| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tetsushi Sadakata, Wataru Kakegawa, Akira Mizoguchi, Miwa Washida, Ritsuko Katoh-Semba, Fumihiro Shutoh, Takehito Okamoto, Hisako Nakashima, Kazushi Kimura, Mika Tanaka, Yukiko Sekine, Shigeyoshi Itohara, Michisuke Yuzaki, Soichi Nagao, Teiichi Furuich. Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 10. 2007-04-09. PMID:17344385. |
here we report that caps2 knock-out mice are deficient in the release of nt-3 and bdnf, and they consequently exhibit suppressed phosphorylation of trk receptors in the cerebellum; these mice exhibit pronounced impairments in cerebellar development and functions, including neuronal survival, differentiation and migration of postmitotic granule cells, dendritogenesis of purkinje cells, lobulation between lobules vi and vii, structure and vesicular distribution of parallel fiber-purkinje cell synapses, paired-pulse facilitation at parallel fiber-purkinje cell synapses, rotarod motor coordination, and eye movement plasticity in optokinetic training. |
2007-04-09 |
2023-08-12 |
mouse |
| Ceri E Oldreive, Gayle H Dohert. Neurotoxic effects of homocysteine on cerebellar Purkinje neurons in vitro. Neuroscience letters. vol 413. issue 1. 2007-04-05. PMID:17157438. |
whilst a plethora of studies that describe the toxicity of homocysteine to cns neurons have been published, the effects of homocysteine on the purkinje neurons of the cerebellum that play a vital role in motor function remain wholly unexplored. |
2007-04-05 |
2023-08-12 |
Not clear |
| Satoko Tokuda, Takashi Kuramoto, Kenta Tanaka, Shuji Kaneko, Ikuo K Takeuchi, Masashi Sasa, Tadao Serikaw. The ataxic groggy rat has a missense mutation in the P/Q-type voltage-gated Ca2+ channel alpha1A subunit gene and exhibits absence seizures. Brain research. vol 1133. issue 1. 2007-04-05. PMID:17196942. |
adults show a reduction in size of the cerebellum and presynaptic and axon terminal abnormalities of purkinje cells. |
2007-04-05 |
2023-08-12 |
mouse |
| Natalia V Gounko, Dharamdajal Kalicharan, Vasily Rybakin, Albert Gramsbergen, Johannes J L van der Wan. The dynamic developmental localization of the full-length corticotropin-releasing factor receptor type 2 in rat cerebellum. The European journal of neuroscience. vol 23. issue 12. 2007-04-03. PMID:16820012. |
corticotropin releasing factor receptor 2 (crf-r2) is strongly expressed in the cerebellum and plays an important role in the development of the cerebellar circuitry, particularly in the development of the dendritic trees and afferent input to purkinje cells. |
2007-04-03 |
2023-08-12 |
rat |
| Kenji Yamamoto, Mitsuo Kawato, Shinya Kotosaka, Shigeru Kitazaw. Encoding of movement dynamics by Purkinje cell simple spike activity during fast arm movements under resistive and assistive force fields. Journal of neurophysiology. vol 97. issue 2. 2007-04-02. PMID:17079350. |
these results show that simple-spike activity of at least a group of purkinje cells in the intermediate part of cerebellar lobules v-vi encodes movement dynamics. |
2007-04-02 |
2023-08-12 |
monkey |
| Osamu Yokota, Kuniaki Tsuchiya, Seishi Terada, Kenichi Oshima, Hideki Ishizu, Masaaki Matsushita, Shigetoshi Kuroda, Haruhiko Akiyam. Frequency and clinicopathological characteristics of alcoholic cerebellar degeneration in Japan: a cross-sectional study of 1,509 postmortems. Acta neuropathologica. vol 112. issue 1. 2007-03-29. PMID:16622656. |
in acd cases, loss of purkinje cells, narrowing of the width of the molecular layer, and tissue rarefaction in the granular layer were observed in the anterior and superior portions of the vermis of the cerebellum. |
2007-03-29 |
2023-08-12 |
human |
| Kailash Manda, Megumi Ueno, Takashi Moritake, Kazunori Anza. Radiation-induced cognitive dysfunction and cerebellar oxidative stress in mice: protective effect of alpha-lipoic acid. Behavioural brain research. vol 177. issue 1. 2007-03-27. PMID:17145083. |
moreover, alpha-lipoic acid treated mice showed an intact cytoarchitecture of cerebellum, higher counts of intact purkinje cells and granular cells in comparison to untreated irradiated mice. |
2007-03-27 |
2023-08-12 |
mouse |
| Alfredo Gimenez-Cassina, Filip Lim, Javier Diaz-Nid. Gene transfer into Purkinje cells using herpesviral amplicon vectors in cerebellar cultures. Neurochemistry international. vol 50. issue 1. 2007-03-20. PMID:16989924. |
gene transfer into purkinje cells using herpesviral amplicon vectors in cerebellar cultures. |
2007-03-20 |
2023-08-12 |
mouse |
| Alfredo Gimenez-Cassina, Filip Lim, Javier Diaz-Nid. Gene transfer into Purkinje cells using herpesviral amplicon vectors in cerebellar cultures. Neurochemistry international. vol 50. issue 1. 2007-03-20. PMID:16989924. |
here we report an easy, robust and reproducible method to obtain purkinje-enriched mixed cerebellar cell cultures from day 16 mouse embryos using papain digestion and a semi-defined culture medium, being the composition of the culture approximately 20% purkinje cells, 70% non-purkinje neurons and 10% glial cells. |
