| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M Meiergerd, T A Patterson, J O Schen. D2 receptors may modulate the function of the striatal transporter for dopamine: kinetic evidence from studies in vitro and in vivo. Journal of neurochemistry. vol 61. issue 2. 1993-08-24. PMID:8336153. |
these results are consistent with a model in which presynaptically released dopamine may feed back onto the function of its transporter to increase the velocity of the clearance of synaptic dopamine following an action potential, suggesting the existence of a mechanism, in addition to release and synthesis modulation, for fine-tuning dopaminergic chemical signaling. |
1993-08-24 |
2023-08-12 |
Not clear |
| J F Chen, V J Aloyo, B Weis. Continuous treatment with the D2 dopamine receptor agonist quinpirole decreases D2 dopamine receptors, D2 dopamine receptor messenger RNA and proenkephalin messenger RNA, and increases mu opioid receptors in mouse striatum. Neuroscience. vol 54. issue 3. 1993-08-19. PMID:8101360. |
they suggest further that the biochemical and molecular changes that take place in dopaminergic and enkephalinergic systems following continuous treatment with dopamine agonists may underlie the mechanisms by which certain dopamine-mediated behaviors occur. |
1993-08-19 |
2023-08-12 |
mouse |
| P Simon, C Panissaud, J Costenti. Anxiogenic-like effects induced by stimulation of dopamine receptors. Pharmacology, biochemistry, and behavior. vol 45. issue 3. 1993-08-19. PMID:8101381. |
it is concluded that an anxiogenic-like effect is linked to an increase in dopaminergic transmission involving both d1 and d2 dopamine receptors. |
1993-08-19 |
2023-08-12 |
mouse |
| S N Schiffmann, J J Vanderhaeghe. Caffeine regulates neurotensin and cholecystokinin messenger RNA expression in the rat striatum. Neuroscience. vol 54. issue 3. 1993-08-19. PMID:8332255. |
we therefore concluded that in the intact striatum normally innervated by dopaminergic fibers, caffeine, probably acting through a presynaptic a2 receptor, induced a relative dopamine depletion which in turn led to the induction of neurotensin and cholecystokinin expression in subsets of striatal neurons. |
1993-08-19 |
2023-08-12 |
rat |
| R M Kostrzewa, D Neel. Enhanced pilocarpine-induced oral activity responses in neonatal 6-OHDA treated rats. Pharmacology, biochemistry, and behavior. vol 45. issue 3. 1993-08-19. PMID:8332633. |
neonatal destruction of rat nigrostriatal dopaminergic fibers results in an enhanced oral activity response to both dopamine (da) d1 and serotonin (5-ht) agonists. |
1993-08-19 |
2023-08-12 |
rat |
| A Pletscher, M DaPrad. Pharmacotherapy of Parkinson's disease: research from 1960 to 1991. Acta neurologica Scandinavica. Supplementum. vol 146. 1993-08-18. PMID:8101413. |
subsequently, the role of dopamine as neurotransmitter and the importance of dopaminergic pathways for the control of extrapyramidal motricity were firmly established. |
1993-08-18 |
2023-08-12 |
rat |
| U K Rinn. Strategies in the treatment of early Parkinson's disease. Acta neurologica Scandinavica. Supplementum. vol 146. 1993-08-18. PMID:8101417. |
thus, it appears advisable to initiate the dopaminergic treatment in early parkinson's disease by using a combination of selegiline, levodopa and a dopamine agonist. |
1993-08-18 |
2023-08-12 |
Not clear |
| H J Wagner, U D Behren. Microanatomy of the dopaminergic system in the rainbow trout retina. Vision research. vol 33. issue 10. 1993-08-17. PMID:8101407. |
we have investigated the morphology of dopaminergic interplexiform cells as well as the distribution of two classes of dopamine receptors in the retina of the rainbow trout. |
1993-08-17 |
2023-08-12 |
rat |
| b' R R Ga\\xc4\\xadnetdinov, I I Miroshnichenko, V S Kudrin, M B Bogdanov, V M Pogorelov, E A Budygin, G I Kovalev, K S Raevski\\xc4\\xa. [A comparative study of the neurochemical profiles of carbidine stereoisomers]. Eksperimental\'naia i klinicheskaia farmakologiia. vol 56. issue 1. 1993-08-12. PMID:8100728.' |
the effects of cis- and trans-isomers of atypical neuroleptic carbidine on the synthesis of dopamine and its autoreceptor regulation in the striatum and nucleus accumbens of rats were examined by blocking decarboxylase of l-aromatic amino acids and interrupting the nerve impulse flow in the dopaminergic neurons. |
1993-08-12 |
2023-08-12 |
rat |
| b' R R Ga\\xc4\\xadnetdinov, I I Miroshnichenko, V S Kudrin, M B Bogdanov, V M Pogorelov, E A Budygin, G I Kovalev, K S Raevski\\xc4\\xa. [A comparative study of the neurochemical profiles of carbidine stereoisomers]. Eksperimental\'naia i klinicheskaia farmakologiia. vol 56. issue 1. 1993-08-12. PMID:8100728.' |
carbidine trans-isomer, unlike its cis-isomer, was shown to enhance the biosynthesis of dopamine via blockade of presynaptic autoreceptors presumably located on the dopaminergic terminals. |
1993-08-12 |
2023-08-12 |
