| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexander Hawlitschka, Stefan J P Haas, Oliver Schmitt, Dieter G Weiss, Andreas Wre. Effects of systemic PSI administration on catecholaminergic cells in the brain, adrenal medulla and carotid body in Wistar rats. Brain research. vol 1173. 2008-01-09. PMID:17850771. |
brain slices containing the substantia nigra and the striatum were stained immunohistochemically against tyrosine hydroxylase, neuronal nuclei antigen, glial fibrillary acidic protein, alpha-synuclein and microglia. |
2008-01-09 |
2023-08-12 |
rat |
| Anne Vroon, Benjamin Drukarch, John G J M Bol, Patrick Cras, John J P Brevé, Stuart M Allan, Jane K Relton, Piet V J M Hoogland, Anne-Marie Van Da. Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system: microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb. Experimental gerontology. vol 42. issue 8. 2007-12-19. PMID:17592750. |
mptp-induced microgliosis in striatum and olfactory bulb was reduced in il-1alpha/beta knockout mice, indicating that il-1 affects microglia activation. |
2007-12-19 |
2023-08-12 |
mouse |
| Alexander H de Haas, Hendricus W G M Boddeke, Nieske Brouwer, Knut Bibe. Optimized isolation enables ex vivo analysis of microglia from various central nervous system regions. Glia. vol 55. issue 13. 2007-11-13. PMID:17661344. |
in addition, this study shows the possibility to analyze microglia isolated from various central nervous system regions such as optic nerve, striatum, hippocampus, spinal cord, cerebellum, and cerebral cortex. |
2007-11-13 |
2023-08-12 |
mouse |
| Heather A Boger, Lawrence D Middaugh, Kennerly S Patrick, Sammanda Ramamoorthy, Emily D Denehy, Haojie Zhu, Alejandra M Pacchioni, Ann-Charlotte Granholm, Jacqueline F McGint. Long-term consequences of methamphetamine exposure in young adults are exacerbated in glial cell line-derived neurotrophic factor heterozygous mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 33. 2007-09-14. PMID:17699663. |
two weeks after a methamphetamine binge (4 x 10 mg/kg, i.p., at 2 h intervals), gdnf(+/-) mice had a significantly greater reduction of tyrosine hydroxylase immunoreactivity in the medial striatum, a proportionally greater depletion of dopamine and 3,4-dihydroxyphenylacetic acid (dopac) levels in the striatum, and a greater increase in activated microglia in the substantia nigra than wild-type mice. |
2007-09-14 |
2023-08-12 |
mouse |
| Toshiyuki Kawasaki, Kotaro Ishihara, Yukio Ago, Akemichi Baba, Toshio Matsud. Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum. The Journal of pharmacology and experimental therapeutics. vol 322. issue 1. 2007-08-30. PMID:17429058. |
edaravone inhibited activation of the microglia and the increased 3-nitrotyrosine immunoreactivity in the snc but not the striatum, and it also inhibited thiobarbituric acid reactive substance levels in the midbrain. |
2007-08-30 |
2023-08-12 |
mouse |
| Andreas Hald, Johan Van Beek, Julie Lothariu. Inflammation in Parkinson's disease: causative or epiphenomenal? Sub-cellular biochemistry. vol 42. 2007-08-06. PMID:17612055. |
not only have activated microglia and increased levels of inflammatory mediators been detected in the striatum of pd patients, but a large body of animal studies points to a contributory role of inflammation in dopaminergic cell loss. |
2007-08-06 |
2023-08-12 |
human |
| Hyun B Choi, Jae K Ryu, Seung U Kim, James G McLarno. Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 18. 2007-06-06. PMID:17475804. |
we investigated the involvement and roles of the ionotropic purinergic receptor p2x(7)r in microglia in mediating lipopolysaccharide (lps)-induced inflammatory responses and neuronal damage in rat striatum. |
2007-06-06 |
2023-08-12 |
human |
| Hyun B Choi, Jae K Ryu, Seung U Kim, James G McLarno. Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 18. 2007-06-06. PMID:17475804. |
a detailed in vivo study showed that lps injection into striatum markedly increased the expression of p2x(7)r in microglia compared with control (saline)-injected animals. |
2007-06-06 |
2023-08-12 |
human |
| Y Yasuda, R Shinagawa, M Yamada, T Mori, N Tateishi, S Fujit. Long-lasting reactive changes observed in microglia in the striatal and substantia nigral of mice after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Brain research. vol 1138. 2007-05-21. PMID:17275793. |
to understand the reasons why the progression does not occur in mptp-treated mice, we used immunohistochemical analyses to study whether activated microglia in the striatum and/or substantia nigra persist long after mptp treatment. |
2007-05-21 |
2023-08-12 |
mouse |
| Y Yasuda, R Shinagawa, M Yamada, T Mori, N Tateishi, S Fujit. Long-lasting reactive changes observed in microglia in the striatal and substantia nigral of mice after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Brain research. vol 1138. 2007-05-21. PMID:17275793. |
after 6 months, the microglia in the striatum and substantia nigra pars compacta of the treated c57bl/6 mice were still more hypertrophic compared with the control, although less hypertrophic than those observed at day two. |
2007-05-21 |
2023-08-12 |
mouse |
| Jason K Wasserman, Lyanne C Schlichte. Neuron death and inflammation in a rat model of intracerebral hemorrhage: effects of delayed minocycline treatment. Brain research. vol 1136. issue 1. 2007-04-27. PMID:17223087. |
