| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kenan Steidel, Marina C Ruppert, Irina Palaghia, Andrea Greuel, Masoud Tahmasian, Franziska Maier, Jochen Hammes, Thilo van Eimeren, Lars Timmermann, Marc Tittgemeyer, Alexander Drzezga, David Pedrosa, Carsten Egger. Dopaminergic pathways and resting-state functional connectivity in Parkinson's disease with freezing of gait. NeuroImage. Clinical. vol 32. 2021-12-16. PMID:34911202. |
seed-to-voxel resting-state functional connectivity maps of the resulting dopamine depleted structures and dopaminergic midbrain regions were created and compared between both groups. |
2021-12-16 |
2023-08-13 |
Not clear |
| Steven M Graves, Sarah E Schwarzschild, Rex A Tai, Yu Chen, D James Surmeie. Mitochondrial oxidant stress mediates methamphetamine neurotoxicity in substantia nigra dopaminergic neurons. Neurobiology of disease. vol 156. 2021-12-11. PMID:34082123. |
recently, it was found that methamphetamine increases mitochondrial oxidant stress in substantia nigra pars compacta (snc) dopaminergic neurons by releasing vesicular dopamine (da) and stimulating mitochondrially-anchored monoamine oxidase (mao). |
2021-12-11 |
2023-08-13 |
mouse |
| Bárbara Coimbra, Ana Verónica Domingues, Carina Soares-Cunha, Raquel Correia, Luísa Pinto, Nuno Sousa, Ana João Rodrigue. Laterodorsal tegmentum-ventral tegmental area projections encode positive reinforcement signals. Journal of neuroscience research. vol 99. issue 11. 2021-12-11. PMID:34374447. |
the laterodorsal tegmentum (ldt) is a brainstem nucleus classically involved in rem sleep and attention, and that has recently been associated with reward-related behaviors, as it controls the activity of ventral tegmental area (vta) dopaminergic neurons, modulating dopamine release in the nucleus accumbens. |
2021-12-11 |
2023-08-13 |
rat |
| Natalia Ninkina, Steven J Millership, Owen M Peters, Natalie Connor-Robson, Kirill Chaprov, Arthur T Kopylov, Alex Montoya, Holger Kramer, Dominic J Withers, Vladimir L Buchma. β-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins. The Journal of biological chemistry. vol 297. issue 6. 2021-12-11. PMID:34736896. |
β-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from mptp-induced death in the absence of other synucleins. |
2021-12-11 |
2023-08-13 |
mouse |
| Russell L Blaylock, Miguel Fari. New concepts in the development of schizophrenia, autism spectrum disorders, and degenerative brain diseases based on chronic inflammation: A working hypothesis from continued advances in neuroscience research. Surgical neurology international. vol 12. 2021-12-11. PMID:34877042. |
most are based on clinical responses to certain drugs, particularly antipsychotic drugs affecting the dopaminergic neurotransmitters; thus, assuming dopamine release was the central cause of the psychotic symptoms of schizophrenia. |
2021-12-11 |
2023-08-13 |
Not clear |
| Zhao-Yan Cheng, Yu-Hui Hu, Qing-Peng Xia, Chen Wang, Ling H. DRD1 agonist A-68930 improves mitochondrial dysfunction and cognitive deficits in a streptozotocin-induced mouse model. Brain research bulletin. vol 175. 2021-12-10. PMID:34284074. |
recently, increasing evidences have shown that dopaminergic system is disturbed in ad conditions, and pharmacological interventions targeting dopamine d1 receptor (drd1) exhibit certain therapeutic benefits in ad models. |
2021-12-10 |
2023-08-13 |
mouse |
| Wisberty J Gordián-Vélez, Dimple Chouhan, Rodrigo A España, H Isaac Chen, Jason A Burdick, John E Duda, D Kacy Culle. Restoring lost nigrostriatal fibers in Parkinson's disease based on clinically-inspired design criteria. Brain research bulletin. vol 175. 2021-12-10. PMID:34332016. |
