| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Wang, Simin Lai, Guodong Li, Ting Zhou, Biao Wang, Fang Cao, Teng Chen, Xia Zhang, Yanjiong Che. Microglial activation contributes to depressive-like behavior in dopamine D3 receptor knockout mice. Brain, behavior, and immunity. vol 83. 2021-03-08. PMID:31626970. |
we previously demonstrated that the dopamine d3 receptor (d3r) inhibitor, ngb2904, increases susceptibility to depressive-like symptoms, elevates pro-inflammatory cytokine expression, and alters brain-derived neurotrophic factor (bdnf) levels in mesolimbic dopaminergic regions, including the medial prefrontal cortex (mpfc), nucleus accumbens (nac), and ventral tegmental area (vta) in mice. |
2021-03-08 |
2023-08-13 |
mouse |
| Xiao-Rui Wang, Song-Xin Zhu, Xiao-Ming Wen, Jun-Xia Xie, Ning Son. [Altered dopamine metabolism and its role in pathogenesis of Parkinson's disease]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 1. 2021-03-08. PMID:33665664. |
dopamine (da) metabolism is a cardinal physiological process in dopaminergic neurons, which is closely related to the loss of dopaminergic neurons in the sn. |
2021-03-08 |
2023-08-13 |
Not clear |
| Glenda E Gillies, Kanwar Virdee, Ilse Pienaar, Felwah Al-Zaid, Jeffrey W Dalle. Enduring, Sexually Dimorphic Impact of In Utero Exposure to Elevated Levels of Glucocorticoids on Midbrain Dopaminergic Populations. Brain sciences. vol 7. issue 1. 2021-03-04. PMID:28042822. |
specifically, using a rodent model of gc exposure in late gestation (approximating human brain development at late second/early third trimester), we demonstrated enduring effects on the shape and volume of the ventral tegmental area (vta) and substantia nigra pars compacta (snc) (origins of the mesocorticolimbic and nigrostriatal dopaminergic pathways) on the topographical organisation and size of the dopaminergic neuronal populations and astrocytes within these nuclei and on target innervation density and neurochemical markers of dopaminergic transmission (receptors, transporters, basal and amphetamine-stimulated dopamine release at striatal and prefrontal cortical sites) that impact on the adult brain. |
2021-03-04 |
2023-08-13 |
human |
| Haiyun Chen, Jie Cao, Ling Zha, Peile Wang, Zheng Liu, Baojian Guo, Gaoxiao Zhang, Yewei Sun, Zaijun Zhang, Yuqiang Wan. Neuroprotective and neurogenic effects of novel tetramethylpyrazine derivative T-006 in Parkinson's disease models through activating the MEF2-PGC1α and BDNF/CREB pathways. Aging. vol 12. issue 14. 2021-03-04. PMID:32710729. |
t-006 was able to improve locomotor behavior, increase survival of nigra dopaminergic neurons and boost striatal dopamine levels in both mptp- and 6-ohda-induced animals. |
2021-03-04 |
2023-08-13 |
rat |
| Suzanne O Nolan, Jennifer E Zachry, Amy R Johnson, Lillian J Brady, Cody A Siciliano, Erin S Calipar. Direct dopamine terminal regulation by local striatal microcircuitry. Journal of neurochemistry. vol 155. issue 5. 2021-03-02. PMID:32356315. |
here we review how these mechanisms work in concert to influence the timing and magnitude of striatal dopamine signaling, independent of action potential activity at the level of dopaminergic cell bodies in the midbrain, thereby providing a parallel pathway by which dopamine can be modulated. |
2021-03-02 |
2023-08-13 |
Not clear |
| Giulia Paparella, Giulia Di Stefano, Alessandra Fasolino, Giuseppe Di Pietro, Donato Colella, Andrea Truini, Giorgio Cruccu, Alfredo Berardelli, Matteo Bologn. Painful stimulation increases spontaneous blink rate in healthy subjects. Scientific reports. vol 10. issue 1. 2021-03-02. PMID:33203984. |