neuron death was limited to the edge of the hematoma, with no degenerating neurons in the striatum surrounding the hematoma, despite robust and prolonged microglia activation. |
2007-04-27 |
2023-08-12 |
human |
| Hanna S Lindgren, Daniella Rylander, K Elisabet Ohlin, Martin Lundblad, M Angela Cenc. The "motor complication syndrome" in rats with 6-OHDA lesions treated chronically with L-DOPA: relation to dose and route of administration. Behavioural brain research. vol 177. issue 1. 2007-03-27. PMID:17157933. |
based on the hypothesis that higher doses of l-dopa may be toxic to dopaminoceptive structures, we compared the total number of neurons and the levels of activated microglia in the striatum. |
2007-03-27 |
2023-08-12 |
rat |
| Lin Zhang, Yukihiko Shirayama, Eiji Shimizu, Masaomi Iyo, Kenji Hashimot. Protective effects of minocycline on 3,4-methylenedioxymethamphetamine-induced neurotoxicity in serotonergic and dopaminergic neurons of mouse brain. European journal of pharmacology. vol 544. issue 1-3. 2007-01-12. PMID:16859675. |
moreover, pretreatment and the subsequent administration of minocycline (40 mg/kg) significantly attenuated the increase of activated microglia in the hippocampus and striatum after the repeated administration of mdma. |
2007-01-12 |
2023-08-12 |
mouse |
| Toshiyuki Kawasaki, Kotaro Ishihara, Yukio Ago, Shigeo Nakamura, Soichi Itoh, Akemichi Baba, Toshio Matsud. Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum. European journal of pharmacology. vol 542. issue 1-3. 2006-12-14. PMID:16784740. |
an immunohistochemical study showed that methamphetamine increased 3-nitrotyrosine immunoreactivity, an in vivo marker of peroxynitrite production, and activated microglia and astrocytes in the striatum. |
2006-12-14 |
2023-08-12 |
mouse |
| Gwendolyn E Goings, Dorothy A Kozlowski, Francis G Szel. Differential activation of microglia in neurogenic versus non-neurogenic regions of the forebrain. Glia. vol 54. issue 4. 2006-10-02. PMID:16862532. |
after aspiration cerebral cortex lesions, microglia became activated in the cerebral cortex, corpus callosum, and striatum. |
2006-10-02 |
2023-08-12 |
mouse |
| Wanida Tripanichkul, Kittisak Sripanichkulchai, David I Finkelstei. Estrogen down-regulates glial activation in male mice following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxication. Brain research. vol 1084. issue 1. 2006-08-10. PMID:16564034. |
immunohistochemistry and quantitative study were used to assess the number of tyrosine hydroxylase-immunoreactive (th-ir) neurons in the substantia nigra pars compacta (snpc) and that of activated astrocytes and activated microglia in the snpc and the striatum. |
2006-08-10 |
2023-08-12 |
mouse |
| Alessia Melani, Susanna Amadio, Marco Gianfriddo, Maria G Vannucchi, Cinzia Volontè, Giorgio Bernardi, Felicita Pedata, Giuseppe Sancesari. P2X7 receptor modulation on microglial cells and reduction of brain infarct caused by middle cerebral artery occlusion in rat. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 26. issue 7. 2006-07-27. PMID:16395292. |
reactive blue 2 improved sensorimotor deficit and restricted the volume of infarction, without preventing the expression of p2x7, but inducing it in the microglia of contralateral frontal and parietal cortex and striatum, which had lost reciprocal connections with the remote infarct area. |
2006-07-27 |
2023-08-12 |
rat |
| Alessia Melani, Marco Gianfriddo, Maria Giuliana Vannucchi, Sara Cipriani, Pier Giovanni Baraldi, Maria Grazia Giovannini, Felicita Pedat. The selective A2A receptor antagonist SCH 58261 protects from neurological deficit, brain damage and activation of p38 MAPK in rat focal cerebral ischemia. Brain research. vol 1073-1074. 2006-07-19. PMID:16443200. |
sch 58261 reduced phospho-p38 mapk immunoreactivity in the striatum and in the cortex without changing the microglial cell morphology. |
2006-07-19 |
2023-08-12 |
rat |
| Justin M Dean, Sherly A George, Guido Wassink, Alistair J Gunn, Laura Benne. Suppression of post-hypoxic-ischemic EEG transients with dizocilpine is associated with partial striatal protection in the preterm fetal sheep. Neuropharmacology. vol 50. issue 4. 2006-07-10. PMID:16376952. |
after 3 days recovery, treatment was associated with a significant reduction in neuronal loss in the striatum (31 +/- 7 versus 58 +/- 2%, p < 0.05), expression of cleaved caspase-3 (111+/-7 versus 159 +/- 10 counts area(-1), p < 0.05) and numbers of activated microglia (57 +/- 9 versus 92 +/- 16 counts area(-1), p < 0.05); there was no significant effect in other regions or on loss of immature o4-positive oligodendrocytes. |
2006-07-10 |
2023-08-12 |
Not clear |
| R Shamekh, J Newcomb, J Mallery, C J Cassady, S Saporta, D F Cameron, P R Sanberg, A E Willin. Survival of rat or mouse ventral mesencephalon neurons after cotransplantation with rat sertoli cells in the mouse striatum. Cell transplantation. vol 14. issue 8. 2006-02-09. PMID:16358409. |
transplanting xenografts of rat scs into the mouse striatum with either rat or mouse ventral mesencephalon prevented astrocytic infiltration of the graft site, although all transplants showed activated microglia within the core of the graft. |
2006-02-09 |
2023-08-12 |
mouse |