| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alejandra R Alvarez, Andrés Klein, Juan Castro, Gonzalo I Cancino, Julio Amigo, Matías Mosqueira, Lina M Vargas, L Fernanda Yévenes, Francisca C Bronfman, Silvana Zanlung. Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 10. 2008-10-21. PMID:18591368. |
furthermore, inhibition of c-abl with imatinib preserved purkinje neurons and reduced general cell apoptosis in the cerebellum, improved neurological symptoms, and increased the survival of npc mice. |
2008-10-21 |
2023-08-12 |
mouse |
| Karina Alviña, Kamran Khodakha. Selective regulation of spontaneous activity of neurons of the deep cerebellar nuclei by N-type calcium channels in juvenile rats. The Journal of physiology. vol 586. issue 10. 2008-10-13. PMID:18372310. |
the main output of the cerebellum is formed by three deep nuclei, which receive direct inhibitory inputs from cerebellar purkinje cells, and excitatory collaterals from mossy and climbing fibres. |
2008-10-13 |
2023-08-12 |
rat |
| Markus Kessler, Bryant Kiliman, Carrie Humes, Amy C Ara. Spontaneous activity in Purkinje cells: multi-electrode recording from organotypic cerebellar slice cultures. Brain research. vol 1218. 2008-10-08. PMID:18533133. |
spontaneous activity in purkinje cells: multi-electrode recording from organotypic cerebellar slice cultures. |
2008-10-08 |
2023-08-12 |
Not clear |
| Lisa A Thomas, Michael R Akins, Thomas Biedere. Expression and adhesion profiles of SynCAM molecules indicate distinct neuronal functions. The Journal of comparative neurology. vol 510. issue 1. 2008-09-30. PMID:18615557. |
this is observed in all regions analyzed and is particularly notable in the cerebellum, where syncams display highly distinct expression in cerebellar granule and purkinje cells. |
2008-09-30 |
2023-08-12 |
mouse |
| Simon Hong, Lance M Optica. Interaction between Purkinje cells and inhibitory interneurons may create adjustable output waveforms to generate timed cerebellar output. PloS one. vol 3. issue 7. 2008-09-24. PMID:18648667. |
interaction between purkinje cells and inhibitory interneurons may create adjustable output waveforms to generate timed cerebellar output. |
2008-09-24 |
2023-08-12 |
Not clear |
| Yara M R Müller, Lilianna B D Rivero, Márcia C Carvalho, Karoline Kobus, Marcelo Farina, Evelise M Nazar. Behavioral impairments related to lead-induced developmental neurotoxicity in chicks. Archives of toxicology. vol 82. issue 7. 2008-09-19. PMID:18157517. |
lead impregnation was observed in both mesencephalon and cerebellum and the cerebellar molecular layer presented higher lead deposition in comparison to granular layer and purkinje cells. |
2008-09-19 |
2023-08-12 |
Not clear |
| Sefa Gulturk, Ramazan Kozan, M Omer Bostanci, Fatih Sefil, Faruk Bagiric. Inhibition of neuronal nitric oxide synthase prevents iron-induced cerebellar Purkinje cell loss in the rat. Acta neurobiologiae experimentalis. vol 68. issue 1. 2008-09-19. PMID:18389011. |
means (value +/- standard deviation) of the total numbers of purkinje cells in the cerebellum were estimated as 337 +/- 23, 209 +/- 16, 167 +/- 19, 305 +/- 26, and 265 +/- 14 thousands in the control, iron, iron plus l-arg, iron plus 7-ni, and iron plus l-arg plus 7-ni groups, respectively. |
2008-09-19 |
2023-08-12 |
rat |
| Ujjwal K Rout, Dirk M Dhossch. A pathogenetic model of autism involving Purkinje cell loss through anti-GAD antibodies. Medical hypotheses. vol 71. issue 2. 2008-09-19. PMID:18514431. |
selective loss of purkinje cells and the cerebellar atrophies are the neurological abnormalities most consistently found in persons diagnosed with autism. |
2008-09-19 |
2023-08-12 |
Not clear |
| Jayanth Ramadoss, Emilie R Lunde, Nengtai Ouyang, Wei-Jung A Chen, Timothy A Cud. Acid-sensitive channel inhibition prevents fetal alcohol spectrum disorders cerebellar Purkinje cell loss. American journal of physiology. Regulatory, integrative and comparative physiology. vol 295. issue 2. 2008-09-09. PMID:18509098. |
we determined immunohistochemically that task 1 channels are expressed in purkinje cells and that the task 3 isoform is expressed in granule cells of the ovine fetal cerebellum. |
2008-09-09 |
2023-08-12 |
human |
| Masanobu Kano, Kouichi Hashimoto, Toshihide Tabat. Type-1 metabotropic glutamate receptor in cerebellar Purkinje cells: a key molecule responsible for long-term depression, endocannabinoid signalling and synapse elimination. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 363. issue 1500. 2008-09-03. PMID:18339599. |
it was also found that mglur1 and its downstream signal transduction in purkinje cells are indispensable for the elimination of redundant synapses during post-natal cerebellar development. |
2008-09-03 |
2023-08-12 |
Not clear |
