| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Klaus J Wirt. Role of Noradrenergic Brain Nuclei in the Regulation of Carotid Artery Blood Flow: Pharmacological Evidence from Anesthetized Pigs with Alpha-2 Adrenergic Receptor Modulator Drugs. Journal of Alzheimer's disease : JAD. vol 66. issue 1. 2019-09-19. PMID:30248055. |
cerebral hypoperfusion and degeneration of the noradrenergic locus coeruleus (lc) occur early in alzheimer's disease (ad). |
2019-09-19 |
2023-08-13 |
Not clear |
| Amielle Moreno, Ankita Gumaste, Geoff K Adams, Kelly K Chong, Michael Nguyen, Kathryn N Shepard, Robert C Li. Familiarity with social sounds alters c-Fos expression in auditory cortex and interacts with estradiol in locus coeruleus. Hearing research. vol 366. 2019-09-02. PMID:29983289. |
here we employed a maternal mouse model of natural sensory cortical plasticity for infant vocalizations to ask whether the engagement of the noradrenergic locus coeruleus (lc) by the playback of pup-calls is affected by either prior experience with the sounds or estrogen availability, using a well-studied cellular activity and plasticity marker, the immediate early gene c-fos. |
2019-09-02 |
2023-08-13 |
mouse |
| Ricardo M Neves, Silvia van Keulen, Mingyu Yang, Nikos K Logothetis, Oxana Eschenk. Locus coeruleus phasic discharge is essential for stimulus-induced gamma oscillations in the prefrontal cortex. Journal of neurophysiology. vol 119. issue 3. 2019-06-10. PMID:29093170. |
the locus coeruleus (lc) noradrenergic (ne) neuromodulatory system is critically involved in regulation of neural excitability via its diffuse ascending projections. |
2019-06-10 |
2023-08-13 |
rat |
| Robert Zorec, Vladimir Parpura, Alexei Verkhratsk. Preventing neurodegeneration by adrenergic astroglial excitation. The FEBS journal. vol 285. issue 19. 2019-06-07. PMID:29630772. |
impairment of the main noradrenergic nucleus of the human brain, the locus coeruleus (lc), which has been discovered in 1784, represents one of defining factors of neurodegenerative diseases progression. |
2019-06-07 |
2023-08-13 |
human |
| Kaylee P Cullen, Laura M Grant, Cynthia A Kelm-Nelson, Alexander F L Brauer, Luke B Bickelhaupt, John A Russell, Michelle R Ciucc. Pink1 -/- Rats Show Early-Onset Swallowing Deficits and Correlative Brainstem Pathology. Dysphagia. vol 33. issue 6. 2019-06-05. PMID:29713896. |
relationships among swallowing variables and neuropathological findings, such as increased alpha-synuclein protein in the nucleus ambiguus and reductions in noradrenergic cells in the locus coeruleus in the pink1 -/- rats, were determined. |
2019-06-05 |
2023-08-13 |
rat |
| Ken-Ichiro Hayashida, Hideaki Obat. Strategies to Treat Chronic Pain and Strengthen Impaired Descending Noradrenergic Inhibitory System. International journal of molecular sciences. vol 20. issue 4. 2019-06-04. PMID:30769838. |
the descending noradrenergic inhibitory system from the locus coeruleus (lc) to the dorsal horn of the spinal cord plays an important role in the analgesic mechanisms of these drugs. |
2019-06-04 |
2023-08-13 |
Not clear |
| Tomas Hökfelt, Swapnali Barde, Zhi-Qing David Xu, Eugenia Kuteeva, Joelle Rüegg, Erwan Le Maitre, Mårten Risling, Jan Kehr, Robert Ihnatko, Elvar Theodorsson, Miklos Palkovits, William Deakin, Gyorgy Bagdy, Gabriella Juhasz, H Josée Prud'homme, Naguib Mechawar, Rochellys Diaz-Heijtz, Sven Ove Ögre. Neuropeptide and Small Transmitter Coexistence: Fundamental Studies and Relevance to Mental Illness. Frontiers in neural circuits. vol 12. 2019-06-03. PMID:30627087. |
in particular, galanin's role as a co-transmitter in both rodent and human noradrenergic locus coeruleus (lc) neurons is addressed. |
2019-06-03 |
