| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Naeem Asad, Duncan E McLain, Alec F Condon, Sangram Gore, Shahienaz E Hampton, Sauparnika Vijay, John T Williams, Timothy M Dor. Photoactivatable Dopamine and Sulpiride to Explore the Function of Dopaminergic Neurons and Circuits. ACS chemical neuroscience. vol 11. issue 6. 2021-05-24. PMID:32077679. |
photoactivatable dopamine and sulpiride to explore the function of dopaminergic neurons and circuits. |
2021-05-24 |
2023-08-13 |
Not clear |
| Julian L Goggi, Lifeng Qiu, Mei Chih Liao, Shivashankar Khanapur, Lingfan Jiang, Ramasamy Boominathan, Siddesh V Hartimath, Peter Cheng, Fui Fong Yong, Vanessa Soh, Xiaozhou Deng, Youshan Melissa Lin, Anna Haslop, Peng Wen Tan, Xiaoxia Zeng, Jolene W L Lee, Zhiwei Zhang, Pragalath Sadasivam, Eng King Tan, Sajinder K Luthra, William D Shingleton, Steve K W Oh, Li Zeng, Edward G Robin. Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson's disease. Stem cell research & therapy. vol 11. issue 1. 2021-05-24. PMID:32771055. |
the current study examines the utility of neuroimaging to characterise the in vivo maturation, innervation and functional dopamine release of transplanted human embryonic stem cell-derived midbrain dopaminergic neurons (hesc-mdas) in a preclinical model of pd. |
2021-05-24 |
2023-08-13 |
human |
| Alyssa G Yocky, Dan P Cove. Evolution of in vivo dopamine monitoring techniques. Pharmacology, biochemistry, and behavior. vol 200. 2021-05-24. PMID:33278398. |
current understanding of how dopamine neurotransmission contributes to behavior and its dysfunction has been driven by technological advancements that permit spatiotemporally-defined measurements of dopaminergic signaling in behaving animals. |
2021-05-24 |
2023-08-13 |
Not clear |
| Rahul Bharatiya, Jessica Bratzu, Carla Lobina, Giulia Corda, Cristina Cocco, Philippe De Deurwaerdere, Antonio Argiolas, Maria Rosaria Melis, Fabrizio Sann. The pesticide fipronil injected into the substantia nigra of male rats decreases striatal dopamine content: A neurochemical, immunohistochemical and behavioral study. Behavioural brain research. vol 384. 2021-05-20. PMID:32070689. |
the results confirm that the unilateral injection of fipronil into the substantia nigra caused the degeneration of nigrostriatal dopaminergic neurons, which leads to a decrease around 50 % in striatal dopamine content and substantia nigra th imunoreactivity. |
2021-05-20 |
2023-08-13 |
rat |
| Michelle S Antunes, Leandro Cattelan Souza, Fernando Vagner Lobo Ladd, Aliny Antunes Barbosa Lobo Ladd, Amanda Lopez Moreira, Vandreza Cardoso Bortolotto, Márcia Rósula Poetini Silva, Stífani Machado Araújo, Marina Prigol, Cristina Wayne Nogueira, Silvana Peterini Boeir. Hesperidin Ameliorates Anxiety-Depressive-Like Behavior in 6-OHDA Model of Parkinson's Disease by Regulating Striatal Cytokine and Neurotrophic Factors Levels and Dopaminergic Innervation Loss in the Striatum of Mice. Molecular neurobiology. vol 57. issue 7. 2021-05-19. PMID:32458386. |
hesperidin treatment was also capable to increase striatal levels of dopamine and its metabolite 3,4-dihydroxyphenylacetic acid and protects against the impairment of dopaminergic neurons in the substantia nigra pars compacta (snpc) (p < 0.05). |
2021-05-19 |
2023-08-13 |
mouse |
| Patricia García-Sanz, Johannes M F G Aerts, Rosario Moratall. The Role of Cholesterol in α-Synuclein and Lewy Body Pathology in GBA1 Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. vol 36. issue 5. 2021-05-19. PMID:33219714. |
parkinson's disease (pd) is a progressive neurodegenerative disease where dopaminergic neurons in the substantia nigra are lost, resulting in a decrease in striatal dopamine and, consequently, motor control. |
2021-05-19 |
2023-08-13 |
Not clear |
| Yong Hui Nies, Nor Haliza Mohamad Najib, Wei Ling Lim, Mohd Amir Kamaruzzaman, Mohamad Fairuz Yahaya, Seong Lin Teo. MicroRNA Dysregulation in Parkinson's Disease: A Narrative Review. Frontiers in neuroscience. vol 15. 2021-05-18. PMID:33994934. |
