| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Ketteler, N A Noble, W A Borde. Transforming growth factor-beta and angiotensin II: the missing link from glomerular hyperfiltration to glomerulosclerosis? Annual review of physiology. vol 57. 1995-07-13. PMID:7778869. |
recent studies reveal that angiotensin ii is a potent inducer of tgf-beta synthesis in a variety of cells and that this mechanism exerts important biological effects including extracellular matrix accumulation, cell proliferation, and hypertrophy. |
1995-07-13 |
2023-08-12 |
Not clear |
| F Descalzi Cancedda, A Melchiori, R Benelli, C Gentili, L Masiello, G Campanile, R Cancedda, A Albin. Production of angiogenesis inhibitors and stimulators is modulated by cultured growth plate chondrocytes during in vitro differentiation: dependence on extracellular matrix assembly. European journal of cell biology. vol 66. issue 1. 1995-06-20. PMID:7538466. |
supernatants from dedifferentiated cells undergoing maturation to hypertrophic chondrocytes in suspension progressively inhibited vascular cell random migration and invasion of basement membrane matrix by endothelial cells. |
1995-06-20 |
2023-08-12 |
mouse |
| F Descalzi Cancedda, A Melchiori, R Benelli, C Gentili, L Masiello, G Campanile, R Cancedda, A Albin. Production of angiogenesis inhibitors and stimulators is modulated by cultured growth plate chondrocytes during in vitro differentiation: dependence on extracellular matrix assembly. European journal of cell biology. vol 66. issue 1. 1995-06-20. PMID:7538466. |
medium conditioned by osteoblast-like cells derived from hypertrophic chondrocytes also induced vascular cell migration and invasion of basement membrane matrix. |
1995-06-20 |
2023-08-12 |
mouse |
| F Descalzi Cancedda, A Melchiori, R Benelli, C Gentili, L Masiello, G Campanile, R Cancedda, A Albin. Production of angiogenesis inhibitors and stimulators is modulated by cultured growth plate chondrocytes during in vitro differentiation: dependence on extracellular matrix assembly. European journal of cell biology. vol 66. issue 1. 1995-06-20. PMID:7538466. |
therefore, interactions of chondrocytes with their extracellular matrix are an absolute requirement for the expression of angiogenic activities by hypertrophic chondrocytes at late developmental stages. |
1995-06-20 |
2023-08-12 |
mouse |
| D Aeschlimann, O Kaupp, M Paulsso. Transglutaminase-catalyzed matrix cross-linking in differentiating cartilage: identification of osteonectin as a major glutaminyl substrate. The Journal of cell biology. vol 129. issue 3. 1995-05-31. PMID:7730416. |
we now demonstrate the transglutaminase reaction product, the gamma-glutamyl-epsilon-lysine cross-link, in the matrix of hypertrophic cartilage using a novel cross-link specific antibody. |
1995-05-31 |
2023-08-12 |
Not clear |
| D Aeschlimann, O Kaupp, M Paulsso. Transglutaminase-catalyzed matrix cross-linking in differentiating cartilage: identification of osteonectin as a major glutaminyl substrate. The Journal of cell biology. vol 129. issue 3. 1995-05-31. PMID:7730416. |
incorporation of the synthetic transglutaminase substrate monodansylcadaverine (amine donor) in cultured tracheal explants reveals enzyme activity in the pericellular matrix of hypertrophic chondrocytes in the central, calcifying areas of the horseshoe-shaped cartilages. |
1995-05-31 |
2023-08-12 |
Not clear |
| A M Garcia, M L Gra. Dimensional growth and extracellular matrix accumulation by neonatal rat mandibular condyles in long-term culture. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 13. issue 2. 1995-05-25. PMID:7722758. |
growth occurred by a combination of cell proliferation, matrix synthesis and accumulation, and cell hypertrophy (with the latter two mechanisms dominating). |
1995-05-25 |
2023-08-12 |
rat |
| T Sawai, J Fujiyama, M Takahashi, T Takahash. The site of elevated vascular resistance in early paraquat lungs: a morphometric study of pulmonary arteries. The Tohoku journal of experimental medicine. vol 174. issue 2. 1995-04-27. PMID:7900152. |
in paraquat lungs, dm began to rise as early as the 8th day, i.e., almost simultaneously with beginning deposition of fibrogenic matrix on alveolar wall, suggesting that the medial hypertrophy is the result of hypoxic vasoconstriction due to alveolar-capillary block. |
1995-04-27 |
2023-08-12 |
Not clear |
| D Chan, W G Cole, J G Rogers, J F Batema. Type X collagen multimer assembly in vitro is prevented by a Gly618 to Val mutation in the alpha 1(X) NC1 domain resulting in Schmid metaphyseal chondrodysplasia. The Journal of biological chemistry. vol 270. issue 9. 1995-04-05. PMID:7876225. |
it is a highly specialized extracellular matrix component, and its synthesis is restricted to hypertrophic chondrocytes in the calcifying cartilage of the growth plate and in zones of secondary ossification. |
1995-04-05 |
2023-08-12 |
Not clear |
| L Brown, C Serni. Angiotensin receptors in cardiovascular diseases. Clinical and experimental pharmacology & physiology. vol 21. issue 10. 1995-03-29. PMID:7867232. |
the cellular effects of aii are extensive and encompass hypertrophy, hyperplasia and the deposition of extracellular matrix. |