2023-08-13 |
human |
| Michael Sommerauer, Tatyana D Fedorova, Allan K Hansen, Karoline Knudsen, Marit Otto, Jesper Jeppesen, Yoon Frederiksen, Jakob U Blicher, Jacob Geday, Adjmal Nahimi, Malene F Damholdt, David J Brooks, Per Borghamme. Evaluation of the noradrenergic system in Parkinson's disease: an 11C-MeNER PET and neuromelanin MRI study. Brain : a journal of neurology. vol 141. issue 2. 2019-05-30. PMID:29272343. |
pathological involvement of the noradrenergic locus coeruleus occurs early in parkinson's disease, and widespread noradrenaline reductions are found at post-mortem. |
2019-05-30 |
2023-08-13 |
human |
| Martin Timo Henrich, Fanni Fruzsina Geibl, Bolam Lee, Wei-Hua Chiu, James Benjamin Koprich, Jonathan Michael Brotchie, Lars Timmermann, Niels Decher, Lina Anita Matschke, Wolfgang Hermann Oerte. A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia. Acta neuropathologica communications. vol 6. issue 1. 2019-05-30. PMID:29747690. |
degeneration of noradrenergic locus coeruleus neurons occurs during the prodromal phase of parkinson's disease and contributes to a variety of non-motor symptoms, e.g. |
2019-05-30 |
2023-08-13 |
mouse |
| Martin Timo Henrich, Fanni Fruzsina Geibl, Bolam Lee, Wei-Hua Chiu, James Benjamin Koprich, Jonathan Michael Brotchie, Lars Timmermann, Niels Decher, Lina Anita Matschke, Wolfgang Hermann Oerte. A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia. Acta neuropathologica communications. vol 6. issue 1. 2019-05-30. PMID:29747690. |
this study was designed to establish the first locus coeruleus α-synucleinopathy mouse model, which should provide sufficient information about the time-course of noradrenergic neurodegeneration, replicate cardinal histopathological features of the human parkinson's disease neuropathology and finally lead to robust histological markers, which are sufficient to assess the pathological changes in a quantitative and qualitative way. |
2019-05-30 |
2023-08-13 |
mouse |
| Martin Timo Henrich, Fanni Fruzsina Geibl, Bolam Lee, Wei-Hua Chiu, James Benjamin Koprich, Jonathan Michael Brotchie, Lars Timmermann, Niels Decher, Lina Anita Matschke, Wolfgang Hermann Oerte. A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia. Acta neuropathologica communications. vol 6. issue 1. 2019-05-30. PMID:29747690. |
we show that targeted viral vector-mediated overexpression of human mutant a53t-α-synuclein in vivo in locus coeruleus neurons of wild-type mice resulted in progressive noradrenergic neurodegeneration over a time frame of 9 weeks. |
2019-05-30 |
2023-08-13 |
mouse |
| Jacki M Rorabaugh, Termpanit Chalermpalanupap, Christian A Botz-Zapp, Vanessa M Fu, Natalie A Lembeck, Robert M Cohen, David Weinshenke. Chemogenetic locus coeruleus activation restores reversal learning in a rat model of Alzheimer's disease. Brain : a journal of neurology. vol 140. issue 11. 2019-05-23. PMID:29053824. |
see grinberg and heinsen (doi:10.1093/brain/awx261) for a scientific commentary on this article.clinical evidence suggests that aberrant tau accumulation in the locus coeruleus and noradrenergic dysfunction may be a critical early step in alzheimer’s disease progression. |
2019-05-23 |
2023-08-13 |
human |
| Jacki M Rorabaugh, Termpanit Chalermpalanupap, Christian A Botz-Zapp, Vanessa M Fu, Natalie A Lembeck, Robert M Cohen, David Weinshenke. Chemogenetic locus coeruleus activation restores reversal learning in a rat model of Alzheimer's disease. Brain : a journal of neurology. vol 140. issue 11. 2019-05-23. PMID:29053824. |
in tgf344-ad rats, hyperphosphorylated tau was detected in the locus coeruleus prior to accrual in the medial entorhinal cortex or hippocampus, and tau pathology in the locus coeruleus was negatively correlated with noradrenergic innervation in the medial entorhinal cortex. |
