| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francesca Logiacco, Pengfei Xia, Svilen Veselinov Georgiev, Celeste Franconi, Yi-Jen Chang, Bilge Ugursu, Anje Sporbert, Ralf Kühn, Helmut Kettenmann, Marcus Semtne. Microglia sense neuronal activity via GABA in the early postnatal hippocampus. Cell reports. vol 37. issue 13. 2021-12-29. PMID:34965412. |
microglia, the resident macrophages in the central nervous system, express receptors for classical neurotransmitters, such as γ-aminobutyric acid (gaba) and glutamate, suggesting that they sense synaptic activity. |
2021-12-29 |
2023-08-13 |
Not clear |
| Teresa Canedo, Camila Cabral Portugal, Renato Socodato, Tiago Oliveira Almeida, Ana Filipa Terceiro, Joana Bravo, Ana Isabel Silva, João Duarte Magalhães, Sónia Guerra-Gomes, João Filipe Oliveira, Nuno Sousa, Ana Magalhães, João Bettencourt Relvas, Teresa Summaviell. Astrocyte-derived TNF and glutamate critically modulate microglia activation by methamphetamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 13. 2021-11-22. PMID:34400780. |
astrocyte-derived tnf and glutamate critically modulate microglia activation by methamphetamine. |
2021-11-22 |
2023-08-13 |
mouse |
| Xin-Ya Qin, Qing-Hong Shan, Hui Fang, Yu Wang, Peng Chen, Zhi-Qi Xiong, Dick F Swaab, Jiang-Ning Zho. PSD-93 up-regulates the synaptic activity of corticotropin-releasing hormone neurons in the paraventricular nucleus in depression. Acta neuropathologica. vol 142. issue 6. 2021-11-08. PMID:34536123. |
furthermore, we found that lps induced increased the release of glutamate from microglia to crh neurons resulted in depression-like behaviors using fiber photometry recordings. |
2021-11-08 |
2023-08-13 |
mouse |
| R Lee Mosley, Eric J Benner, Irena Kadiu, Mark Thomas, Michael D Boska, Khader Hasan, Chad Laurie, Howard E Gendelma. Neuroinflammation, Oxidative Stress and the Pathogenesis of Parkinson's Disease. Clinical neuroscience research. vol 6. issue 5. 2021-10-20. PMID:18060039. |
in neurodegenerative diseases, activated microglia affect neuronal injury and death through production of glutamate, pro-inflammatory factors, reactive oxygen species, quinolinic acid amongst others and by mobilization of adaptive immune responses and cell chemotaxis leading to transendothelial migration of immunocytes across the blood-brain barrier and perpetuation of neural damage. |
2021-10-20 |
2023-08-12 |
human |
| Ya-Nan Zhang, Jing-Kai Fan, Li Gu, Hui-Min Yang, Shu-Qin Zhan, Hong Zhan. Metabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in Parkinson's disease. Journal of neuroinflammation. vol 18. issue 1. 2021-10-13. PMID:33461598. |
metabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in parkinson's disease. |
2021-10-13 |
2023-08-13 |
Not clear |
| Ya-Nan Zhang, Jing-Kai Fan, Li Gu, Hui-Min Yang, Shu-Qin Zhan, Hong Zhan. Metabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in Parkinson's disease. Journal of neuroinflammation. vol 18. issue 1. 2021-10-13. PMID:33461598. |
targeting metabotropic glutamate receptor 5 (mglur5) has been an attractive strategy to mediate microglia activation for neuroprotection, which might be an essential regulator to modulate α-syn-induced neuroinflammation for the treatment of pd. |
2021-10-13 |
2023-08-13 |
Not clear |
| Manuela Zinni, Jérôme Mairesse, Julien Pansiot, Francesco Fazio, Luisa Iacovelli, Nico Antenucci, Rosamaria Orlando, Ferdinando Nicoletti, Daniel Vaiman, Olivier Bau. mGlu3 receptor regulates microglial cell reactivity in neonatal rats. Journal of neuroinflammation. vol 18. issue 1. 2021-10-07. PMID:33407565. |
although some evidence supports a role for metabotropic glutamate receptor 3 (mglu3 receptor) in modulation of neuroinflammation, its functions are still unknown in the developing microglia. |
2021-10-07 |
2023-08-13 |
rat |
| Barbara M Fenner, Mark E Fenner, Natalie Prowse, Shawn P Hayle. LRRK2 and WAVE2 regulate microglial-transition through distinct morphological phenotypes to induce neurotoxicity in a novel two-hit in vitro model of neurodegeneration. Journal of cellular physiology. 2021-09-20. PMID:34543438. |
we found that healthy neurons were resistant to microglial-mediated inflammation, whereas glutamate pre-stressed neurons were highly susceptible and in fact, appeared to recruit microglia. |
2021-09-20 |
2023-08-13 |
Not clear |
| Xinyue Zhang, Dan Wang, Bo Zhang, Jie Zhu, Zhulin Zhou, Li Cu. Regulation of microglia by glutamate and its signal pathway in neurodegenerative diseases. Drug discovery today. vol 25. issue 6. 2021-08-31. PMID:32320851. |
regulation of microglia by glutamate and its signal pathway in neurodegenerative diseases. |
2021-08-31 |
2023-08-13 |
Not clear |
| Xinyue Zhang, Dan Wang, Bo Zhang, Jie Zhu, Zhulin Zhou, Li Cu. Regulation of microglia by glutamate and its signal pathway in neurodegenerative diseases. Drug discovery today. vol 25. issue 6. 2021-08-31. PMID:32320851. |
in this review, we focus on recent progress in determining microglial characteristics and the role of glutamate and its receptors in microglia regulation, which could be a novel therapeutic strategy for neurodegenerative diseases. |
