| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jakob Linne. The anticipatory dopamine response in addiction: A common neurobiological underpinning of gambling disorder and substance use disorder? Progress in neuro-psychopharmacology & biological psychiatry. vol 98. 2021-11-22. PMID:31678482. |
the notion of the anticipatory dopamine response as a common underpinning of gambling disorder and substance use disorder is consistent with dopaminergic models of addictions such as the incentive-sensitization model, the ingrative neurodevelopmental model of vulnerability toward addiction and the reward prediction error model. |
2021-11-22 |
2023-08-13 |
Not clear |
| Anton Jm Loonen, Svetlana A Ivanov. Neurobiological mechanisms associated with antipsychotic drug-induced dystonia. Journal of psychopharmacology (Oxford, England). vol 35. issue 1. 2021-11-22. PMID:32900259. |
furthermore, striatal cholinergic interneurons have an important role to play in integrating cerebellar input with the output of cerebral cortex, and are also targeted by dopaminergic nigrostriatal fibres affecting dopamine d2 receptors. |
2021-11-22 |
2023-08-13 |
Not clear |
| Yang Hyun Lee, Sangwon Lee, Seok Jong Chung, Han Soo Yoo, Jin Ho Jung, Kyoungwon Baik, Byoung Seok Ye, Young H Sohn, Mijin Yun, Phil Hyu Le. The pattern of FP-CIT PET in pure white matter hyperintensities-related vascular parkinsonism. Parkinsonism & related disorders. vol 82. 2021-11-22. PMID:33220520. |
to determine whether vascular parkinsonism (vap) patients with visually normal dopamine transporter (dat) scans have presynaptic dopaminergic depletion. |
2021-11-22 |
2023-08-13 |
Not clear |
| Khadga Raj, Pawandeep Kaur, G D Gupta, Shamsher Sing. Metals associated neurodegeneration in Parkinson's disease: Insight to physiological, pathological mechanisms and management. Neuroscience letters. vol 753. 2021-11-22. PMID:33812934. |
the loss of dopaminergic nerves and dopamine deficiency leads to motor symptoms characterized by rigidity, tremor, and bradykinesia. |
2021-11-22 |
2023-08-13 |
human |
| Debora Dreher Nabinger, Stefani Altenhofen, Julia Vasconcellos Peixoto, Julia Maria Kuhl da Silva, Carla Denise Bona. Long-lasting behavioral effects of quinpirole exposure on zebrafish. Neurotoxicology and teratology. vol 88. 2021-11-22. PMID:34600099. |
we investigated the long-lasting behavioral effects on adult zebrafish after quinpirole (a dopamine d2/d3 receptor agonist) exposure during early life stages of development (24 h exposure at 5 days post-fertilization, dpf) to better understand the mechanisms underlying neurological disorders related to the dopaminergic system. |
2021-11-22 |
2023-08-13 |
human |
| Natalie M Frederick, Morgan M Pooler, Parth Shah, Alessandro Didonna, Puneet Opa. Pharmacological perturbation reveals deficits in D2 receptor responses in Thap1 null mice. Annals of clinical and translational neurology. 2021-11-21. PMID:34802187. |
since many of the genes misregulated involve dopaminergic signaling, we pharmacologically challenged the two striatal canonical dopamine pathways: the direct, regulated by the d1 receptor, and the indirect, regulated by the d2 receptor. |
2021-11-21 |
2023-08-13 |
mouse |
| Xiaolin Tia. Enhancing mask activity in dopaminergic neurons extends lifespan in flies. Aging cell. vol 20. issue 11. 2021-11-20. PMID:34626525. |
this mask-induced beneficial effect requires dopaminergic transmission but cannot be recapitulated by elevating dopamine production alone in the dans. |
2021-11-20 |
2023-08-13 |
Not clear |
| Cathy K Cui, Simon J G Lewi. Future Therapeutic Strategies for Freezing of Gait in Parkinson's Disease. Frontiers in human neuroscience. vol 15. 2021-11-20. PMID:34795568. |
