| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mirjam Wolfschlag, Anders Håkansso. Increased risk for developing gambling disorder under the treatment with pramipexole, ropinirole, and aripiprazole: A nationwide register study in Sweden. PloS one. vol 16. issue 6. 2021-11-12. PMID:34061895. |
compared to patients with any other dopaminergic drug prescription (38.7% with gd), the diagnosis was more common in patients with a dopamine agonist prescription (69.8% with gd), resulting in an odds ratio of 3.2. |
2021-11-12 |
2023-08-13 |
Not clear |
| Fabrizio Sanna, Jessica Bratzu, Laura Angioni, Maria Pina Sorighe, Cristina Cocco, Antonio Argiolas, Maria Rosaria Meli. Oxytocin-conjugated saporin injected into the substantia nigra of male rats alters the activity of the nigrostriatal dopaminergic system: A behavioral and neurochemical study. Brain research. vol 1773. 2021-11-12. PMID:34744015. |
these results show that oxy-sap destroys nigrostriatal dopaminergic neurons expressing oxytocin receptors leading to a reduced striatal dopamine function. |
2021-11-12 |
2023-08-13 |
rat |
| Amber D Van Laar, Victor S Van Laar, Waldy San Sebastian, Aristide Merola, J Bradley Elder, Russell R Lonser, Krystof S Bankiewic. An Update on Gene Therapy Approaches for Parkinson's Disease: Restoration of Dopaminergic Function. Journal of Parkinson's disease. vol 11. issue s2. 2021-11-11. PMID:34366374. |
gene therapy is an attractive approach to impart a durable effect on neuronal function through introduction of genetic material to reestablish dopamine levels and/or functionally recover dopaminergic signaling by improving neuronal health. |
2021-11-11 |
2023-08-13 |
Not clear |
| Amber D Van Laar, Victor S Van Laar, Waldy San Sebastian, Aristide Merola, J Bradley Elder, Russell R Lonser, Krystof S Bankiewic. An Update on Gene Therapy Approaches for Parkinson's Disease: Restoration of Dopaminergic Function. Journal of Parkinson's disease. vol 11. issue s2. 2021-11-11. PMID:34366374. |
ongoing clinical gene therapy trials in pd are focused on enzymatic enhancement of dopamine production and/or the restoration of the nigrostriatal pathway to improve dopaminergic network function. |
2021-11-11 |
2023-08-13 |
Not clear |
| Serena Venezia, Walter A Kaufmann, Gregor K Wenning, Nadia Stefanov. Toll-like receptor 4 deficiency facilitates α-synuclein propagation and neurodegeneration in a mouse model of prodromal Parkinson's disease. Parkinsonism & related disorders. vol 91. 2021-11-11. PMID:34530328. |
the facilitated propagation of α-synuclein is associated with early loss of dopamine transporter (dat) signal in the striatum and loss of dopaminergic neurons in substantia nigra pars compacta of tlr4 deficient mice. |
2021-11-11 |
2023-08-13 |
mouse |
| Jing Wang, Xiao-Na Zhang, Jin-Ni Fang, Fei-Fei Hua, Jing-Yang Han, Zeng-Qiang Yuan, An-Mu Xi. The mechanism behind activation of the Nod-like receptor family protein 3 inflammasome in Parkinson's disease. Neural regeneration research. vol 17. issue 4. 2021-11-10. PMID:34472491. |
our results suggest that the atp-p2x4 receptor signaling pathway mediates nlrp3 inflammasome activation, dopaminergic neurodegeneration, and dopamine levels. |
2021-11-10 |
2023-08-13 |
rat |
| Kate L Harris, Sarah L Mason, Benjamin Vallin, Roger A Barke. Reduced expression of dopamine D2 receptors on astrocytes in R6/1 HD mice and HD post-mortem tissue. Neuroscience letters. 2021-11-10. PMID:34637857. |