2019-05-23 |
2023-08-13 |
human |
| Jacki M Rorabaugh, Termpanit Chalermpalanupap, Christian A Botz-Zapp, Vanessa M Fu, Natalie A Lembeck, Robert M Cohen, David Weinshenke. Chemogenetic locus coeruleus activation restores reversal learning in a rat model of Alzheimer's disease. Brain : a journal of neurology. vol 140. issue 11. 2019-05-23. PMID:29053824. |
likewise, tgf344-ad rats displayed progressive loss of hippocampal norepinephrine levels and locus coeruleus fibres in the medial entorhinal cortex and dentate gyrus, with no frank noradrenergic cell body loss. |
2019-05-23 |
2023-08-13 |
human |
| Pooja Choudhary, Anthony G Pacholko, Josh Palaschuk, Lane K Beka. The locus coeruleus neurotoxin, DSP4, and/or a high sugar diet induce behavioral and biochemical alterations in wild-type mice consistent with Alzheimers related pathology. Metabolic brain disease. vol 33. issue 5. 2019-05-07. PMID:29862455. |
as chronic stress and depression are associated with loss of locus coeruleus (lc) noradrenergic neurons and projections (source of anti-inflammatory and trophic factor control), we assessed the ability for a selective lc neurotoxin (dsp4) to accelerate and aggravate a high-sucrose mediated ad-related phenotype in wild-type mice. |
2019-05-07 |
2023-08-13 |
mouse |
| Adrian J Duszkiewicz, Colin G McNamara, Tomonori Takeuchi, Lisa Genze. Novelty and Dopaminergic Modulation of Memory Persistence: A Tale of Two Systems. Trends in neurosciences. vol 42. issue 2. 2019-04-19. PMID:30455050. |
while axons from the ventral tegmental area (vta) were generally thought to be the exclusive source of hippocampal dopamine, recent studies have demonstrated that noradrenergic neurons in the locus coeruleus (lc) corelease noradrenaline and dopamine in the hippocampus and that their dopamine release boosts memory retention as well. |
2019-04-19 |
2023-08-13 |
Not clear |
| Gerd Wagner, Feliberto de la Cruz, Stefanie Köhler, Karl-Jürgen Bä. Treatment Associated Changes of Functional Connectivity of Midbrain/Brainstem Nuclei in Major Depressive Disorder. Scientific reports. vol 7. issue 1. 2019-03-15. PMID:28819132. |
patients treated with antidepressants influencing noradrenergic and serotonergic neurotransmission showed different rsfc from locus coeruleus to dlpfc compared to patients treated with antidepressants influencing serotonergic neurotransmission only. |
2019-03-15 |
2023-08-13 |
Not clear |
| Xiang-Yu Cui, Guang Yang, Su-Ying Cui, Qing Cao, Yuan-Li Huang, Hui Ding, Hui Ye, Xue-Qiong Zhang, Zi-Jun Wang, Yong-He Zhan. Sleep patterns deteriorate over time in chronic corticosterone-treated rats. Neuroscience letters. vol 682. 2019-03-11. PMID:29894769. |
the noradrenergic system and gr pathway in the locus coeruleus may be involved in the formation of depression concomitant with sleep disturbances. |
2019-03-11 |
2023-08-13 |
rat |
| Hossein Mohammad-Pour Kargar, Hossein Azizi, Javad Mirnajafi-Zadeh, Ali Reza Mani, Saeed Semnania. Orexin A presynaptically decreases inhibitory synaptic transmission in rat locus coeruleus neurons. Neuroscience letters. vol 683. 2019-03-11. PMID:29908258. |
locus coeruleus nucleus (lc) is a major noradrenergic nucleus in the brain. |
2019-03-11 |
2023-08-13 |
rat |
| Colin G McNamara, David Dupre. Two sources of dopamine for the hippocampus. Trends in neurosciences. vol 40. issue 7. 2019-03-07. PMID:28511793. |
two recent studies have identified the noradrenergic fibres originating in the locus coeruleus as an additional source of neurotransmitter acting on dopaminergic receptors in the hippocampus. |
2019-03-07 |
2023-08-13 |
Not clear |