| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aliasghar Karimi, Mitra Elmi, Zahra Shiri, Hossein Baharvan. Therapeutic potential of pluripotent stem cell-derived dopaminergic progenitors in Parkinson's disease: a systematic review protocol. Systematic reviews. vol 10. issue 1. 2021-07-05. PMID:34172098. |
this disease is associated with a loss of dopamine content within the putamen, which stems from the degeneration of dopaminergic (da) neurons in the substantia nigra pars compacta (snc). |
2021-07-05 |
2023-08-13 |
human |
| Shaili Aggarwal, Mary Hongying Cheng, Joseph M Salvino, Ivet Bahar, Ole Valente Mortense. Functional Characterization of the Dopaminergic Psychostimulant Sydnocarb as an Allosteric Modulator of the Human Dopamine Transporter. Biomedicines. vol 9. issue 6. 2021-07-05. PMID:34199621. |
functional characterization of the dopaminergic psychostimulant sydnocarb as an allosteric modulator of the human dopamine transporter. |
2021-07-05 |
2023-08-13 |
human |
| Steven Vetel, Laura Foucault-Fruchard, Claire Tronel, Frédéric Buron, Jackie Vergote, Sylvie Bodard, Sylvain Routier, Sophie Sérrière, Sylvie Chalo. Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson's disease. Neural regeneration research. vol 16. issue 6. 2021-07-03. PMID:33269756. |
although no effect was noticed in the amphetamine-induced rotation test, our data has shown that the pha/pre treatment induced partial protection of the dopaminergic neurons (15-20%), assessed by the dopamine transporter density in the striatum and immunoreactive tyrosine hydroxylase in the substantia nigra. |
2021-07-03 |
2023-08-13 |
rat |
| Zhuang-Yao D Wei, Ashok K Shett. Treating Parkinson's disease by astrocyte reprogramming: Progress and challenges. Science advances. vol 7. issue 26. 2021-07-02. PMID:34162545. |
such in vivo astrocyte reprogramming in the mouse model of pd has successfully added new dopaminergic neurons to the substantia nigra and increased dopamine levels associated with axonal projections into the striatum. |
2021-07-02 |
2023-08-13 |
mouse |
| Khadga Raj, G D Gupta, Shamsher Sing. l-Theanine ameliorates motor deficit, mitochondrial dysfunction, and neurodegeneration against chronic tramadol induced rats model of Parkinson's disease. Drug and chemical toxicology. 2021-07-02. PMID:34210222. |
parkinson's disease (pd) is the second most prevalent progressive neurodegenerative disease, characterized by loss of dopaminergic neurons in substantia nigra, with deficiency of dopamine in the striatum. |
2021-07-02 |
2023-08-13 |
rat |
| Meghan L Bucher, Caitlyn W Barrett, Connor J Moon, Amanda D Mortimer, Edward A Burton, J Timothy Greenamyre, Teresa G Hasting. Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson's disease. NPJ Parkinson's disease. vol 6. issue 1. 2021-06-30. PMID:33298952. |
despite postmortem analyses from patients with parkinson's disease that demonstrate decreased vesicular sequestration of dopamine with a corresponding increase in dopamine metabolism, dopamine's contribution to nigrostriatal dopaminergic degeneration in parkinson's disease has been debated. |
2021-06-30 |
2023-08-13 |
rat |
| Meghan L Bucher, Caitlyn W Barrett, Connor J Moon, Amanda D Mortimer, Edward A Burton, J Timothy Greenamyre, Teresa G Hasting. Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson's disease. NPJ Parkinson's disease. vol 6. issue 1. 2021-06-30. PMID:33298952. |
here, we present a new in vivo model demonstrating the induction of parkinson's disease-associated pathogenic mechanisms of degeneration resulting from acquired dysregulation of dopamine sequestration in nigrostriatal dopaminergic neurons in adult rats. |
2021-06-30 |
2023-08-13 |
rat |
| Meghan L Bucher, Caitlyn W Barrett, Connor J Moon, Amanda D Mortimer, Edward A Burton, J Timothy Greenamyre, Teresa G Hasting. Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson's disease. NPJ Parkinson's disease. vol 6. issue 1. 2021-06-30. PMID:33298952. |
the loss of vmat2 resulted in an accumulation of cytosolic dopamine and subsequent increased dopamine metabolism, deficits in dopamine-mediated behaviors, and degeneration of nigrostriatal dopaminergic neurons that was rescued through reintroduction of exogenous vmat2, demonstrating that the toxicity was specific to the loss of vmat2. |
2021-06-30 |
2023-08-13 |
rat |
| Maritza Oñate, Alejandra Catenaccio, Natalia Salvadores, Cristian Saquel, Alexis Martinez, Ines Moreno-Gonzalez, Nazaret Gamez, Paulina Soto, Claudio Soto, Claudio Hetz, Felipe A Cour. The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease. Cell death and differentiation. vol 27. issue 4. 2021-06-29. PMID:31591470. |
parkinson's disease (pd) is the second most common neurodegenerative condition, characterized by motor impairment due to the progressive degeneration of dopaminergic neurons in the substantia nigra and depletion of dopamine release in the striatum. |
2021-06-29 |
2023-08-13 |
mouse |
| Robert Lindroos, Jeanette Hellgren Kotalesk. Predicting complex spikes in striatal projection neurons of the direct pathway following neuromodulation by acetylcholine and dopamine. The European journal of neuroscience. vol 53. issue 7. 2021-06-29. PMID:32609903. |
the two systems are tightly connected, for example, synchronized activity of cholinergic interneurons, leading to increased acetylcholine release, has been shown to directly trigger dopamine release from dopaminergic terminals in striatum. |
