| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mareike Fauser, Francisco Pan-Montojo, Christian Richter, Philipp J Kahle, Sigrid C Schwarz, Johannes Schwarz, Alexander Storch, Andreas Herman. Chronic-Progressive Dopaminergic Deficiency Does Not Induce Midbrain Neurogenesis. Cells. vol 10. issue 4. 2021-10-22. PMID:33807497. |
dopamine is a known modulator of adult neural stem cell (ansc) proliferation and dopaminergic neurogenesis in the olfactory bulb, though a possible interplay between local dopaminergic neurodegeneration and induction of ansc proliferation in mid/hindbrain pvrs is currently enigmatic. |
2021-10-22 |
2023-08-13 |
Not clear |
| Angel Carvajal-Oliveros, Carmen Domínguez-Baleón, Rafaella V Zárate, Jorge M Campusano, Verónica Narváez-Padilla, Enrique Reynau. Nicotine suppresses Parkinson's disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels. Scientific reports. vol 11. issue 1. 2021-10-22. PMID:33953275. |
nicotine is beneficial on fly survival and motility increasing tyrosine hydroxylase and dopamine levels, suggesting that cholinergic agonists may promote survival and metabolic function of the dopaminergic neurons that express sph-1. |
2021-10-22 |
2023-08-13 |
drosophila_melanogaster |
| James W Bales, Anthony E Kline, Amy K Wagner, C Edward Dixo. Targeting Dopamine in Acute Traumatic Brain Injury. The open drug discovery journal. vol 2. 2021-10-21. PMID:22308176. |
the purpose of this review is to discuss dopamine in acute tbi and the role that dopaminergic therapies have as neuroprotective strategies. |
2021-10-21 |
2023-08-12 |
Not clear |
| Trisha L Vickrey, B Jill Vento. Drosophila Dopamine2-like receptors function as autoreceptors. ACS chemical neuroscience. vol 2. issue 12. 2021-10-21. PMID:22308204. |
dopamine release was evoked using 5-second blue light stimulations that open channelrhodopsin-2, a blue light activated cation channel that was specifically expressed in dopaminergic neurons. |
2021-10-21 |
2023-08-12 |
drosophila_melanogaster |
| Trisha L Vickrey, B Jill Vento. Drosophila Dopamine2-like receptors function as autoreceptors. ACS chemical neuroscience. vol 2. issue 12. 2021-10-21. PMID:22308204. |
the similarities in dopamine regulation validate drosophila as a model system for studying the basic neurobiology of dopaminergic signaling. |
2021-10-21 |
2023-08-12 |
drosophila_melanogaster |
| Hui Zhang, David Sulze. Regulation of striatal dopamine release by presynaptic auto- and heteroreceptors. Basal ganglia. vol 2. issue 1. 2021-10-21. PMID:22712055. |
extracellular dopamine levels result from a dynamic equilibrium between release and reuptake by dopaminergic terminals. |
2021-10-21 |
2023-08-12 |
mouse |
| Gyan Modi, Horrick Sharma, Prashant S Kharkar, Aloke K Dutt. Understanding the Structural Requirements of Hybrid (S)-6-((2-(4-Phenylpiperazin-1-yl)ethyl)(propyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol and its Analogs as D2/D3 Receptor Ligands: A Three-Dimensional Quantitative Structure-Activity Relationship (3D QSAR) Investigation. MedChemComm. vol 5. issue 9. 2021-10-21. PMID:25221669. |
to gain insights into the structural requirements for dopamine d2 and d3 agonists in the treatment of parkinson's disease (pd) and to elucidate the basis of selectivity for d3 over d2 (d2/d3), 3d quantitative structure-activity relationship (3d qsar) investigations using comfa (comparative molecular field analysis) and comsia (comparative molecular similarity indices analysis) methods were performed on a series of 45 structurally related d2 and d3 dopaminergic ligands. |
2021-10-21 |