whilst there already exist a number of pharmacological (e.g., dopaminergic and beyond dopamine), non-pharmacological (physiotherapy and cueing, cognitive training, and non-invasive brain stimulation) and surgical approaches to freezing (i.e., dual-site deep brain stimulation, closed-loop programming), an integrated collaborative approach to future research in this complex area will be necessary to systematically investigate new therapeutic avenues. |
2021-11-20 |
2023-08-13 |
Not clear |
| Jingyi Wang, Yohan John, Helen Barba. Pathways for Contextual Memory: The Primate Hippocampal Pathway to Anterior Cingulate Cortex. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 3. 2021-11-19. PMID:33207365. |
the proximity of hippocampal terminations to d1 receptors may enable dopamine to enhance information transfer from the hippocampus to a25 and contribute to dopaminergic influence downstream on goal-directed action and emotional control by prefrontal cortices, in processes that may be disrupted by excessive dopamine release during uncontrollable stress. |
2021-11-19 |
2023-08-13 |
monkey |
| Douglas R Miller, Dylan T Guenther, Andrew P Maurer, Carissa A Hansen, Andrew Zalesky, Habibeh Khoshboue. Dopamine Transporter Is a Master Regulator of Dopaminergic Neural Network Connectivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 25. 2021-11-19. PMID:33980544. |
dopamine transporter is a master regulator of dopaminergic neural network connectivity. |
2021-11-19 |
2023-08-13 |
mouse |
| Douglas R Miller, Dylan T Guenther, Andrew P Maurer, Carissa A Hansen, Andrew Zalesky, Habibeh Khoshboue. Dopamine Transporter Is a Master Regulator of Dopaminergic Neural Network Connectivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 25. 2021-11-19. PMID:33980544. |
the dopaminergic neurons in these regions have been shown to exhibit differential sensitivity to neuronal loss and psychostimulants targeting dopamine transporter. |
2021-11-19 |
2023-08-13 |
mouse |
| Hongli Li, Yaru Feng, Ziyu Chen, Xi Jiang, Zhenyu Zhou, Jinfeng Yuan, Fei Li, Yu Zhang, Xingxu Huang, Shengjie Fan, Xiaojun Wu, Cheng Huan. Pepper component 7-ethoxy-4-methylcoumarin, a novel dopamine D2 receptor agonist, ameliorates experimental Parkinson's disease in mice and Caenorhabditis elegans. Pharmacological research. vol 163. 2021-11-18. PMID:33007422. |
parkinson's disease (pd) is a progressive neurodegenerative disease resulting from the degeneration of dopaminergic (daergic) neurons in the substantia nigra pars compacta (snpc) and subsequent deficit of dopamine in the striatum. |
2021-11-18 |
2023-08-13 |
mouse |
| Peiling Zhou, Meiping Deng, Jiashan Wu, Qinghui Lan, Huifang Yang, Changzheng Zhan. Ventral Tegmental Area Dysfunction and Disruption of Dopaminergic Homeostasis: Implications for Post-traumatic Stress Disorder. Molecular neurobiology. vol 58. issue 5. 2021-11-18. PMID:33428093. |
this article reviews recent advances in our knowledge of the relationship between dopaminergic dyshomeostasis and ptsd, including the contributions of specific dopaminergic gene variants to disease susceptibility, alterations in vta dopamine neuron activity, dysregulation of dopaminergic transmission, and potential pharmacological and psychological interventions for ptsd targeting the dopaminergic system. |
2021-11-18 |
2023-08-13 |
Not clear |
| Andrew Kayse. Dopamine and Gambling Disorder: Prospects for Personalized Treatment. Current addiction reports. vol 6. issue 2. 2021-11-17. PMID:31728265. |
to address variation in the severity of gambling disorder, this review evaluates the contribution of mesocorticolimbic dopamine neurons to potential behavioral endophenotypes, the influence of individual differences in the dopamine system on gambling and related behaviors, and the possible role for dopaminergic medications in the treatment of gambling disorder. |
2021-11-17 |
2023-08-13 |
Not clear |
