| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P M Whitaker-Azmitia, L J Molino, J Caruso, A V Sheme. Serotonergic agents restore appropriate decision-making in neonatal rats displaying dopamine D1 receptor-mediated vacillatory behavior. European journal of pharmacology. vol 180. issue 2-3. 1990-08-13. PMID:2365008. |
these data suggest that the serotonergic and dopaminergic neurotransmitter systems must be in a proper balance for appropriate decision-making behaviors to occur. |
1990-08-13 |
2023-08-11 |
rat |
| P L Smiley, M Johnson, L Bush, J W Gibb, G R Hanso. Effects of cocaine on extrapyramidal and limbic dynorphin systems. The Journal of pharmacology and experimental therapeutics. vol 253. issue 3. 1990-07-31. PMID:1972755. |
several peptidergic neurotransmitter systems, such as the dynorphin pathways, have been shown to be distal to and regulated by the postsynaptic activity of dopaminergic pathways; therefore, we evaluated the response of extrapyramidal and limbic dynorphin a1-17 (dyn) systems to cocaine by measuring dyn content in associated structures. |
1990-07-31 |
2023-08-11 |
Not clear |
| H Ishizawa, B Tabakoff, I N Mefford, P L Hoffma. Reduction of arginine vasopressin binding sites in mouse lateral septum by treatment with 6-hydroxydopamine. Brain research. vol 507. issue 2. 1990-06-20. PMID:2110843. |
the results suggest that a portion of septal vasopressin receptors are localized on the terminals of noradrenergic and, possibly, dopaminergic neurons, consistent with the hypothesis that certain neuroadaptive responses to vasopressin could be mediated by modulation of neurotransmitter release. |
1990-06-20 |
2023-08-11 |
mouse |
| J C Crabbe, D J Feller, E S Terdal, C D Merril. Genetic components of ethanol responses. Alcohol (Fayetteville, N.Y.). vol 7. issue 3. 1990-06-05. PMID:2184836. |
when tested for sensitivity to a number of drugs with specific effects on neurotransmitter systems, cold and hot mice did not differ in sensitivity to drugs affecting dopaminergic, alpha-adrenergic, or nicotinic acetylcholinergic systems. |
1990-06-05 |
2023-08-11 |
mouse |
| R M Booze, C F Mactutu. Developmental exposure to organic lead causes permanent hippocampal damage in Fischer-344 rats. Experientia. vol 46. issue 3. 1990-04-26. PMID:2311721. |
pharmacological probes of neurotransmitter system integrity suggested a functional and dose-dependent relationship between this behavioral hyperreactivity and hippocampal damage via cholinergic, but not dopaminergic, pathways. |
1990-04-26 |
2023-08-11 |
rat |
| S F Ali, G Ahmad, W Slikker, S C Bond. Effects of gestational exposure to phencyclidine: distribution and neurochemical alterations in maternal and fetal brain. Neurotoxicology. vol 10. issue 3. 1990-04-12. PMID:2576301. |
fetal dopaminergic and muscarinic cholinergic receptor binding and neurotransmitter concentrations were unaffected by prenatal pcp exposure. |
1990-04-12 |
2023-08-11 |
rat |
| T Beck, J Wenzel, K Kuschinsky, J Krieglstei. Morphine-induced alterations of local cerebral glucose utilization in the basal ganglia of rats. Brain research. vol 497. issue 2. 1990-01-11. PMID:2684341. |
part of these effects might be, in addition, due to an activation of dopaminergic neurons, since dopamine mainly acts as an inhibitory neurotransmitter. |
1990-01-11 |
2023-08-11 |
rat |
| F Auth, B Kiss, I Laszlovszky, E Lapi. Substituted ergolines: potential antipsychotics with unique profile. II. Neurochemical characterization. Polish journal of pharmacology and pharmacy. vol 40. issue 6. 1990-01-03. PMID:2479935. |
on the basis of the effects of the drugs on the mouse whole brain monoamine neurotransmitter and metabolite levels and neurotransmitter biosynthesis rates along with the receptor binding data we conclude that their actions are mainly related to the central dopaminergic system(s). |
1990-01-03 |
2023-08-11 |
mouse |
| R Testa, G Abbiati, R Ceserani, G Restelli, A Vanasia, D Barone, M Gobbi, T Mennin. Profile of in vitro binding affinities of neuroleptics at different rat brain receptors: cluster analysis comparison with pharmacological and clinical profiles. Pharmaceutical research. vol 6. issue 7. 1989-10-28. PMID:2571988. |
was examined for their in vitro interactions with 12 neurotransmitter binding sites in the rat brain (alpha- and beta-noradrenergic, dopaminergic, muscarinic, serotoninergic, histaminic, and opioid receptors, calcium channels, and serotonin uptake binding sites). |
1989-10-28 |
2023-08-11 |
rat |
| M B Youdi. Brain monoamine oxidase (MAO) B: a unique neurotoxin and neurotransmitter producing enzyme. Progress in neuro-psychopharmacology & biological psychiatry. vol 13. issue 3-4. 1989-08-21. PMID:2568664. |
it is now apparent that mao-b is capable of oxidizing inert non-polar amines such as mptp (n-methyl-4-phenyl-1,2,3,6, tetrahydropyridine) and milacemide (2-n-pentylaminoacetamide) into neuroactive substances giving rise to parkinson inducing dopaminergic neurotoxin, mpp+ and inhibitory amino acid neurotransmitter, glycine respectively. |
