| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanying Miao, Guo-Li Zhao, Shuo Cheng, Zhongfeng Wang, Xiong-Li Yan. Activation of retinal glial cells contributes to the degeneration of ganglion cells in experimental glaucoma. Progress in retinal and eye research. vol 93. 2023-02-03. PMID:36736070. |
activated müller cells contribute to rgc degeneration through generating glutamate receptor-mediated excitotoxicity, releasing cytotoxic factors and inducing microglia activation. |
2023-02-03 |
2023-08-14 |
Not clear |
| Mariangela Chisari, Michele Barraco, Claudio Bucolo, Lucia Ciranna, Maria Angela Sortin. Purinergic ionotropic P2X7 and metabotropic glutamate mGlu European journal of pharmacology. 2022-11-26. PMID:36435235. |
purinergic ionotropic p2x7 and metabotropic glutamate mglu microglia represent the resident immune system in the brain. |
2022-11-26 |
2023-08-14 |
Not clear |
| Emily Sun, Aishat Motolani, Leonardo Campos, Tao L. The Pivotal Role of NF-kB in the Pathogenesis and Therapeutics of Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012242. |
some of these cell types and molecules include reactive microglia and astrocytes, β-secretase, apoe, glutamate, mirna, and tau protein, among others. |
2022-08-26 |
2023-08-14 |
mouse |
| Andrea de Bartolomeis, Annarita Barone, Licia Vellucci, Benedetta Mazza, Mark C Austin, Felice Iasevoli, Mariateresa Ciccarell. Linking Inflammation, Aberrant Glutamate-Dopamine Interaction, and Post-synaptic Changes: Translational Relevance for Schizophrenia and Antipsychotic Treatment: a Systematic Review. Molecular neurobiology. 2022-08-13. PMID:35963926. |
furthermore, the link between inflammation and glutamate is strongly supported by clinical studies aimed at exploring overactive microglia in schizophrenia patients and maternal immune activation models, indicating impaired glutamate regulation and reduced n-methyl-d-aspartate receptor (nmdar) function. |
2022-08-13 |
2023-08-14 |
Not clear |
| Benjamin J Bell, Kristen R Hollinger, Pragney Deme, Shinji Sakamoto, Yuto Hasegawa, David Volsky, Atsushi Kamiya, Norman Haughey, Xiaolei Zhu, Barbara S Slushe. Glutamine antagonist JHU083 improves psychosocial behavior and sleep deficits in EcoHIV-infected mice. Brain, behavior, & immunity - health. vol 23. 2022-06-23. PMID:35734753. |
thus, brain-penetrable gls inhibitors like jhu083 could act as a potential therapeutic modality for both glutamate excitotoxicity and aberrant immune activation in microglia in chronic hiv infection. |
2022-06-23 |
2023-08-14 |
mouse |
| David H Allendorf, Guy C Brow. Neu1 Is Released From Activated Microglia, Stimulating Microglial Phagocytosis and Sensitizing Neurons to Glutamate. Frontiers in cellular neuroscience. vol 16. 2022-06-13. PMID:35693885. |
neu1 is released from activated microglia, stimulating microglial phagocytosis and sensitizing neurons to glutamate. |
2022-06-13 |
2023-08-14 |
Not clear |
| David H Allendorf, Guy C Brow. Neu1 Is Released From Activated Microglia, Stimulating Microglial Phagocytosis and Sensitizing Neurons to Glutamate. Frontiers in cellular neuroscience. vol 16. 2022-06-13. PMID:35693885. |
culture media from activated microglia contained neu1, and when incubated with neurons induced their desialylation, and increased the neuronal death induced by low levels of glutamate. |
2022-06-13 |
2023-08-14 |
Not clear |
| David H Allendorf, Guy C Brow. Neu1 Is Released From Activated Microglia, Stimulating Microglial Phagocytosis and Sensitizing Neurons to Glutamate. Frontiers in cellular neuroscience. vol 16. 2022-06-13. PMID:35693885. |
we conclude that activated microglia can release active neu1, possibly by lysosomal exocytosis, and this can both increase microglial phagocytosis and sensitize neurons to glutamate, thus potentiating neuronal death. |
2022-06-13 |
2023-08-14 |
Not clear |
