| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Y Lo. Dopamine depresses non-adrenergic, non-cholinergic neurotransmission in the rat bladder. The Journal of pharmacy and pharmacology. vol 45. issue 6. 1993-09-30. PMID:8103108. |
it is suggested that depression of nanc neurotransmission induced by dopamine in the rat bladder is partly mediated by dopaminergic receptors. |
1993-09-30 |
2023-08-12 |
rat |
| B J Snow, I Tooyama, E G McGeer, T Yamada, D B Calne, H Takahashi, H Kimur. Human positron emission tomographic [18F]fluorodopa studies correlate with dopamine cell counts and levels. Annals of neurology. vol 34. issue 3. 1993-09-30. PMID:8363349. |
postmortem counts of dopaminergic cell densities in the substantia nigra (5 subjects) and striatal levels of dopamine (da) and its metabolites (6 subjects) were determined on 1 parkinsonian (pd), 3 progressive supranuclear palsy (psp), 1 amyotrophic lateral sclerosis, and 1 alzheimer's case who had been positron emission tomography scanned with 6-[18f]fluorodopa during life. |
1993-09-30 |
2023-08-12 |
human |
| B D Pate, T Kawamata, T Yamada, E G McGeer, K A Hewitt, B J Snow, T J Ruth, D B Caln. Correlation of striatal fluorodopa uptake in the MPTP monkey with dopaminergic indices. Annals of neurology. vol 34. issue 3. 1993-09-30. PMID:8363350. |
striatal levels of dopamine and its metabolites, and the striatal activities of the dopaminergic synthetic enzymes, were also determined. |
1993-09-30 |
2023-08-12 |
monkey |
| J J Frost, A J Rosier, S G Reich, J S Smith, M D Ehlers, S H Snyder, H T Ravert, R F Dannal. Positron emission tomographic imaging of the dopamine transporter with 11C-WIN 35,428 reveals marked declines in mild Parkinson's disease. Annals of neurology. vol 34. issue 3. 1993-09-30. PMID:8363363. |
recently, 11c-win 35,428, a cocaine analogue that specifically labels the dopamine transporter, was developed and can be used to label dopaminergic nerve terminals in vivo by positron emission tomography. |
1993-09-30 |
2023-08-12 |
human |
| C A Heidbreder, S R Goldberg, T S Shippenber. The kappa-opioid receptor agonist U-69593 attenuates cocaine-induced behavioral sensitization in the rat. Brain research. vol 616. issue 1-2. 1993-09-30. PMID:8395306. |
given the inhibitory effects ascribed to both exogenous and endogenous kappa-opioid agonists upon dopamine release in the mesolimbic dopaminergic system, it is suggested that this action may underlie the observed effects of u-69593 on cocaine-induced changes in locomotor activity and stereotypy. |
1993-09-30 |
2023-08-12 |
rat |
| M Santiago, A Machado, J Can. In vivo release of dopamine from rat striatum, substantia nigra and prefrontal cortex: differential modulation by baclofen. British journal of pharmacology. vol 109. issue 3. 1993-09-28. PMID:7689406. |
the results suggest that gabab receptors modulate the release of dopamine in the sn and pfc, but do not affect the striatal release of dopamine, which indicates that the role of gaba receptor activation is different in the dopaminergic terminals of the st and pfc. |
1993-09-28 |
2023-08-12 |
rat |
| M Del Zompo, M P Piccardi, S Ruiu, M Quartu, G L Gessa, A Vaccar. Selective MPP+ uptake into synaptic dopamine vesicles: possible involvement in MPTP neurotoxicity. British journal of pharmacology. vol 109. issue 2. 1993-09-27. PMID:8102929. |
the restriction of active mpp+ uptake to the dopaminergic regions, which reflects the previously shown distribution of [3h]-mpp+ binding sites in mouse brain membranes, indicates mpp+ as a marker of the vesicular carrier for dopamine in dopaminergic neurones. |
1993-09-27 |
2023-08-12 |
mouse |
| A Kastner, E C Hirsch, M T Herrero, F Javoy-Agid, Y Agi. Immunocytochemical quantification of tyrosine hydroxylase at a cellular level in the mesencephalon of control subjects and patients with Parkinson's and Alzheimer's disease. Journal of neurochemistry. vol 61. issue 3. 1993-09-27. PMID:8103078. |
this is apparently in contraction with the known overactivity of dopamine synthesis and release that occurs in the remaining dopaminergic terminals. |
1993-09-27 |
2023-08-12 |
human |
| K O Schoeps, C Halldin, K Någren, C G Swahn, P Karlsson, H Hall, L Fard. Preparation of [1-11C]dopamine, [1-11C]p-tyramine and [1-11C]m-tyramine. Autoradiography and PET examination of [1-11C]dopamine in primates. Nuclear medicine and biology. vol 20. issue 5. 1993-09-27. PMID:8358354. |
autoradiographic examination of [11c]dopamine binding on human brain section post-mortem demonstrated specific binding in the caudate putamen and the substantia nigra, regions with a dense dopaminergic innervation. |
1993-09-27 |
2023-08-12 |
human |
| H Wetzel, O Benker. Dopamine autoreceptor agonists in the treatment of schizophrenic disorders. Progress in neuro-psychopharmacology & biological psychiatry. vol 17. issue 4. 1993-09-24. PMID:8103233. |
synthesis and release of dopamine as well as firing rates of dopaminergic neurons are controlled by stimulation of autoreceptors via a negative feedback regulation. |
1993-09-24 |
2023-08-12 |
Not clear |
| H Wetzel, O Benker. Dopamine autoreceptor agonists in the treatment of schizophrenic disorders. Progress in neuro-psychopharmacology & biological psychiatry. vol 17. issue 4. 1993-09-24. PMID:8103233. |
