| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nader Pazyar, Sedigheh Sananzadeh, Reza Yaghoobi, Nima Bakhtiar. Comparison of Intralesional Vitamin D with Intralesional Triamcinolone Acetonide in the Treatment of Keloids. World journal of plastic surgery. vol 13. issue 2. 2024-08-28. PMID:39193238. |
hypertrophic scars and keloids are disorders caused by the excessive growth of connective tissue, associated with the accumulation of collagen and cellular matrix components. |
2024-08-28 |
2024-08-30 |
Not clear |
| Manuel Sigle, Anne-Katrin Rohlfing, Melanie Cruz Santos, Timo Kopp, Konstantin Krutzke, Vincent Gidlund, Ferdinand Kollotzek, Julia Marzi, Saskia von Ungern-Sternberg, Antti Poso, Mathias Heikenwälder, Katja Schenke-Layland, Peter Seizer, Julia Möllmann, Nikolaus Marx, Robert Feil, Susanne Feil, Robert Lukowski, Oliver Borst, Tilman E Schäffer, Karin Anne Lydia Müller, Meinrad P Gawaz, David Heinzman. Targeting Cyclophilin A in the Cardiac Microenvironment Preserves Heart Function and Structure in Failing Hearts. Circulation research. 2024-08-14. PMID:39140165. |
cardiac hypertrophy is characterized by remodeling of the myocardium, which involves alterations in the ecm (extracellular matrix) and cardiomyocyte structure. |
2024-08-14 |
2024-08-16 |
Not clear |
| Kaili Ye, Yanling Zhao, Wen Huang, Yonglin Zh. Sodium butyrate improves renal injury in diabetic nephropathy through AMPK/SIRT1/PGC-1α signaling pathway. Scientific reports. vol 14. issue 1. 2024-08-01. PMID:39090182. |
our findings demonstrate that exogenous nab supplementation can improve hyperglycemia and albuminuria, reduce renal tissue inflammation, inhibit extracellular matrix accumulation and glomerular hypertrophy, and could alter the gut microbiota composition in dn. |
2024-08-01 |
2024-08-05 |
mouse |
| L C Nath, A Saljic, R Buhl, A Elliott, A La Gerche, C Ye, H Schmidt Royal, K Lundgren Virklund, T A Agbaedeng, A Stent, S Frankli. Histological evaluation of cardiac remodelling in equine athletes. Scientific reports. vol 14. issue 1. 2024-07-19. PMID:39030282. |
horses in the ath group had myocyte hypertrophy at all sites; increased fibrosis at all sites other than the laa; increased fibroblast infiltration but a reduction in the overall extracellular matrix (ecm) volume in the raa, lvapm, and ivs-r compared to sed horses. |
2024-07-19 |
2024-07-22 |
Not clear |
| Caterina Redwanz, Ricardo H Pires, Doreen Biedenweg, Stefan Groß, Oliver Otto, Stephanie Köneman. Endothelin-1 influences mechanical properties and contractility of hiPSC derived cardiomyocytes resulting in diastolic dysfunction. Journal of molecular and cellular cardiology. 2024-07-17. PMID:39019395. |
gene expression patterns in et-1 treated hipsc derived cardiomyocytes showed that pathways associated with cardiovascular diseases, cardiac hypertrophy and extracellular matrix were upregulated while those associated with fatty acid metabolism were downregulated. |
2024-07-17 |
2024-07-20 |
human |
| Tiantian Yang, Li Wang, Haiyang Ma, Kailun Li, Yajing Wang, Wenjie Tang, Zichen Wang, Meiwen An, Xiang Gao, Ludan Xu, Yunyun Guo, Jiqiang Guo, Yong Liu, Hugen Wang, Yang Liu, Quanyou Zhan. Role of Emerin in regulating fibroblast differentiation and migration at the substrate of stiffness coupled topology. Acta biochimica et biophysica Sinica. 2024-07-09. PMID:38978507. |
in hypertrophic scars, the differentiation and migration of fibroblasts are influenced by the extracellular matrix microenvironment, which includes factors such as stiffness, restraint, and tensile force. |
2024-07-09 |
2024-07-12 |
Not clear |
| Tiantian Yang, Li Wang, Haiyang Ma, Kailun Li, Yajing Wang, Wenjie Tang, Zichen Wang, Meiwen An, Xiang Gao, Ludan Xu, Yunyun Guo, Jiqiang Guo, Yong Liu, Hugen Wang, Yang Liu, Quanyou Zhan. Role of Emerin in regulating fibroblast differentiation and migration at the substrate of stiffness coupled topology. Acta biochimica et biophysica Sinica. 2024-07-09. PMID:38978507. |
