| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ze Cao, Xia Min, Xingxing Xie, Maoqing Huang, Yingying Liu, Weimin Sun, Guifang Xu, Miao He, Kaiwen He, Ying Li, Junying Yua. RIPK1 activation in Mecp2-deficient microglia promotes inflammation and glutamate release in RTT. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 6. 2024-01-30. PMID:38289948. |
ripk1 inhibition in mecp2-deficient microglia reduced oxidative stress, cytokines production and induction of slc7a11, slc38a1, and gls, which mediate the release of glutamate. |
2024-01-30 |
2024-02-02 |
mouse |
| Ze Cao, Xia Min, Xingxing Xie, Maoqing Huang, Yingying Liu, Weimin Sun, Guifang Xu, Miao He, Kaiwen He, Ying Li, Junying Yua. RIPK1 activation in Mecp2-deficient microglia promotes inflammation and glutamate release in RTT. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 6. 2024-01-30. PMID:38289948. |
mecp2-deficient microglia release high levels of glutamate to impair glutamate-mediated excitatory neurotransmission and promote increased levels of glua1 and glua2/3 proteins in vivo, which was reduced upon ripk1 inhibition. |
2024-01-30 |
2024-02-02 |
mouse |
| Jiang-Ping Wei, Zi-Xuan Zhao, Jing Zeng, Fang-Hong Shang, Lei Hua, Yong Yang, Xiao-Mei Zhan. [Yigong Powder regulates CXCL12/CXCR4 signaling to reduce glutamate release and prevent cognitive decline in mouse model of aging]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 23. 2024-01-11. PMID:38212005. |
furthermore, yigong powder decreased the average fluorescence intensity of cxcl12 and cxcr4, reduced cxcr4-positive astrocytes and microglia, down-regulated the protein levels of p-erk/erk and tnfr1, and lowered the level of glutamate in the brain tissue. |
2024-01-11 |
2024-01-14 |
mouse |
| Mariusz P Gajewski, Steven W Barge. Design, synthesis, and characterization of novel system x Journal of neuroinflammation. vol 20. issue 1. 2023-12-07. PMID:38057869. |
design, synthesis, and characterization of novel system x neuroinflammation appears to involve some degree of excitotoxicity promulgated by microglia, which release glutamate via the system x |
2023-12-07 |
2023-12-10 |
Not clear |
| Dongxia Duan, Lian Wang, Yueyang Feng, Daiyu Hu, Donghong Cu. Picroside Ⅱ attenuates neuropathic pain by regulating inflammation and spinal excitatory synaptic transmission. Canadian journal of physiology and pharmacology. 2023-11-17. PMID:37976472. |
thus, this study suggested that pⅡ attenuated neuropathic pain by inhibiting excitatory glutamate transmission of spinal synapses induced by an inflammatory response on microglia. |
2023-11-17 |
2023-11-20 |
rat |
| Alicja Maciejska, Bartosz Pomierny, Weronika Krzyżanowska, Beata Starek-Świechowicz, Alicja Skórkowska, Bogusława Budziszewsk. Mechanism of microglial cell activation in the benzophenone-3 exposure model. Neuroscience. 2023-10-12. PMID:37827357. |
this compound increases extracellular glutamate concentrations, lipid peroxidation, the number of microglia cells and induces process of apoptosis. |
2023-10-12 |
2023-10-15 |
rat |
| Qihui Zhao, Junli Chen, Mengjun Wu, Xiaoli Yin, Qiaoying Jiang, Hongchang Gao, Hong Zhen. Microbiota from healthy mice alleviates cognitive decline via reshaping the gut-brain metabolic axis in diabetic mice. Chemico-biological interactions. 2023-07-20. PMID:37473910. |
in vitro study, we found that glutamate notably decreased microglia activation and the expression levels of proinflammatory factor. |
2023-07-20 |
2023-08-14 |
mouse |
| Shengwen Wang, Ye Liu, Zekang Wu, Yuwen Jin, Tao Zhang, Zhuo Yang, Chunhua Li. Inhibition of xCT by sulfasalazine alleviates the depression-like behavior of adult male mice subjected to maternal separation stress. Behavioural brain research. 2023-07-01. PMID:37392785. |
