| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J A Clemens, T Okimura, E B Smalsti. Dopamine agonist activities of pergolide, its metabolites, and bromocriptine as measured by prolactin inhibition, compulsive turning, and stereotypic behavior. Arzneimittel-Forschung. vol 43. issue 3. 1993-06-04. PMID:8489554. |
bromocriptine, while possessing some dopamine agonist activity at higher doses in some of these animal models, was much less potent (1/200 to 1/20) than either pergolide or its two dopaminergic metabolites. |
1993-06-04 |
2023-08-12 |
Not clear |
| J M Trugman, C L Jame. D1 dopamine agonist and antagonist effects on regional cerebral glucose utilization in rats with intact dopaminergic innervation. Brain research. vol 607. issue 1-2. 1993-06-03. PMID:8481802. |
d1 dopamine agonist and antagonist effects on regional cerebral glucose utilization in rats with intact dopaminergic innervation. |
1993-06-03 |
2023-08-12 |
rat |
| J M Trugman, C L Jame. D1 dopamine agonist and antagonist effects on regional cerebral glucose utilization in rats with intact dopaminergic innervation. Brain research. vol 607. issue 1-2. 1993-06-03. PMID:8481802. |
these results suggest that endogenous dopamine stimulates both d1 and d2 receptors in vivo and provide metabolic evidence to support the concept of a functional linkage of d1 and d2 receptor systems in animals with intact dopaminergic innervation. |
1993-06-03 |
2023-08-12 |
rat |
| H K Choi, L Won, A Helle. Dopaminergic neurons grown in three-dimensional reaggregate culture for periods of up to one year. Journal of neuroscience methods. vol 46. issue 3. 1993-06-02. PMID:8097798. |
dopaminergic neurons grown in dialyzed serum in reaggregate cultures show an increase in neurotransmitter level over the first 2 months in culture, and these levels of dopamine are maintained or increased over the next 4-12 months. |
1993-06-02 |
2023-08-12 |
Not clear |
| R Jackisch, T Link, B Neufang, R Koc. Studies on the mechanism of action of the antiparkinsonian drugs memantine and amantadine: no evidence for direct dopaminomimetic or antimuscarinic properties. Archives internationales de pharmacodynamie et de therapie. vol 320. 1993-05-26. PMID:1284458. |
since only high concentrations of amantadine and memantine (exceeding those which, according to the literature, may be reached in vivo) showed effects in the present in vitro dopamine and acetylcholine release models, it is concluded that the clinical efficacy of these antiparkinsonian drugs is most probably unrelated to an enhancement of dopaminergic transmission as suggested from earlier in vitro and in vivo findings. |
1993-05-26 |
2023-08-11 |
rabbit |
| H Ooboshi, S Sadoshima, S Ibayashi, H Yao, H Uchimura, M Fujishim. Isradipine attenuates the ischemia-induced release of dopamine in the striatum of the rat. European journal of pharmacology. vol 233. issue 1. 1993-05-19. PMID:8472744. |
these results suggest that isradipine attenuates the ischemia-induced release of dopamine via blockade of l-type vsccs on dopaminergic neurons. |
1993-05-19 |
2023-08-12 |
rat |
| M Morissette, T Di Paol. Effect of chronic estradiol and progesterone treatments of ovariectomized rats on brain dopamine uptake sites. Journal of neurochemistry. vol 60. issue 5. 1993-05-18. PMID:8473903. |
in summary, chronic exposure to 17 beta-estradiol and/or progesterone increased dopamine uptake site density in the nigrostriatal dopaminergic system, whereas the nucleus accumbens and the substantia nigra pars reticulata were unaffected. |
1993-05-18 |
2023-08-12 |
rat |
| L Desrues, M Lamacz, B G Jenks, H Vaudry, M C Tono. Effect of dopamine on adenylate cyclase activity, polyphosphoinositide metabolism and cytosolic calcium concentrations in frog pituitary melanotrophs. The Journal of endocrinology. vol 136. issue 3. 1993-05-17. PMID:8386214. |
dopamine reduced forskolin-stimulated cyclic adenosine monophosphate (camp) production and the inhibitory effect of dopamine was blocked by the dopaminergic d2 receptor antagonist sulpiride. |
1993-05-17 |
2023-08-12 |
Not clear |
| P Hantraye, M Varastet, M Peschanski, D Riche, P Cesaro, J C Willer, M Mazier. Stable parkinsonian syndrome and uneven loss of striatal dopamine fibres following chronic MPTP administration in baboons. Neuroscience. vol 53. issue 1. 1993-05-12. PMID:8469305. |
neuropathological examination of caudate nucleus, putamen, substantia nigra and ventral tegmental area in brain sections stained for tyrosine hydroxylase showed a typical uneven striatal dopamine fibre loss and a neuronal depletion in the dopaminergic mesencephalic cell groups that reproduce those observed in idiopathic parkinson's disease. |
1993-05-12 |
2023-08-12 |
Not clear |
| S Ahleniu. Brain monoaminergic neurotransmission in the mediation of lordosis behavior in the female rat. Neuroscience and biobehavioral reviews. vol 17. issue 1. 1993-04-20. PMID:8384349. |
as regards brain dopaminergic neurotransmission, it appears that brain dopamine (da) d2 receptors mediate an inhibitory effect on the lordosis behavior, whereas no distinct role has been ascribed to da d1 receptors. |
1993-04-20 |
2023-08-12 |
rat |
