| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gregor Leicht, Christina Andreou, Till Nafe, Felix Nägele, Jonas Rauh, Stjepan Curic, Paul Schauer, Daniel Schöttle, Saskia Steinmann, Christoph Muler. Alterations of oscillatory neuronal activity during reward processing in schizophrenia. Journal of psychiatric research. vol 129. 2021-05-14. PMID:32619750. |
remarkably, midbrain dopaminergic signalling also includes theta and high-beta frequency modes, which have been assumed to reflect tonic and phasic dopamine responses, respectively. |
2021-05-14 |
2023-08-13 |
Not clear |
| Li-Ping Liang, Ruth Fulton, Erica L Bradshaw-Pierce, Jennifer Pearson-Smith, Brian J Day, Manisha Pate. Optimization of Lipophilic Metalloporphyrins Modifies Disease Outcomes in a Rat Model of Parkinsonism. The Journal of pharmacology and experimental therapeutics. vol 377. issue 1. 2021-05-14. PMID:33500265. |
in addition, both compounds significantly attenuated 6-hydroxydopamine (6-ohda)-induced neurotoxic damage, including dopamine depletion, cytokine production, and microglial activation in the striata; dopaminergic neuronal loss in the substantia nigra; oxidative/nitrative stress indices (glutathione disulfide and 3-nitrotyrosine) in the ventral midbrain; and rotation behavioral abnormality in rats. |
2021-05-14 |
2023-08-13 |
mouse |
| Li-Ping Liang, Ruth Fulton, Erica L Bradshaw-Pierce, Jennifer Pearson-Smith, Brian J Day, Manisha Pate. Optimization of Lipophilic Metalloporphyrins Modifies Disease Outcomes in a Rat Model of Parkinsonism. The Journal of pharmacology and experimental therapeutics. vol 377. issue 1. 2021-05-14. PMID:33500265. |
both compounds significantly attenuated dopamine depletion, cytokine production, microglial activation, dopaminergic neuronal loss, oxidative/nitrative stress indices, and behavioral abnormality in a parkinson disease rat model. |
2021-05-14 |
2023-08-13 |
mouse |
| Ryuichi Takahashi, Kazunari Ishii, Kaoru Sousa, Kohei Marumoto, Tetsuo Kashibayashi, Jun Fujita, Kazumasa Yokoyam. Distinctive regional asymmetry in dopaminergic and serotoninergic dysfunction in degenerative Parkinsonisms. Journal of the neurological sciences. vol 423. 2021-05-14. PMID:33640580. |
this study aimed to identify regional asymmetry in dopaminergic and serotoninergic dysfunction in degenerative parkinsonisms, using dopamine transporter single-photon emission computed tomography images. |
2021-05-14 |
2023-08-13 |
Not clear |
| Lang Li, Yang Lu, Ziting Qian, Zhaoyan Yang, Kuo Yang, Shenfei Zong, Zhuyuan Wang, Yiping Cu. Ultra-sensitive surface enhanced Raman spectroscopy sensor for in-situ monitoring of dopamine release using zipper-like ortho-nanodimers. Biosensors & bioelectronics. vol 180. 2021-05-14. PMID:33677355. |
accurate quantitative detection of dopamine (da) in blood is essential for the early diagnosis and the pathogenesis analysis of dopaminergic dysfunction, which still remains a great challenge because of the extremely low concentration in patients. |
2021-05-14 |
2023-08-13 |
human |
| Agnès Benvenutto, Eric Guedj, Olivier Felician, Alexandre Eusebio, Jean-Philippe Azulay, Mathieu Ceccaldi, Lejla Kori. Clinical Phenotypes in Corticobasal Syndrome with or without Amyloidosis Biomarkers. Journal of Alzheimer's disease : JAD. vol 74. issue 1. 2021-05-13. PMID:32039846. |
interestingly, dopamine transporter spect imaging showed similar levels of dopaminergic degeneration in both groups. |
2021-05-13 |
2023-08-13 |
Not clear |
| Jung Yoon Choi, Hee Jae Jang, Sharon Ornelas, Weston T Fleming, Daniel Fürth, Jennifer Au, Akhil Bandi, Esteban A Engel, Ilana B Witte. A Comparison of Dopaminergic and Cholinergic Populations Reveals Unique Contributions of VTA Dopamine Neurons to Short-Term Memory. Cell reports. vol 33. issue 11. 2021-05-13. PMID:33326775. |
