| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cleide Dos Santos Souza, Maria Socorro Grangeiro, Erica Patricia Lima Pereira, Cleonice Creusa Dos Santos, Alessandra Bispo da Silva, Geraldo Pedral Sampaio, Daiana Dias Ribeiro Figueiredo, Jorge Mauricio David, Juceni Pereira David, Victor Diogenes Amaral da Silva, Arthur Morgan Butt, Silvia Lima Cost. Agathisflavone, a flavonoid derived from Poincianella pyramidalis (Tul.), enhances neuronal population and protects against glutamate excitotoxicity. Neurotoxicology. vol 65. 2019-03-27. PMID:29425760. |
in addition, treatment with fab significantly reduced cell death induced by glutamate and this was associated with reduced expression levels of pro-inflammatory (m1) microglial cytokines, including tnfα, il1β and il6, which are associated with neurotoxicity, and increased expression of il10 and arginase 1, which are associated with anti-inflammatory (m2) neuroprotective microglia. |
2019-03-27 |
2023-08-13 |
rat |
| Balázs Pá. Involvement of extrasynaptic glutamate in physiological and pathophysiological changes of neuronal excitability. Cellular and molecular life sciences : CMLS. vol 75. issue 16. 2019-03-15. PMID:29766217. |
extrasynaptic glutamate originates from spillover of synaptic release, as well as from astrocytes and microglia. |
2019-03-15 |
2023-08-13 |
Not clear |
| Balázs Pá. Involvement of extrasynaptic glutamate in physiological and pathophysiological changes of neuronal excitability. Cellular and molecular life sciences : CMLS. vol 75. issue 16. 2019-03-15. PMID:29766217. |
extrasynaptic glutamate receptors can be found in neuronal somatodendritic location, on astroglia, oligodendrocytes or microglia. |
2019-03-15 |
2023-08-13 |
Not clear |
| Francesco Fazio, Martina Ulivieri, Claudia Volpi, Marco Gargaro, Francesca Fallarin. Targeting metabotropic glutamate receptors for the treatment of neuroinflammation. Current opinion in pharmacology. vol 38. 2019-03-14. PMID:29471184. |
both lymphocytes and microglia express metabotropic glutamate (mglu) receptors, which respond to glutamate or other endogenous activators (e.g. |
2019-03-14 |
2023-08-13 |
Not clear |
| Masatake Toshimitsu, Yoshimasa Kamei, Mari Ichinose, Takahiro Seyama, Shinya Imada, Takayuki Iriyama, Tomoyuki Fuji. Atomoxetine, a selective norepinephrine reuptake inhibitor, improves short-term histological outcomes after hypoxic-ischemic brain injury in the neonatal male rat. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 70. 2019-01-28. PMID:29608930. |
neurotransmitters, such as norepinephrine (ne) and glutamate, are involved in the pathogenesis of hypoxic-ischemic encephalopathy via the interaction between neurons and microglia. |
2019-01-28 |
2023-08-13 |
rat |
| Dhiraj Kumar Singh, Eng-Ang Ling, Charanjit Kau. Hypoxia and myelination deficits in the developing brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 70. 2019-01-28. PMID:29964158. |
several factors such as augmented release of proinflammatory cytokines by activated microglia and astrocytes, extracellular accumulation of excess glutamate and increased levels of nitric oxide are some of the underlying factors for hypoxia induced damage to the opcs. |
2019-01-28 |
2023-08-13 |
Not clear |
| Michael Fricker, Aviva M Tolkovsky, Vilmante Borutaite, Michael Coleman, Guy C Brow. Neuronal Cell Death. Physiological reviews. vol 98. issue 2. 2018-11-01. PMID:29488822. |
we next explore the mechanisms of neuronal death during development, and those induced by axotomy, aberrant cell-cycle reentry, glutamate (excitoxicity and oxytosis), loss of connected neurons, aggregated proteins and the unfolded protein response, oxidants, inflammation, and microglia. |