the severe loss of dopaminergic neurons in the substantia nigra pars compacta causes striatal dopamine deficiency and the presence of lewy bodies indicates a pathological hallmark of pd. |
2021-05-18 |
2023-08-13 |
Not clear |
| Yong Hui Nies, Nor Haliza Mohamad Najib, Wei Ling Lim, Mohd Amir Kamaruzzaman, Mohamad Fairuz Yahaya, Seong Lin Teo. MicroRNA Dysregulation in Parkinson's Disease: A Narrative Review. Frontiers in neuroscience. vol 15. 2021-05-18. PMID:33994934. |
although the current treatment of pd aims to preserve dopaminergic neurons or to replace dopamine depletion in the brain, it is notable that complete recovery from the disease is yet to be achieved. |
2021-05-18 |
2023-08-13 |
Not clear |
| Davide Amato, Fabio Canneva, Paul Cumming, Simone Maschauer, Dominik Groos, Jana Katharina Dahlmanns, Teja W Grömer, Lisa Chiofalo, Marc Dahlmanns, Fang Zheng, Johannes Kornhuber, Olaf Prante, Christian Alzheimer, Stephan von Hörsten, Christian P Mülle. A dopaminergic mechanism of antipsychotic drug efficacy, failure, and failure reversal: the role of the dopamine transporter. Molecular psychiatry. vol 25. issue 9. 2021-05-14. PMID:30038229. |
a dopaminergic mechanism of antipsychotic drug efficacy, failure, and failure reversal: the role of the dopamine transporter. |
2021-05-14 |
2023-08-13 |
rat |
| Miguel Perez de la Mora, Carlos Hernandez-Mondragon, Minerva Crespo-Ramirez, José Rejon-Orantes, Dasiel O Borroto-Escuela, Kjell Fux. Conventional and Novel Pharmacological Approaches to Treat Dopamine-Related Disorders: Focus on Parkinson's Disease and Schizophrenia. Neuroscience. vol 439. 2021-05-14. PMID:31349007. |
dopamine released from these neurons operates mainly via the short distance extrasynaptic volume transmission and activates five different dopaminergic receptor subtypes modulating synaptic gaba and glutamate transmission. |
2021-05-14 |
2023-08-13 |
Not clear |
| Enrico D'Ambrosio, Sameer Jauhar, Seoyoung Kim, Mattia Veronese, Maria Rogdaki, Fiona Pepper, Ilaria Bonoldi, Vasileia Kotoula, Matthew J Kempton, Federico Turkheimer, Jun Soo Kwon, Euitae Kim, Oliver D Howe. The relationship between grey matter volume and striatal dopamine function in psychosis: a multimodal Molecular psychiatry. vol 26. issue 4. 2021-05-14. PMID:31690805. |
the relationship between grey matter volume and striatal dopamine function in psychosis: a multimodal a leading hypothesis for schizophrenia and related psychotic disorders proposes that cortical brain disruption leads to subcortical dopaminergic dysfunction, which underlies psychosis in the majority of patients who respond to treatment. |
2021-05-14 |
2023-08-13 |
Not clear |
| Enrico D'Ambrosio, Sameer Jauhar, Seoyoung Kim, Mattia Veronese, Maria Rogdaki, Fiona Pepper, Ilaria Bonoldi, Vasileia Kotoula, Matthew J Kempton, Federico Turkheimer, Jun Soo Kwon, Euitae Kim, Oliver D Howe. The relationship between grey matter volume and striatal dopamine function in psychosis: a multimodal Molecular psychiatry. vol 26. issue 4. 2021-05-14. PMID:31690805. |
we therefore investigated the in vivo relationship between striatal dopamine synthesis capacity and prefrontal grey matter volume in treatment-responsive patients with psychosis, and compared them to treatment non-responsive patients, where dopaminergic mechanisms are not thought to be central. |
2021-05-14 |
2023-08-13 |
Not clear |
| Muhammed Khairujjaman Mazumder, Anupom Borah, Shuvasish Choudhur. Inhibitory potential of plant secondary metabolites on anti-Parkinsonian drug targets: Relevance to pathophysiology, and motor and non-motor behavioural abnormalities. Medical hypotheses. vol 137. 2021-05-14. PMID:31954292. |
parkinson's disease (pd), a progressive neurodegenerative motor disorder, is caused due to the loss of dopaminergic neurons in the substantia nigra pars compacta region of mid-brain and the resultant depletion of the levels of the neurotransmitter dopamine. |
2021-05-14 |
2023-08-13 |
Not clear |
