| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Teresa Alberts, Veronica Antipova, Carsten Holzmann, Alexander Hawlitschka, Oliver Schmitt, Jens Kurth, Jan Stenzel, Tobias Lindner, Bernd J Krause, Andreas Wree, Martin Wit. Olfactory Bulb D Toxins. vol 14. issue 2. 2022-02-24. PMID:35202123. |
the first central relay of the olfactory pathway, the olfactory bulb (ob), depends, among other things, on an intact, functional crosstalk between dopaminergic interneurons and dopamine receptors (d |
2022-02-24 |
2023-08-13 |
Not clear |
| Tao He, Chaojun Han, Chun Liu, Jiaojiao Chen, Huicui Yang, Longtai Zheng, John L Waddington, Xuechu Zhe. Dopamine D1 receptors mediate methamphetamine-induced dopaminergic damage: involvement of autophagy regulation via the AMPK/FOXO3A pathway. Psychopharmacology. 2022-02-22. PMID:35190859. |
dopamine d1 receptors mediate methamphetamine-induced dopaminergic damage: involvement of autophagy regulation via the ampk/foxo3a pathway. |
2022-02-22 |
2023-08-13 |
Not clear |
| Adrianne F Pike, Francesca Longhena, Gaia Faustini, Jean-Marc van Eik, Iris Gombert, Maaike A C Herrebout, Mona M H E Fayed, Michele Sandre, Tatiana Varanita, Charlotte E Teunissen, Jeroen J M Hoozemans, Arianna Bellucci, Robert Veerhuis, Luigi Bubacc. Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson's disease. Journal of neuroinflammation. vol 19. issue 1. 2022-02-17. PMID:35172843. |
parkinson's disease (pd) is characterized by the loss of nigral dopaminergic neurons leading to impaired striatal dopamine signaling, α-synuclein- (α-syn-) rich inclusions, and neuroinflammation. |
2022-02-17 |
2023-08-13 |
mouse |
| Michele Salemi, Giuseppe Lanza, Maria Paola Mogavero, Filomena I I Cosentino, Eugenia Borgione, Roberta Iorio, Giovanna Maria Ventola, Giovanna Marchese, Maria Grazia Salluzzo, Maria Ravo, Raffaele Ferr. A Transcriptome Analysis of mRNAs and Long Non-Coding RNAs in Patients with Parkinson's Disease. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163455. |
clinical symptoms include the progressive loss of dopaminergic neurons in the substantia nigra of the midbrain, which leads to striatal dopamine deficiency and, subsequently, causes motor dysfunction. |
2022-02-15 |
2023-08-13 |
human |
| Elham Ghanavati, Mohammad Ali Salehinejad, Lorena De Melo, Michael A Nitsche, Min-Fang Ku. NMDA receptor-related mechanisms of dopaminergic modulation of tDCS-induced neuroplasticity. Cerebral cortex (New York, N.Y. : 1991). 2022-02-15. PMID:35165699. |
eleven healthy, right-handed volunteers received anodal tdcs (1 ma, 13 min) over the left motor cortex combined with dopaminergic agents (the d2 receptor agonist bromocriptine, levodopa for general dopamine enhancement, or placebo) and the partial nmda receptor agonist d-cycloserine (dosages of 50, 100, and 200 mg, or placebo). |
2022-02-15 |
2023-08-13 |
human |
| Li Zhou, Qian Xie, Quanyun Zhang, Mengxi Hu, Tengfei Ma, Hong Xi. Dexmedetomidine attenuates motor deficits via restoring the function of neurons in the nigrostriatal circuit in Parkinson's disease model mice. European journal of pharmacology. 2022-02-12. PMID:35150656. |
the dex acted on the neurons in the nigrostriatal circuits, including activation of dopaminergic neurons and the reduction of the excitabilities of striatal neurons via dopamine d2 receptors. |
2022-02-12 |
2023-08-13 |
mouse |
| Haruo Nishijima, Fumiaki Mori, Tamaki Kimura, Yasuo Miki, Iku Kinoshita, Takashi Nakamura, Tomoya Kon, Chieko Suzuki, Koichi Wakabayashi, Masahiko Tomiyam. Cabergoline, a long-acting dopamine agonist, attenuates L-dopa-induced dyskinesia without L-dopa sparing in a rat model of Parkinson's disease. Neuroscience research. 2022-02-12. PMID:35150767. |
