| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nabeel Ali, Amna Syeda, Tenzin Topgyal, Naseem Gaur, Asimul Isla. Parkinson's disease: A current perspectives on Parkinson's disease and key bioactive natural compounds as future potential drug candidates. Current drug targets. 2021-06-24. PMID:34165406. |
the hallmark of pd includes dopamine deficiency (neurotransmitter imbalance) due to the gradual loss of dopaminergic nerves in the substantia nigra in the midbrain. |
2021-06-24 |
2023-08-13 |
Not clear |
| Maria Grazia Zizzo, Annalisa Bellanca, Antonella Amato, Rosa Seri. Opposite effects of dopamine on the mechanical activity of circular and longitudinal muscle of human colon. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 32. issue 6. 2021-06-23. PMID:32012410. |
because dopamine (da) has gained increasing evidence as modulator of gut motility, we aimed to characterize dopaminergic response in human colon, evaluating function and distribution of dopamine receptors in circular vs longitudinal muscle strips. |
2021-06-23 |
2023-08-13 |
human |
| Ottavia Dipasquale, Daniel Martins, Arjun Sethi, Mattia Veronese, Swen Hesse, Michael Rullmann, Osama Sabri, Federico Turkheimer, Neil A Harrison, Mitul A Mehta, Mara Cercignan. Unravelling the effects of methylphenidate on the dopaminergic and noradrenergic functional circuits. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 9. 2021-06-23. PMID:32473593. |
here, we focus on methylphenidate (mph), which binds to the dopamine transporter (dat) and the norepinephrine transporter (net), to unravel its effects on dopaminergic and noradrenergic functional circuits in the healthy brain at rest. |
2021-06-23 |
2023-08-13 |
Not clear |
| Sara Schiavi, Francesca Melancia, Emilia Carbone, Valeria Buzzelli, Antonia Manduca, Patricia Jiménez Peinado, Clemens Zwergel, Antonello Mai, Patrizia Campolongo, Louk J M J Vanderschuren, Viviana Trezz. Detrimental effects of the 'bath salt' methylenedioxypyrovalerone on social play behavior in male rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 12. 2021-06-23. PMID:32506112. |
as the behavioral effects of mdpv have been ascribed to dopaminergic and noradrenergic neurotransmission, and given the role of these neurotransmitters in social play, we investigated the involvement of dopamine and noradrenaline in the play-suppressant effects of mdpv. |
2021-06-23 |
2023-08-13 |
human |
| Alberto F Cintrón-Colón, Gabriel Almeida-Alves, Alicia M Boynton, John M Spitsberge. GDNF synthesis, signaling, and retrograde transport in motor neurons. Cell and tissue research. vol 382. issue 1. 2021-06-23. PMID:32897420. |
gdnf was originally isolated from rat glial cell lines and identified as a neurotrophic factor with the ability to promote dopamine uptake within midbrain dopaminergic neurons. |
2021-06-23 |
2023-08-13 |
rat |
| F Y Wong, A Gogos, N Hale, S A Ingelse, N Brew, K L Shepherd, M van den Buuse, D W Walke. Impact of hypoxia-ischemia and dopamine treatment on dopamine receptor binding density in the preterm fetal sheep brain. Journal of applied physiology (Bethesda, Md. : 1985). vol 129. issue 6. 2021-06-23. PMID:33054660. |
however, the effects of exogenous dopamine and cerebral hi on dopaminergic signaling in the immature brain are unknown. |
2021-06-23 |
2023-08-13 |
Not clear |
| Nicole L Jenni, Yi Tao Li, Stan B Floresc. Medial orbitofrontal cortex dopamine D Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 7. 2021-06-23. PMID:33452435. |
the mofc receives considerable dopaminergic input, yet how dopamine (da) modulates mofc function has been virtually unexplored. |
2021-06-23 |