2023-08-13 |
Not clear |
| Mingzheng Wu, Samuel Minkowicz, Vasin Dumrongprechachan, Pauline Hamilton, Lei Xiao, Yevgenia Kozorovitski. Attenuated dopamine signaling after aversive learning is restored by ketamine to rescue escape actions. eLife. vol 10. 2021-10-21. PMID:33904412. |
rather than directly altering the activity of dopaminergic neurons, ketamine appears to rescue dopamine dynamics through actions in the medial prefrontal cortex (mpfc). |
2021-10-21 |
2023-08-13 |
mouse |
| Lucile Cathiard, Valerie Fraulob, Daniel D Lam, Miguel Torres, Juliane Winkelmann, Wojciech Kręże. Investigation of dopaminergic signalling in Meis homeobox 1 (Meis1) deficient mice as an animal model of restless legs syndrome. Journal of sleep research. vol 30. issue 5. 2021-10-21. PMID:34008292. |
the efficacy of dopaminergic agonists, including dopamine d |
2021-10-21 |
2023-08-13 |
mouse |
| Giuseppina Natale, Annabella Pignataro, Gioia Marino, Federica Campanelli, Valeria Calabrese, Antonella Cardinale, Silvia Pelucchi, Elena Marcello, Fabrizio Gardoni, Maria Teresa Viscomi, Barbara Picconi, Martine Ammassari-Teule, Paolo Calabresi, Veronica Ghiglier. Transcranial Magnetic Stimulation Exerts "Rejuvenation" Effects on Corticostriatal Synapses after Partial Dopamine Depletion. Movement disorders : official journal of the Movement Disorder Society. vol 36. issue 10. 2021-10-21. PMID:34339069. |
repetitive transcranial magnetic stimulation (rtms) induces modifications in glutamatergic and dopaminergic systems, suggesting that it may have an impact on glutamatergic synapses modulated by dopamine neurotransmission. |
2021-10-21 |
2023-08-13 |
Not clear |
| S De Bruyne, T L Boos, L Wyffels, J L Goeman, K C Rice, F De Vo. Synthesis, radiosynthesis and in vivo evaluation of [I]-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(4-iodobenzyl)piperidine as a selective tracer for imaging the dopamine transporter. Journal of labelled compounds & radiopharmaceuticals. vol 52. issue 8. 2021-10-20. PMID:19746191. |
dopamine transporter (dat) neuroimaging is a useful tool in parkinson's disease diagnosis, staging and follow-up providing information on the integrity of the dopaminergic neurotransmitter system in vivo. |
2021-10-20 |
2023-08-12 |
mouse |
| George F Koob, Eric J Simo. The Neurobiology of Addiction: Where We Have Been and Where We Are Going. Journal of drug issues. vol 39. issue 1. 2021-10-20. PMID:20622969. |
in human imaging studies, decreases in dopaminergic function have been identified as a key element of addiction, lending support for research on the role of dopamine in addiction. |
2021-10-20 |
2023-08-12 |
human |
| Kendall H Lee, Charles D Blaha, Paul A Garris, Pedram Mohseni, April E Horne, Kevin E Bennet, Filippo Agnesi, Jonathan M Bledsoe, Deranda B Lester, Chris Kimble, Hoon-Ki Min, Young-Bo Kim, Zang-Hee Ch. Evolution of Deep Brain Stimulation: Human Electrometer and Smart Devices Supporting the Next Generation of Therapy. Neuromodulation : journal of the International Neuromodulation Society. vol 12. issue 2. 2021-10-20. PMID:20657744. |
this hypothesis states that therapeutic benefit is provided, at least in part, by activation of surviving nigrostriatal dopaminergic neurons, subsequent striatal dopamine release, and resumption of striatal target cell control by dopamine. |
2021-10-20 |
2023-08-12 |
human |
| Colin G Deyoung, Dante Cicchetti, Fred A Rogosch, Jeremy R Gray, Maria Eastman, Elena L Grigorenk. Sources of Cognitive Exploration: Genetic Variation in the Prefrontal Dopamine System Predicts Openness/Intellect. Journal of research in personality. vol 45. issue 4. 2021-10-20. PMID:21804655. |