2021-08-31 |
2023-08-13 |
Not clear |
| Sami Piirainen, Keerthana Chithanathan, Kanchan Bisht, Maria Piirsalu, Julie Conner Savage, Marie-Eve Tremblay, Li Tia. Microglia contribute to social behavioral adaptation to chronic stress. Glia. vol 69. issue 10. 2021-08-18. PMID:34145941. |
microglia in wt mice underwent a series of region-specific changes involving their phagocytosis of presynaptic vesicular glutamate transporter 2 protein, contacts with synaptic elements, cd206 |
2021-08-18 |
2023-08-13 |
mouse |
| O Arteaga Cabeza, Z Zhang, E Smith Khoury, R A Sheldon, A Sharma, F Zhang, B S Slusher, R M Kannan, S Kannan, D M Ferrier. Neuroprotective effects of a dendrimer-based glutamate carboxypeptidase inhibitor on superoxide dismutase transgenic mice after neonatal hypoxic-ischemic brain injury. Neurobiology of disease. vol 148. 2021-08-11. PMID:33271328. |
we have previously shown that the enzyme glutamate carboxypeptidase (gcpii) is overexpressed in activated microglia in the presence of inflammation in fetal/newborn rabbit brain. |
2021-08-11 |
2023-08-13 |
mouse |
| Sheng-Jun Wen, Xi-Min Zheng, Li-Fen Liu, Na-Na Li, Hai-An Mao, Liang Huang, Qiong-Lan Yua. Effects of primary microglia and astrocytes on neural stem cells in Neural regeneration research. vol 16. issue 9. 2021-08-10. PMID:33510055. |
in a transwell co-culture system, primary cultured astrocytes, microglia or mixed glial cells were exposed to glutamate or h |
2021-08-10 |
2023-08-13 |
rat |
| Lu-Min Liu, Yu-Chao Hou, Yue-Lai Che. [Research advances of studies on involvement of the anterior cingulate cortex involved in acupuncture-induced amelioration treatment of affective pain]. Zhen ci yan jiu = Acupuncture research. vol 46. issue 7. 2021-08-10. PMID:34369685. |
the mechanism includes various signal pathways, such as extracellular regulated protein kinases-mitogen activated protein kinase-camp-response element binding protein pathway, adenylate cyclase 1 protein kinase mζ- glutamate receptor 1 pathway, contains many biomolecules, such as opioid receptors, neuropeptide s and its receptor, and refers to microglia at the cellular level. |
2021-08-10 |
2023-08-13 |
Not clear |
| Gelareh Abulwerdi, Bogdan A Stoica, David J Loane, Alan I Fade. Putative mGluR4 positive allosteric modulators activate G Neurochemistry international. vol 138. 2021-07-30. PMID:32454165. |
a previous study reported that adx88178, a putative metabotropic glutamate receptor 4 (mglur4) positive allosteric modulator (pam), exerts anti-inflammatory effects in microglia by activating mglur4. |
2021-07-30 |
2023-08-13 |
Not clear |
| b' Eduard Parellada, Patricia Gass\\xc3\\xb. Glutamate and microglia activation as a driver of dendritic apoptosis: a core pathophysiological mechanism to understand schizophrenia. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33958577.' |
glutamate and microglia activation as a driver of dendritic apoptosis: a core pathophysiological mechanism to understand schizophrenia. |
2021-06-28 |
2023-08-13 |
Not clear |
| b' Eduard Parellada, Patricia Gass\\xc3\\xb. Glutamate and microglia activation as a driver of dendritic apoptosis: a core pathophysiological mechanism to understand schizophrenia. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33958577.' |
this driving hypothesis has relevant therapeutic implications, including the importance of pharmacological interventions during the prodromal phase or the transition to psychosis, targeting apoptosis, microglia cells or the glutamate storm. |
2021-06-28 |
2023-08-13 |
Not clear |
| Dániel Pukoli, Helga Polyák, Cecilia Rajda, László Vécse. Kynurenines and Neurofilament Light Chain in Multiple Sclerosis. Frontiers in neuroscience. vol 15. 2021-06-12. PMID:34113231. |
this process can initiate a pathogenic cascade, including microglia activation, glutamate excitotoxicity, chronic oxidative stress or accumulated mitochondrial damage in the axons, that finally disrupt the homeostasis of neurons, leads to destabilization of neuronal cell cytoskeleton, contributes to neuro-axonal damage and neurodegeneration. |
2021-06-12 |
2023-08-13 |
Not clear |
| Mohammed E Choudhury, Yuka Kigami, Junya Tanak. Dual Roles of Microglia in the Basal Ganglia in Parkinson's Disease. International journal of molecular sciences. vol 22. issue 8. 2021-05-25. PMID:33918947. |
on the other hand, microglia are also activated in the basal ganglia outputs (the substantia nigra pars reticulata and the globus pallidus) in response to excess glutamate released from hyperactive subthalamic nuclei-derived synapses. |
2021-05-25 |
2023-08-13 |
Not clear |
| Jeniffer Sanguino-Gómez, Jacobus C Buurstede, Oihane Abiega, Carlos P Fitzsimons, Paul J Lucassen, Bart J L Eggen, Sylvie L Lesuis, Onno C Meijer, Harm J Kruger. An emerging role for microglia in stress-effects on memory. The European journal of neuroscience. 2021-05-05. PMID:33724565. |
these microglia have (3) impaired crosstalk with neurons and (4) disrupted glutamate signaling. |
2021-05-05 |
2023-08-13 |
Not clear |