| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Witkovsky, C Nicholson, M E Rice, K Bohmaker, E Melle. Extracellular dopamine concentration in the retina of the clawed frog, Xenopus laevis. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 12. 1993-07-22. PMID:8516316. |
the model predicted an increase in the dopamine concentration from the vitreous to the layer of dopaminergic cells, remaining constant from that layer to the distal tips of the photoreceptors. |
1993-07-22 |
2023-08-12 |
xenopus_laevis |
| A M Young, M H Joseph, J A Gra. Latent inhibition of conditioned dopamine release in rat nucleus accumbens. Neuroscience. vol 54. issue 1. 1993-07-20. PMID:8515846. |
this is the first report of direct measurement of potentiated dopamine release during conditioning, and may provide a neurochemical basis for the effects of dopaminergic drugs on conditioning and latent inhibition. |
1993-07-20 |
2023-08-12 |
rat |
| A M Palmer, S T DeKosk. Monoamine neurons in aging and Alzheimer's disease. Journal of neural transmission. General section. vol 91. issue 2-3. 1993-07-16. PMID:8099796. |
alzheimer's disease is associated with more pronounced noradrenergic and serotonergic denervation but, unlike normal aging, dopaminergic innervation of neostriatum is intact; although dopamine neurons are probably dysfunctional in this region. |
1993-07-16 |
2023-08-12 |
Not clear |
| A Y Deutc. Prefrontal cortical dopamine systems and the elaboration of functional corticostriatal circuits: implications for schizophrenia and Parkinson's disease. Journal of neural transmission. General section. vol 91. issue 2-3. 1993-07-16. PMID:8099797. |
the dopaminergic innervation of the prefrontal cortex is able to transsynaptically regulate the activity of subcortical dopamine innervations. |
1993-07-16 |
2023-08-12 |
Not clear |
| K A Keefe, M J Zigmond, E D Abercrombi. In vivo regulation of extracellular dopamine in the neostriatum: influence of impulse activity and local excitatory amino acids. Journal of neural transmission. General section. vol 91. issue 2-3. 1993-07-16. PMID:8099798. |
it has been suggested that dopamine release can be evoked by excitatory amino acids acting on dopaminergic terminals, as well as by the classical process of impulse-evoked exocytosis. |
1993-07-16 |
2023-08-12 |
Not clear |
| A S Brown, S Gersho. Dopamine and depression. Journal of neural transmission. General section. vol 91. issue 2-3. 1993-07-16. PMID:8099801. |
the clinical evidence includes alterations in depressive symptoms with aging (concomitant with possible changes in dopamine metabolism), potential dopaminergic involvement in several subtypes of depression, similarities between some of the symptoms of parkinson's disease and those of depression (including psychomotor retardation and diminished motivation), and potential dopaminergic abnormalities in seasonal mood disorder. |
1993-07-16 |
2023-08-12 |
Not clear |
| B V Kumar, P S Sastr. Dopamine receptors in human foetal brains: characterization, regulation and ontogeny of [3H]spiperone binding sites in striatum. Neurochemistry international. vol 20. issue 4. 1993-07-15. PMID:1304871. |
spiperone binding sites were characterized in a 40-week-old foetal brain to be dopamine receptors by the following criteria: (1) it was localized in a crude mitochondrial pellet that included synaptosomes; (2) binding was saturable at 0.8 nm concentration; (3) dopaminergic antagonists spiperone, haloperidol, pimozide, trifluperazine and chlorpromazine competed for the binding with ic50 values in the range of 0.3-14 nm while agonists--apomorphine and dopamine gave ic50 values of 2.5 and 10 microm, respectively suggesting a d2 type receptor. |
1993-07-15 |
2023-08-11 |
human |
| G Pelletie. Regulation of proopiomelanocortin gene expression in rat brain and pituitary as studied by in situ hybridization. Annals of the New York Academy of Sciences. vol 680. 1993-07-15. PMID:8512219. |
the role of dopamine was investigated following the administration of the dopaminergic antagonist haloperidol and the d2 dopaminergic receptor agonist bromocriptine. |
1993-07-15 |
2023-08-12 |
rat |
| H K Tjon Tien Ril, T J De Vries, G Wardeh, F Hogenboom, A H Mulder, A N Schoffelmee. Long-lasting reciprocal changes in striatal dopamine and acetylcholine release upon morphine withdrawal. European journal of pharmacology. vol 235. issue 2-3. 1993-07-13. PMID:8508912. |
the lasting nature of the reduced dopamine release at the level of dopaminergic nerve terminals and the concomittant enhanced excitability of neurons tonically inhibited by released dopamine, such as cholinergic interneurons, could play an important role in the maintenance of opiate dependence. |
1993-07-13 |
2023-08-12 |
rat |
| H J Wagner, B G Luo, M A Ariano, D R Sibley, W K Stel. Localization of D2 dopamine receptors in vertebrate retinae with anti-peptide antibodies. The Journal of comparative neurology. vol 331. issue 4. 1993-07-13. PMID:8509505. |
in an attempt to better understand dopaminergic mechanisms at the cellular level, we used antisera against d2 receptors and investigated the localization of the dopamine d2 receptor in the retinae of rat, rabbit, cow, chick, turtle, frog, and two fish species with immunofluorescence techniques. |