long-acting dopamine agonists may reduce the risk of lid by continuous dopaminergic stimulation. |
2022-02-12 |
2023-08-13 |
rat |
| P Riedel, I M Domachowska, Y Lee, P T Neukam, L Tönges, S C Li, T Goschke, M N Smolk. L-DOPA administration shifts the stability-flexibility balance towards attentional capture by distractors during a visual search task. Psychopharmacology. 2022-02-11. PMID:35147724. |
however, in humans, studies on the stability-flexibility balance using a dopaminergic agent and/or measurement of brain dopamine are scarce. |
2022-02-11 |
2023-08-13 |
Not clear |
| Amy C Leach, Elizabeth G Pitts, Cody A Siciliano, Mark J Ferri. α7 nicotinic acetylcholine receptor modulation of accumbal dopamine release covaries with novelty seeking. The European journal of neuroscience. 2022-02-10. PMID:35141983. |
dopamine release dynamics in the nucleus accumbens (nac) covaries with response to novelty and differences in dopaminergic signaling are thought to be a major underlying driver of the link between novelty seeking and drug use vulnerability. |
2022-02-10 |
2023-08-13 |
rat |
| Haruka Takeshige-Amano, Taku Hatano, Koji Kamagata, Christina Andica, Wataru Uchida, Masahiro Abe, Takashi Ogawa, Yasushi Shimo, Genko Oyama, Atsushi Umemura, Masanobu Ito, Masaaki Hori, Shigeki Aoki, Nobutaka Hattor. White matter microstructures in Parkinson's disease with and without impulse control behaviors. Annals of clinical and translational neurology. 2022-02-09. PMID:35137566. |
impulse control behaviors (icbs) in parkinson's disease (pd) are thought to be caused by an overdose of dopaminergic therapy in the relatively spared ventral striatum, or by hypersensitivity of this region to dopamine. |
2022-02-09 |
2023-08-13 |
Not clear |
| Pan Chen, Hong Cheng, Fuli Zheng, Shaojun Li, Julia Bornhorst, Bobo Yang, Kun He Lee, Tao Ke, Yunhui Li, Tanja Schwerdtle, Xiaobo Yang, Aaron B Bowman, Michael Aschne. BTBD9 attenuates manganese induced oxidative stress and neurotoxicity by regulating insulin growth factor signaling pathway. Human molecular genetics. 2022-02-08. PMID:35134179. |
in caenorhabditis elegans, loss of hpo-9 (btbd9 homolog) resulted in more susceptibility to mn-induced oxidative stress and mitochondrial dysfunction, as well as decreased dopamine levels and alternations of dopaminergic neuronal morphology and behavior. |
2022-02-08 |
2023-08-13 |
human |
| Tõnis Tokko, Grete Miškinyte, Diva Eensoo, Jaanus Harr. Driving risks of young drivers with symptoms of attention deficit hyperactivity disorder: association with the dopamine transporter gene VNTR polymorphism. Nordic journal of psychiatry. 2022-02-07. PMID:35130472. |
dopaminergic dysfunction has been found to occur in adhd, with the dopamine transporter (dat) gene vntr polymorphism ( |
2022-02-07 |
2023-08-13 |
Not clear |
| Lauren Cummins, Marshall E Cate. Istradefylline: A novel agent in the treatment of "off" episodes associated with levodopa/carbidopa use in Parkinson disease. The mental health clinician. vol 12. issue 1. 2022-02-04. PMID:35116210. |
istradefylline is an alternative option to dopaminergic drugs such as dopamine agonists, monoamine oxidase b inhibitors, and catechol-o-methyltransferase inhibitors as an adjunct to l/c in patients with motor fluctuations, but clinical use will further define its role in treatment of pd. |
2022-02-04 |
2023-08-13 |
Not clear |
