| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Hyung Seo, Bo-Ram Jin, Hyo-Jung Kim, Hyo-Jin An, Sujung Ye. Reduction of tyrosine hydroxylase expression and increase of α-synuclein in the substantia nigra in a rat model of benign prostatic hyperplasia. Neuroscience letters. 2021-12-07. PMID:34875351. |
parkinson's disease (pd) occurs when dopaminergic cells in the substantia nigra (sn) region are destroyed; however, the cause of the destruction of dopamine cells has not yet been determined. |
2021-12-07 |
2023-08-13 |
rat |
| Victor N Almeida, Marcia Radanovi. Semantic priming and neurobiology in schizophrenia: A theoretical review. Neuropsychologia. vol 163. 2021-12-06. PMID:34655651. |
we further assess the literature on the endophenotype of formal thought disorder from multiple standpoints, ranging from neurophysiology to cognition: considerations are weaved on neuronal (pv basket cell, sst, vip) and receptor deficits (drd1, nmda), neurotransmitter imbalances (dopamine), cortical and dopaminergic lateralisation, inter alia. |
2021-12-06 |
2023-08-13 |
Not clear |
| Liping Yang, Honghui Guo, Yu Kuang, Hui Yang, Xi Zhang, Rong Tang, Dapeng Li, Li L. Neurotoxicity induced by combined exposure of microcystin-LR and nitrite in male zebrafish (Danio rerio): Effects of oxidant-antioxidant system and neurotransmitter system. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 253. 2021-12-06. PMID:34826614. |
the decreases in dopamine content, acetylcholinesterase activity and related gene mrna levels indicated that mc-lr and nitrite adversely affected the normal function of the dopaminergic and cholinergic systems in zebrafish brain. |
2021-12-06 |
2023-08-13 |
zebrafish |
| Kevin Chen, Tamara Palagashvili, W Hsu, Yibu Chen, Boris Tabakoff, Frank Hong, Abigail T Shih, Jean C Shi. Brain injury and inflammation genes common to a number of neurological diseases and the genes involved in the genesis of GABAnergic neurons are altered in monoamine oxidase B knockout mice. Brain research. vol 1774. 2021-12-03. PMID:34780749. |
pea and dopamine are both synthesized from phenylalanine by aromatic l-amino acid decarboxylase in dopaminergic neurons in the striatum. |
2021-12-03 |
2023-08-13 |
mouse |
| Darshini Mahadevia, Rinki Saha, Alessia Manganaro, Nao Chuhma, Annette Ziolkowski-Blake, Ashlea A Morgan, Dani Dumitriu, Stephen Rayport, Mark S Ansorg. Dopamine promotes aggression in mice via ventral tegmental area to lateral septum projections. Nature communications. vol 12. issue 1. 2021-12-03. PMID:34815379. |
within the ls, dopamine acts on d2-receptors to inhibit gabaergic neurons, and septal d2-signaling is necessary for vta dopaminergic activity to promote aggression. |
2021-12-03 |
2023-08-13 |
mouse |
| Fatemeh Shaerzadeh, Leah Phan, Douglas Miller, Maxwell Dacquel, William Hachmeister, Carissa Hansen, Alexandra Bechtle, Duan Tu, Maia Martcheva, Thomas C Foster, Ashok Kumar, Wolfgang J Streit, Habibeh Khoshboue. Microglia senescence occurs in both substantia nigra and ventral tegmental area. Glia. vol 68. issue 11. 2021-11-30. PMID:32275335. |
contact sites between microglia and dopaminergic neurons in both regions increase with aging, suggesting increased microglial support/surveillance of dopamine neurons. |
2021-11-30 |
2023-08-13 |
mouse |
| Serge A Mitelman, Monte S Buchsbaum, Nora S Vyas, Bradley T Christian, Brian M Merrill, Bradley R Buchsbaum, Alexis M Mitelman, Jogeshwar Mukherjee, Douglas S Lehre. Reading abilities and dopamine D Brain and language. vol 223. 2021-11-30. PMID:34763166. |
reading abilities and dopamine d reading impairments are prominent trait-like features of cognitive deficits in schizophrenia, predictive of overall cognitive functioning and presumably linked to dopaminergic abnormalities. |
2021-11-30 |
2023-08-13 |
Not clear |