2018-11-01 |
2023-08-13 |
Not clear |
| Mandy Busse, Vanessa Hettler, Victoria Fischer, Christian Mawrin, Roland Hartig, Henrik Dobrowolny, Bernhard Bogerts, Thomas Frodl, Stefan Buss. Increased quinolinic acid in peripheral mononuclear cells in Alzheimer's dementia. European archives of psychiatry and clinical neuroscience. vol 268. issue 5. 2018-10-26. PMID:28386767. |
although only little is known about the function of activated macrophages and microglia in ad, one important mechanism involves the expression of quinolinic acid (quin), an endogenous n-methyl-d-aspartate glutamate receptor (nmda-r) agonist which mediates excitotoxicity especially in the hippocampus. |
2018-10-26 |
2023-08-13 |
human |
| Makoto Horiuchi, Lucas Smith, Izumi Maezawa, Lee-Way Ji. CX Brain, behavior, and immunity. vol 60. 2018-08-16. PMID:26883520. |
because microglia in the mecp2 knockout (mecp2ko) mouse model of rtt over-produce neurotoxic mediators glutamate and reactive oxygen species, we hypothesize that blocking neuron-microglia interaction by ablation of cx |
2018-08-16 |
2023-08-13 |
mouse |
| A R Jayakumar, M Taherian, K S Panickar, N Shamaladevi, M E Rodriguez, B G Price, M D Norenber. Differential Response of Neural Cells to Trauma-Induced Swelling In Vitro. Neurochemical research. vol 43. issue 2. 2018-08-16. PMID:29150743. |
since extracellular levels of glutamate are increased in brain post-tbi and microglia are known to release cytokine, and direct exposure of astrocytes to these molecules are known to stimulate cell swelling, we examined whether glutamate or cytokines have any additive effect on trauma-induced cell swelling. |
2018-08-16 |
2023-08-13 |
Not clear |
| Christine Altmann, Mirko H H Schmid. The Role of Microglia in Diabetic Retinopathy: Inflammation, Microvasculature Defects and Neurodegeneration. International journal of molecular sciences. vol 19. issue 1. 2018-08-01. PMID:29301251. |
transcriptional changes in activated microglia, mediated via the nuclear factor kappa-light-chain-enhancer of activated b cells (nfκb) and extracellular signal-regulated kinase (erk) signaling pathways, results in release of various pro-inflammatory mediators, including cytokines, chemokines, caspases and glutamate. |
2018-08-01 |
2023-08-13 |
Not clear |
| Yuangui Lin, Lian Liu, Haixia Jiang, Jieshu Zhou, Yuying Tan. Inhibition of interleukin-6 function attenuates the central sensitization and pain behavior induced by osteoarthritis. European journal of pharmacology. vol 811. 2018-05-30. PMID:28663035. |
blockade of il-6 function by tocilizumab markedly suppressed the activation of astrocytes and microglia in the ipsilateral dorsal horn, reduced c-fos immunoreactivity in dorsal horn neurons, and attenuated the upregulation of glutamate receptor subunits glur1 and nr2b in dorsal horn in the rats with mia-induced oa. |
2018-05-30 |
2023-08-13 |
rat |
| Amila Omeragic, Md Tozammel Hoque, U-Yeong Choi, Reina Bendaya. Peroxisome proliferator-activated receptor-gamma: potential molecular therapeutic target for HIV-1-associated brain inflammation. Journal of neuroinflammation. vol 14. issue 1. 2018-05-29. PMID:28886715. |
primary cellular targets of hiv-1 in the brain are macrophages, microglia, and to a certain extent astrocytes which in response to infection release inflammatory markers, viral proteins [i.e., glycoprotein 120 (gp120)] and exhibit impaired glutamate uptake. |
2018-05-29 |
2023-08-13 |
Not clear |
| Kathryn M Madalena, Jessica K Lerc. The Effect of Glucocorticoid and Glucocorticoid Receptor Interactions on Brain, Spinal Cord, and Glial Cell Plasticity. Neural plasticity. vol 2017. 2018-05-24. PMID:28928988. |