our study provides evidence on the role of dopamine in nociception and suggests that dopaminergic activity may be involved in pain modulation. |
2021-03-02 |
2023-08-13 |
human |
| Rui Wang, Hongyang Sun, Guanghui Wang, Haigang Re. Imbalance of Lysine Acetylation Contributes to the Pathogenesis of Parkinson's Disease. International journal of molecular sciences. vol 21. issue 19. 2021-03-01. PMID:33003340. |
the neuropathological features of pd are selective and progressive loss of dopaminergic neurons in the substantia nigra pars compacta, deficiencies in striatal dopamine levels, and the presence of intracellular lewy bodies. |
2021-03-01 |
2023-08-13 |
Not clear |
| Annelies J van Nuland, Rick C Helmich, Michiel F Dirkx, Heidemarie Zach, Ivan Toni, Roshan Cools, Hanneke E M den Oude. Effects of dopamine on reinforcement learning in Parkinson's disease depend on motor phenotype. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33147621. |
here we ask whether interindividual heterogeneity in tremor symptoms could account for the puzzlingly large variability in the effects of dopaminergic medication on reinforcement learning, a fundamental cognitive function known to rely on dopamine. |
2021-03-01 |
2023-08-13 |
human |
| Yue Lang, Yu Li, Haojia Yu, Lulu Lin, Xingchi Chen, Sainan Wang, Hui Zhan. HOTAIR drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of Parkinson's disease by elevating NPTX2 Aging. vol 12. issue 9. 2021-02-25. PMID:32396526. |
hotair drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of parkinson's disease by elevating nptx2 parkinson's disease (pd) is a neurodegenerative disorder characterized by progressive cell loss, largely confined to mesencephalic dopamine neurons of the substantia nigra. |
2021-02-25 |
2023-08-13 |
mouse |
| Huanhuan Chen, Xuelian Li, Hui Ma, Wei Zheng, Xiaoli She. Reduction in Nesfatin-1 Levels in the Cerebrospinal Fluid and Increased Nigrostriatal Degeneration Following Ventricular Administration of Anti-nesfatin-1 Antibody in Mice. Frontiers in neuroscience. vol 15. 2021-02-24. PMID:33613183. |
treatment with anti-nesfatin-1 antibody resulted in a substantial loss (23%) of th-positive (th+) dopaminergic neurons in the substantia nigra pars compacta (snpc), as shown by immunofluorescence staining, a depletion in dopamine and its metabolites in the striatum detected by high-performance liquid chromatography (hplc), and obvious nuclear shrinkage and mitochondrial lesions in dopaminergic neurons in the snpc detected by transmission electron microscopy (tem). |
2021-02-24 |
2023-08-13 |
mouse |
| Zhiqian Xu, Futong Liu, Tingting Zhang, Yue Gu, Nannan Lu, Haixin Xu, Xiaoyi Yan, Yu Song, Yue Xing, Dexun Yu, Zhiquan Zhang, Ping L. Density Functional Theory-Assisted Electrochemical Assay Manipulated by a Donor-Acceptor Structure toward Pharmaceutical Diagnostic. Analytical chemistry. vol 92. issue 23. 2021-02-23. PMID:33185440. |
moreover, this is also one of the main reasons for the loss of dopaminergic neurons and the abnormal content of dopamine (da). |
2021-02-23 |
2023-08-13 |
Not clear |
| Mahdi Eskandarian Boroujeni, Abbas Aliaghaei, Nader Maghsoudi, Mossa Gardane. Complementation of dopaminergic signaling by Pitx3-GDNF synergy induces dopamine secretion by multipotent Ntera2 cells. Journal of cellular biochemistry. vol 121. issue 1. 2021-02-22. PMID:31310388. |
complementation of dopaminergic signaling by pitx3-gdnf synergy induces dopamine secretion by multipotent ntera2 cells. |