| Khalid A El-Saiy, Rabab H Sayed, Ayman E El-Sahar, Esraa A Kandi. Modulation of histone deacetylase, the ubiquitin proteasome system, and autophagy underlies the neuroprotective effects of venlafaxine in a rotenone-induced Parkinson's disease model in rats. Chemico-biological interactions. 2022-02-01. PMID:35104487. |
venlafaxine administration was noted to decrease α-synuclein accumulation and preserve dopaminergic neurons along with restoration of striatal dopamine levels and motor recovery. |
2022-02-01 |
2023-08-13 |
rat |
| Jan Kehr, Fu-Hua Wang, Fumio Ichinose, Shimako Yoshitake, Bence Farkas, Béla Kiss, Nika Adha. Preferential Effects of Cariprazine on Counteracting the Disruption of Social Interaction and Decrease in Extracellular Dopamine Levels Induced by the Dopamine D Frontiers in psychiatry. vol 12. 2022-01-31. PMID:35095615. |
preferential effects of cariprazine on counteracting the disruption of social interaction and decrease in extracellular dopamine levels induced by the dopamine d the negative and cognitive symptoms of schizophrenia and related disorders may be due to reduced dopaminergic tone in cortical brain areas. |
2022-01-31 |
2023-08-13 |
Not clear |
| Benjamin D Hobson, Se Joon Choi, Eugene V Mosharov, Rajesh K Soni, David Sulzer, Peter Sim. Subcellular proteomics of dopamine neurons in the mouse brain. eLife. vol 11. 2022-01-31. PMID:35098924. |
dopaminergic neurons modulate neural circuits and behaviors via dopamine release from expansive, long range axonal projections. |
2022-01-31 |
2023-08-13 |
mouse |
| Benjamin D Hobson, Se Joon Choi, Eugene V Mosharov, Rajesh K Soni, David Sulzer, Peter Sim. Subcellular proteomics of dopamine neurons in the mouse brain. eLife. vol 11. 2022-01-31. PMID:35098924. |
we identify numerous proteins encoded by dopamine neuron-enriched genes in striatal dopaminergic axons, including ion channels with previously undescribed axonal localization. |
2022-01-31 |
2023-08-13 |
mouse |
| Mengyao Zhao, Linlin Deng, Xiaoxuan Lu, Liqiang Fan, Yang Zhu, Liming Zha. The involvement of oxidative stress, neuronal lesions, neurotransmission impairment, and neuroinflammation in acrylamide-induced neurotoxicity in C57/BL6 mice. Environmental science and pollution research international. 2022-01-28. PMID:35088269. |
moreover, acr caused neurological defects associated with gait abnormality and neuronal loss while suppressing the acetylcholine (ach) and dopamine (da) levels and increasing the protein expression of α-synuclein (α-syn), further inhibiting cholinergic and dopaminergic neuronal function. |
2022-01-28 |
2023-08-13 |
mouse |
| Narmadhaa Sivagurunathan, Aghil T S Ambatt, Latchoumycandane Calivaratha. Role of Long Non-Coding RNAs in the Pathogenesis of Alzheimer's and Parkinson's diseases. Current aging science. 2022-01-27. PMID:35081899. |
ad is a neurological condition that leads to dementia and cognitive decline due to neuronal cell death in the brain, whereas pd is a movement disorder affecting neuro-motor function and is developed due to the death of the dopaminergic neurons in the brain which results in decreased dopamine levels. |
2022-01-27 |
2023-08-13 |
Not clear |
| Javed Ahmed Ujjan, William Morani, Naz Memon, Sugumar Mohanasundaram, Shibili Nuhmani, Bhupesh Kumar Sing. Force Platform-Based Intervention Program for Individuals Suffering with Neurodegenerative Diseases like Parkinson. Computational and mathematical methods in medicine. vol 2022. 2022-01-27. PMID:35082910. |
substantia nigra (a midbrain dopaminergic nucleus) with lack of hormone called dopamine causes parkinson's disease (pd), a neurological disorder. |
2022-01-27 |
2023-08-13 |
human |