dysfunction of the central dopaminergic system is thought to contribute to some of the clinical features of huntington's disease (hd), and dopamine (da) receptor antagonists are commonly used to good effect in its treatment. |
2021-11-10 |
2023-08-13 |
mouse |
| Aryeh Zolin, Raphael Cohn, Rich Pang, Andrew F Siliciano, Adrienne L Fairhall, Vanessa Rut. Context-dependent representations of movement in Drosophila dopaminergic reinforcement pathways. Nature neuroscience. vol 24. issue 11. 2021-11-10. PMID:34697455. |
furthermore, we show that these motor correlates are translated to ongoing dopamine release, and acutely perturbing dopaminergic signaling alters the strength of odor tracking. |
2021-11-10 |
2023-08-13 |
drosophila_melanogaster |
| Inka Brockhausen, John Schutzbach, Jiabei Wang, Beth Fishwick, Jennifer Brockhause. Glycoconjugate journal special issue on: the glycobiology of Parkinson's disease. Glycoconjugate journal. 2021-11-10. PMID:34757539. |
the replacement of dopamine and dopaminergic neurons are at the forefront of therapeutic development. |
2021-11-10 |
2023-08-13 |
Not clear |
| Ümit Özgür Akdemir, Ayşe Bora Tokçaer, Lütfiye Özlem Ata. Dopamine transporter SPECT imaging in Parkinson’s disease and parkinsonian disorders Turkish journal of medical sciences. vol 51. issue 2. 2021-11-08. PMID:33237660. |
dopamine transporter spect imaging in parkinson’s disease and parkinsonian disorders the dopamine transporter (dat) imaging provides an objective tool for the assessment of dopaminergic function of presynaptic terminals which is valuable for the differential diagnosis of parkinsonian disorders related to a striatal dopaminergic deficiency from movement disorders not related a striatal dopaminergic deficiency. |
2021-11-08 |
2023-08-13 |
human |
| Naveen Sharma, Eun-Joo Shin, Duc Toan Pham, Garima Sharma, Duy-Khanh Dang, Chu Xuan Duong, Sang Won Kang, Seung-Yeol Nah, Choon-Gon Jang, Xin Gen Lei, Toshitaka Nabeshima, Guoying Bing, Ji Hoon Jeong, Hyoung-Chun Ki. GPx-1-encoded adenoviral vector attenuates dopaminergic impairments induced by methamphetamine in GPx-1 knockout mice through modulation of NF-κB transcription factor. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 154. 2021-11-08. PMID:34082047. |
ma-induced dopaminergic impairments [i.e., hyperthermia; increased nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb) dna-binding activity; and decreased dopamine levels, th activity, and behavioral activity] were more pronounced in gpx-1-ko mice than in wt mice. |
2021-11-08 |
2023-08-13 |
mouse |
| Anne Korning Sigvard, Mette Ødegaard Nielsen, Albert Gjedde, Kirsten Borup Bojesen, Dan Fuglø, Karen Tangmose, Yoshitaka Kumakura, Kim Heltø, Bjørn H Ebdrup, Lars Thorbjørn Jensen, Egill Rostrup, Birte Yding Glenthø. Dopaminergic Activity in Antipsychotic-Naïve Patients Assessed With Positron Emission Tomography Before and After Partial Dopamine D Biological psychiatry. 2021-11-08. PMID:34743917. |
dopaminergic activity in antipsychotic-naïve patients assessed with positron emission tomography before and after partial dopamine d dopamine activity has been associated with the response to antipsychotic treatment. |
2021-11-08 |
2023-08-13 |
Not clear |
| Alcmène Chalazonitis, ZhiShan Li, Tuan D Pham, Jason Chen, Meenakshi Rao, Päivi Lindholm, Mart Saarma, Maria Lindahl, Michael D Gersho. Cerebral dopamine neurotrophic factor is essential for enteric neuronal development, maintenance, and regulation of gastrointestinal transit. The Journal of comparative neurology. vol 528. issue 14. 2021-11-05. PMID:32154930. |
