| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M B Lazarova-Bakarova, B P Petkova, I K Todorov, V D Petko. Memory impairment induced by combined disturbance of noradrenergic and dopaminergic neurotransmissions: effects of nootropic drugs. Acta physiologica et pharmacologica Bulgarica. vol 17. issue 1. 1992-06-22. PMID:1667717. |
the paper discusses the role of the noradrenergic and dopaminergic neurotransmitter systems for the amnestic effect of the clonidine + haloperidol combination, as well as for the favourable effect on the cognitive functions of the tested nootropic drugs adafenoxate and p-p. |
1992-06-22 |
2023-08-11 |
rat |
| A Yamada, H Takeuchi, H Miki, T Touge, M Nishiok. [Decreased dopaminergic activity in hepatic encephalopathy in rats with galactosamine-induced acute liver failure]. No to shinkei = Brain and nerve. vol 44. issue 2. 1992-05-26. PMID:1567728. |
the results of this study indicate that hepatic encephalopathy in rats with galactosamine-induced acute liver failure is associated with a decreased activity of the dopaminergic neurotransmitter system. |
1992-05-26 |
2023-08-11 |
rat |
| J L Blac. Obsessive compulsive disorder: a clinical update. Mayo Clinic proceedings. vol 67. issue 3. 1992-04-13. PMID:1545595. |
currently, etiologic hypotheses revolve around serotonergic and dopaminergic neurotransmitter systems. |
1992-04-13 |
2023-08-11 |
Not clear |
| F Zhang, R N Goyal, C L Blank, G Dryhurs. Oxidation chemistry and biochemistry of the central mammalian alkaloid 1-methyl-6-hydroxy-1,2,3,4-tetrahydro-beta-carboline. Journal of medicinal chemistry. vol 35. issue 1. 1992-02-21. PMID:1732536. |
neurotransmitter and related metabolite analyses of whole brain reveal that 5 and 6 cause a general increase in dopaminergic and serotonergic activity and a small but significant decrease in cholinergic activity. |
1992-02-21 |
2023-08-11 |
mouse |
| M Y Morga. The treatment of chronic hepatic encephalopathy. Hepato-gastroenterology. vol 38. issue 5. 1992-02-20. PMID:1662661. |
treatment is, therefore, based on mechanisms to reduce the production and absorption of gut-derived toxins such as decreasing and modifying dietary protein intake, altering the intestinal bacterial flora and bowel cleansing, and on mechanisms designed to modify central neurotransmitter balance either directly by use of dopaminergic agents or benzodiazepine antagonists or indirectly by use of amino-acid mixtures. |
1992-02-20 |
2023-08-11 |
Not clear |
| H Wachte. Antiparkinsonian dopamine agonists: a review of the pharmacokinetics and neuropharmacology in animals and humans. Journal of neural transmission. Parkinson's disease and dementia section. vol 3. issue 3. 1992-01-07. PMID:1683537. |
therefore, apart from summarizing the pharmacokinetics, biotransformation, neuropharmacology and neurobiochemistry of the da agonists employed clinically, the present article also reviews physiological aspects of (a) central dopaminergic neurotransmission including the topographical distribution of da receptor subtypes and their functional significance, (b) the intracellular signal processing in striatal output neurons and (c) the intraneuronal mechanisms which integrate the various neurotransmitter signals converging on the striatal output neuron to a demand-adjusted effector cell response via the cross-talk between the different second messenger systems. |
1992-01-07 |
2023-08-11 |
monkey |
| M J Kuhar, M C Ritz, J W Boj. The dopamine hypothesis of the reinforcing properties of cocaine. Trends in neurosciences. vol 14. issue 7. 1991-12-02. PMID:1719677. |
this hypothesis proposes that cocaine binds at the dopamine transporter and mainly inhibits neurotransmitter re-uptake; the resulting potentiation of dopaminergic neurotransmission in mesolimbocortical pathways ultimately causes reinforcement. |
1991-12-02 |
2023-08-11 |
Not clear |
| W G Rossmanit. [Neuroendocrine control of human reproduction. The role of dopaminergic neurotransmitter systems]. Zentralblatt fur Gynakologie. vol 113. issue 14. 1991-11-21. PMID:1681634. |
the role of dopaminergic neurotransmitter systems]. |
1991-11-21 |
2023-08-11 |
human |
| W G Rossmanit. [Neuroendocrine control of human reproduction. The role of dopaminergic neurotransmitter systems]. Zentralblatt fur Gynakologie. vol 113. issue 14. 1991-11-21. PMID:1681634. |
serum gonadotropin profiles as an indirect reflection of central activity can consecutively indicate dopaminergic neurotransmitter activity and its changes by pharmacologic manipulation. |
1991-11-21 |
2023-08-11 |
human |
| B D Waterhouse, Z N Stowe, C A Jimenez-Rivera, F M Sessler, D J Woodwar. Cocaine actions in a central noradrenergic circuit: enhancement of cerebellar Purkinje neuron responses to iontophoretically applied GABA. Brain research. vol 546. issue 2. 1991-08-22. PMID:2070264. |
many recent studies have implicated the mesolimbic dopaminergic pathway as the central neurotransmitter system which is most likely responsible for the euphoria and abuse potential associated with cocaine self-administration. |
1991-08-22 |
2023-08-11 |
Not clear |
