| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shun-Ming Ting, Xiurong Zhao, Xueping Zheng, Jaroslaw Aronowsk. Excitatory pathway engaging glutamate, calcineurin, and NFAT upregulates IL-4 in ischemic neurons to polarize microglia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 40. issue 3. 2020-09-21. PMID:30890073. |
excitatory pathway engaging glutamate, calcineurin, and nfat upregulates il-4 in ischemic neurons to polarize microglia. |
2020-09-21 |
2023-08-13 |
rat |
| Kirsten S Evonuk, Ryan E Doyle, Carson E Moseley, Ian M Thornell, Keith Adler, Amanda M Bingaman, Mark O Bevensee, Casey T Weaver, Booki Min, Tara M DeSilv. Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammation. Science advances. vol 6. issue 2. 2020-09-17. PMID:31934627. |
glutamate is elevated before t2-visible white matter lesions appear in ms. we previously reported that myelin-reactive t cells provoke microglia to release glutamate from the system x |
2020-09-17 |
2023-08-13 |
Not clear |
| Cinzia Volonté, Susanna Amadio, Paola Fabbrizio, Savina Apollon. Functional microglia neurotransmitters in amyotrophic lateral sclerosis. Seminars in cell & developmental biology. vol 94. 2020-06-03. PMID:31009755. |
we will discuss that als microglia can express a variety of classical neurotransmitter receptors comprising those for extracellular atp, glutamate and histamine. |
2020-06-03 |
2023-08-13 |
Not clear |
| Nicole Pukos, Matthew T Goodus, Fatma R Sahinkaya, Dana M McTigu. Myelin status and oligodendrocyte lineage cells over time after spinal cord injury: What do we know and what still needs to be unwrapped? Glia. vol 67. issue 11. 2020-03-27. PMID:31444938. |
opcs are highly sensitive to microenvironmental changes, and therefore respond to the ever-changing post-sci milieu, including influx of blood, monocytes and neutrophils; activation of microglia and macrophages; changes in cytokines, chemokines and growth factors such as ciliary neurotrophic factor and fibroblast growth factor-2; glutamate excitotoxicity; and axon degeneration and sprouting. |
2020-03-27 |
2023-08-13 |
Not clear |
| Shimaa A Ali, Sawsan A Zaitone, Amina A Dessouki, Azaa A Al. Pregabalin affords retinal neuroprotection in diabetic rats: Suppression of retinal glutamate, microglia cell expression and apoptotic cell death. Experimental eye research. vol 184. 2020-02-14. PMID:31002823. |
pregabalin affords retinal neuroprotection in diabetic rats: suppression of retinal glutamate, microglia cell expression and apoptotic cell death. |
2020-02-14 |
2023-08-13 |
rat |
| b' Lei Liu, Mary K Vollmer, Abdullah S Ahmad, Victoria M Fernandez, Hocheol Kim, Sylvain Dor\\xc3\\xa. Pretreatment with Korean red ginseng or dimethyl fumarate attenuates reactive gliosis and confers sustained neuroprotection against cerebral hypoxic-ischemic damage by an Nrf2-dependent mechanism. Free radical biology & medicine. vol 131. 2020-01-21. PMID:30458277.' |
in both ischemic striatum and cortex, the dynamic pattern of attenuated reactive gliosis in astrocytes and microglia, including affected astrocytic dysfunction in glutamate metabolism and water homeostasis, correlated well with the nrf2-dependent neuroprotection by ginseng or dmf. |
2020-01-21 |
2023-08-13 |
mouse |
| Sheng-Zhou Wu, Angela M Bodles, Mandy M Porter, W Sue T Griffin, Anthony S Basile, Steven W Barge. Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide. Journal of neuroinflammation. vol 1. issue 1. 2019-11-20. PMID:15285800. |
proinflammatory stimuli, including amyloid beta-peptide (abeta), elicit a release of glutamate from microglia. |
2019-11-20 |
2023-08-12 |
human |
| Jianfeng Liang, Hideyuki Takeuchi, Shijie Jin, Mariko Noda, Hua Li, Yukiko Doi, Jun Kawanokuchi, Yoshifumi Sonobe, Tetsuya Mizuno, Akio Suzumur. Corrigendum to "Glutamate induces neurotrophic factor production from microglia via protein kinase C pathway" [Brain Research 1322 (2010) 8-23]. Brain research. vol 1644. 2019-11-20. PMID:27079835. |
corrigendum to "glutamate induces neurotrophic factor production from microglia via protein kinase c pathway" [brain research 1322 (2010) 8-23]. |
2019-11-20 |
2023-08-13 |
Not clear |
| Alfredo Cerisola, Federico Baltar, Ceila Ferrán, Emilio Turcatt. [Mechanisms of brain injury of the premature baby]. Medicina. vol 79 Suppl 3. 2019-10-31. PMID:31603836. |
anatomical and physiological characteristics of periventricular vascular structures predispose white matter to cerebral ischemia and, interacting with infection/inflammation factors, activate microglia, generating oxidative stress (mediated by free oxygen and nitrogen radicals), pro-inflammatory cytokine and glutamate toxicity, energetic failure and vascular integrity disturbances. |
2019-10-31 |
2023-08-13 |
Not clear |
| Kamaldeep S Dhami, Matthew A Churchward, Glen B Baker, Kathryn G Tod. Fluoxetine and its metabolite norfluoxetine induce microglial apoptosis. Journal of neurochemistry. vol 148. issue 6. 2019-10-28. PMID:30613984. |