expression of cdnf, moreover, is essential for the normal development and survival of enteric dopaminergic neurons; thus, expression of the dopaminergic neuronal markers, dopamine, tyrosine hydroxylase, and dopamine transporter are deficient in the ileum of cdnf |
2021-11-05 |
2023-08-13 |
Not clear |
| Warren D Taylor, David H Zald, Jennifer C Felger, Seth Christman, Daniel O Claassen, Guillermo Horga, Jeffrey M Miller, Katherine Gifford, Baxter Rogers, Sarah M Szymkowicz, Bret R Rutherfor. Influences of dopaminergic system dysfunction on late-life depression. Molecular psychiatry. 2021-11-05. PMID:34404915. |
as dopaminergic function declines with normal aging and increased inflammatory burden, the role of dopamine may be particularly salient for late-life depression. |
2021-11-05 |
2023-08-13 |
Not clear |
| Annakarina Mundorf, Nadja Kubitza, Karola Hünten, Hiroshi Matsui, Georg Juckel, Sebastian Ocklenburg, Nadja Freun. Maternal immune activation leads to atypical turning asymmetry and reduced DRD2 mRNA expression in a rat model of schizophrenia. Behavioural brain research. vol 414. 2021-11-04. PMID:34331971. |
as the dopaminergic system is a key player in both, we analyzed neuronal dopamine d2 receptor (drd2) mrna expression. |
2021-11-04 |
2023-08-13 |
rat |
| Deborah Amstutz, Steffen Paschen, Martin Lenard Lachenmayer, Marie Elise Maradan-Gachet, Günther Deuschl, Paul Krack, Ines Debov. Management of Impulse Control Disorders with Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease. CNS & neurological disorders drug targets. vol 19. issue 8. 2021-11-02. PMID:32691720. |
current management options are limited, as a reduction of dopaminergic medication often leads to worsening of motor symptoms or dopamine agonist withdrawal syndrome. |
2021-11-02 |
2023-08-13 |
human |
| James R Docherty, Hadeel A Alsufyan. Pharmacology of Drugs Used as Stimulants. Journal of clinical pharmacology. vol 61 Suppl 2. 2021-11-01. PMID:34396557. |
psychostimulant, cardiovascular, and temperature actions of stimulants involve adrenergic (norepinephrine), dopaminergic (dopamine), and serotonergic (serotonin) pathways. |
2021-11-01 |
2023-08-13 |
Not clear |
| Mattia Ferraiolo, Hicham Atik, Romane Ponthot, Inês Belo do Nascimento, Pauline Beckers, Christophe Stove, Emmanuel Herman. Receptor density influences ligand-induced dopamine D European journal of pharmacology. vol 911. 2021-11-01. PMID:34626593. |
taken together, our findings indicate that both receptor density and receptor ligands influence dopamine d2l receptor homodimerization, albeit excluding any strict correlation with ligands' intrinsic activity and highlighting further complexity to dopaminergic pharmacology. |
2021-11-01 |
2023-08-13 |
Not clear |
| A A Kolacheva, M V Ugrumo. A Mouse Model of Nigrostriatal Dopaminergic Axonal Degeneration As a Tool for Testing Neuroprotectors. Acta naturae. vol 13. issue 3. 2021-10-30. PMID:34707903. |
we have shown that the degeneration rate of dopaminergic axonal terminals changes over time, and that the striatal dopamine concentration is the most sensitive parameter to the action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
2021-10-30 |
2023-08-13 |
mouse |
| A A Kolacheva, M V Ugrumo. A Mouse Model of Nigrostriatal Dopaminergic Axonal Degeneration As a Tool for Testing Neuroprotectors. Acta naturae. vol 13. issue 3. 2021-10-30. PMID:34707903. |
nomifensine was shown to almost completely protect dopaminergic fibers from the toxic effect of mptp and maintain the striatal dopamine concentration at the control level. |
2021-10-30 |
2023-08-13 |
mouse |