| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nelson K B Totah, Nikos K Logothetis, Oxana Eschenk. Noradrenergic ensemble-based modulation of cognition over multiple timescales. Brain research. vol 1709. 2020-07-16. PMID:30586547. |
fast and slow cognitive processes, such as reorienting to surprising stimuli or using experience to develop a behavioral strategy, are also sensitive to neuromodulation by the diffusely-projecting brainstem noradrenergic nucleus, locus coeruleus. |
2020-07-16 |
2023-08-13 |
Not clear |
| Abhinaba Ghosh, Sarah E Torraville, Bandhan Mukherjee, Susan G Walling, Gerard M Martin, Carolyn W Harley, Qi Yua. An experimental model of Braak's pretangle proposal for the origin of Alzheimer's disease: the role of locus coeruleus in early symptom development. Alzheimer's research & therapy. vol 11. issue 1. 2020-07-16. PMID:31266535. |
the earliest brain pathology related to alzheimer's disease (ad) is hyperphosphorylated soluble tau in the noradrenergic locus coeruleus (lc) neurons. |
2020-07-16 |
2023-08-13 |
human |
| Lauren Jacobso. Glucocorticoid receptor deletion from locus coeruleus norepinephrine neurons promotes depression-like social withdrawal in female but not male mice. Brain research. vol 1710. 2020-07-08. PMID:30576626. |
we have also shown that gr in the drn and noradrenergic locus coeruleus (lc) exhibit divergent regulation by antidepressants that have differential efficacy for depression subtypes with opposing abnormalities in glucocorticoids. |
2020-07-08 |
2023-08-13 |
mouse |
| Priyanka Singh, Rajiv Bha. Binding of Noradrenaline to Native and Intermediate States during the Fibrillation of α-Synuclein Leads to the Formation of Stable and Structured Cytotoxic Species. ACS chemical neuroscience. vol 10. issue 6. 2020-07-07. PMID:30917654. |
parkinson's disease is characterized by the deterioration of dopaminergic neurons of substantia nigra pars compacta along with a substantial loss of noradrenergic neurons of the locus coeruleus, which is the major source of noradrenaline (na) in the brain. |
2020-07-07 |
2023-08-13 |
human |
| Maria Paola Tramonti Fantozzi, Tommaso Banfi, Vincenzo De Cicco, Massimo Barresi, Enrico Cataldo, Davide De Cicco, Luca Bruschini, Paola d'Ascanio, Gastone Ciuti, Ugo Faraguna, Diego Manzon. Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation. Journal of visualized experiments : JoVE. issue 153. 2020-07-06. PMID:31840660. |
these effects may be due to widespread connections of the trigeminal system to the ascending reticular activating system (aras), to which noradrenergic neurons of the locus coeruleus (lc) belongs. |
2020-07-06 |
2023-08-13 |
Not clear |
| Dan J Chandler, Patricia Jensen, Jordan G McCall, Anthony E Pickering, Lindsay A Schwarz, Nelson K Tota. Redefining Noradrenergic Neuromodulation of Behavior: Impacts of a Modular Locus Coeruleus Architecture. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 42. 2020-07-03. PMID:31619493. |
redefining noradrenergic neuromodulation of behavior: impacts of a modular locus coeruleus architecture. |
2020-07-03 |
2023-08-13 |
Not clear |
| Dan J Chandler, Patricia Jensen, Jordan G McCall, Anthony E Pickering, Lindsay A Schwarz, Nelson K Tota. Redefining Noradrenergic Neuromodulation of Behavior: Impacts of a Modular Locus Coeruleus Architecture. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 42. 2020-07-03. PMID:31619493. |
the locus coeruleus (lc) is a seemingly singular and compact neuromodulatory nucleus that is a prominent component of disparate theories of brain function due to its broad noradrenergic projections throughout the cns. |
2020-07-03 |
2023-08-13 |
Not clear |
| Bálint Király, Balázs Hangy. Cartographers of the Cognitive Map: Locus Coeruleus Is Part of the Guild. Neuron. vol 105. issue 6. 2020-07-01. PMID:32191855. |
noradrenergic cells of the locus coeruleus were associated with aversive learning and arousal. |
2020-07-01 |
2023-08-13 |
Not clear |