2023-08-13 |
rat |
| Mary K Estes, Jasric J Bland, Kenya K Ector, Melissa J Puppa, Douglas W Powell, Deranda B Leste. A high fat western diet attenuates phasic dopamine release. Neuroscience letters. vol 756. 2021-06-22. PMID:33979702. |
mice that consumed the wd demonstrated a hypodopaminergic profile, specifically reduced baseline dopamine release and an attenuated dopaminergic response to dat inhibition compared to the control diet group. |
2021-06-22 |
2023-08-13 |
mouse |
| Kung-Chun Kao, Tatsuhiro Hisatsun. Differential effects of dopamine D1-like and D2-like receptor agonists on water drinking behaviour under thirsty conditions in mice with reduced dopamine secretion. The European journal of neuroscience. vol 51. issue 2. 2021-06-21. PMID:31472080. |
however, the precise involvement of dopaminergic neurons and dopamine receptors in water drinking behaviour remains unclear. |
2021-06-21 |
2023-08-13 |
mouse |
| Ana Clara Cristóvão, Filipa L Campos, Goun Je, Marta Esteves, Subhrangshu Guhathakurta, Lichuan Yang, M Flint Beal, Beatriz M Fonseca, Antonio J Salgado, João Queiroz, Nuno Sousa, Liliana Bernardino, Gilberto Alves, Kyung-Sik Yoon, Yoon-Seong Ki. Characterization of a Parkinson's disease rat model using an upgraded paraquat exposure paradigm. The European journal of neuroscience. vol 52. issue 4. 2021-06-21. PMID:31958881. |
the pq exposure paradigm used lead to a rodent model of pd depicting progressive nigrostriatal dopaminergic neurodegeneration, characterized by a 41% significant loss of dopaminergic neuron in the substantia nigra pars compacta (snpc), a significant decrease of 18% and 40% of dopamine levels in striatum at week 5 and 8, respectively, and a significant 1.5-fold decrease in motor performance. |
2021-06-21 |
2023-08-13 |
human |
| Mauro Pettorruso, Francesca Zoratto, Andrea Miuli, Luisa De Risio, Mario Santorelli, Alice Pierotti, Giovanni Martinotti, Walter Adriani, Massimo di Giannantoni. Exploring dopaminergic transmission in gambling addiction: A systematic translational review. Neuroscience and biobehavioral reviews. vol 119. 2021-06-21. PMID:33035523. |
though no postsynaptic dopaminergic alterations were observed, several studies point at dysfunctions in presynaptic dopamine trafficking in gd, suggestive of hyperdopaminergic states. |
2021-06-21 |
2023-08-13 |
human |
| Hossein Khaleghzadeh-Ahangar, Mina Rashvand, Abbas Haghparas. Role of D1- and D2-like dopamine receptors within the dentate gyrus in antinociception induced by chemical stimulation of the lateral hypothalamus in an animal model of acute pain. Physiology & behavior. vol 229. 2021-06-21. PMID:33091437. |
so, given the presence of dopamine receptors in the dg and the undeniable role of the dopaminergic system in pain modulation, the current study was conducted to investigate the role of dopamine receptors located within the dg in the lh stimulation-induced pain modulation. |
2021-06-21 |
2023-08-13 |
rat |
| Pamela C Lovejoy, Kate E Foley, Melissa M Conti, Samantha M Meadows, Christopher Bishop, Anthony C Fiumer. Genetic basis of susceptibility to low-dose paraquat and variation between the sexes in Drosophila melanogaster. Molecular ecology. vol 30. issue 9. 2021-06-21. PMID:33710693. |
paraquat, one such toxicant, is a commonly used herbicide and is known to produce mitochondrial oxidative stress, decrease dopaminergic neurons and dopamine (da) levels, and decrease motor ability. |
2021-06-21 |
2023-08-13 |
drosophila_melanogaster |