the death of dopaminergic neurons in the substantia nigra and the axonal fibers that constitute the nigrostriatal pathway leads to a loss of dopamine in the striatum that causes the motor symptoms of this disease. |
2021-12-10 |
2023-08-13 |
human |
| Olivia K Swanson, Rosa Semaan, Arianna Maffe. Reduced Dopamine Signaling Impacts Pyramidal Neuron Excitability in Mouse Motor Cortex. eNeuro. vol 8. issue 5. 2021-12-10. PMID:34556558. |
dopaminergic modulation is essential for the control of voluntary movement; however, the role of dopamine in regulating the neural excitability of the primary motor cortex (m1) is not well understood. |
2021-12-10 |
2023-08-13 |
mouse |
| Mitsuaki Kashiwagi, Mika Kanuka, Kaeko Tanaka, Masayo Fujita, Ayaka Nakai, Chika Tatsuzawa, Kazuto Kobayashi, Kazutaka Ikeda, Yu Hayash. Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice. Molecular brain. vol 14. issue 1. 2021-12-10. PMID:34794460. |
despite the established roles of the dopaminergic system in promoting arousal, the effects of loss of dopamine on the patterns of sleep and wakefulness remain elusive. |
2021-12-10 |
2023-08-13 |
mouse |
| Dmitry Troshev, Daniil Berezhnoy, Olga Kulikova, Denis Abaimov, Olga Muzychuk, Denis Nalobin, Sergey Stvolinsky, Tatiana Fedorov. The dynamics of nigrostriatal system damage and neurobehavioral changes in the rotenone rat model of Parkinson's disease. Brain research bulletin. vol 173. 2021-12-09. PMID:33892082. |
the motor stage developed after a decrease in the number of cells in the snpc by more than 30 %, and was characterized by changes in the dopaminergic system, leading up to a 71 % reduction in dopamine levels in the striatum. |
2021-12-09 |
2023-08-13 |
rat |
| N Zareifopoulos, M Skaltsa, A Dimitriou, M Karveli, P Efthimiou, M Lagadinou, A Tsigkou, D Velissari. Converging dopaminergic neurotoxicity mechanisms of antipsychotics, methamphetamine and levodopa. European review for medical and pharmacological sciences. vol 25. issue 13. 2021-12-09. PMID:34286493. |
the purpose of this review was to investigate the mechanisms of dopaminergic neurotoxicity induced by neuroleptic drugs, dopamine agonists, levodopa, stimulants and known dopaminergic neurotoxins materials and methods: a pubmed search for each of the dopaminergic compounds in question was carried out. |
2021-12-09 |
2023-08-13 |
Not clear |
| Balestrino Roberta, Barone Paolo, Filippi Massimo, Erro Robert. Unexpected ( Journal of neurology. 2021-12-09. PMID:34537866. |
magnetic resonance imaging-mri, computerized tomography-ct) are used to exclude secondary syndromes, presynaptic dopaminergic imaging including imaging of dopamine transporter (dat)-can help the neurologist in the differential diagnosis between neurodegenerative parkinsonian syndromes and parkinsonism without dopamine deficiency. |
2021-12-09 |
2023-08-13 |
Not clear |
| Leor Zmigrod, Trevor W Robbin. Dopamine, Cognitive Flexibility, and IQ: Epistatic Catechol-O-MethylTransferase:DRD2 Gene-Gene Interactions Modulate Mental Rigidity. Journal of cognitive neuroscience. vol 34. issue 1. 2021-12-09. PMID:34818409. |
the study has therefore revealed a form of epistatic redundancy or substitutability among dopamine systems in shaping adaptable thought and action, thus defining boundary conditions for dopaminergic effects on flexible behavior. |
2021-12-09 |
2023-08-13 |
human |