we have previously shown that the selective serotonin reuptake inhibitors (ssris) fluoxetine and citalopram promote neuronal survival after oxygen-glucose deprivation, an in vitro model of ischemia, by attenuating the release of glutamate and d-serine from activated microglia. |
2019-10-28 |
2023-08-13 |
Not clear |
| Kamaldeep S Dhami, Matthew A Churchward, Glen B Baker, Kathryn G Tod. Fluoxetine and its metabolite norfluoxetine induce microglial apoptosis. Journal of neurochemistry. vol 148. issue 6. 2019-10-28. PMID:30613984. |
interestingly, we found that fluoxetine-treated microglial cultures contained fewer numbers of cells compared to other groups and hypothesized that fluoxetine and citalopram attenuated the release of glutamate and d-serine by promoting the apoptosis of microglia. |
2019-10-28 |
2023-08-13 |
Not clear |
| Kamaldeep S Dhami, Matthew A Churchward, Glen B Baker, Kathryn G Tod. Fluoxetine and its metabolite norfluoxetine induce microglial apoptosis. Journal of neurochemistry. vol 148. issue 6. 2019-10-28. PMID:30613984. |
our results demonstrate that fluoxetine and norfluoxetine induce the apoptotic death of microglia, which may serve as a mechanism to attenuate the release of glutamate and d-serine from activated microglia. |
2019-10-28 |
2023-08-13 |
Not clear |
| Yi-Ying Huang, Qian Zhang, Jian-Nan Zhang, Ya-Nan Zhang, Li Gu, Hui-Min Yang, Ning Xia, Xiao-Min Wang, Hong Zhan. Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson's disease. Brain, behavior, and immunity. vol 71. 2019-07-15. PMID:29649522. |
triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of parkinson's disease. |
2019-07-15 |
2023-08-13 |
Not clear |
| Sanae Hasegawa-Ishii, Atsuyoshi Shimada, Fumiaki Imamur. Lipopolysaccharide-initiated persistent rhinitis causes gliosis and synaptic loss in the olfactory bulb. Scientific reports. vol 7. issue 1. 2019-06-25. PMID:28912588. |
in the ob, we observed activation of microglia and astrocytes and decreased expression of tyrosine hydroxylase in periglomerular cells, vesicular glutamate transporter 1, a presynaptic protein, in mitral and tufted projection neurons, and 5t4 in granule cells. |
2019-06-25 |
2023-08-13 |
mouse |
| Xisheng Yan, Fen Li, Dylan W Maixner, Ruchi Yadav, Mei Gao, Mourad Wagdy Ali, Shelley B Hooks, Han-Rong Wen. Interleukin-1beta released by microglia initiates the enhanced glutamatergic activity in the spinal dorsal horn during paclitaxel-associated acute pain syndrome. Glia. vol 67. issue 3. 2019-06-13. PMID:30578561. |
il-1β release from microglia depended on capthepsin b. il-1β acted on astrocytes, leading to elevated calcium activity and suppressed glutamate uptake. |
2019-06-13 |
2023-08-13 |
mouse |
| Renato Socodato, Camila C Portugal, Artur Rodrigues, Joana Henriques, Carla Rodrigues, Cláudia Figueira, João B Relva. Redox tuning of Ca Free radical biology & medicine. vol 118. 2019-05-14. PMID:29501565. |
upon activation, microglia release high amounts of the neurotransmitter glutamate, contributing for neuronal excitotoxicity during brain insults. |
2019-05-14 |
2023-08-13 |
human |
| Renato Socodato, Camila C Portugal, Artur Rodrigues, Joana Henriques, Carla Rodrigues, Cláudia Figueira, João B Relva. Redox tuning of Ca Free radical biology & medicine. vol 118. 2019-05-14. PMID:29501565. |
here, we reveal a signaling pathway controlling glutamate release from human microglia during hypoxia. |
2019-05-14 |
2023-08-13 |
human |
| Andrea Cabrera-Pastor, Tiziano Balzano, Vicente Hernández-Rabaza, Michele Malaguarnera, Marta Llansola, Vicente Felip. Increasing extracellular cGMP in cerebellum in vivo reduces neuroinflammation, GABAergic tone and motor in-coordination in hyperammonemic rats. Brain, behavior, and immunity. vol 69. 2019-04-23. PMID:29288802. |
the data support that extracellular cgmp restores motor coordination in hyperammonemic rats by reducing microglia activation and neuroinflammation, leading to normalization of extracellular glutamate and gaba levels in cerebellum and of motor coordination. |
2019-04-23 |
2023-08-13 |
rat |
| Won Jin Lee, Sun Ah Ham, Hyunjin Yoo, Jung Seok Hwang, Taesik Yoo, Kyung Shin Paek, Dae-Seog Lim, Sung Gu Han, Chi-Ho Lee, Kwonho Hong, Han Geuk Se. Activation of PPARδ attenuates neurotoxicity by inhibiting lipopolysaccharide-triggered glutamate release in BV-2 microglial cells. Journal of cellular biochemistry. vol 119. issue 7. 2019-04-12. PMID:29388693. |
neuroinflammation-associated release of glutamate from activated microglia has been implicated in the progression of neurodegenerative diseases. |
2019-04-12 |
2023-08-13 |
Not clear |
| Ivan Domith, Aline T Duarte-Silva, Carlos Gustavo Garcia, Karin da Costa Calaza, Roberto Paes-de-Carvalho, Marcelo Cossenz. Chlorogenic acids inhibit glutamate dehydrogenase and decrease intracellular ATP levels in cultures of chick embryo retina cells. Biochemical pharmacology. vol 155. 2019-04-04. PMID:30031809. |
cgas can also modulate glutamate release from microglia by a mechanism involving a decrease of reactive oxygen species (ros). |
2019-04-04 |
2023-08-13 |
chicken |