| Miguel Skirzewski, Marie E Cronin, Ricardo Murphy, Wambura Fobbs, Alexxai V Kravitz, Andres Buonann. ErbB4 Null Mice Display Altered Mesocorticolimbic and Nigrostriatal Dopamine Levels as well as Deficits in Cognitive and Motivational Behaviors. eNeuro. vol 7. issue 3. 2021-06-18. PMID:32354758. |
whereas most studies on nrg1-erbb4 signaling have focused on gabaergic interneurons, erbb4 is also expressed by midbrain dopaminergic neurons where it modulates extracellular dopamine (da) levels. |
2021-06-18 |
2023-08-13 |
mouse |
| Kuntal Sen, Melesilika Finau, Pritha Ghos. Bi-allelic variants in PNPLA6 possibly associated with Parkinsonian features in addition to spastic paraplegia phenotype. Journal of neurology. vol 267. issue 9. 2021-06-18. PMID:32623594. |
the proband had a positive dopamine transporter scan, indicating degeneration in dopaminergic neurons, and dopa-responsive extrapyramidal symptoms. |
2021-06-18 |
2023-08-13 |
Not clear |
| Joseph R Driscoll, Tanya L Wallace, Kasra A Mansourian, William J Martin, Elyssa B Margoli. Differential Modulation of Ventral Tegmental Area Circuits by the Nociceptin/Orphanin FQ System. eNeuro. vol 7. issue 5. 2021-06-18. PMID:32747458. |
n/ofq and its receptor, nop, are enriched in dopaminergic pathways, and intra-ventricular agonist delivery decreases dopamine levels in the dorsal striatum, nucleus accumbens (nac), and ventral tegmental area (vta). |
2021-06-18 |
2023-08-13 |
rat |
| Daryl A Guthrie, Carmen Klein Herenbrink, Matthew Domenic Lycas, Therese Ku, Alessandro Bonifazi, Brian T DeVree, Signe Mathiasen, Jonathan A Javitch, Jonathan B Grimm, Luke Lavis, Ulrik Gether, Amy Hauck Newma. Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter. ACS chemical neuroscience. vol 11. issue 20. 2021-06-18. PMID:32926777. |
the dopamine transporter (dat) is critical for spatiotemporal control of dopaminergic neurotransmission and is the target for therapeutic agents, including adhd medications, and abused substances, such as cocaine. |
2021-06-18 |
2023-08-13 |
Not clear |
| Kathleen S Lynch, Michael J Rya. Understanding the Role of Incentive Salience in Sexual Decision-Making. Integrative and comparative biology. vol 60. issue 3. 2021-06-17. PMID:32483613. |
this review includes studies of dopamine agonist or antagonist administration in females during mate choice or partner preference tests, measures of neural activity in dopaminergic neural circuits during mate choice or partner preference tests, and social regulation of dopamine in females when entering reproductive contexts and/or exposure to mate signals. |
2021-06-17 |
2023-08-13 |
Not clear |
| M E Chávez-Pichardo, D Y Reyes-Bravo, M S Mendoza-Trejo, A G Marín-López, M Giordano, N Hernández-Chan, K Domínguez-Marchan, L C Ortega-Rosales, V M Rodrígue. Brain alterations in GABA, glutamate and glutamine markers after chronic atrazine exposure in the male albino rat. Archives of toxicology. vol 94. issue 9. 2021-06-16. PMID:32561961. |
studies in rodents have shown that chronic atr exposure is associated with alterations in the nigrostriatal dopaminergic pathway such as hyperactivity, decreased striatal dopamine levels, and diminished numbers of tyrosine hydroxylase positive cells in substantia nigra pars compacta. |
2021-06-16 |
2023-08-13 |
rat |
| Victoria Sofie Witzig, Daniel Komnig, Björn H Falkenburge. Changes in Striatal Medium Spiny Neuron Morphology Resulting from Dopamine Depletion Are Reversible. Cells. vol 9. issue 11. 2021-06-16. PMID:33182316. |
in order to define the potential benefits and limitations of dopamine substitution, we tested in a mouse model whether dendritic pruning and spine loss can be reversible when dopaminergic axon terminals regenerate. |
2021-06-16 |
2023-08-13 |
mouse |