| Hendrik Theis, Catharina Probst, Pierre-Olivier Fernagut, Thilo van Eimere. Unlucky punches: the vulnerability-stress model for the development of impulse control disorders in Parkinson's disease. NPJ Parkinson's disease. vol 7. issue 1. 2021-12-09. PMID:34880241. |
a series of imaging studies of the dopaminergic system point toward a presynaptic reduction of dopamine-reuptake transporter density and dopamine synthesis capacity. |
2021-12-09 |
2023-08-13 |
Not clear |
| Josefine Waldthaler, Lena Stock, Charlotte Krüger-Zechlin, Lars Timmerman. Age at Parkinson's disease onset modulates the effect of levodopa on response inhibition: Support for the dopamine overdose hypothesis from the antisaccade task. Neuropsychologia. vol 163. 2021-12-07. PMID:34728241. |
assuming less dopaminergic loss in ventral parts of the striatum in early compared to late onset pd, these findings support the dopamine overdose hypothesis. |
2021-12-07 |
2023-08-13 |
Not clear |
| Mennatallah Elshennawy, Omar Ouachikh, Youssef Aissouni, Shahira Youssef, Shahira S Zaki, Franck Durif, Aziz Hafid. Behavioral, Cellular and Molecular Responses to Cold and Mechanical Stimuli in Rats with Bilateral Dopamine Depletion in the Mesencephalic Dopaminergic Neurons. Neuroscience. vol 479. 2021-12-07. PMID:34748858. |
behavioral, cellular and molecular responses to cold and mechanical stimuli in rats with bilateral dopamine depletion in the mesencephalic dopaminergic neurons. |
2021-12-07 |
2023-08-13 |
rat |
| Shefali R Bijwadia, Katherine Morton, Joel N Meye. Quantifying Levels of Dopaminergic Neuron Morphological Alteration and Degeneration in Caenorhabditis elegans. Journal of visualized experiments : JoVE. issue 177. 2021-12-07. PMID:34866619. |
in particular, hermaphroditic c. elegans' dopaminergic neuron morphological changes can be visualized using strains with fluorescent reporters driven by cell-specific promotors such as the dat-1 dopamine transporter gene, which is expressed exclusively in their eight dopaminergic neurons. |
2021-12-07 |
2023-08-13 |
caenorhabditis_elegans |
| Min Hyung Seo, Bo-Ram Jin, Hyo-Jung Kim, Hyo-Jin An, Sujung Ye. Reduction of tyrosine hydroxylase expression and increase of α-synuclein in the substantia nigra in a rat model of benign prostatic hyperplasia. Neuroscience letters. 2021-12-07. PMID:34875351. |
parkinson's disease (pd) occurs when dopaminergic cells in the substantia nigra (sn) region are destroyed; however, the cause of the destruction of dopamine cells has not yet been determined. |
2021-12-07 |
2023-08-13 |
rat |
| Victor N Almeida, Marcia Radanovi. Semantic priming and neurobiology in schizophrenia: A theoretical review. Neuropsychologia. vol 163. 2021-12-06. PMID:34655651. |
we further assess the literature on the endophenotype of formal thought disorder from multiple standpoints, ranging from neurophysiology to cognition: considerations are weaved on neuronal (pv basket cell, sst, vip) and receptor deficits (drd1, nmda), neurotransmitter imbalances (dopamine), cortical and dopaminergic lateralisation, inter alia. |
2021-12-06 |
2023-08-13 |
Not clear |
| Liping Yang, Honghui Guo, Yu Kuang, Hui Yang, Xi Zhang, Rong Tang, Dapeng Li, Li L. Neurotoxicity induced by combined exposure of microcystin-LR and nitrite in male zebrafish (Danio rerio): Effects of oxidant-antioxidant system and neurotransmitter system. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 253. 2021-12-06. PMID:34826614. |
the decreases in dopamine content, acetylcholinesterase activity and related gene mrna levels indicated that mc-lr and nitrite adversely affected the normal function of the dopaminergic and cholinergic systems in zebrafish brain. |
2021-12-06 |
2023-08-13 |
zebrafish |