| Ruili Guan, Tao Wang, Xiaoru Dong, Kejun Du, Juan Li, Fang Zhao, Jie Xu, Bin Li, Gang Zheng, Xuefeng Shen, Baohua Cao, Jing Wang, Michael Aschner, Mingchao Liu, Rui Che. Effects of co-exposure to lead and manganese on learning and memory deficits. Journal of environmental sciences (China). vol 121. 2022-06-02. PMID:35654517. |
the reason may involve abnormal activation of microglia leading to excessive regulation of astrocytes, resulting in glutamate reuptake dysfunction in astrocytes and leading to perturbed cognition and synaptic plasticity. |
2022-06-02 |
2023-08-14 |
human |
| Ciro De Luca, Assunta Virtuoso, Michele Papa, Francesco Certo, Giuseppe Maria Vincenzo Barbagallo, Roberto Altier. Regional Development of Glioblastoma: The Anatomical Conundrum of Cancer Biology and Its Surgical Implication. Cells. vol 11. issue 8. 2022-04-23. PMID:35456027. |
in this review, we analyze the anatomical and biological basis of gliomagenesis considering neural stem cells, the spatiotemporal diversity of astrocytes, microglia, neurons and glutamate transporters, extracellular matrix and the peritumoral environment. |
2022-04-23 |
2023-08-13 |
Not clear |
| Angela Maria Casaril, Athanasios Katsalifis, Rolf M Schmidt, Carlos Bas-Ort. Activated glia cells cause bioenergetic impairment of neurons that can be rescued by knock-down of the mitochondrial calcium uniporter. Biochemical and biophysical research communications. vol 608. 2022-04-07. PMID:35390671. |
in neuroinflammation, activated microglia and astrocytes release soluble mediators such as cytokines, glutamate, and reactive oxygen species that negatively affect neuronal function and viability, and thus contribute to neurodegeneration during disease progression. |
2022-04-07 |
2023-08-13 |
rat |
| Yan Zhang, Suliman Khan, Yang Liu, Guofeng Wu, V Wee Yong, Mengzhou Xu. Oxidative Stress Following Intracerebral Hemorrhage: From Molecular Mechanisms to Therapeutic Targets. Frontiers in immunology. vol 13. 2022-03-31. PMID:35355999. |
important sources of reactive oxygen species after hemorrhage are mitochondria dysfunction, degradated products of erythrocytes, excitotoxic glutamate, activated microglia and infiltrated neutrophils. |
2022-03-31 |
2023-08-13 |
Not clear |
| Zhuo Wang, Yunhui Li, Zhikun Zeng, Shuang Guo, Wei Chen, Yi Lu. Leucine-rich repeat containing 8A contributes to the expansion of The potential role of leucine-rich repeat-containing protein 8A in central nervous system: current situation and prospect. Neuroscience. 2022-03-11. PMID:35276302. |
after cerebral ischemia, the swollen astrocytes, neurons and microglia can activate lrrc8a-dependent vracs, which may respectively promote the release of excitatory amino acids (eaa), interaction with ionotropic glutamate receptors, and regulating inflammation, suggesting the pleiotropic roles of lrrc8a in swollen brain cells. |
2022-03-11 |
2023-08-13 |
Not clear |
| Joana Bravo, Inês Ribeiro, Ana Filipa Terceiro, Elva B Andrade, Camila Cabral Portugal, Igor M Lopes, Maria M Azevedo, Mafalda Sousa, Cátia D F Lopes, Andrea C Lobo, Teresa Canedo, João Bettencourt Relvas, Teresa Summaviell. Neuron-Microglia Contact-Dependent Mechanisms Attenuate Methamphetamine-Induced Microglia Reactivity and Enhance Neuronal Plasticity. Cells. vol 11. issue 3. 2022-02-15. PMID:35159165. |
recently, we demonstrated that binge meth administration promotes microgliosis and microglia pro-inflammation via astrocytic glutamate release in a tnf/ip |
2022-02-15 |
2023-08-13 |
Not clear |
| Xi-Biao He, Yi Wu, Haozhi Huang, Fang Gu. A novel histone deacetylase inhibitor-based approach to eliminate microglia and retain astrocyte properties in glial cell culture. Journal of neurochemistry. 2022-01-29. PMID:35092690. |
however, withdrawal of tsa not only ensures no microglia repopulation, but also restores all the gene expression changes in terms of astrocyte functions, including neurotrophic factors, glutamate and potassium transporters, and reactive astrocyte subtypes. |