moreover, the levels of eaat2 and mglur2/3 were ameliorated, the over-activation of the microglia was mitigated, and the levels of glutamate and pro-inflammatory factors were decreased. |
2023-07-01 |
2023-08-14 |
mouse |
| Chenhui Ji, Yalin Tang, Yanyan Zhang, Xiaoyan Huang, Congcong Li, Yuhong Yang, Qihui Wu, Xiaohuan Xia, Qingyuan Cai, Xin-Rui Qi, Jialin C Zhen. Glutaminase 1 deficiency confined in forebrain neurons causes autism spectrum disorder-like behaviors. Cell reports. vol 42. issue 7. 2023-06-29. PMID:37384529. |
mice lacking gls1 in camkiiα-positive neurons display a series of asd-like behaviors, synaptic excitatory and inhibitory (e/i) imbalance, higher spine density, and glutamate receptor expression in the prefrontal cortex, as well as a compromised expression pattern of genes involved in synapse pruning and less engulfed synaptic puncta in microglia. |
2023-06-29 |
2023-08-14 |
mouse |
| Mariusz Gajewski, Steven Barge. Design, synthesis, and characterization of novel Xc- transport inhibitors: Inhibition of microglial glutamate release and neurotoxicity. Research square. 2023-06-09. PMID:37292591. |
neuroinflammation appears to involve some degree of excitotoxicity promulgated by microglia, which release glutamate via the system xc- cystine-glutamate antiporter. |
2023-06-09 |
2023-08-14 |
Not clear |
| Mariusz Gajewski, Steven Barge. Design, synthesis, and characterization of novel Xc- transport inhibitors: Inhibition of microglial glutamate release and neurotoxicity. Research square. 2023-06-09. PMID:37292591. |
these agents were tested for the ability to inhibit release of glutamate from microglia activated with lipopolysaccharide (lps), an activity exhibited by eight of the compounds. |
2023-06-09 |
2023-08-14 |
Not clear |
| Rosanna Tarkany Basting, Marcelo Henrique Napimoga, Carlos Antônio Trindade Silva, Henrique Ballassini Abdalla, Braz Campos Durso, Leopoldo Henrique Barboza Martins, Herbert de Abreu Cavalcanti, Bruce D Hammock, Juliana Trindade Clemente-Napimog. Soluble epoxide hydrolase inhibitor blockage microglial cell activation in subnucleus caudalis in a persistent model of arthritis. International immunopharmacology. vol 120. 2023-05-25. PMID:37230034. |
in tsc, tppu reduces the cytokine storm and attenuates the microglia activated p2x7/cathepsin s/fractalkine pathway and reduces the astrocyte activation and glutamate levels. |
2023-05-25 |
2023-08-14 |
rat |
| b' Marzia Moretti, Riccardo Caraffi, Luca Lorenzini, Ilaria Ottonelli, Michele Sannia, Giuseppe Alastra, Vito Antonio Baldassarro, Alessandro Giuliani, Jason Thomas Duskey, Maura Cescatti, Barbara Ruozi, Luigi Aloe, Maria Angela Vandelli, Luciana Giardino, Giovanni Tosi, Laura Calz\\xc3\\xa. "Combo" Multi-Target Pharmacological Therapy and New Formulations to Reduce Inflammation and Improve Endogenous Remyelination in Traumatic Spinal Cord Injury. Cells. vol 12. issue 9. 2023-05-14. PMID:37174731.' |
a strong anti-inflammatory effect was observed in the short term with a reduction of type m1 microglia and glutamate levels, but with a subsequent increase of trem2. |
2023-05-14 |
2023-08-14 |
mouse |
| Yi-Wen Bai, Qi-Hao Yang, Pei-Jie Chen, Xue-Qiang Wan. Repetitive transcranial magnetic stimulation regulates neuroinflammation in neuropathic pain. Frontiers in immunology. vol 14. 2023-05-14. PMID:37180127. |
in addition, rtms reduces the expression of glutamate receptors (mglur5 and nmdar2b) and microglia and astrocyte markers (iba1 and gfap). |
2023-05-14 |
2023-08-14 |
Not clear |
