggression specifically in the orbitofrontal cortex (ofc), given that our own studies and an extensive literature indicate that serotonergic disturbances in the ofc are linked to aggression. |
2010-10-25 |
2023-08-12 |
Not clear |
| Leigh-Anne Dell, Jean-Leigh Kruger, Adhil Bhagwandin, Ngalla E Jillani, John D Pettigrew, Paul R Mange. Nuclear organization of cholinergic, putative catecholaminergic and serotonergic systems in the brains of two megachiropteran species. Journal of chemical neuroanatomy. vol 40. issue 2. 2010-10-25. PMID:20566331. |
the nuclear organization of the cholinergic, putative catecholaminergic and serotonergic systems within the brains of the megachiropteran straw-coloured fruit bat (eidolon helvum) and wahlberg's epauletted fruit bat (epomophorus wahlbergi) were identified following immunohistochemistry for cholineacetyltransferase, tyrosine hydroxylase and serotonin. |
2010-10-25 |
2023-08-12 |
Not clear |
| Hiroki Sato, Ivan Skelin, Mirko Diksi. Chronic buspirone treatment decreases 5-HT1B receptor densities and the serotonin transporter but increases the density of 5-HT2A receptors in the bulbectomized rat model of depression: an autoradiographic study. Brain research. vol 1345. 2010-10-21. PMID:20501324. |
the deregulation of the serotonergic (5-ht) system is implicated in the pathophysiology of depression. |
2010-10-21 |
2023-08-12 |
rat |
| Chen Liu, Takashi Maejima, Steven C Wyler, Gemma Casadesus, Stefan Herlitze, Evan S Deneri. Pet-1 is required across different stages of life to regulate serotonergic function. Nature neuroscience. vol 13. issue 10. 2010-10-20. PMID:20818386. |
pet-1 was still required in adult 5-ht neurons to preserve normal anxiety-related behaviors through direct autoregulated control of serotonergic gene expression. |
2010-10-20 |
2023-08-12 |
mouse |
| Tatjana Bordukalo-Niksic, Gordana Mokrovic, Jasminka Stefulj, Marko Zivin, Branimir Jernej, Lipa Cicin-Sai. 5HT-1A receptors and anxiety-like behaviours: studies in rats with constitutionally upregulated/downregulated serotonin transporter. Behavioural brain research. vol 213. issue 2. 2010-10-19. PMID:20457184. |
altered activity of brain serotonergic (5ht) system has been implicated in a wide range of behaviours and behavioural disorders, including anxiety. |
2010-10-19 |
2023-08-12 |
rat |
| Tatjana Bordukalo-Niksic, Gordana Mokrovic, Jasminka Stefulj, Marko Zivin, Branimir Jernej, Lipa Cicin-Sai. 5HT-1A receptors and anxiety-like behaviours: studies in rats with constitutionally upregulated/downregulated serotonin transporter. Behavioural brain research. vol 213. issue 2. 2010-10-19. PMID:20457184. |
here, we studied serotonergic modulation of anxiety-like behaviour using a genetic rat model with constitutional differences in 5ht homeostasis, named wistar-zagreb 5ht (wz-5ht) rats. |
2010-10-19 |
2023-08-12 |
rat |
| Joachim Frost, Pål Sandvik, Olav Spigse. [Sexual dysfunction induced by antidepressants]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. vol 130. issue 19. 2010-10-19. PMID:20930882. |
about 40% of all patients treated with selective serotonin reuptake inhibitors, or other serotonergic agents, report such effects. |
2010-10-19 |
2023-08-12 |
Not clear |
| Bibiana M Gay, Marina Prigol, André L Stein, Cristina W Nogueir. Antidepressant-like pharmacological profile of 3-(4-fluorophenylselenyl)-2,5-diphenylselenophene: Involvement of serotonergic system. Neuropharmacology. vol 59. issue 3. 2010-10-14. PMID:20488195. |
these results suggest that dps produced an antidepressant-like effect in the mouse fst and tst and this effect seems most likely to be mediated through an interaction with serotonergic system, particularly by 5-ht reuptake inhibition. |
2010-10-14 |
2023-08-12 |
mouse |
| Julie L Wang, Eric C Deutsch, Shunichi Oya, Hank F Kun. FlipADAM: a potential new SPECT imaging agent for the serotonin transporter. Nuclear medicine and biology. vol 37. issue 5. 2010-10-14. PMID:20610162. |
single photon emission computed tomography (spect) imaging of the serotonin transporter (sert) in the brain is a useful tool for examining normal physiological functions and disease states involving the serotonergic system. |
2010-10-14 |
2023-08-12 |
Not clear |
| E A T Evers, A Sambeth, J G Ramaekers, W J Riedel, F M van der Vee. The effects of acute tryptophan depletion on brain activation during cognition and emotional processing in healthy volunteers. Current pharmaceutical design. vol 16. issue 18. 2010-10-08. PMID:20370668. |