| Kara B Duffy, Balmiki Ray, Debomoy K Lahiri, Edward M Tilmont, Gregory P Tinkler, Richard L Herbert, Nigel H Greig, Donald K Ingram, Mary Ann Ottinger, Julie A Mattiso. Effects of Reducing Norepinephrine Levels via DSP4 Treatment on Amyloid-β Pathology in Female Rhesus Macaques (Macaca Mulatta). Journal of Alzheimer's disease : JAD. vol 68. issue 1. 2020-06-18. PMID:30689563. |
the degeneration in the locus coeruleus associated with alzheimer's disease suggests an involvement of the noradrenergic system in the disease pathogenesis. |
2020-06-18 |
2023-08-13 |
monkey |
| Fumiya Shinohara, Yuta Asaoka, Hironori Kamii, Masabumi Minami, Katsuyuki Kaned. Stress augments the rewarding memory of cocaine via the activation of brainstem-reward circuitry. Addiction biology. vol 24. issue 3. 2020-05-18. PMID:29480583. |
these findings suggest a mechanism wherein the ldt is activated by noradrenergic input from the locus coeruleus, leading to the activation of vta dopamine neurons via both cholinergic and glutamatergic transmission and the subsequent excitation of the mpfc to enhance the memory of cocaine-induced reward value. |
2020-05-18 |
2023-08-13 |
rat |
| Yu Zhang, Bao Fu, Chengxi Liu, Shouyang Yu, Tianyuan Luo, Lin Zhang, Wenjing Zhou, Tian Y. Activation of noradrenergic terminals in the reticular thalamus delays arousal from propofol anesthesia in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 6. 2020-05-18. PMID:30860868. |
trn receives noradrenergic inputs from the locus coeruleus (lc). |
2020-05-18 |
2023-08-13 |
mouse |
| Julie E Finnell, Casey M Moffitt, L Ande Hesser, Evelynn Harrington, Michael N Melson, Christopher S Wood, Susan K Woo. The contribution of the locus coeruleus-norepinephrine system in the emergence of defeat-induced inflammatory priming. Brain, behavior, and immunity. vol 79. 2020-05-13. PMID:30707932. |
the locus coeruleus (lc) is the major source of norepinephrine (ne) to the brain and therefore the current study utilized n-(2-chloroethyl)-n-ethyl-2-bromobenzylamine (dsp-4), an lc selective noradrenergic neurotoxin, to determine the discrete involvement of the lc-ne system in social defeat-induced inflammation in lc projection regions including the central amygdala (cea), dorsal raphe (dr) and plasma. |
2020-05-13 |
2023-08-13 |
rat |
| Matthew J Betts, Evgeniya Kirilina, Maria C G Otaduy, Dimo Ivanov, Julio Acosta-Cabronero, Martina F Callaghan, Christian Lambert, Arturo Cardenas-Blanco, Kerrin Pine, Luca Passamonti, Clare Loane, Max C Keuken, Paula Trujillo, Falk Lüsebrink, Hendrik Mattern, Kathy Y Liu, Nikos Priovoulos, Klaus Fliessbach, Martin J Dahl, Anne Maaß, Christopher F Madelung, David Meder, Alexander J Ehrenberg, Oliver Speck, Nikolaus Weiskopf, Raymond Dolan, Ben Inglis, Duygu Tosun, Markus Morawski, Fabio A Zucca, Hartwig R Siebner, Mara Mather, Kamil Uludag, Helmut Heinsen, Benedikt A Poser, Robert Howard, Luigi Zecca, James B Rowe, Lea T Grinberg, Heidi I L Jacobs, Emrah Düzel, Dorothea Hämmere. Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases. Brain : a journal of neurology. vol 142. issue 9. 2020-05-12. PMID:31327002. |
locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases. |
2020-05-12 |
2023-08-13 |
Not clear |
| Matthew J Betts, Evgeniya Kirilina, Maria C G Otaduy, Dimo Ivanov, Julio Acosta-Cabronero, Martina F Callaghan, Christian Lambert, Arturo Cardenas-Blanco, Kerrin Pine, Luca Passamonti, Clare Loane, Max C Keuken, Paula Trujillo, Falk Lüsebrink, Hendrik Mattern, Kathy Y Liu, Nikos Priovoulos, Klaus Fliessbach, Martin J Dahl, Anne Maaß, Christopher F Madelung, David Meder, Alexander J Ehrenberg, Oliver Speck, Nikolaus Weiskopf, Raymond Dolan, Ben Inglis, Duygu Tosun, Markus Morawski, Fabio A Zucca, Hartwig R Siebner, Mara Mather, Kamil Uludag, Helmut Heinsen, Benedikt A Poser, Robert Howard, Luigi Zecca, James B Rowe, Lea T Grinberg, Heidi I L Jacobs, Emrah Düzel, Dorothea Hämmere. Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases. Brain : a journal of neurology. vol 142. issue 9. 2020-05-12. PMID:31327002. |