a comparison of dopaminergic and cholinergic populations reveals unique contributions of vta dopamine neurons to short-term memory. |
2021-05-13 |
2023-08-13 |
rat |
| Mustafa Makav, Hüseyin Avni Eroğl. Recuperative effect of estrogen on rotenone-induced experimental model of Parkinson's disease in rats. Environmental science and pollution research international. vol 28. issue 17. 2021-05-12. PMID:33410082. |
histopathological examination indicated a significant difference in tyrosine hydroxylase-stained cells (dopaminergic neurons and dopamine) between the parkinson's + estrogen group and the parkinson's group. |
2021-05-12 |
2023-08-13 |
rat |
| Andrea Fabbrini, Andrea Guerr. Pathophysiological Mechanisms and Experimental Pharmacotherapy for L-Dopa-Induced Dyskinesia. Journal of experimental pharmacology. vol 13. 2021-05-08. PMID:33953618. |
recent advances in the understanding of the pathophysiological mechanisms underlying lid suggest that abnormalities in multiple neurotransmitter systems, in addition to dopaminergic nigrostriatal denervation and altered dopamine release and reuptake dynamics at the synaptic level, are involved in lid development. |
2021-05-08 |
2023-08-13 |
Not clear |
| Anupam Raina, Kristian Leite, Sofia Guerin, Sameehan U Mahajani, Kalyan S Chakrabarti, Diana Voll, Stefan Becker, Christian Griesinger, Mathias Bähr, Sebastian Kügle. Dopamine promotes the neurodegenerative potential of β-synuclein. Journal of neurochemistry. vol 156. issue 5. 2021-05-04. PMID:32730640. |
given that dopaminergic nigral neurons are selectively vulnerable to neurodegeneration in pd, we now investigated if dopamine can promote the neurodegenerative potential of β-syn. |
2021-05-04 |
2023-08-13 |
human |
| Anupam Raina, Kristian Leite, Sofia Guerin, Sameehan U Mahajani, Kalyan S Chakrabarti, Diana Voll, Stefan Becker, Christian Griesinger, Mathias Bähr, Sebastian Kügle. Dopamine promotes the neurodegenerative potential of β-synuclein. Journal of neurochemistry. vol 156. issue 5. 2021-05-04. PMID:32730640. |
we show that in cultured rodent and human neurons a dopaminergic neurotransmitter phenotype substantially enhanced β-syn-induced neurodegeneration, irrespective if dopamine is synthesized within neurons or up-taken from extracellular space. |
2021-05-04 |
2023-08-13 |
human |
| Anupam Raina, Kristian Leite, Sofia Guerin, Sameehan U Mahajani, Kalyan S Chakrabarti, Diana Voll, Stefan Becker, Christian Griesinger, Mathias Bähr, Sebastian Kügle. Dopamine promotes the neurodegenerative potential of β-synuclein. Journal of neurochemistry. vol 156. issue 5. 2021-05-04. PMID:32730640. |
in conclusion, our results suggest that β-syn can play a significant pathophysiological role in etiology of pd through its interaction with dopamine metabolites and thus should be re-considered as a disease-relevant factor, at least for those symptoms of pd that depend on degeneration of nigral dopaminergic neurons. |
2021-05-04 |
2023-08-13 |
human |
| Samuel Floren, Nicholas King, Allonso Carrasco, Nachum Dafn. Glutamate and dopamine in the VTA participate differently in the acute and chronic effect of methylphenidate. Behavioural brain research. vol 380. 2021-05-03. PMID:31783089. |
psychostimulants such as mpd are indirect dopamine antagonists and are known to act on the dopaminergic system of the brain to produce their effects. |
2021-05-03 |
2023-08-13 |
rat |
| Kadri Kõiv, Kai Tiitsaar, Karita Laugus, Jaanus Harr. Extracellular Dopamine Levels in Nucleus Accumbens after Chronic Stress in Rats with Persistently High vs. Low 50-kHz Ultrasonic Vocalization Response. Brain sciences. vol 11. issue 4. 2021-05-02. PMID:33917789. |