these observations indicate that variations in nuclear skeletal proteins, prompted by diverse matrix microenvironments, play a pivotal role in the pathogenesis of hypertrophic scars (hss). |
2024-07-09 |
2024-07-12 |
Not clear |
| Ilhem Lilia Jaabar, Brittany Foley, Alberto Mezzetti, Françoise Pillier, Francis Berenbaum, Jessem Landoulsi, Xavier Houar. Unraveling the Mechanisms of Hypertrophy-Induced Matrix Mineralization and Modifications in Articular Chondrocytes. Calcified tissue international. 2024-06-25. PMID:38918254. |
it is associated with matrix remodeling and mineralization, the dynamics of which is not well characterized during chondrocyte hypertrophic differentiation in articular cartilage. |
2024-06-25 |
2024-06-29 |
Not clear |
| Ilhem Lilia Jaabar, Brittany Foley, Alberto Mezzetti, Françoise Pillier, Francis Berenbaum, Jessem Landoulsi, Xavier Houar. Unraveling the Mechanisms of Hypertrophy-Induced Matrix Mineralization and Modifications in Articular Chondrocytes. Calcified tissue international. 2024-06-25. PMID:38918254. |
based on an in vitro model of progressive differentiation of immature murine articular chondrocytes (imacs) into prehypertrophic (prehyp) and hypertrophic (hyp) chondrocytes, we performed kinetics of chondrocyte differentiation from prehyp to hyp to follow matrix mineralization and remodeling by immunofluorescence, biochemical, molecular, and physicochemical approaches, including atomic force microscopy, scanning electron microscopy associated with energy-dispersive x-ray spectroscopy (sem-eds), attenuated total reflection infrared analyses, and x-ray diffraction. |
2024-06-25 |
2024-06-29 |
Not clear |
| Kelly Campbell, Shailesh Naire, Jan-Herman Kuipe. A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation. Journal of theoretical biology. 2024-06-22. PMID:38908475. |
we model cell proliferation, migration and chondrocyte hypertrophy, and matrix production and conversion, spatially and temporally. |
2024-06-22 |
2024-06-25 |
Not clear |
| Kelly Campbell, Shailesh Naire, Jan-Herman Kuipe. A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation. Journal of theoretical biology. 2024-06-22. PMID:38908475. |
this is followed by chondrocyte hypertrophy, matrix calcification and bone formation deep inside the defect, while cartilage at the surface is maintained and eventually separated from the deeper bone by a thin layer of calcified cartilage. |
2024-06-22 |
2024-06-25 |
Not clear |
| Chunyan Guo, Xiaoxiao Liu, Keqing Qiu, Longxiang Tu, Dewu Li. MALAT1 Knockdown Inhibits the Proliferation, Migration, and Collagen Deposition of Human Hypertrophic Scar Fibroblasts via Targeting miR-29a-3p/Smurf2 Axis. Clinical, cosmetic and investigational dermatology. vol 17. 2024-06-17. PMID:38881700. |
hypertrophic scarring (hs) is commonly described as an abnormal post-traumatic tissue repair characterized by excessive hypercellularity and extracellular matrix (ecm) deposition. |
2024-06-17 |
2024-06-19 |
human |
| Tianbai Wang, Sedat Dogru, Zhonghao Dai, Sung Yeon Kim, Nicholas Vickers, Michael B Albr. Physiologic Doses of TGF-β Improve the Composition of Engineered Articular Cartilage. Tissue engineering. Part A. 2024-06-14. PMID:38874527. |
while these doses accelerate extracellular matrix (ecm) biosynthesis, they may also contribute to features detrimental to hyaline cartilage function, including tissue swelling, type-i collagen (col-i) deposition, cellular hypertrophy, and cellular hyperplasia. |
2024-06-14 |
2024-06-16 |
cattle |
| Falguni Das, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Kumar Sharma, Goutam Ghosh Choudhur. High glucose-induced downregulation of PTEN-Long is sufficient for proximal tubular cell injury in diabetic kidney disease. Experimental cell research. 2024-06-03. PMID:38830568. |