| Fan Zhang, Zhi Zhang, Jesse Alt, Siva P Kambhampati, Anjali Sharma, Sarabdeep Singh, Elizabeth Nance, Ajit G Thomas, Camilo Rojas, Rana Rais, Barbara S Slusher, Rangaramanujam M Kannan, Sujatha Kanna. Dendrimer-enabled targeted delivery attenuates glutamate excitotoxicity and improves motor function in a rabbit model of cerebral palsy. Journal of controlled release : official journal of the Controlled Release Society. 2023-04-13. PMID:37054778. |
glutamate carboxypeptidase ii (gcpii), localized on the surface of astrocytes and activated microglia, regulates extracellular glutamate concentration in the central nervous system (cns). |
2023-04-13 |
2023-08-14 |
rabbit |
| Fan Zhang, Zhi Zhang, Jesse Alt, Siva P Kambhampati, Anjali Sharma, Sarabdeep Singh, Elizabeth Nance, Ajit G Thomas, Camilo Rojas, Rana Rais, Barbara S Slusher, Rangaramanujam M Kannan, Sujatha Kanna. Dendrimer-enabled targeted delivery attenuates glutamate excitotoxicity and improves motor function in a rabbit model of cerebral palsy. Journal of controlled release : official journal of the Controlled Release Society. 2023-04-13. PMID:37054778. |
targeted delivery of 2-mppa specifically to activated microglia and astrocytes that over-express gcpii has the potential to mitigate glutamate excitotoxicity and attenuate neuroinflammation. |
2023-04-13 |
2023-08-14 |
rabbit |
| Fan Zhang, Zhi Zhang, Jesse Alt, Siva P Kambhampati, Anjali Sharma, Sarabdeep Singh, Elizabeth Nance, Ajit G Thomas, Camilo Rojas, Rana Rais, Barbara S Slusher, Rangaramanujam M Kannan, Sujatha Kanna. Dendrimer-enabled targeted delivery attenuates glutamate excitotoxicity and improves motor function in a rabbit model of cerebral palsy. Journal of controlled release : official journal of the Controlled Release Society. 2023-04-13. PMID:37054778. |
these results indicate that targeted dendrimer-based delivery specifically to activated microglia and astrocytes can improve the efficacy of 2-mppa by attenuating glutamate excitotoxicity and microglial activation. |
2023-04-13 |
2023-08-14 |
rabbit |
| Matilde Balbi, Giambattista Bonanno, Tiziana Bonifacino, Marco Milanes. The Physio-Pathological Role of Group I Metabotropic Glutamate Receptors Expressed by Microglia in Health and Disease with a Focus on Amyotrophic Lateral Sclerosis. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982315. |
the physio-pathological role of group i metabotropic glutamate receptors expressed by microglia in health and disease with a focus on amyotrophic lateral sclerosis. |
2023-03-29 |
2023-08-14 |
Not clear |
| Matilde Balbi, Giambattista Bonanno, Tiziana Bonifacino, Marco Milanes. The Physio-Pathological Role of Group I Metabotropic Glutamate Receptors Expressed by Microglia in Health and Disease with a Focus on Amyotrophic Lateral Sclerosis. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982315. |
in this context, group i metabotropic glutamate receptors (mglurs) are molecular structures that may contribute to the modulation of the reactive phenotype of microglia cells, and this is worthy of exploration. |
2023-03-29 |
2023-08-14 |
Not clear |
| Nirnath Sah, Zhi Zhang, Alicia Chime, Amanda Fowler, Antonio Mendez-Trendler, Anjali Sharma, Kannan Rangaramanujam, Barbara Slusher, Sujatha Kanna. Dendrimer conjugated glutamate carboxypeptidase II inhibitor restores microglial changes in a rabbit model of cerebral palsy. Developmental neuroscience. 2023-03-29. PMID:36990069. |
'activated' microglia overexpress the enzyme glutamate carboxypeptidase ii (gcpii) that hydrolyzes n-acetylaspartylglutamate (naag) to n-acetylaspartate (naa) and glutamate, and we have shown previously that inhibiting microglial gcpii is neuroprotective. |
2023-03-29 |
2023-08-14 |
rabbit |