2021-06-29 |
2023-08-13 |
Not clear |
| Kyoungjune Pak, Ju Won Seok, Hyun-Yeol Nam, Seongho Seo, Myung Jun Lee, Keunyoung Kim, In Joo Ki. The association of DAT gene methylation with striatal DAT availability in healthy subjects. EJNMMI research. vol 11. issue 1. 2021-06-29. PMID:34120227. |
functioning of nigrostriatal dopaminergic neurons is influenced by the expression of the dopamine transporter (dat), and genetic variations in the gene encoding dat contribute to differences in reward processing. |
2021-06-29 |
2023-08-13 |
human |
| Despoina Aslanoglou, Suzanne Bertera, Marta Sánchez-Soto, R Benjamin Free, Jeongkyung Lee, Wei Zong, Xiangning Xue, Shristi Shrestha, Marcela Brissova, Ryan W Logan, Claes B Wollheim, Massimo Trucco, Vijay K Yechoor, David R Sibley, Rita Bottino, Zachary Freyber. Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33589583. |
dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors. |
2021-06-28 |
2023-08-13 |
mouse |
| Hidekazu Sotoyama, Hisaaki Namba, Yutaro Kobayashi, Taku Hasegawa, Dai Watanabe, Ena Nakatsukasa, Kenji Sakimura, Tomoyuki Furuyashiki, Hiroyuki Naw. Resting-state dopaminergic cell firing in the ventral tegmental area negatively regulates affiliative social interactions in a developmental animal model of schizophrenia. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33888687. |
in vivo single-unit recording and microdialysis revealed that the baseline firing frequency of and dopamine release from vta dopaminergic neurons were chronically increased in egf model rats, and their social interaction was concomitantly reduced. |
2021-06-28 |
2023-08-13 |
rat |
| Aditi Mishra, Patrick Cronley, Mathangi Ganesan, David J Schulz, Troy Zar. Dopaminergic neurons can influence heat-box place learning in Journal of neurogenetics. vol 34. issue 1. 2021-06-25. PMID:31997669. |
dopaminergic neurons can influence heat-box place learning in dopamine provides crucial neuromodulatory functions in several insect and rodent learning and memory paradigms. |
2021-06-25 |
2023-08-13 |
Not clear |
| Lilian R F Faro, Lorenzo A Justo, Miguel Alfonso, Rafael Durá. Possible synergies between isatin, an endogenous MAO inhibitor, and antiparkinsonian agents on the dopamine release from striatum of freely moving rats. Neuropharmacology. vol 171. 2021-06-25. PMID:32304702. |
for this, we co-administered isatin with the mao inhibitors selegiline and clorgyline, l-dopa, the catechol-o-methyl-transferase (comt) inhibitors tropolone and dinitrocatechol, with the dopaminergic agonist ropinirole, and with the psychostimulant caffeine, in order to evaluate possible synergies between these substances to increase the dopamine extracellular levels in freely moving rats. |
2021-06-25 |
2023-08-13 |
rat |
| Marilena Mangiardi, Guido Alfan. A clinical improvement of a idiopathic cervical dystonia in a patient treated with transdermal Rotigotine: a case-report. Acta bio-medica : Atenei Parmensis. vol 91. issue 3. 2021-06-25. PMID:32921774. |
we report a case of focal cervical dystonia successful treated with a dopamine agonist (d3>d2>d1) rotigotine, a transdermal drug that induces a continuous dopaminergic stimulation. |
2021-06-25 |
2023-08-13 |
mouse |
| Emilia Pascale, Giuseppina Divisato, Renata Palladino, Margherita Auriemma, Edward Faustine Ngalya, Massimiliano Caiazz. Noncoding RNAs and Midbrain DA Neurons: Novel Molecular Mechanisms and Therapeutic Targets in Health and Disease. Biomolecules. vol 10. issue 9. 2021-06-24. PMID:32899172. |
the identification of noncoding rna networks underlying all stages of dopamine neuron development and plasticity is an essential step to deeply understand their physiological role and also their involvement in the etiology of dopaminergic diseases. |
2021-06-24 |
2023-08-13 |
Not clear |
| Chenyang Han, Heping Shen, Yi Yang, Yongjia Sheng, Jin Wang, Wenyan Li, Xiaohong Zhou, Li Guo, Liping Zhai, Qiaobing Gua. Antrodia camphorata polysaccharide resists 6-OHDA-induced dopaminergic neuronal damage by inhibiting ROS-NLRP3 activation. Brain and behavior. vol 10. issue 11. 2021-06-24. PMID:32902155. |
the main pathological change is the apoptosis of dopaminergic neurons in the substantia nigra pars compacta (snpc), thereby leading to dopamine reduction in nigral striatum. |
2021-06-24 |
2023-08-13 |
mouse |
| T C Peixoto, E G Moura, P N Soares, V S T Rodrigues, S Claudio-Neto, E Oliveira, A C Manhães, P C Lisbo. Nicotine exposure during lactation causes disruption of hedonic eating behavior and alters dopaminergic system in adult female rats. Appetite. vol 160. 2021-06-24. PMID:33453337. |
nicotine is transferred through milk and alters the dopaminergic reward system of adult male rats, reducing dopamine action in the nucleus accumbens (nac) and hypothalamic arcuate nucleus. |
2021-06-24 |
2023-08-13 |
rat |
| Nabeel Ali, Amna Syeda, Tenzin Topgyal, Naseem Gaur, Asimul Isla. Parkinson's disease: A current perspectives on Parkinson's disease and key bioactive natural compounds as future potential drug candidates. Current drug targets. 2021-06-24. PMID:34165406. |
the hallmark of pd includes dopamine deficiency (neurotransmitter imbalance) due to the gradual loss of dopaminergic nerves in the substantia nigra in the midbrain. |
2021-06-24 |
2023-08-13 |
Not clear |