to examine whether these differential responses are associated with dopaminergic neurotransmission in the nucleus accumbens (nac), juvenile male wistar rats were categorized as of high or low positive affectivity (hc and lc, respectively), and after reaching adulthood, extracellular dopamine (da) levels in the nac shell were measured using in vivo microdialysis after three weeks of cvs. |
2021-05-02 |
2023-08-13 |
rat |
| Brooke J Olson, Mohan S Dhariwa. Neuroleptic Malignant Syndrome: A Case of Unknown Causation and Unique Clinical Course. Cureus. vol 13. issue 3. 2021-05-02. PMID:33927924. |
neuroleptic malignant syndrome (nms) is a rare, potentially lethal syndrome known to be related to the initiation of dopamine antagonist medications or rapid withdrawal of dopaminergic medications. it is a diagnosis of exclusion with a known sequela of symptoms, but not all patients experience these characteristic symptoms making it difficult at times to diagnose and treat. |
2021-05-02 |
2023-08-13 |
Not clear |
| Govindarajan Karthivashan, Palanivel Ganesan, Shin-Young Park, Ho-Won Lee, Dong-Kug Cho. Lipid-based nanodelivery approaches for dopamine-replacement therapies in Parkinson's disease: From preclinical to translational studies. Biomaterials. vol 232. 2021-04-30. PMID:31901690. |
pd is primarily characterized by the progressive loss of dopaminergic (daergic) neurons and/or associated neuronal networks and the subsequent depletion of dopamine (da) levels in the brain. |
2021-04-30 |
2023-08-13 |
Not clear |
| Siddhartha Sahai, Emaan T Effendi, Emily C Mahoney, Heidi R Tucker, Benjamin J Moolick, Gianna Mamone, Saisree Mikkilineni, Megan Gupta, Alycia Nicholson, Fu Yee Chua, Kainat Akhtar, Zall Hirschstein, Eric S Molho, Julie G Pilitsis, Damian S Shi. Effects of subthalamic nucleus deep brain stimulation on neuronal spiking activity in the substantia nigra pars compacta in a rat model of Parkinson's disease. Neuroscience letters. vol 739. 2021-04-30. PMID:33141067. |
the underlying mechanisms contributing to this reduction remain unclear, but studies posit that stn-dbs may increase striatal dopamine levels by exciting remaining dopaminergic cells in the substantia nigra pars compacta (snc). |
2021-04-30 |
2023-08-13 |
rat |
| Akanksha Mishra, Sonu Singh, Virendra Tiwari, Shameema Bano, Shubha Shukl. Dopamine D1 receptor agonism induces dynamin related protein-1 inhibition to improve mitochondrial biogenesis and dopaminergic neurogenesis in rat model of Parkinson's disease. Behavioural brain research. vol 378. 2021-04-29. PMID:31626851. |
dopamine d1 receptor agonism induces dynamin related protein-1 inhibition to improve mitochondrial biogenesis and dopaminergic neurogenesis in rat model of parkinson's disease. |
2021-04-29 |
2023-08-13 |
rat |
| Lukas Meyerolbersleben, Christine Winter, Nadine Bernhard. Dissociation of wanting and liking in the sucrose preference test in dopamine transporter overexpressing rats. Behavioural brain research. vol 378. 2021-04-28. PMID:31629834. |
the predominant theory of mesolimbic dopamine function in recent years has been the incentive salience hypothesis, which describes the role of midbrain dopaminergic circuits as encoding 'wanting', but not 'liking' of rewards, resulting in a dissociation of the two functions. |
2021-04-28 |
2023-08-13 |
rat |
| Alexandra Perebikovsky, Alexander T Hwu, Andrew R Yale, Maziar Ghazinejad, Marc Mado. Nanofibrous Carbon Multifunctional Smart Scaffolds for Simultaneous Cell Differentiation and Dopamine Detection. ACS biomaterials science & engineering. vol 6. issue 1. 2021-04-28. PMID:33463198. |
carbon mss is used to (1) enhance the morphology and differentiation of mouse neural stem/progenitor cells (mnspcs) derived from different regions of the developing brain and (2) simultaneously detect a neurotransmitter, dopamine, from a model dopaminergic cell line growing on the electrode. |
2021-04-28 |
2023-08-13 |
mouse |