1989-08-21 |
2023-08-11 |
Not clear |
| W R Klem. Drug effects on active immobility responses: what they tell us about neurotransmitter systems and motor functions. Progress in neurobiology. vol 32. issue 5. 1989-07-18. PMID:2567528. |
the literature reviewed indicates that active immobility can be promoted by systemic injections of various neurotransmitter systems, as follows: (1) dopaminergic blockade of both d1 and d2 receptor subtypes. |
1989-07-18 |
2023-08-11 |
Not clear |
| W R Klem. Drug effects on active immobility responses: what they tell us about neurotransmitter systems and motor functions. Progress in neurobiology. vol 32. issue 5. 1989-07-18. PMID:2567528. |
among the major interactions of neurotransmitter systems that regulate immobility, are the following: (1) cholinergic-dopaminergic (cholinolytics disrupt catalepsy of dopaminergic blockade and dopaminergic agonists tend to disrupt cholinomimetic catalepsy). |
1989-07-18 |
2023-08-11 |
Not clear |
| N A Alie. [Effect of the neuromediator systems of the neostriatum on immunocompetent cells]. Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova. vol 74. issue 12. 1989-06-02. PMID:2907493. |
the stimulation of the rat neostriatum dopaminergic system (with apomorphine) or blocking of the gaba-ergic (with picrotoxin) and serotoninergic (with parachlorphenylalanin) systems increased the level of immunological indices, whereas the lesion of dopaminergic system (with 6-hydroxydopamine) or the activation of two latter neurotransmitter systems (with gaba and serotonin, resp.) |
1989-06-02 |
2023-08-11 |
rat |
| R M Guerrero, K A Shifra. Diagnosis and treatment of neuroleptic malignant syndrome. Clinical pharmacy. vol 7. issue 9. 1989-05-12. PMID:3240662. |
mechanisms believed to cause nms include alteration of central neuoregulatory mechanisms and neuroleptic-induced imbalance between central dopaminergic and gamma-aminobutyric acid neurotransmitter systems. |
1989-05-12 |
2023-08-11 |
Not clear |
| M Ansseau, R Von Frenckell, J L Cerfontaine, P Papart, G Franck, M Timsit-Berthier, V Geenen, J J Legro. Blunted response of growth hormone to clonidine and apomorphine in endogenous depression. The British journal of psychiatry : the journal of mental science. vol 153. 1989-04-05. PMID:3224252. |
these results support the hypothesis of both noradrenergic and dopaminergic neurotransmitter disturbances in major depression, with individual variability with regard to those biochemical anomalies. |
1989-04-05 |
2023-08-11 |
Not clear |
| M B Spina, G Cohe. Dopamine turnover and glutathione oxidation: implications for Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. vol 86. issue 4. 1989-03-27. PMID:2919185. |
parkinson disease is characterized by a major loss (approximately 80% or more) of dopaminergic nigrostriatal neurons and by an increased turnover of neurotransmitter by surviving neurons of the nigrostriatal tract. |
1989-03-27 |
2023-08-11 |
mouse |
| T J Mahali. Direct demonstration of interactions between substance P immunoreactive terminals and tyrosine hydroxylase immunoreactive neurons in the substantia nigra of the rat: an ultrastructural study. Synapse (New York, N.Y.). vol 2. issue 5. 1988-12-21. PMID:2460962. |
these findings support the idea that substance p is a major neurotransmitter in the striatonigral loop, and suggest that striatal substance p neurons act directly upon nigral dopaminergic cells. |
1988-12-21 |
2023-08-11 |
rat |
| G Debonnel, C de Montign. Increased neuronal responsiveness to cholecystokinin and dopamine induced by lesioning mesolimbic dopaminergic neurons: an electrophysiological study in the rat. Synapse (New York, N.Y.). vol 2. issue 5. 1988-12-21. PMID:2903570. |
however, in the dorsal hippocampus, dopaminergic projections from the vta do not contain cck, the latter neurotransmitter being mainly localized in intrinsic hippocampal neurons. |
1988-12-21 |
2023-08-11 |
rat |
| M S Fiandaca, J H Kordower, J T Hansen, S S Jiao, D M Gas. Adrenal medullary autografts into the basal ganglia of Cebus monkeys: injury-induced regeneration. Experimental neurology. vol 102. issue 1. 1988-12-07. PMID:2903068. |
there are two major hypotheses proposed to explain why adrenal medullary grafts may promote functional recovery in human parkinsonism: (1) replacement of lost striatal neurotransmitter (dopamine) by the viable grafted tissue, or (2) induction of recovery of remaining host dopaminergic systems by the implantation procedure. |
1988-12-07 |
2023-08-11 |
human |
| D M Vaughn, E Coleman, S T Simpson, C Satjawatcharaphon. Analysis of neurotransmitter metabolite concentrations in canine cerebrospinal fluid. American journal of veterinary research. vol 49. issue 8. 1988-11-15. PMID:2459997. |
the neurotransmitter index, hva/5-hiaa, was found to be more indicative of the dopaminergic metabolite hva than the acid metabolite of serotonin, 5-hiaa (correlation coefficient with hva = 0.5529 vs a correlation coefficient with 5-hiaa = -0.4462). |
1988-11-15 |
2023-08-11 |
Not clear |