| Anna Maria Lavezz. Altered Development of Mesencephalic Dopaminergic Neurons in SIDS: New Insights into Understanding Sudden Infant Death Pathogenesis. Biomedicines. vol 9. issue 11. 2021-11-30. PMID:34829763. |
dopaminergic structures in midbrain sections of a large series of sudden infant deaths (36 sids and 26 controls) were identified using polyclonal rabbit antibodies against tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, and the dopamine transporter, a membrane protein specifically expressed in dopaminergic cells. |
2021-11-30 |
2023-08-13 |
human |
| Hayrettin Ozan Gulca. Selected natural and synthetic agents effective against Parkinson's disease with diverse mechanisms. Current topics in medicinal chemistry. 2021-11-30. PMID:34844541. |
since the symptomatic outcomes are generally related to dopamine deficiency, the current treatment strategies towards pd mainly employ dopaminergic agonists as well as the compounds acting on dopamine metabolism. |
2021-11-30 |
2023-08-13 |
Not clear |
| Sara Simorgh, Rafieh Alizadeh, Ronk Shabani, Fariba Karimzadeh, Elham Seidkhani, Jamal Majidpoor, Fatemeh Moradi, Hamidreza Kasbiya. Olfactory mucosa stem cells delivery via nasal route: a simple way for the treatment of Parkinson disease. Neurotoxicity research. vol 39. issue 3. 2021-11-29. PMID:33433781. |
the results of real-time pcr and immunohistochemistry (ihc) analysis showed the expression of dopaminergic neuron markers such as pitx3, pax2, pax5 (as dopaminergic neurons markers), tyrosine hydroxylase (th), and dopamine transporter (dat) 2 months after ina of 1 × 10 |
2021-11-29 |
2023-08-13 |
rat |
| Hannah V Oakes, David McWethy, Shannon Ketchem, Lily Tran, Kaitlyn Phillips, Laura Oakley, Richard J Smeyne, Brooks B Pon. Effect of Chronic Methylphenidate Treatment in a Female Experimental Model of Parkinsonism. Neurotoxicity research. vol 39. issue 3. 2021-11-29. PMID:33666887. |
chronic mph exposure contributed to gsh depletion, but surprisingly, it did not increase dopamine quinone levels or dopaminergic cell loss. |
2021-11-29 |
2023-08-13 |
mouse |
| Jamie van Son, Katy A van Galen, Anne Marijn Bruijn, Karin E Koopman, Ruth I Versteeg, Susanne E la Fleur, Mireille J Serlie, Jan Booi. Striatal Dopamine Transporter Availability Is Not Associated with Food Craving in Lean and Obese Humans; a Molecular Imaging Study. Brain sciences. vol 11. issue 11. 2021-11-29. PMID:34827426. |
brain dopamine signaling is essential for the motivation to eat, and obesity is associated with altered dopaminergic signaling and increased food craving. |
2021-11-29 |
2023-08-13 |
Not clear |
| Kaidong Wang, Baofu Zhang, Tian Tian, Bingyang Zhang, Ge Shi, Chunhui Zhang, Guoliang Li, Min Huan. Taurine protects dopaminergic neurons in paraquat-induced Parkinson's disease mouse model through PI3K/Akt signaling pathways. Amino acids. 2021-11-27. PMID:34837554. |
our study showed that pd mice with tau intervention recovered motor and non-motor functions to some extent, and the number of dopaminergic (dac) neurons in the substantia nigra and the level of dopamine (da) secretion in the striatum were also significantly increased compared with the pq-dyed group, and the protein content of pi3k and pdk-1 and the phosphorylation level of akt were reduced in parallel with the reduction in the expression of microglia and related inflammatory factors. |
2021-11-27 |
2023-08-13 |
mouse |
| Rajeev K Singla, Tanya Agarwal, Xuefei He, Bairong She. Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson's Disease. Current drug targets. vol 22. issue 6. 2021-11-26. PMID:33050857. |
parkinson's disease is one of the most common adult-onset, a chronic disorder involving neurodegeneration, which progressively leads to deprivation of dopaminergic neurons in substantia nigra, causing a subsequent reduction of dopamine levels in the striatum resulting in tremor, myotonia, and dyskinesia. |