the hypothesis that dopamine is involved in openness/intellect was supported by examining its association with two genes that are central components of the prefrontal dopaminergic system. |
2021-10-20 |
2023-08-12 |
Not clear |
| E A Nickoloff-Bybel, T M Calderon, P J Gaskill, J W Berma. HIV Neuropathogenesis in the Presence of a Disrupted Dopamine System. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 15. issue 4. 2021-10-20. PMID:32506353. |
both substance abuse disorders and the use of dopaminergic medications for age-related diseases are associated with changes in cns dopamine concentrations and dopaminergic neurotransmission. |
2021-10-20 |
2023-08-13 |
human |
| E A Nickoloff-Bybel, T M Calderon, P J Gaskill, J W Berma. HIV Neuropathogenesis in the Presence of a Disrupted Dopamine System. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 15. issue 4. 2021-10-20. PMID:32506353. |
thus, in individuals with elevated dopamine, the bi-directional interaction between aberrant dopaminergic neurotransmission and hiv infection creates a feedback loop contributing to hiv associated neurocognitive dysfunction and neurohiv. |
2021-10-20 |
2023-08-13 |
human |
| Jessica M Illenberger, Steven B Harrod, Charles F Mactutus, Kristen A McLaurin, Asha Kallianpur, Rosemarie M Booz. HIV Infection and Neurocognitive Disorders in the Context of Chronic Drug Abuse: Evidence for Divergent Findings Dependent upon Prior Drug History. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 15. issue 4. 2021-10-20. PMID:32533296. |
specifically, chronic drug use leads to reduced dopaminergic tone, upregulation of dopamine transporters, and altered circuit connectivity, sending users into an allosteric state in which goal-directed behaviors are dysregulated (i.e., addiction). |
2021-10-20 |
2023-08-13 |
Not clear |
| Michiko Yamane, Nanako Takaoka, Koya Obara, Kyoumi Shirai, Ryoichi Aki, Yuko Hamada, Nobuko Arakawa, Robert M Hoffman, Yasuyuki Amo. Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Can Extensively Differentiate to Tyrosine-Hydroxylase-Expressing Dopamine-Secreting Neurons. Cells. vol 10. issue 4. 2021-10-20. PMID:33920157. |
in the present study, we demonstrated that mouse hap stem cells cultured in neural-induction medium can extensively differentiate to dopaminergic neurons, which express tyrosine hydroxylase and secrete dopamine. |
2021-10-20 |
2023-08-13 |
mouse |
| Vicky Katsidoni, Manolis N Tzatzarakis, Vasiliki Karzi, Kyriaki Thermos, Andreas Kastellakis, George Panagi. Differential effects of chronic voluntary wheel-running on morphine induced brain stimulation reward, motor activity and striatal dopaminergic activity. Behavioural brain research. vol 394. 2021-10-19. PMID:32721470. |
lastly, dopaminergic activity was decreased in the striatum of exercised animals under basal conditions, whereas morphine administration led to an increase in dopamine turnover. |
2021-10-19 |
2023-08-13 |
rat |
| Rathinasamy Baskaran, Chuan-Ching Lai, Wai-Yu Li, Li-Heng Tuan, Chia-Chuan Wang, Lukas J-H Lee, Chih-Min Liu, Hai-Gwo Hwu, Li-Jen Le. Characterization of striatal phenotypes in heterozygous Disc1 mutant mice, a model of haploinsufficiency. The Journal of comparative neurology. vol 528. issue 7. 2021-10-18. PMID:31721208. |
moreover, amphetamine-induced elevations of c-fos expression and dopamine level in the striatum were greater in het mice than in wt controls, suggesting an altered dopaminergic regulation in the striatum of het mice. |
2021-10-18 |
2023-08-13 |
mouse |