2007-03-20 |
2023-08-12 |
mouse |
| Alfredo Gimenez-Cassina, Filip Lim, Javier Diaz-Nid. Gene transfer into Purkinje cells using herpesviral amplicon vectors in cerebellar cultures. Neurochemistry international. vol 50. issue 1. 2007-03-20. PMID:16989924. |
we demonstrate that efficient gene transfer into purkinje cells (as well as into other cerebellar populations) is possible using herpes simplex virus-1 (hsv-1)-derived vectors. |
2007-03-20 |
2023-08-12 |
mouse |
| Alfredo Gimenez-Cassina, Filip Lim, Javier Diaz-Nid. Gene transfer into Purkinje cells using herpesviral amplicon vectors in cerebellar cultures. Neurochemistry international. vol 50. issue 1. 2007-03-20. PMID:16989924. |
in summary, we have established reproducible and reliable cerebellar cell cultures enriched for purkinje cells which enables gene transfer studies to be carried out using herpesviral vectors. |
2007-03-20 |
2023-08-12 |
mouse |
| Alain Bessis, Catherine Béchade, Delphine Bernard, Anne Roumie. Microglial control of neuronal death and synaptic properties. Glia. vol 55. issue 3. 2007-03-16. PMID:17106878. |
similarly, in cerebellum, microglia induces developmental purkinje cells death through respiratory burst. |
2007-03-16 |
2023-08-12 |
Not clear |
| Diana Mutz, Christoph Weise, Nadja Mechai, Werner Hofmann, Rüdiger Horstkorte, Gerold Brüning, Kerstin Danke. Integrin alpha3beta1 interacts with I1PP2A/lanp and phosphatase PP1. Journal of neuroscience research. vol 84. issue 8. 2007-03-13. PMID:17016859. |
i1pp2a/lanp colocalizes with the alpha3a integrin subunit in differentiated pc12 cells in the cell body and in neurites as well as in purkinje cells of mouse cerebellum. |
2007-03-13 |
2023-08-12 |
mouse |
| Srinivasan Kanumilli, Elizabeth W Tringham, C Elizabeth Payne, Jonathan R B Dupere, Kanamarlapudi Venkateswarlu, Maria M Usowic. Alternative splicing generates a smaller assortment of CaV2.1 transcripts in cerebellar Purkinje cells than in the cerebellum. Physiological genomics. vol 24. issue 2. 2007-03-06. PMID:16278278. |
alternative splicing generates a smaller assortment of cav2.1 transcripts in cerebellar purkinje cells than in the cerebellum. |
2007-03-06 |
2023-08-12 |
mouse |
| Kunjumon I Vadakkan, Baoxiang Li, Umberto De Bon. Cell-type specific proximity of centromeric domains of one homologue each of chromosomes 2 and 11 in nuclei of cerebellar Purkinje neurons. Chromosoma. vol 115. issue 5. 2007-02-20. PMID:16741706. |
in purkinje neurons of the mouse cerebellum, the centromeres of several chromosomes are placed in close proximity to form a distinct pattern of clusters and exhibit reproducible spatial redistributions during development. |
2007-02-20 |
2023-08-12 |
mouse |
| Kunjumon I Vadakkan, Baoxiang Li, Umberto De Bon. Cell-type specific proximity of centromeric domains of one homologue each of chromosomes 2 and 11 in nuclei of cerebellar Purkinje neurons. Chromosoma. vol 115. issue 5. 2007-02-20. PMID:16741706. |
in granule neurons, an adjacent cell type in the cerebellum, the pattern, size, and number of centromeric aggregations are different from those of purkinje neurons. |
2007-02-20 |
2023-08-12 |
mouse |
| Takanori Ikenaga, Masayuki Yoshida, Kazumasa Uemats. Cerebellar efferent neurons in teleost fish. Cerebellum (London, England). vol 5. issue 4. 2007-01-29. PMID:17134989. |
anti-gaba and anti-zebrin ii antibodies that are known as markers for the purkinje cells in mammals also recognize the purkinje cells in the teleost cerebellum, but do not recognize the eurydendroid cells. |
2007-01-29 |
2023-08-12 |
Not clear |
| V Yakhnitsa, N H Barmac. Antiphasic Purkinje cell responses in mouse uvula-nodulus are sensitive to static roll-tilt and topographically organized. Neuroscience. vol 143. issue 2. 2007-01-26. PMID:16973298. |
the amplitude of ss modulation may depend on parallel fiber-mediated signals to purkinje cells as well as on the state of cerebellar interneurons. |
2007-01-26 |
2023-08-12 |
mouse |
| H-B Yuan, Y Huang, S Zheng, Z Zu. Hypothermic preconditioning reduces Purkinje cell death possibly by preventing the over-expression of inducible nitric oxide synthase in rat cerebellar slices after an in vitro simulated ischemia. Neuroscience. vol 142. issue 2. 2007-01-23. PMID:16890370. |
we showed that hypothermic preconditioning (hpc) increased survival of purkinje neurons in rat cerebellar slices after oxygen-glucose deprivation (ogd). |
2007-01-23 |
2023-08-12 |
rat |
| Bela Szabo, Michal J Urbanski, Tiziana Bisogno, Vincenzo Di Marzo, Aitziber Mendiguren, Wolfram U Baer, Ilka Freima. Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol. The Journal of physiology. vol 577. issue Pt 1. 2007-01-23. PMID:16973696. |
depolarization of purkinje cells in the mouse cerebellum led to an increase in intracellular calcium concentration and to suppression of the inhibitory input to these neurons (i.e. |
2007-01-23 |
2023-08-12 |
mouse |