| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Vamvakidè. [Action mechanism of L-dopa: dopaminergic activation or glutamatergic inhibition?]. Annales pharmaceutiques francaises. vol 51. issue 1. 1993-11-23. PMID:8215122. |
since 25 years ago, it was postulated that the antiparkinsonian activity of l-dopa was due to the activation of the synthesis and the release of dopamine that it could trigger in the dopaminergic terminals preserved during the parkinson's disease. |
1993-11-23 |
2023-08-12 |
Not clear |
| A Vamvakidè. [Action mechanism of L-dopa: dopaminergic activation or glutamatergic inhibition?]. Annales pharmaceutiques francaises. vol 51. issue 1. 1993-11-23. PMID:8215122. |
recent experimental data, presented in this paper could show that l-dopa, far from activate the nigro-striatal dopaminergic neurons, would rather inhibit them and that its antiparkinsonian action could be attributed to the antiglutamatergic activity that l-dopa, converted to dopamine, could exert by acting on the d2 receptors of the striatal glutamatergic afferences. |
1993-11-23 |
2023-08-12 |
Not clear |
| D Bravi, M M Mouradian, J W Roberts, T L Davis, T N Chas. End-of-dose dystonia in Parkinson's disease. Neurology. vol 43. issue 10. 1993-11-12. PMID:8413978. |
dystonia onset thus appears to reflect the degree, rather than the rate, of reduction in dopaminergic stimulation, and may involve the preferential interaction of dopamine with a receptor subpopulation that does not mediate its antiparkinsonian efficacy. |
1993-11-12 |
2023-08-12 |
Not clear |
| S H Yoon, N S Bodor, J W Simpkin. Synthesis and in vitro dopaminergic activity of (2-aminoethyl)-1-hydroxy-2-pyridone type dopamine analogs. Drug design and discovery. vol 10. issue 1. 1993-11-04. PMID:8104516. |
synthesis and in vitro dopaminergic activity of (2-aminoethyl)-1-hydroxy-2-pyridone type dopamine analogs. |
1993-11-04 |
2023-08-12 |
rat |
| F Claudi, G Giorgioni, A Di Stefano, A Cagnotto, M Skorupsk. Synthesis and dopamine receptor binding of 4-(2-aminoethyl)-1H-pyrazole and its N,N-dialkyl derivatives. Drug design and discovery. vol 10. issue 1. 1993-11-04. PMID:8104517. |
the agnostic activity of quinpirole (3a) at the d2 dopamine (da) receptor suggested that the dopaminergic pharmacophore embedded in 3a was the 4-(2-aminoethyl)-1h-pyrazole (5) moiety. |
1993-11-04 |
2023-08-12 |
rat |
| T Momiyama, N Todo, M Sas. A mechanism underlying dopamine D1 and D2 receptor-mediated inhibition of dopaminergic neurones in the ventral tegmental area in vitro. British journal of pharmacology. vol 109. issue 4. 1993-11-02. PMID:8104652. |
a mechanism underlying dopamine d1 and d2 receptor-mediated inhibition of dopaminergic neurones in the ventral tegmental area in vitro. |
1993-11-02 |
2023-08-12 |
rat |
| T Momiyama, N Todo, M Sas. A mechanism underlying dopamine D1 and D2 receptor-mediated inhibition of dopaminergic neurones in the ventral tegmental area in vitro. British journal of pharmacology. vol 109. issue 4. 1993-11-02. PMID:8104652. |
these findings suggest that activation of dopamine d2 receptors of dopaminergic neurones in the vta increases potassium conductance, thereby hyperpolarizing the membrane and eventually inhibiting neuronal activities. |
1993-11-02 |
2023-08-12 |
rat |
| K Ossowsk. Disturbances in neurotransmission processes in aging and age-related diseases. Polish journal of pharmacology. vol 45. issue 2. 1993-11-02. PMID:8401765. |
dopaminergic neurotransmission is impaired with age due to degeneration of the substantia nigra pars compacta neurons and reduction of the density of postsynaptic d1 and d2 dopamine receptors in the striatum. |
1993-11-02 |
2023-08-12 |
Not clear |
| K Ossowsk. Disturbances in neurotransmission processes in aging and age-related diseases. Polish journal of pharmacology. vol 45. issue 2. 1993-11-02. PMID:8401765. |
pd is believed to be caused by a severe loss of dopaminergic neurons, which leads to nearly complete depletion of dopamine in the striatum, particularly in the putamen. |
1993-11-02 |
2023-08-12 |
Not clear |
| K Ossowsk. Disturbances in neurotransmission processes in aging and age-related diseases. Polish journal of pharmacology. vol 45. issue 2. 1993-11-02. PMID:8401765. |
the supersensitivity of postsynaptic dopamine receptors, reported by some authors, may result from compensatory mechanisms to degeneration of dopaminergic neurons. |
1993-11-02 |
2023-08-12 |
Not clear |
| A Ishikawa, T Miyatak. Effects of smoking in patients with early-onset Parkinson's disease. Journal of the neurological sciences. vol 117. issue 1-2. 1993-11-01. PMID:8410063. |