1995-03-29 |
2023-08-12 |
human |
| T Omura, S Kim, K Takeuchi, H Iwao, T Taked. Transforming growth factor beta 1 and extracellular matrix gene expression in isoprenaline induced cardiac hypertrophy: effects of inhibition of the renin-angiotensin system. Cardiovascular research. vol 28. issue 12. 1995-03-28. PMID:7867037. |
transforming growth factor beta 1 and extracellular matrix gene expression in isoprenaline induced cardiac hypertrophy: effects of inhibition of the renin-angiotensin system. |
1995-03-28 |
2023-08-12 |
Not clear |
| W O Twal, R Vasilatos-Younken, C V Gay, R M Leac. Isolation and localization of basic fibroblast growth factor-immunoreactive substance in the epiphyseal growth plate. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 9. issue 11. 1995-03-20. PMID:7863825. |
basic fgf appears to be associated with the extracellular matrix of the proliferative zone, but it is predominantly intracellular in the hypertrophic and mineralizing zone chondrocytes. |
1995-03-20 |
2023-08-12 |
Not clear |
| G D Walker, M Fischer, J Gannon, R C Thompson, T R Oegem. Expression of type-X collagen in osteoarthritis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 13. issue 1. 1995-03-16. PMID:7853102. |
thus, the osteoarthritic process may damage the matrix in the superficial layer and induce changes leading to the expression of the hypertrophic chondrocyte phenotype. |
1995-03-16 |
2023-08-12 |
mouse |
| D Le Guellec, F Mallein-Gerin, I Treilleux, J Bonaventure, P Peysson, D Herbag. Localization of the expression of type I, II and III collagen genes in human normal and hypochondrogenesis cartilage canals. The Histochemical journal. vol 26. issue 9. 1995-03-03. PMID:7843983. |
the canal hypertrophy observed in this pathological case could thus be due to a modification in the regulation of the growth of cartilage canals caused by a defective cartilage matrix. |
1995-03-03 |
2023-08-12 |
human |
| V Lefebvre, S Garofalo, B de Crombruggh. Type X collagen gene expression in mouse chondrocytes immortalized by a temperature-sensitive simian virus 40 large tumor antigen. The Journal of cell biology. vol 128. issue 1-2. 1995-02-14. PMID:7822418. |
the cells from all pools and from most clones expressed the genes for several markers of hypertrophic chondrocytes, such as type x collagen, matrix gla protein, and osteopontin, but had lost expression of type ii collagen mrna and failed to be stained by alcian blue which detects cartilage-specific proteoglycans. |
1995-02-14 |
2023-08-12 |
mouse |
| Y Tajima, K Kato, M Kashimata, M Hiramatsu, N Utsum. Immunohistochemical analysis of EGF in epiphyseal growth plate from normal, hypophysectomized, and growth hormone-treated hypophysectomized rats. Cell and tissue research. vol 278. issue 2. 1995-01-25. PMID:8001084. |
hypophysectomy resulted in considerable atrophy of the chondrocytes and the cartilage matrix (a decreased number of mature-type chondrocytes and a decreased ratio of proliferating to hypertrophic chondrocytes) and a significant diminution of egf immunoreactivity. |
1995-01-25 |
2023-08-12 |
rat |
| H S Sharma, H A van Heugten, M A Goedbloed, P D Verdouw, J M Lamer. Angiotensin II induced expression of transcription factors precedes increase in transforming growth factor-beta 1 mRNA in neonatal cardiac fibroblasts. Biochemical and biophysical research communications. vol 205. issue 1. 1995-01-17. PMID:7999008. |
our results indicate that ang ii transiently stimulates the expression of transcription factors, which may up-regulate tgf-beta 1, that in turn could contribute to the process of myocardial extra-cellular matrix remodeling in hypertrophy. |
1995-01-17 |
2023-08-12 |
rat |
| T Nakase, K Takaoka, K Hirakawa, S Hirota, T Takemura, H Onoue, K Takebayashi, Y Kitamura, S Nomur. Alterations in the expression of osteonectin, osteopontin and osteocalcin mRNAs during the development of skeletal tissues in vivo. Bone and mineral. vol 26. issue 2. 1995-01-13. PMID:7994183. |
in growth cartilage, osn mrna was observed in chondrocytes in non-mineralized cartilage, whereas osp mrna was detected in hypertrophic chondrocytes in mineralized cartilage matrix with a characteristic switch in expression. |
1995-01-13 |
2023-08-12 |
mouse |
| J Secchi, D Lecaque, F W Dunn, S Jouquey, U D Auberval, F Benzoni, O Sirugue, G Hamo. Effects of subchronic treatment with trandolapril and enalapril on cardiovascular morphologic alterations in the aged spontaneously hypertensive rat with heart failure. Journal of cardiovascular pharmacology. vol 23 Suppl 4. 1995-01-05. PMID:7527099. |
in the mesenteric artery, trandolapril treatment induced a complete regression of the media hypertrophy and a marked decrease in extracellular matrix surface. |
1995-01-05 |
2023-08-12 |
rat |
| H J Swa. Left ventricular dysfunction in ischemic heart disease: fundamental importance of the fibrous matrix. Cardiovascular drugs and therapy. vol 8 Suppl 2. 1994-12-28. PMID:7947372. |
in the normal heart, and apparently in physiological hypertrophy, this matrix is submicroscopic. |
1994-12-28 |
2023-08-12 |
Not clear |