during the progression of diabetic kidney disease, proximal tubular epithelial cells respond to high glucose to induce hypertrophy and matrix expansion leading to renal fibrosis. |
2024-06-03 |
2024-06-06 |
mouse |
| Chae Syng Lee, Rui Shang, Fulong Wang, Parisa Khayambashi, Hualin Wang, Gala Araujo, Karanjit Puri, Israel Vlodavsky, Bahira Hussein, Brian Rodrigue. Heparanase Stimulation of Physiological Cardiac Hypertrophy is Suppressed Following Chronic Diabetes Resulting in Cardiac Remodeling and Dysfunction. Diabetes. 2024-05-21. PMID:38771953. |
as heparanase, with exclusive expression in endothelial cells, enables extracellular matrix remodeling, angiogenesis, metabolic reprogramming, and cell survival, it is conceivable that it could also encourage development of cardiac hypertrophy. |
2024-05-21 |
2024-05-27 |
rat |
| Somanshu Banerjee, Varina R Clark Onwunyi, Jason Hong, Sandra Martineau, Gregory A Fishbein, Sandra Breuils Bonnet, Steeve Provencher, Sébastien Bonnet, Soban Uma. RV-specific Targeting of Snai1 Rescues Pulmonary Hypertension-induced Right Ventricular Failure by Inhibiting EndMT and Fibrosis bioRxiv : the preprint server for biology. 2024-05-15. PMID:38746200. |
rv-specific targeting of snai1 rescues pulmonary hypertension-induced right ventricular failure by inhibiting endmt and fibrosis pulmonary hypertension (ph)-induced right ventricular (rv) failure (ph-rvf) is a significant prognostic determinant of mortality and is characterized by rv hypertrophy, endothelial-to-mesenchymal transition (endmt), fibroblast-to-myofibroblast transition (fmt), fibrosis, and extracellular matrix (ecm)-remodeling. |
2024-05-15 |
2024-05-27 |
Not clear |
| I V Zyubanova, A Yu Falkovckaya, M A Manukyan, E I Solonskaya, A A Vtorushina, S A Khunkhinova, A M Gusakova, S E Pekarskiy, V F Mordovi. Features of The Dynamics of Profibrotic Markers and Regression of Left Ventricular Hypertrophy After Renal Denervation in Patients With Resistant Hypertension and Stenosing Atherosclerosis of the Coronary Arteries. Kardiologiia. vol 64. issue 4. 2024-05-14. PMID:38742515. |
to compare the changes in serum concentrations of matrix metalloproteinases (mmps) and their tissue inhibitor (timp) to the dynamics of blood pressure (bp) and parameters of left ventricular hypertrophy (lvh) 6 months after renal denervation (rd) in patients with resistant arterial hypertension (rah) and complicated coronary atherosclerosis. |
2024-05-14 |
2024-05-27 |
Not clear |
| Yize Li, Yujie Xiao, Yongfeng Han, Huayu Zhu, Juntao Han, Hongtao Wan. Blocking the MIR155HG/miR-155 axis reduces CTGF-induced inflammatory cytokine production and α-SMA expression via upregulating AZGP1 in hypertrophic scar fibroblasts. Cellular signalling. 2024-05-10. PMID:38729323. |
hypertrophic scarring (hs) is a pathological condition characterized by excessive fibrosis and inflammation, resulting in excessive extracellular matrix formation in the skin. |
2024-05-10 |
2024-05-27 |
Not clear |
| Kumara Kaluarachchi, Lakshman Samaranayak. The first report of the presence of collagen X in mammalian dentinal matrix. Morphologie : bulletin de l'Association des anatomistes. vol 108. issue 362. 2024-04-05. PMID:38579391. |
collagen x is an extracellular matrix protein, usually found in the hypertrophic cartilage destined to be mineralized. |
2024-04-05 |
2024-04-10 |
Not clear |
| Laura Dönges, Atharva Damle, Andrea Mainardi, Thomas Bock, Monica Schönenberger, Ivan Martin, Andrea Barber. Engineered human osteoarthritic cartilage organoids. Biomaterials. vol 308. 2024-03-30. PMID:38554643. |
here, by imposing specific inflammatory challenges upon mesenchymal stromal cells at a defined stage of chondrogenesis, we engineered a human organotypic model which recapitulates main oa pathological traits such as chondrocyte hypertrophy, cartilage matrix mineralization, enhanced catabolism and mechanical stiffening. |
2024-03-30 |
2024-04-02 |
human |