stress/gcs induce structural plasticity in neurons, schwann cells, microglia, oligodendrocytes, and astrocytes as well as affect neurotransmission by changing the release and reuptake of glutamate. |
2018-05-24 |
2023-08-13 |
Not clear |
| Hitomi Aono, Mohammed Emamussalehin Choudhury, Hiromi Higaki, Kazuya Miyanishi, Yuka Kigami, Kohdai Fujita, Jun-Ichi Akiyama, Hisaaki Takahashi, Hajime Yano, Madoka Kubo, Noriko Nishikawa, Masahiro Nomoto, Junya Tanak. Microglia may compensate for dopaminergic neuron loss in experimental Parkinsonism through selective elimination of glutamatergic synapses from the subthalamic nucleus. Glia. vol 65. issue 11. 2018-05-14. PMID:28836295. |
rat primary microglia increased their phagocytic activities in response to glutamate, with increased expression of mrna encoding phagocytosis-related factors. |
2018-05-14 |
2023-08-13 |
rat |
| Vikas Singh, Ruchi Gera, Rajesh Kushwaha, Anuj Kumar Sharma, Satyakam Patnaik, Debabrata Ghos. Hijacking microglial glutathione by inorganic arsenic impels bystander death of immature neurons through extracellular cystine/glutamate imbalance. Scientific reports. vol 6. 2018-04-19. PMID:27477106. |
ex-vivo primary microglia culture supernatant from gestationally exposed mice measured to contain lower cystine and higher glutamate compared to control and n-acetyl cysteine co-treated group. |
2018-04-19 |
2023-08-13 |
mouse |
| Zhi Zhang, Bassam Bassam, Ajit G Thomas, Monica Williams, Jinhuan Liu, Elizabeth Nance, Camilo Rojas, Barbara S Slusher, Sujatha Kanna. Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal/newborn rabbit brain. Neurobiology of disease. vol 94. 2018-02-27. PMID:27326668. |
maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase ii in activated microglia in the fetal/newborn rabbit brain. |
2018-02-27 |
2023-08-13 |
rabbit |
| Zhi Zhang, Bassam Bassam, Ajit G Thomas, Monica Williams, Jinhuan Liu, Elizabeth Nance, Camilo Rojas, Barbara S Slusher, Sujatha Kanna. Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal/newborn rabbit brain. Neurobiology of disease. vol 94. 2018-02-27. PMID:27326668. |
we also show for the first time that glutamate carboxypeptidase ii (gcpii) was significantly increased in the activated microglia at the periventricular white matter area in both g29 and pnd1 cp kits. |
2018-02-27 |
2023-08-13 |
rabbit |
| Zhi Zhang, Bassam Bassam, Ajit G Thomas, Monica Williams, Jinhuan Liu, Elizabeth Nance, Camilo Rojas, Barbara S Slusher, Sujatha Kanna. Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal/newborn rabbit brain. Neurobiology of disease. vol 94. 2018-02-27. PMID:27326668. |
these results suggest that maternal intrauterine endotoxin exposure results in early onset and long-lasting dysregulation of glutamate homeostasis, which may be mediated by impaired astrocyte function and gcpii upregulation in activated microglia. |
2018-02-27 |
2023-08-13 |
rabbit |
| F Vilhardt, J Haslund-Vinding, V Jaquet, G McBea. Microglia antioxidant systems and redox signalling. British journal of pharmacology. vol 174. issue 12. 2018-01-29. PMID:26754582. |
we discuss in general terms, and where available in microglia, gsh synthesis and relation to cystine import and glutamate export, and the thioredoxin system as the most important antioxidative defence mechanism, and further, we discuss in the context of protein thiolation of target redox proteins the necessity for tightly localized, timed and confined oxidant production to work in concert with antioxidant proteins to promote redox signalling. |
2018-01-29 |
2023-08-13 |
Not clear |