1993-07-13 |
2023-08-12 |
rat |
| C Giroud, T Colassis, L Rivier, E Ottinge. [Cocaine and alcohol: an explosive cocktail!]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis. vol 82. issue 15. 1993-07-13. PMID:8511449. |
cocaine inhibits the reuptake of dopamine into presynaptic terminals, resulting in an overstimulation of the dopaminergic system. |
1993-07-13 |
2023-08-12 |
Not clear |
| J P Herman, F Rouge-Pont, M Le Moal, D N Abrou. Mechanisms of amphetamine-induced rotation in rats with unilateral intrastriatal grafts of embryonic dopaminergic neurons: a pharmacological and biochemical analysis. Neuroscience. vol 53. issue 4. 1993-07-08. PMID:8099430. |
in a second experiment, dopamine release was monitored by microdialysis in the graft-bearing and the contralateral normal striatum of awake, behaving animals following the administration of amphetamine to test whether the observed rotation could be explained by a higher than normal dopamine release from the implanted dopaminergic neurons. |
1993-07-08 |
2023-08-12 |
rat |
| N Yoshimura, E Mizuta, S Kuno, M Sasa, O Yoshid. The dopamine D1 receptor agonist SKF 38393 suppresses detrusor hyperreflexia in the monkey with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Neuropharmacology. vol 32. issue 4. 1993-06-21. PMID:8098860. |
these results indicate that, in parkinsonism, the degeneration of dopaminergic neurons in the substantia nigra leads to the detrusor hyperreflexia, probably due to a failure of activation of dopamine d1 receptors. |
1993-06-21 |
2023-08-12 |
monkey |
| L F Lin, D H Doherty, J D Lile, S Bektesh, F Collin. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science (New York, N.Y.). vol 260. issue 5111. 1993-06-16. PMID:8493557. |
in embryonic midbrain cultures, recombinant human gdnf promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake. |
1993-06-16 |
2023-08-12 |
human |
| K Campbell, P Kalén, K Wictorin, C Lundberg, R J Mandel, A Björklun. Characterization of GABA release from intrastriatal striatal transplants: dependence on host-derived afferents. Neuroscience. vol 53. issue 2. 1993-06-11. PMID:8098510. |
the dopamine denervating lesion resulted in an increased k(+)-evoked gaba overflow both in the intact (+76%) and the grafted striata (+181%), suggesting that the tonic dopaminergic inhibitory control of gaba release, seen in the intact striatum, is also present in the grafted striata. |
1993-06-11 |
2023-08-12 |
rat |
| J M Aubry, M F Schulz, S Pagliusi, P Schulz, J Z Kis. Coexpression of dopamine D2 and substance P (neurokinin-1) receptor messenger RNAs by a subpopulation of cholinergic neurons in the rat striatum. Neuroscience. vol 53. issue 2. 1993-06-11. PMID:8388085. |
amongst different intrinsic and extrinsic inputs, cholinergic striatal interneurons receive afferents from the dopaminergic nigrostriatal projection and from local collaterals of striatonigral cells containing substance p. the following study demonstrates that both dopamine d2 and substance p (neurokinin-1) receptors are expressed by a large proportion of cholinergic interneurons. |
1993-06-11 |
2023-08-12 |
rat |
| O Iimura, K Shimamot. Salt and hypertension: water-sodium handling in essential hypertension. Annals of the New York Academy of Sciences. vol 676. 1993-06-10. PMID:8489125. |
the reduction of conversion from l-dopa to dopamine by dopa-decarboxylase in the proximal tubules was suggested from our clearance studies as the mechanism of the suppression of renal dopaminergic activity. |
1993-06-10 |
2023-08-12 |
Not clear |
| P A Lapchak, K D Beck, D M Araujo, I Irwin, J W Langston, F Heft. Chronic intranigral administration of brain-derived neurotrophic factor produces striatal dopaminergic hypofunction in unlesioned adult rats and fails to attenuate the decline of striatal dopaminergic function following medial forebrain bundle transection. Neuroscience. vol 53. issue 3. 1993-06-08. PMID:8098137. |
the medial forebrain lesions decreased the following markers of striatal dopaminergic function: [3h]opamine uptake (65%), tyrosine hydroxylase activity (79%), dopamine content (80%) and [3h]mazindol binding site density (52%), induced a pronounced loss of tyrosine hydroxylase-positive cell bodies within the substantia nigra and also reduced tyrosine hydroxylase messenger rna levels. |
1993-06-08 |
2023-08-12 |
human |
| C Kowalski, P Girau. Dopamine decreases striatal enkephalin turnover and proenkephalin messenger RNA abundance via D2 receptor activation in primary striatal cell cultures. Neuroscience. vol 53. issue 3. 1993-06-08. PMID:8487949. |
to ensure dopamine regulation of enkephalin secretion, shorter dopaminergic treatments were performed. |
1993-06-08 |
2023-08-12 |
rat |
| S Lov. Equine Cushing's disease. The British veterinary journal. vol 149. issue 2. 1993-06-07. PMID:8485640. |
pars intermedia peptide secretion is under dopaminergic control and compounds such as pergolide or bromocriptine, which are dopamine agonists, can palliate the clinical signs. |
1993-06-07 |
2023-08-12 |
Not clear |