| J De Reuck, J Van Aken, W Van Landegem, F Colardy. Positron emission tomographic studies of changes in cerebral blood flow and oxygen metabolism in neuroleptic malignant syndrome. European neurology. vol 31. issue 1. 1991-05-17. PMID:2015829. |
in 2 patients, under treatment with bromocriptine, high blood flow and oxygen metabolism were demonstrated in the striatum, cerebellum and occipital cerebral cortex during the neuroleptic malignant phase, showing that not only the dopaminergic system is disturbed but also other neurotransmitter systems are involved. |
1991-05-17 |
2023-08-11 |
Not clear |
| L Angelucci, G Lorentz, S Maccari, F R Patacchioli, S Scaccianoce, G Taglialatel. [Pharmacologic profile of protirelin tartrate]. Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna. vol 5. issue 3 Pt 2. 1991-05-01. PMID:2127684. |
in fact this tripeptide elicits an increase in spontaneous motor and explorative activities by interacting with the dopaminergic neurotransmitter system at the nucleus accumbens level. |
1991-05-01 |
2023-08-11 |
rat |
| E Hollander, M R Liebowitz, C M DeCari. Conceptual and methodological issues in studies of obsessive-compulsive and Tourette's disorders. Psychiatric developments. vol 7. issue 4. 1991-04-03. PMID:2577300. |
while studies of neurotransmitter function have primarily implicated dopaminergic dysfunction in ts and serotonergic function in ocd, other systems may be involved in each disorder, and neurotransmitter systems may be tightly linked, such that alterations of one system will affect other systems. |
1991-04-03 |
2023-08-11 |
Not clear |
| M B Youdim, J P Finber. New directions in monoamine oxidase A and B selective inhibitors and substrates. Biochemical pharmacology. vol 41. issue 2. 1991-02-28. PMID:1989626. |
in addition, mao oxidizes the inert uncharacteristic tertiary amine, mptp, to the parkinson inducing dopaminergic neurotoxin, mpp+, and the novel secondary amine anticonvulsant milacemide to the inhibitory amino acid neurotransmitter, glycine. |
1991-02-28 |
2023-08-11 |
Not clear |
| D Samuel, L Kerkerian-Le Goff, U Kumar, M Errami, E Scarfone, A Nieoullo. Changes in striatal cholinergic, gabaergic, dopaminergic and serotoninergic biochemical markers after kainic acid-induced thalamic lesions in the rat. Journal of neural transmission. Parkinson's disease and dementia section. vol 2. issue 3. 1991-01-31. PMID:1979492. |
taken together, all these changes in neurotransmitter markers suggest that, directly through the thalamostriatal pathway or indirectly, the thalamus can exert a complex influence on striatal cholinergic and gabaergic neuronal functions as well as on the activity of dopaminergic and serotoninergic striatal afferent fibers. |
1991-01-31 |
2023-08-11 |
rat |
| M Halman, D S Goldbloo. Fluoxetine and neuroleptic malignant syndrome. Biological psychiatry. vol 28. issue 6. 1990-12-07. PMID:2223920. |
on reviewing the literature on the pathogenesis of nms, the authors hypothesize a facilitative role of the neurotransmitter serotonin (5-ht) in conjunction with central dopaminergic blockade in the precipitation of nms. |
1990-12-07 |
2023-08-11 |
Not clear |
| L Ereshefsky, T K Tran-Johnson, M D Watanab. Pathophysiologic basis for schizophrenia and the efficacy of antipsychotics. Clinical pharmacy. vol 9. issue 9. 1990-12-04. PMID:1977544. |
atypical antipsychotics may act by stabilizing presynaptic activity at a new set point, activating prefrontal dopaminergic systems and inhibiting mesolimbic systems, or exerting pharmacologic or functional effects on other neurotransmitter and neuropeptidergic systems. |
1990-12-04 |
2023-08-11 |
Not clear |
| P S Goldman-Rakic, M S Lidow, D W Gallage. Overlap of dopaminergic, adrenergic, and serotoninergic receptors and complementarity of their subtypes in primate prefrontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 10. issue 7. 1990-08-31. PMID:2165520. |
quantitative in vitro autoradiography was used to determine and compare the areal and laminar distribution of the major dopaminergic, adrenergic, and serotonergic neurotransmitter receptors in 4 cytoarchitectonic regions of the prefrontal cortex (walker's areas 12, 46, 9, and 25) in adult rhesus monkeys. |
1990-08-31 |
2023-08-11 |
monkey |
| E A Gordon, T A Kohout, P H Fishma. Characterization of functional neuropeptide Y receptors in a human neuroblastoma cell line. Journal of neurochemistry. vol 55. issue 2. 1990-08-17. PMID:2164571. |
the receptors on sk-n-mc cells appeared to be specific for npy, as other neurotransmitter drugs, such as alpha-adrenergic, dopaminergic, muscarinic, and serotonergic antagonists, did not compete for either npy binding or npy inhibition of adenylate cyclase. |
1990-08-17 |
2023-08-11 |
human |
| M Manier, C Feuerstein, J G Passagia, P Mouchet, N Mons, M Geffard, J Thibaul. Evidence for the existence of L-dopa- and dopamine-immunoreactive nerve cell bodies in the caudal part of the dorsal motor nucleus of the vagus nerve. Journal of chemical neuroanatomy. vol 3. issue 3. 1990-08-13. PMID:1973044. |
these results led us to conclude that these tyrosine hydroxylase-positive cells were effectively of dopaminergic nature and therefore that dopamine is a neurotransmitter contained in some neurons of the dorsal motor vagal nucleus. |
1990-08-13 |
2023-08-11 |
rat |