nicotine is thought to activate the nigrostriatal dopaminergic pathway and increase the release of dopamine in the striatum, and this can explain the effects of smoking in these patients. |
1993-11-01 |
2023-08-12 |
Not clear |
| M Derrien, C Durieux, V Daugé, B P Roque. Involvement of D2 dopaminergic receptors in the emotional and motivational responses induced by injection of CCK-8 in the posterior part of the rat nucleus accumbens. Brain research. vol 617. issue 2. 1993-10-29. PMID:8402145. |
moreover, an ex vivo measurement of the dopaminergic metabolism has been performed after injection of cck-8 in the posterior nucleus accumbens by electrochemical detection of dopamine and its metabolites extracted from punches of brain tissue. |
1993-10-29 |
2023-08-12 |
rat |
| J M Schaus, E C Kornfeld, R D Titus, C L Nichols, D L Huser, J A Clemens, E B Smalstig, R W Fulle. Progress in the medicinal chemistry of dopaminergic agents. Drug design and discovery. vol 9. issue 3-4. 1993-10-25. PMID:8104521. |
in an effort to develop more selective dopamine agonists, studies were directed to elucidate the dopaminergic pharmacophore of the ergoline nucleus. |
1993-10-25 |
2023-08-12 |
Not clear |
| G E Duncan, G R Breese, H E Criswell, K B Johnson, U B Schambra, R A Mueller, M G Caron, R T Fremea. D1 dopamine receptor binding and mRNA levels are not altered after neonatal 6-hydroxydopamine treatment: evidence against dopamine-mediated induction of D1 dopamine receptors during postnatal development. Journal of neurochemistry. vol 61. issue 4. 1993-10-21. PMID:8376983. |
the role of dopaminergic innervation on the postnatal developmental expression of d1 dopamine receptors was investigated. |
1993-10-21 |
2023-08-12 |
rat |
| C Cerruti, M J Drian, J M Kamenka, A Priva. Protection by BTCP of cultured dopaminergic neurons exposed to neurotoxins. Brain research. vol 617. issue 1. 1993-10-15. PMID:8104081. |
this study presents 'in vitro' evidence for a protection of cultured dopaminergic neurons against the toxicity of 6-hydroxydopamine (6-ohda) and 1-methyl-4-phenylpyridinium (mpp+) by pretreatment with btcp, a selective and potent dopamine (da) uptake blocker. |
1993-10-15 |
2023-08-12 |
Not clear |
| A Buck, K Leender. [Positron-emission tomography (PET) in epilepsy and extrapyramidal disorders]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis. vol 82. issue 34. 1993-10-14. PMID:8372295. |
pet studies of these areas center around measurements of glucose metabolism, synthesis of dopamine and dopaminergic receptors. |
1993-10-14 |
2023-08-12 |
Not clear |
| S Läer, F Block, G Huether, C Heim, K H Sonta. Effect of transient reduction of cerebral blood flow in normotensive rats on striatal dopamine-release. Journal of neural transmission. General section. vol 92. issue 2-3. 1993-10-12. PMID:7690231. |
a sudden reduction of blood flow appears to disrupt the compartmentation of dopamine in striatal dopaminergic nerve endings in a similar but more moderate manner as compared to ischemia. |
1993-10-12 |
2023-08-12 |
rat |
| E Van Haesendonck, R E Marc, L Missotte. New aspects of dopaminergic interplexiform cell organization in the goldfish retina. The Journal of comparative neurology. vol 333. issue 4. 1993-10-12. PMID:8103778. |
dopaminergic interplexiform cells (da-ipcs) in the goldfish retina have been reexamined by light and electron microscopic immunocytochemistry with antisera against dopamine (da) or tyrosine hydroxylase (th). |
1993-10-12 |
2023-08-12 |
Not clear |
| V L Trudeau, B D Sloley, R E Pete. GABA stimulation of gonadotropin-II release in goldfish: involvement of GABAA receptors, dopamine, and sex steroids. The American journal of physiology. vol 265. issue 2 Pt 2. 1993-10-07. PMID:8396353. |
elevation of brain and pituitary gaba levels with the gaba transaminase inhibitor, gamma-vinyl-gaba (gvg), decreased hypothalamic and pituitary dopamine (da) turnover rates, indicating that gaba may stimulate gth-ii release in the goldfish by decreasing dopaminergic inhibition of gth-ii release. |
1993-10-07 |
2023-08-12 |
Not clear |
| R A Lahti, D L Evans, N C Stratman, L M Figu. Dopamine D4 versus D2 receptor selectivity of dopamine receptor antagonists: possible therapeutic implications. European journal of pharmacology. vol 236. issue 3. 1993-09-30. PMID:8102973. |
comparative binding affinity studies have been carried out for a number of interesting dopaminergic agents using membranes prepared from cloned dopamine d2 and d4 receptor containing cells. |
1993-09-30 |
2023-08-12 |
Not clear |