acute tryptophan depletion (atd), a method to temporarily lower central serotonin levels, has been used to study the functioning of the serotonergic system. |
2010-10-08 |
2023-08-12 |
human |
| D Erritzoe, V G Frokjaer, M T Haahr, J Kalbitzer, C Svarer, K K Holst, D L Hansen, T L Jernigan, S Lehel, G M Knudse. Cerebral serotonin transporter binding is inversely related to body mass index. NeuroImage. vol 52. issue 1. 2010-09-30. PMID:20382236. |
serotonergic neurotransmission is critically involved in eating behaviour; cerebral level of serotonin (5-ht) in animal models is inversely related to food intake and body weight and some effective anti-obesity agents involve blockade of the serotonin transporter (sert). |
2010-09-30 |
2023-08-12 |
human |
| D Erritzoe, V G Frokjaer, M T Haahr, J Kalbitzer, C Svarer, K K Holst, D L Hansen, T L Jernigan, S Lehel, G M Knudse. Cerebral serotonin transporter binding is inversely related to body mass index. NeuroImage. vol 52. issue 1. 2010-09-30. PMID:20382236. |
whether the sert has a direct role in the regulation of appetite and eating behaviour or whether the finding is due to a compensatory downregulation of sert secondary to other dysfunction(s) in the serotonergic transmitter system, such as low baseline serotonin levels, remains to be established. |
2010-09-30 |
2023-08-12 |
human |
| Anne Baudry, Juliette Bitard, Sophie Mouillet-Richard, Morgane Locker, Anne Poliard, Jean-Marie Launay, Odile Kellerman. Serotonergic 5-HT(2B) receptor controls tissue-nonspecific alkaline phosphatase activity in osteoblasts via eicosanoids and phosphatidylinositol-specific phospholipase C. The Journal of biological chemistry. vol 285. issue 34. 2010-09-30. PMID:20573958. |
serotonergic 5-ht(2b) receptor controls tissue-nonspecific alkaline phosphatase activity in osteoblasts via eicosanoids and phosphatidylinositol-specific phospholipase c. in previous studies, we observed that mice knocked out for the serotonin-2b receptor (5-ht(2b)r) show defects in bone homeostasis. |
2010-09-30 |
2023-08-12 |
mouse |
| Gonzalo Laje, Dara M Cannon, Andrew S Allen, Jackie M Klaver, Summer A Peck, Xinmin Liu, Husseini K Manji, Wayne C Drevets, Francis J McMaho. Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASB. The international journal of neuropsychopharmacology. vol 13. issue 6. 2010-09-29. PMID:20047709. |
since chronic administration of citalopram, which selectively and potently inhibits the serotonin transporter (5-htt), putatively enhances serotonergic transmission, it is conceivable that genetic variation within htr2a also influences pretreatment 5-htt function or serotonergic transmission. |
2010-09-29 |
2023-08-12 |
human |
| Tomoyuki Saijo, Akihiro Takano, Tetsuya Suhara, Ryosuke Arakawa, Masaki Okumura, Tetsuya Ichimiya, Hiroshi Ito, Yoshiro Okub. Effect of electroconvulsive therapy on 5-HT1A receptor binding in patients with depression: a PET study with [11C]WAY 100635. The international journal of neuropsychopharmacology. vol 13. issue 6. 2010-09-29. PMID:20067660. |
although many animal studies have focused on the effect of ect on serotonergic neurotransmission, no human study has directly examined the effect of ect on brain serotonin [5-hydroxytryptamine (5-ht)] 1a receptors (5-ht1ars). |
2010-09-29 |
2023-08-12 |
human |
| B M Ruf, Z Bhagwaga. The 5-HT1B receptor: a novel target for the pathophysiology of depression. Current drug targets. vol 10. issue 11. 2010-09-27. PMID:19702551. |
the serotonergic (5-ht) system has been widely implicated in the pathophysiology of major depressive disorder (mdd). |
2010-09-27 |
2023-08-12 |
rat |
| Ken-ichi Ohta, Hiromi Sakata-Haga, Yoshihiro Fuku. Alteration in anxiety-related behaviors and reduction of serotonergic neurons in raphe nuclei in adult rats prenatally exposed to ethanol. Congenital anomalies. vol 50. issue 2. 2010-09-27. PMID:20156240. |
because serotonin has multiple functions in both mature and immature brains, disturbance of the serotonergic system by ethanol exposure in utero can be cause of a wide range of psychiatric problems in adulthood. |
2010-09-27 |
2023-08-12 |
rat |
| Elizabeth A Daubert, Daniel S Heffron, James W Mandell, Barry G Condro. Serotonergic dystrophy induced by excess serotonin. Molecular and cellular neurosciences. vol 44. issue 3. 2010-09-27. PMID:20394820. |
serotonergic dystrophy induced by excess serotonin. |
2010-09-27 |
2023-08-12 |
drosophila_melanogaster |