moreover, as the functional sensitivity of the noradrenergic system is likely to change with disease progression, in vivo measures of locus coeruleus integrity could provide new pathophysiological insights into cognitive and behavioural symptoms. |
2020-05-12 |
2023-08-13 |
Not clear |
| Matthew J Betts, Evgeniya Kirilina, Maria C G Otaduy, Dimo Ivanov, Julio Acosta-Cabronero, Martina F Callaghan, Christian Lambert, Arturo Cardenas-Blanco, Kerrin Pine, Luca Passamonti, Clare Loane, Max C Keuken, Paula Trujillo, Falk Lüsebrink, Hendrik Mattern, Kathy Y Liu, Nikos Priovoulos, Klaus Fliessbach, Martin J Dahl, Anne Maaß, Christopher F Madelung, David Meder, Alexander J Ehrenberg, Oliver Speck, Nikolaus Weiskopf, Raymond Dolan, Ben Inglis, Duygu Tosun, Markus Morawski, Fabio A Zucca, Hartwig R Siebner, Mara Mather, Kamil Uludag, Helmut Heinsen, Benedikt A Poser, Robert Howard, Luigi Zecca, James B Rowe, Lea T Grinberg, Heidi I L Jacobs, Emrah Düzel, Dorothea Hämmere. Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases. Brain : a journal of neurology. vol 142. issue 9. 2020-05-12. PMID:31327002. |
locus coeruleus imaging also holds the promise to stratify patients into clinical trials according to noradrenergic dysfunction. |
2020-05-12 |
2023-08-13 |
Not clear |
| Shu-Xia Cao, Ying Zhang, Xing-Yue Hu, Bin Hong, Peng Sun, Hai-Yang He, Hong-Yan Geng, Ai-Min Bao, Shu-Min Duan, Jian-Ming Yang, Tian-Ming Gao, Hong Lian, Xiao-Ming L. Correction: ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines. eLife. vol 8. 2020-05-11. PMID:30618378. |
correction: erbb4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines. |
2020-05-11 |
2023-08-13 |
Not clear |
| Alex L Deal, Maria A Mikhailova, Valentina P Grinevich, Jeff L Weiner, Raul R Gainetdinov, Evgeny A Budygi. In vivo voltammetric evidence that locus coeruleus activation predominantly releases norepinephrine in the infralimbic cortex: Effect of acute ethanol. Synapse (New York, N.Y.). vol 73. issue 4. 2020-04-23. PMID:30447016. |
using fast-scan cyclic voltammetry paired with pharmacology, the authors show that infralimbic catecholamine release following locus coeruleus stimulation is noradrenergic, but not dopaminergic, and not affected by acute ethanol. |
2020-04-23 |
2023-08-13 |
Not clear |
| Stefanie Köhler, Gerd Wagner, Karl-Jürgen Bä. Activation of brainstem and midbrain nuclei during cognitive control in medicated patients with schizophrenia. Human brain mapping. vol 40. issue 1. 2020-04-06. PMID:30184301. |
we sought to investigate the putatively abnormal activation pattern of the dopaminergic midbrain nuclei, that is, ventral tegmental area (vta) and substantia nigra as well as that of the noradrenergic locus coeruleus (lc) in patients with schizophrenia during cognitive control. |
2020-04-06 |
2023-08-13 |
Not clear |
| Samira Aminihajibashi, Thomas Hagen, Maja Dyhre Foldal, Bruno Laeng, Thomas Espeset. Individual differences in resting-state pupil size: Evidence for association between working memory capacity and pupil size variability. International journal of psychophysiology : official journal of the International Organization of Psychophysiology. vol 140. 2020-04-02. PMID:30894328. |
dynamic non-luminance-mediated changes in pupil diameter have frequently been shown to be a reliable index for the level of arousal, mental effort, and activity in the locus coeruleus, the brainstem's noradrenergic arousal center. |
2020-04-02 |
2023-08-13 |
human |
| Hiroyuki Nakamori, Kiyotada Naitou, Yuuki Horii, Hiroki Shimaoka, Kazuhiro Horii, Hiroki Sakai, Akihiro Yamada, Hidemasa Furue, Takahiko Shiina, Yasutake Shimiz. Roles of the noradrenergic nucleus locus coeruleus and dopaminergic nucleus A11 region as supraspinal defecation centers in rats. American journal of physiology. Gastrointestinal and liver physiology. vol 317. issue 4. 2020-03-30. PMID:31460791. |
roles of the noradrenergic nucleus locus coeruleus and dopaminergic nucleus a11 region as supraspinal defecation centers in rats. |
2020-03-30 |
2023-08-13 |
rat |