2021-11-26 |
2023-08-13 |
Not clear |
| J Haarsma, P C Fletcher, J D Griffin, H J Taverne, H Ziauddeen, T J Spencer, C Miller, T Katthagen, I Goodyer, K M J Diederen, G K Murra. Precision weighting of cortical unsigned prediction error signals benefits learning, is mediated by dopamine, and is impaired in psychosis. Molecular psychiatry. vol 26. issue 9. 2021-11-25. PMID:32576965. |
to test these hypotheses, we studied learning with variable outcome-precision in healthy individuals after dopaminergic modulation with a placebo, a dopamine receptor agonist bromocriptine or a dopamine receptor antagonist sulpiride (dopamine study n = 59) and in patients with early psychosis (psychosis study n = 74: 20 participants with first-episode psychosis, 30 healthy controls and 24 participants with at-risk mental state attenuated psychotic symptoms). |
2021-11-25 |
2023-08-13 |
human |
| Rumpa Banerjee, Mukesh Kumar, Isha Gaurav, Sudha Thakur, Abhimanyu Thakur, Kunal Singh, Sanchari Karak, Rajeswar Das, Mohit Chhabr. In-silico Prediction of the Beta-carboline Alkaloids Harmine and Harmaline as Potent Drug Candidates for the Treatment of Parkinson's disease. Anti-inflammatory & anti-allergy agents in medicinal chemistry. vol 20. issue 3. 2021-11-25. PMID:33183209. |
loss of dopaminergic neurons is the cause of pd, thus enhancing dopamine level by pharmacological treatment is one of the key treatment strategies for pd. |
2021-11-25 |
2023-08-13 |
Not clear |
| Lennart R B Spindler, Andrea I Luppi, Ram M Adapa, Michael M Craig, Peter Coppola, Alexander R D Peattie, Anne E Manktelow, Paola Finoia, Barbara J Sahakian, Guy B Williams, Judith Allanson, John D Pickard, David K Menon, Emmanuel A Stamataki. Dopaminergic brainstem disconnection is common to pharmacological and pathological consciousness perturbation. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 30. 2021-11-25. PMID:34301891. |
despite dopaminergic agonist efficacy in doc patients equally pointing to dopamine, the vta has not been studied in human perturbed consciousness. |
2021-11-25 |
2023-08-13 |
human |
| R Matthew Hutchison, Karleyton C Evans, Tara Fox, Minhua Yang, Jerome Barakos, Barry J Bedell, Jesse M Cedarbaum, Miroslaw Brys, Andrew Siderowf, Anthony E Lan. Evaluating dopamine transporter imaging as an enrichment biomarker in a phase 2 Parkinson's disease trial. BMC neurology. vol 21. issue 1. 2021-11-25. PMID:34814867. |
dopamine transporter single-photon emission computed tomography (dat-spect) can quantify the functional integrity of the dopaminergic nerve terminals and has been suggested as an imaging modality to verify the clinical diagnosis of parkinson's disease (pd). |
2021-11-25 |
2023-08-13 |
human |
| Samaneh Mirzaei, Ketav Kulkarni, Kun Zhou, Peter J Crack, Marie-Isabel Aguilar, David I Finkelstein, John S Forsyth. Biomaterial Strategies for Restorative Therapies in Parkinson's Disease. ACS chemical neuroscience. vol 12. issue 22. 2021-11-23. PMID:34634903. |
parkinson's disease (pd) is a progressive neurological disorder, in which dopaminergic midbrain neurons degenerate, leading to dopamine depletion that is associated with neuronal death. |
2021-11-23 |
2023-08-13 |
Not clear |
| Jakob Linne. The anticipatory dopamine response in addiction: A common neurobiological underpinning of gambling disorder and substance use disorder? Progress in neuro-psychopharmacology & biological psychiatry. vol 98. 2021-11-22. PMID:31678482. |
second, it is suggested that dopaminergic reward response may be not a common pathway, since substance use disorder is associated with a blunted dopamine response toward drugs, while conflicting findings of reward response has been reported in gambling disorder. |
2021-11-22 |
2023-08-13 |
Not clear |