rat |
| C L Smith, O M Conneely, B W O'Malle. Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 13. 1993-08-06. PMID:8327492. |
dopamine alone was unable to induce gene expression in cells expressing [val400]er mutant receptors, but concomitant treatment with 17 beta-estradiol produced a synergistic increase in transcription, suggesting that the ligand may alter the mutant receptor's conformation such that it can be activated subsequently by a dopaminergic signaling mechanism. |
1993-08-06 |
2023-08-12 |
human |
| D Malek, G Münch, D Pal. Two sites in the third inner loop of the dopamine D2 receptor are involved in functional G protein-mediated coupling to adenylate cyclase. FEBS letters. vol 325. issue 3. 1993-08-05. PMID:8319806. |
synthetic peptides, corresponding to the amino acid sequences of the n- and c-terminal parts of the 3rd intracellular loop of the dopamine d2 receptor, attenuate dopaminergic adenylate cyclase inhibition in membranes. |
1993-08-05 |
2023-08-12 |
Not clear |
| K Mizoguchi, H Yokoo, M Yoshida, T Tanaka, M Tanak. Dopamine formation from L-dopa administered exogenously is independent of dopaminergic neuronal activity: studies with in vivo microdialysis. Brain research. vol 611. issue 1. 1993-07-29. PMID:8518942. |
dopamine formation from l-dopa administered exogenously is independent of dopaminergic neuronal activity: studies with in vivo microdialysis. |
1993-07-29 |
2023-08-12 |
rat |
| K Mizoguchi, H Yokoo, M Yoshida, T Tanaka, M Tanak. Dopamine formation from L-dopa administered exogenously is independent of dopaminergic neuronal activity: studies with in vivo microdialysis. Brain research. vol 611. issue 1. 1993-07-29. PMID:8518942. |
extracellular dopamine (da) levels in the steady state were not detected in the hippocampus of rats where sparse dopaminergic innervations were demonstrated. |
1993-07-29 |
2023-08-12 |
rat |
| M Sakai, I Nagats. Alteration of carnosine expression in olfactory system of mouse after unilateral naris closure and partial bulbectomy. Journal of neuroscience research. vol 34. issue 6. 1993-07-23. PMID:8100280. |
after unilateral naris closure, carnosine staining showed no alteration, but immunoreactivity of tyrosine hydroxylase (th), the rate-limiting enzyme for biosynthesis of dopamine in dopaminergic neurons, decreased dramatically in periglomerular neurons. |
1993-07-23 |
2023-08-12 |
mouse |
| M Koulu, U Pesonen, S Koskinen, H Scheinin, R Virtanen, M Scheini. Reduced turnover of dopamine and 5-hydroxytryptamine in discrete dopaminergic, noradrenergic and serotonergic rat brain areas after acutely administered medetomidine, a selective alpha 2-adrenoceptor agonist. Pharmacology & toxicology. vol 72. issue 3. 1993-07-22. PMID:8100065. |
reduced turnover of dopamine and 5-hydroxytryptamine in discrete dopaminergic, noradrenergic and serotonergic rat brain areas after acutely administered medetomidine, a selective alpha 2-adrenoceptor agonist. |
1993-07-22 |
2023-08-12 |
rat |
| J Caboche, P Vernier, M Rogard, M J Besso. Haloperidol increases PPE mRNA levels in the caudal part of the nucleus accumbens in the rat. Neuroreport. vol 4. issue 5. 1993-07-22. PMID:8513136. |
in this study, the effects of an interruption of dopamine transmission by haloperidol (a dopaminergic receptor antagonist) were examined in the rat nucleus accumbens. |
1993-07-22 |
2023-08-12 |
rat |
| W A Cass, G A Gerhardt, K Gillespie, P Curella, R D Mayfield, N R Zahnise. Reduced clearance of exogenous dopamine in rat nucleus accumbens, but not in dorsal striatum, following cocaine challenge in rats withdrawn from repeated cocaine administration. Journal of neurochemistry. vol 61. issue 1. 1993-07-22. PMID:8515274. |
the decrease in dopamine clearance rate observed in the nucleus accumbens of the cocaine-treated rats after a challenge injection of cocaine is consistent with increased dopaminergic transmission, but does not appear to be sufficient in itself for producing behavioral sensitization. |
1993-07-22 |
2023-08-12 |
rat |
| G W Lambert, G Eisenhofer, G L Jennings, M D Esle. Regional homovanillic acid production in humans. Life sciences. vol 53. issue 1. 1993-07-22. PMID:8515683. |
peripheral plasma levels of homovanillic acid (hva), the deaminated and o-methylated metabolite of dopamine, are often used as an indicator of central nervous system dopaminergic activity. |
1993-07-22 |
2023-08-12 |
human |
| P Witkovsky, C Nicholson, M E Rice, K Bohmaker, E Melle. Extracellular dopamine concentration in the retina of the clawed frog, Xenopus laevis. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 12. 1993-07-22. PMID:8516316. |
dopamine reaches targets in the outer retina of the clawed frog (xenopus laevis) by diffusion from a network of dopaminergic cells and processes located predominantly at the junction of inner nuclear and inner plexiform layers. |
1993-07-22 |
2023-08-12 |
xenopus_laevis |