2022-01-29 |
2023-08-13 |
Not clear |
| Qian Jiang, Chao-Ran Li, Wen-Feng Zeng, Hui-Jing Xu, Jia-Mei Li, Ting Zhang, Guang-Hui Deng, Yun-Xia Wan. Inhibition of Connexin 36 attenuates HMGB1-mediated depressive-like behaviors induced by chronic unpredictable mild stress. Brain and behavior. 2022-01-28. PMID:35089644. |
high mobility group box 1 (hmgb1) released by neurons and microglia was demonstrated to be an important mediator in depressive-like behaviors induced by chronic unpredictable mild stress (cums), which could lead to the imbalance of two different metabolic approaches in kynurenine pathway (kp), thus enhancing glutamate transmission and exacerbating depressive-like behaviors. |
2022-01-28 |
2023-08-13 |
Not clear |
| Samara J Brown, Amelia M Brown, Tertia D Purves-Tyson, Xu-Feng Huang, Cynthia Shannon Weickert, Kelly A Newel. Alterations in the kynurenine pathway and excitatory amino acid transporter-2 in depression with and without psychosis: Evidence of a potential astrocyte pathology. Journal of psychiatric research. vol 147. 2022-01-22. PMID:35063739. |
stimulation of the kynurenine pathway leads to the formation of neuroactive metabolites, including kynurenic acid (predominantly in astrocytes) and quinolinic acid (predominantly in microglia), which are antagonists and agonists of the glutamate nmda receptor, respectively. |
2022-01-22 |
2023-08-13 |
human |
| María Paula Avalos, Andrea Susana Guzmán, Daiana Rigoni, Ezequiel Axel Gorostiza, Marianela Adela Sanchez, Bethania Mongi-Bragato, Constanza García-Keller, Eduardo Marcelo Perassi, Miriam Beatriz Virgolini, Javier María Peralta Ramos, Pablo Iribarren, Gastón Diego Calfa, Flavia Andrea Bollati, Liliana Marina Cancel. Minocycline prevents chronic restraint stress-induced vulnerability to developing cocaine self-administration and associated glutamatergic mechanisms: a potential role of microglia. Brain, behavior, and immunity. 2022-01-22. PMID:35065197. |
glutamate transmission is tightly linked to microglia functioning. |
2022-01-22 |
2023-08-13 |
rat |
| María Paula Avalos, Andrea Susana Guzmán, Daiana Rigoni, Ezequiel Axel Gorostiza, Marianela Adela Sanchez, Bethania Mongi-Bragato, Constanza García-Keller, Eduardo Marcelo Perassi, Miriam Beatriz Virgolini, Javier María Peralta Ramos, Pablo Iribarren, Gastón Diego Calfa, Flavia Andrea Bollati, Liliana Marina Cancel. Minocycline prevents chronic restraint stress-induced vulnerability to developing cocaine self-administration and associated glutamatergic mechanisms: a potential role of microglia. Brain, behavior, and immunity. 2022-01-22. PMID:35065197. |
by using minocycline, a potent inhibitor of microglia activation with anti-inflammatory properties, we determined whether microglia could aid chronic restraint stress (crs)-induced glutamate homeostasis disruption in the nacore, underpinning stress-induced cocaine self-administration. |
2022-01-22 |
2023-08-13 |
rat |
| María Paula Avalos, Andrea Susana Guzmán, Daiana Rigoni, Ezequiel Axel Gorostiza, Marianela Adela Sanchez, Bethania Mongi-Bragato, Constanza García-Keller, Eduardo Marcelo Perassi, Miriam Beatriz Virgolini, Javier María Peralta Ramos, Pablo Iribarren, Gastón Diego Calfa, Flavia Andrea Bollati, Liliana Marina Cancel. Minocycline prevents chronic restraint stress-induced vulnerability to developing cocaine self-administration and associated glutamatergic mechanisms: a potential role of microglia. Brain, behavior, and immunity. 2022-01-22. PMID:35065197. |
these alterations were strongly related to the crs-induced reactive microglia and increased tnf-α mrna and protein expression, since by administering minocycline, the impaired glutamate homeostasis and the facilitation of cocaine self-administration were prevented. |
2022-01-22 |
2023-08-13 |
rat |