| Jincheol Seo, Junghyung Park, Keonwoo Kim, Jinyoung Won, Hyeon-Gu Yeo, Yeung Bae Jin, Bon-Sang Koo, Kyung Seob Lim, Kang-Jin Jeong, Philyong Kang, Hwal-Yong Lee, Won Seok Choi, Seung Ho Baek, Chang-Yeop Jeon, Jung-Joo Hong, Jae-Won Huh, Young-Hyun Kim, Sang Je Park, Sun-Uk Kim, Dong-Seok Lee, Sang-Rae Lee, Youngjeon Le. Chronic Infiltration of T Lymphocytes into the Brain in a Non-human Primate Model of Parkinson's Disease. Neuroscience. vol 431. 2021-05-14. PMID:32036014. |
we found selective and local chronic infiltration of cd4+ and cd8+ t lymphocytes, loss of dopaminergic neurons, dopamine transporter expression, chronic normalization of rantes in the peripheral blood, and altered microglial morphology at 48 weeks after mptp injection. |
2021-05-14 |
2023-08-13 |
Not clear |
| Zhourui Wu, Yiyuan Xia, Zhihao Wang, Seong Su Kang, Kecheng Lei, Xia Liu, Lingjing Jin, Xiaochuan Wang, Liming Cheng, Keqiang Y. C/EBPβ/δ-secretase signaling mediates Parkinson's disease pathogenesis via regulating transcription and proteolytic cleavage of α-synuclein and MAOB. Molecular psychiatry. vol 26. issue 2. 2021-05-14. PMID:32086435. |
maob, a crucial monoamine oxidase for dopamine metabolism, triggers oxidative stress in dopaminergic neurons and α-syn aggregation. |
2021-05-14 |
2023-08-13 |
mouse |
| Kenneth Blum, David Baron, Thomas McLaughlin, Mark S Gol. Molecular neurological correlates of endorphinergic/dopaminergic mechanisms in reward circuitry linked to endorphinergic deficiency syndrome (EDS). Journal of the neurological sciences. vol 411. 2021-05-14. PMID:32088516. |
the role of dopamine in terms of alcohol withdrawal symptomology, cocaine craving behavior, dopamine -condensation products (tiqs), and more recently, the genetic aspects of drug-seeking and pro-dopamine regulation, provide compelling evidence of the relevant molecular neurological correlates of dopaminergic /endorphinergic mechanisms in reward circuitry due to genetic polymorphisms and epigenetic insults. |
2021-05-14 |
2023-08-13 |
Not clear |
| Claire E Meyer, Juan Liu, Ioana Craciun, Dalin Wu, Hui Wang, Mingqi Xie, Martin Fussenegger, Cornelia G Paliva. Segregated Nanocompartments Containing Therapeutic Enzymes and Imaging Compounds within DNA-Zipped Polymersome Clusters for Advanced Nanotheranostic Platform. Small (Weinheim an der Bergstrasse, Germany). vol 16. issue 27. 2021-05-14. PMID:32130785. |
the therapeutic compartment, loaded with active ddc, triggers the cellular expression of a secreted reporter enzyme via production of dopamine and activation of dopaminergic receptors implicated in atherosclerosis. |
2021-05-14 |
2023-08-13 |
human |
| Yuanjing Feng, Wenxuan Yan, Jingqiang Wang, Jiahao Song, Qingrun Zeng, Changchen Zha. Local White Matter Fiber Clustering Differentiates Parkinson's Disease Diagnoses. Neuroscience. vol 435. 2021-05-14. PMID:32272152. |
scans without evidence of dopaminergic deficit (swedd) patients are often misdiagnosed with parkinson's disease (pd) but have normal dopamine transporter scans. |
2021-05-14 |
2023-08-13 |
Not clear |
| Nae Saito, Kazuki Tainaka, Tom Macpherson, Takatoshi Hikida, Shun Yamaguchi, Toshikuni Sasaok. Neurotransmission through dopamine D1 receptors is required for aversive memory formation and Arc activation in the cerebral cortex. Neuroscience research. vol 156. 2021-05-14. PMID:32380131. |
here, we investigated the role of dopaminergic neurotransmission via dopamine d1 receptors (d1rs) in aversive memory formation in a passive avoidance test using d1r knockdown (kd) mice, in which the expression of d1rs can conditionally and reversibly be controlled by doxycycline (dox) treatment. |
2021-05-14 |
2023-08-13 |
mouse |
| Nian-Ting Yao, Qian Zheng, Zi-Qian Xu, Jian-Hong Yin, Lin-Guang Lu, Qi Zuo, Su Yang, Chun-Lin Zhang, Ling Jia. Positron emission computed tomography/single photon emission computed tomography in Parkinson disease. Chinese medical journal. vol 133. issue 12. 2021-05-14. PMID:32404694. |
its main pathological mechanism is the selective degeneration and deletion of dopaminergic neurons in the dense part of the substantia nigra and the damage of dopaminergic neurons caused by the abnormal deposition of a lewy body, leading to a decreased dopamine level. |
2021-05-14 |
2023-08-13 |
Not clear |