| Charlotte P Magee, BaoMinh D Le, Yasmeen H Siripathane, Diana G Wilkins, Glen R Hanson, Annette E Fleckenstei. Methcathinone decreases dopamine transporter function: Role of protein kinase C. Journal of neurochemistry. vol 159. issue 1. 2021-11-17. PMID:34320222. |
methcathinone decreases dopamine transporter function: role of protein kinase c. methcathinone (mcat) is a psychostimulant of abuse that can cause both persistent striatal dopaminergic and serotonergic, as well as hippocampal serotonergic, deficits. |
2021-11-17 |
2023-08-13 |
rat |
| Emma A Honkanen, Mikael Eklund, Simo Nuuttila, Tommi Noponen, Elina Jaakkola, Elina Mäkinen, Risto Hirvilammi, Marko Seppänen, Kari Lindholm, Filip Scheperjans, Riitta Parkkola, Juho Joutsa, Andrea Varrone, Valtteri Kaasine. Dopamine transporter binding in symptomatic controls and healthy volunteers: Considerations for neuroimaging trials. NeuroImage. Clinical. vol 32. 2021-11-17. PMID:34482280. |
to evaluate possible differences between brain dopamine transporter (dat) binding in a group of symptomatic parkinsonism patients without dopaminergic degeneration and healthy individuals. |
2021-11-17 |
2023-08-13 |
human |
| Eleanor Porter, Andreas-Antonios Roussakis, Nicholas P Lao-Kaim, Paola Piccin. Multimodal dopamine transporter (DAT) imaging and magnetic resonance imaging (MRI) to characterise early Parkinson's disease. Parkinsonism & related disorders. vol 79. 2021-11-15. PMID:32861103. |
currently, in early idiopathic pd, dopamine transporter (dat)-specific imaging assesses the extent of striatal dopaminergic deficits, and conventional magnetic resonance imaging (mri) of the brain excludes the presence of significant ischaemic load in the basal ganglia as well as signs indicative of other forms of parkinsonism. |
2021-11-15 |
2023-08-13 |
Not clear |
| Aqilah M McCane, Meredyth A Wegener, Mojdeh Faraji, Maria T Rivera-Garcia, Kathryn G Wallin-Miller, Vincent D Costa, Bita Moghadda. Adolescent Dopamine Neurons Represent Reward Differently during Action and State Guided Learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 45. 2021-11-14. PMID:34611024. |
static characteristics of dopamine neurons, such as dopamine cell number and size, were similar in the vta and sn of both ages, but there were age-related differences in stimulated dopamine release and correlated spike activity, suggesting that differences in reward responsiveness by adolescent dopamine neurons are not because of differences in intrinsic properties of these neurons but engagement of different dopaminergic networks. |
2021-11-14 |
2023-08-13 |
rat |
| Piniel Alphayo Kambey, Ma Chengcheng, Guo Xiaoxiao, Ayanlaja Abiola Abdulrahman, Kouminin Kanwore, Iqra Nadeem, Wu Jiao, Dianshuai Ga. The orphan nuclear receptor Nurr1 agonist amodiaquine mediates neuroprotective effects in 6-OHDA Parkinson's disease animal model by enhancing the phosphorylation of P38 mitogen-activated kinase but not PI3K/AKT signaling pathway. Metabolic brain disease. vol 36. issue 4. 2021-11-12. PMID:33507465. |
we first demonstrated that amodiaquine treatment ameliorated behavioural deficits in 6-ohda parkinson's disease mouse model, and it promoted dopaminergic neurons protection signified by tyrosine hydroxylase (th) and dopamine transporter (dat) mrna; tyrosine hydroxylase (th) protein expression level and the immunoreactivity in the substantia nigra compacta. |
2021-11-12 |
2023-08-13 |
mouse |
| Tina Kazemi, Shuyan Huang, Naze G Avci, Yasemin M Akay, Metin Aka. Investigating the effects of chronic perinatal alcohol and combined nicotine and alcohol exposure on dopaminergic and non-dopaminergic neurons in the VTA. Scientific reports. vol 11. issue 1. 2021-11-12. PMID:33888815. |
the ventral tegmental area (vta) is the origin of dopaminergic neurons and the dopamine (da) reward pathway. |
2021-11-12 |
2023-08-13 |
rat |