with respect to the dopamine hypothesis of schizophrenia, dopamine autoreceptor agonists have been tested in positive schizophrenic symptomatology in order to reduce the postulated excess of central dopaminergic activity. |
1993-09-24 |
2023-08-12 |
Not clear |
| Y Nishizak. [The effects of exogenous and endogenous dopamine on the gastric microcirculation and their action sites in rat stomach]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology. vol 90. issue 8. 1993-09-24. PMID:8361055. |
the effects of graded doses of dopamine on the gastric mucosal blood flow were different from those on the systemic blood flow, implying that there may exist a dopaminergic control of gastric mucosal blood flow independent from the systemic circulation. |
1993-09-24 |
2023-08-12 |
rat |
| G J LaHoste, J Yu, J F Marshal. Striatal Fos expression is indicative of dopamine D1/D2 synergism and receptor supersensitivity. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 16. 1993-09-23. PMID:8102797. |
thus, they may mediate some of the long-term consequences of altered dopaminergic transmission on striatal neurons, such as the supersensitivity to dopamine and its agonists that occurs in response to dopamine denervation. |
1993-09-23 |
2023-08-12 |
rat |
| S M Sorensen, J H Kehne, G M Fadayel, T M Humphreys, H J Ketteler, C K Sullivan, V L Taylor, C J Schmid. Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. The Journal of pharmacology and experimental therapeutics. vol 266. issue 2. 1993-09-17. PMID:8102646. |
mdl 100,907 blocked the slowing of ventral tegmental area (a10) dopaminergic neurons by amphetamine but, like clozapine, produced only small increases in the number of active substantia nigra zona compacta (a9) and a10 dopamine neurons after acute administration. |
1993-09-17 |
2023-08-12 |
mouse |
| T Vuvan, M Geffard, P Denis, A Simon, J Nguyen-Legro. Radioimmunoligand characterization and immunohistochemical localization of dopamine D2 receptors on rods in the rat retina. Brain research. vol 614. issue 1-2. 1993-09-14. PMID:8348331. |
the retinal neurotransmitter dopamine (da), elaborated from intrinsic dopaminergic neurons as amacrine and interplexiform cells, is known to modulate several complex functions mediated by d1 and d2 receptors in the vertebrate retina. |
1993-09-14 |
2023-08-12 |
rat |
| J R Sladek, J D Elsworth, R H Roth, L E Evans, T J Collier, S J Cooper, J R Taylor, D E Redmon. Fetal dopamine cell survival after transplantation is dramatically improved at a critical donor gestational age in nonhuman primates. Experimental neurology. vol 122. issue 1. 1993-09-02. PMID:8101820. |
the attainment of large, well-differentiated grafts with thousands of dopaminergic neurons from early gestation tissue suggests that optimal cell survival in primates is dependent on the degree of postgerminal development of the dopamine neuron. |
1993-09-02 |
2023-08-12 |
monkey |
| P O'Donnell, A A Grac. Dopaminergic modulation of dye coupling between neurons in the core and shell regions of the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 8. 1993-09-02. PMID:8340817. |
to examine whether this coupling is regulated by dopamine (da), the extent of dye coupling was assessed in the presence of dopaminergic agonists and antagonists. |
1993-09-02 |
2023-08-12 |
rat |
| M Nakayam. [Changes of the dopamine uptake sites in the rat striatum induced by repeated methamphetamine administration: a neurochemical approach to a mechanism of relapse in amphetamine psychosis]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science. vol 68. issue 4. 1993-08-31. PMID:8340048. |
for an understanding of neurochemical basis of these findings, we investigated the effects of pharmacological manipulations in the presynaptic dopaminergic system by the pretreatment of alpha-methyl-p-tyrosine, reserpine or amfonelic acid and the blockade of postsynaptic dopamine receptor by a pretreatment of sch23390 or ym-09151-2, on decrease in the dopamine uptake sites following the repeated administration of methamphetamine in the rat striatum. |
1993-08-31 |
2023-08-12 |
rat |
| M L Rao, G Gross, A Halaris, G Huber, M Marler, B Strebel, P Bräuni. Hyperdopaminergia in schizophreniform psychosis: a chronobiological study. Psychiatry research. vol 47. issue 2. 1993-08-31. PMID:8341771. |
these data confirm the indirect pharmacologic evidence of increased dopaminergic activity in schizophrenic patients that relates to dopamine's precursors and to the neuroendocrine regulation of prolactin. |
1993-08-31 |
2023-08-12 |
human |
| P A Garris, L B Collins, S R Jones, R M Wightma. Evoked extracellular dopamine in vivo in the medial prefrontal cortex. Journal of neurochemistry. vol 61. issue 2. 1993-08-24. PMID:8336146. |
despite the sparse dopaminergic innervation and the presence of more dense noradrenergic and serotonergic innervations overall in the medial prefrontal cortex, the measurement of extracellular dopamine was achieved by selective recording in dopamine-rich terminal fields and selective activation of ascending dopamine neurons. |
1993-08-24 |
2023-08-12 |
rat |