2021-02-22 |
2023-08-13 |
human |
| Mahdi Eskandarian Boroujeni, Abbas Aliaghaei, Nader Maghsoudi, Mossa Gardane. Complementation of dopaminergic signaling by Pitx3-GDNF synergy induces dopamine secretion by multipotent Ntera2 cells. Journal of cellular biochemistry. vol 121. issue 1. 2021-02-22. PMID:31310388. |
attempts to restore complete dopaminergic (daergic) phenotype enabling these cells to secrete dopamine have not been fully successful so far. |
2021-02-22 |
2023-08-13 |
human |
| Kristin M Scaplen, Mustafa Talay, Kavin M Nunez, Sarah Salamon, Amanda G Waterman, Sydney Gang, Sophia L Song, Gilad Barnea, Karla R Kau. Circuits that encode and guide alcohol-associated preference. eLife. vol 9. 2021-02-22. PMID:32497004. |
we show that circuits required for alcohol-associated preference shift from population level dopaminergic activation to select dopamine neurons that predict behavioral choice in |
2021-02-22 |
2023-08-13 |
Not clear |
| Rafal Bogac. Dopamine role in learning and action inference. eLife. vol 9. 2021-02-22. PMID:32633715. |
presented models account for dopaminergic responses during movements, effects of dopamine depletion on behaviour, and make several experimental predictions. |
2021-02-22 |
2023-08-13 |
Not clear |
| Aaron E Rusheen, Taylor A Gee, Dong P Jang, Charles D Blaha, Kevin E Bennet, Kendall H Lee, Michael L Heien, Yoonbae O. Evaluation of electrochemical methods for tonic dopamine detection Trends in analytical chemistry : TRAC. vol 132. 2021-02-20. PMID:33597790. |
evaluation of electrochemical methods for tonic dopamine detection dysfunction in dopaminergic neuronal systems underlie a number of neurologic and psychiatric disorders such as parkinson's disease, drug addiction, and schizophrenia. |
2021-02-20 |
2023-08-13 |
Not clear |
| Mark W Mille. Dopamine as a Multifunctional Neurotransmitter in Gastropod Molluscs: An Evolutionary Hypothesis. The Biological bulletin. vol 239. issue 3. 2021-02-19. PMID:33347799. |
the functional properties of identified dopaminergic neurons in well-characterized neural circuits suggest a hypothetical incremental sequence by which dopamine accumulated its diverse roles. |
2021-02-19 |
2023-08-13 |
Not clear |
| Giovanni Schepici, Serena Silvestro, Placido Bramanti, Emanuela Mazzo. Caffeine: An Overview of Its Beneficial Effects in Experimental Models and Clinical Trials of Parkinson's Disease. International journal of molecular sciences. vol 21. issue 13. 2021-02-18. PMID:32635541. |
parkinson's disease (pd) is a neurological disease characterized by the progressive degeneration of the nigrostriatal dopaminergic pathway with consequent loss of neurons in the substantia nigra pars compacta and dopamine depletion. |
2021-02-18 |
2023-08-13 |
Not clear |
| Jaromir Myslivece. Two Players in the Field: Hierarchical Model of Interaction between the Dopamine and Acetylcholine Signaling Systems in the Striatum. Biomedicines. vol 9. issue 1. 2021-02-18. PMID:33401461. |
dopaminergic neurons express muscarinic and nicotinic receptors, and cholinergic interneurons express dopamine receptors. |
2021-02-18 |
2023-08-13 |
mouse |
| Ichiro Kawahata, Tomoki Sekimori, Haoyang Wang, Yanyan Wang, Toshikuni Sasaoka, Luc Bousset, Ronald Melki, Tomohiro Mizobata, Yasushi Kawata, Kohji Fukunag. Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons. Biomedicines. vol 9. issue 1. 2021-02-18. PMID:33429895. |
dopamine d2 long receptors are critical for caveolae-mediated α-synuclein uptake in cultured dopaminergic neurons. |
2021-02-18 |
2023-08-13 |
Not clear |