| C J Chang, H Ishii, H Yamamoto, T Yamamoto, M Spat. Effects of cerebral ischemia on regional dopamine release and D1 and D2 receptors. Journal of neurochemistry. vol 60. issue 4. 1993-04-19. PMID:7681104. |
to expand on the nature of regional cerebral vulnerability to ischemia, the release of dopamine (da) and dopaminergic (d1 and d2) receptors were investigated in mongolian gerbils subjected to bilateral carotid artery occlusion (15 min) alone or with reflow (1-2 h). |
1993-04-19 |
2023-08-12 |
Not clear |
| T Bailhache, J Balthazar. The catecholaminergic system of the quail brain: immunocytochemical studies of dopamine beta-hydroxylase and tyrosine hydroxylase. The Journal of comparative neurology. vol 329. issue 2. 1993-04-19. PMID:8095939. |
cells or fibers showing dopamine beta-hydroxylase and tyrosine hydroxylase immunoreactivity were considered to be noradrenergic or adrenergic, while all structures showing only tyrosine hydroxylase immunoreactivity were tentatively considered to be dopaminergic. |
1993-04-19 |
2023-08-12 |
Not clear |
| A M Persico, C W Schindler, M T Brannock, A M Gonzalez, C K Surratt, G R Uh. Dopaminergic gene expression during amphetamine withdrawal. Neuroreport. vol 4. issue 1. 1993-04-16. PMID:8095821. |
amphetamine withdrawal could involve the dopaminergic systems that are thought to underlie psychostimulant rewarding effects, and may thus conceivably alter expression of key genes for dopaminergic transmission, including those encoding tyrosine hydroxylase (th), the membrane dopamine transporter (dat) and the synaptic vesicle amine transporter (svat). |
1993-04-16 |
2023-08-12 |
rat |
| K D Beck, B Knüsel, F Heft. The nature of the trophic action of brain-derived neurotrophic factor, des(1-3)-insulin-like growth factor-1, and basic fibroblast growth factor on mesencephalic dopaminergic neurons developing in culture. Neuroscience. vol 52. issue 4. 1993-04-15. PMID:8095710. |
des-insulin-like growth factor-1 was most effective in promoting survival, stimulated dopamine uptake less effectively than brain-derived neurotrophic factor and did not alter the morphology of dopaminergic cells. |
1993-04-15 |
2023-08-12 |
rat |
| C Bouvier, J A Salon, R A Johnson, O Civell. Dopaminergic activity measured in D1- and D2-transfected fibroblasts by silicon-microphysiometry. Journal of receptor research. vol 13. issue 1-4. 1993-04-15. PMID:8450504. |
the dopaminergic system implicated in human disorders such as parkinson's disease, schizophrenia and prolactinomas, exerts its effects through several dopamine receptors. |
1993-04-15 |
2023-08-12 |
human |
| C Bouvier, J A Salon, R A Johnson, O Civell. Dopaminergic activity measured in D1- and D2-transfected fibroblasts by silicon-microphysiometry. Journal of receptor research. vol 13. issue 1-4. 1993-04-15. PMID:8450504. |
the diversity of the dopaminergic system has been revealed by the application of molecular biology techniques to this system, which allowed the identification of five different types of dopamine receptors to date. |
1993-04-15 |
2023-08-12 |
human |
| C Bouvier, J A Salon, R A Johnson, O Civell. Dopaminergic activity measured in D1- and D2-transfected fibroblasts by silicon-microphysiometry. Journal of receptor research. vol 13. issue 1-4. 1993-04-15. PMID:8450504. |
we present here real-time measurement of events induced by dopaminergic agents on either the d1 or the d2 dopamine receptors using a novel technique employing a silicon-based microphysiometer. |
1993-04-15 |
2023-08-12 |
human |
| G S Robertson, C S Tham, C Wilson, A Jakubovic, H C Fibige. In vivo comparisons of the effects of quinpirole and the putative presynaptic dopaminergic agonists B-HT 920 and SND 919 on striatal dopamine and acetylcholine release. The Journal of pharmacology and experimental therapeutics. vol 264. issue 3. 1993-04-14. PMID:8095550. |
in vivo comparisons of the effects of quinpirole and the putative presynaptic dopaminergic agonists b-ht 920 and snd 919 on striatal dopamine and acetylcholine release. |
1993-04-14 |
2023-08-12 |
rat |
| W C Graham, M A Sambrook, A R Crossma. Differential effect of chronic dopaminergic treatment on dopamine D1 and D2 receptors in the monkey brain in MPTP-induced parkinsonism. Brain research. vol 602. issue 2. 1993-04-13. PMID:8095431. |
differential effect of chronic dopaminergic treatment on dopamine d1 and d2 receptors in the monkey brain in mptp-induced parkinsonism. |
1993-04-13 |
2023-08-12 |
monkey |
| W C Graham, M A Sambrook, A R Crossma. Differential effect of chronic dopaminergic treatment on dopamine D1 and D2 receptors in the monkey brain in MPTP-induced parkinsonism. Brain research. vol 602. issue 2. 1993-04-13. PMID:8095431. |
dopamine d1 and d2 receptors located within the striatum (caudate nucleus and putamen) were studied autoradiographically, using [3h]sch 23390 and [3h]sulpiride respectively, in (i) seven monkeys rendered parkinsonian by the systemic administration of mptp, four of which were chronically exposed to anti-parkinsonian drugs (levodopa or apomorphine), (ii) two hemi-parkinsonian monkeys (induced by intra-carotid infusion of mptp), one of which received chronic exposure to apomorphine, and (iii) three control monkeys which received neither mptp nor dopaminergic drugs. |
1993-04-13 |
2023-08-12 |
monkey |