| Tomonori Takeuchi, Gen Ohtsuki, Takashi Yoshida, Masahiro Fukaya, Tasuku Wainai, Manami Yamashita, Yoshito Yamazaki, Hisashi Mori, Kenji Sakimura, Susumu Kawamoto, Masahiko Watanabe, Tomoo Hirano, Masayoshi Mishin. Enhancement of both long-term depression induction and optokinetic response adaptation in mice lacking delphilin. PloS one. vol 3. issue 5. 2008-09-02. PMID:18509461. |
in the cerebellum, delphilin is expressed selectively in purkinje cells (pcs) and is localized exclusively at parallel fiber (pf) synapses, where it interacts with glutamate receptor (glur) delta2 that is essential for long-term depression (ltd), motor learning and cerebellar wiring. |
2008-09-02 |
2023-08-12 |
mouse |
| Jenny T Davie, Beverley A Clark, Michael Häusse. The origin of the complex spike in cerebellar Purkinje cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 30. 2008-09-02. PMID:18650337. |
to investigate the relationship between dendritic spikes and the spikelets within the somatic complex spike, and to evaluate the importance of the dendritic distribution of climbing fiber synapses, we made simultaneous somatic and dendritic patch-clamp recordings from purkinje cells in cerebellar slices. |
2008-09-02 |
2023-08-12 |
Not clear |
| Nazanin Majdzadeh, Lulu Wang, Brad E Morrison, Rhonda Bassel-Duby, Eric N Olson, Santosh R D'Mell. HDAC4 inhibits cell-cycle progression and protects neurons from cell death. Developmental neurobiology. vol 68. issue 8. 2008-08-22. PMID:18498087. |
mice-lacking hdac4 have elevated cdk1 activity and display cerebellar abnormalities including a progressive loss of purkinje neurons postnatally in posterior lobes. |
2008-08-22 |
2023-08-12 |
Not clear |
| Youngki Lee, Julie Rowe, Kyle Eskue, James R West, Susan E Maie. Alcohol exposure on postnatal day 5 induces Purkinje cell loss and evidence of Purkinje cell degradation in lobule I of rat cerebellum. Alcohol (Fayetteville, N.Y.). vol 42. issue 4. 2008-08-20. PMID:18400452. |
at the end of 24h, stereology cell counting techniques were used to estimate the number of purkinje cells in lobule i of the cerebellum. |
2008-08-20 |
2023-08-12 |
rat |
| Sarah Marti, Dominik Straumann, Ulrich Büttner, Stefan Glasaue. A model-based theory on the origin of downbeat nystagmus. Experimental brain research. vol 188. issue 4. 2008-08-20. PMID:18463856. |
we propose a new hypothesis, which explains the ocular motor signs of dbn by damage of the inhibitory vertical gaze-velocity sensitive purkinje cells (pcs) in the cerebellar flocculus (fl). |
2008-08-20 |
2023-08-12 |
human |
| Ulrich F O Luhmann, John Neidhardt, Barbara Kloeckener-Gruissem, Nikolaus F Schäfer, Esther Glaus, Silke Feil, Wolfgang Berge. Vascular changes in the cerebellum of Norrin /Ndph knockout mice correlate with high expression of Norrin and Frizzled-4. The European journal of neuroscience. vol 27. issue 10. 2008-08-20. PMID:18547247. |
vessel density was reduced in the cerebellum of ndph knockout mice but the number of purkinje and granular cells was not altered. |
2008-08-20 |
2023-08-12 |
mouse |
| L-M Chen, M L Kelly, M D Parker, P Bouyer, H S Gill, J M Felie, B A Davis, W F Boro. Expression and localization of Na-driven Cl-HCO(3)(-) exchanger (SLC4A8) in rodent CNS. Neuroscience. vol 153. issue 1. 2008-08-18. PMID:18359573. |
by immunohistochemistry, the ap antibody recognizes high levels of ndcbe in neurons of cx, hc (including pyramidal neurons in cornu ammonis (ca)1-3 and dentate gyrus), substantial nigra, medulla, cerebellum (especially purkinje and granular cells), and the basolateral membrane of fetal choroid plexus. |
2008-08-18 |
2023-08-12 |
mouse |
| Hai-xia Lu, Hannah Levis, Nabil Melhem, Terry Parke. Toxin-produced Purkinje cell death: a model for neural stem cell transplantation studies. Brain research. vol 1207. 2008-08-13. PMID:18374311. |
quantification of cresyl violet stained sections showed that purkinje cells were preferentially lost in the cerebellar vermis and specifically in folia vi to ix (p<0.001-0.05). |
2008-08-13 |
2023-08-12 |
rat |
| Hai-xia Lu, Hannah Levis, Nabil Melhem, Terry Parke. Toxin-produced Purkinje cell death: a model for neural stem cell transplantation studies. Brain research. vol 1207. 2008-08-13. PMID:18374311. |
the results of the present study show that the penitrem a can remove purkinje cells in the immature rat cerebellum and thus provide a potential model to study the micro-environmental cues in vivo for the differentiation of purkinje cells from transplanted and/or intrinsic neural stem cells. |
2008-08-13 |
2023-08-12 |
rat |
| Dana-Lynn T Koomoa, Ramon Christopher V Go, Kenneth Wester, André S Bachman. Expression profile of PRAF2 in the human brain and enrichment in synaptic vesicles. Neuroscience letters. vol 436. issue 2. 2008-08-13. PMID:18395978. |
analysis by immunohistochemistry revealed that in the human cerebellum, the praf2 protein was strongly expressed in purkinje cells and, more moderately, in cells of the molecular and the granular layers. |
2008-08-13 |
2023-08-12 |
human |