| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexander N Rodichkin, Melissa K Edler, Jennifer L McGlothan, Tomás R Guilart. Pathophysiological studies of aging Slc39a14 knockout mice to assess the progression of Manganese-Induced Dystonia-Parkinsonism. Neurotoxicology. 2022-09-24. PMID:36152728. |
neurochemical, neuropathological, and functional assessment of the dopaminergic system of the basal ganglia revealed absence of neurodegenerative changes of dopamine (da) neurons in the substantia nigra pars compacta (snc), with no changes in da or metabolite concentrations in the striatum of slc39a14-ko mice relative to wildtype (wt). |
2022-09-24 |
2023-08-14 |
mouse |
| Emma Veronica Carsana, Matteo Audano, Silvia Breviario, Silvia Pedretti, Massimo Aureli, Giulia Lunghi, Nico Mitr. Metabolic Profile Variations along the Differentiation of Human-Induced Pluripotent Stem Cells to Dopaminergic Neurons. Biomedicines. vol 10. issue 9. 2022-09-23. PMID:36140170. |
interestingly, in neuronal precursors, we observed an increase in amino acids that are likely the result of increased uptake or synthesis, while in mature dopaminergic neurons, we also observed an augmented content of those amino acids needed for dopamine synthesis. |
2022-09-23 |
2023-08-14 |
Not clear |
| Valeria V Goloborshcheva, Valerian G Kucheryanu, Natalia A Voronina, Ekaterina V Teterina, Aleksey A Ustyugov, Sergei G Morozo. Synuclein Proteins in MPTP-Induced Death of Substantia Nigra Pars Compacta Dopaminergic Neurons. Biomedicines. vol 10. issue 9. 2022-09-23. PMID:36140378. |
parkinson's disease (pd) is one of the key neurodegenerative disorders caused by a dopamine deficiency in the striatum due to the death of dopaminergic (da) neurons of the substantia nigra pars compacta. |
2022-09-23 |
2023-08-14 |
Not clear |
| Luoyi Huang, Chiara Palmieri, François-René Berti. Correlation of pituitary histomorphometry with dopamine and dopamine D2 receptor expression in horses with pituitary pars intermedia dysfunction. Research in veterinary science. vol 152. 2022-09-20. PMID:36126509. |
previous studies have observed neurodegeneration of the dopaminergic inhibition of melanotrophs, which leads to decreased dopamine (da) in the pars intermedia (pi) and increased pro-opiomelanocortin-derived peptides circulating in plasma. |
2022-09-20 |
2023-08-14 |
rat |
| Soomin Jeong, Soogyeong Jang, Seong Soon Kim, Myung Ae Bae, Junnyung Shin, Ki-Baek Lee, Ki-Tae Ki. Size-dependent seizurogenic effect of polystyrene microplastics in zebrafish embryos. Journal of hazardous materials. vol 439. 2022-09-15. PMID:36104895. |
additionally, an increase in the levels of neurochemicals choline, betaine, dopamine, 3-methoxytyramine, and gamma-aminobutyric acid indicated that the observed hypoactivity and seizure-like behavior were associated with the dysregulation of the cholinergic, dopaminergic, and gabaergic systems. |
2022-09-15 |
2023-08-14 |
zebrafish |
| Seong Shoon Yoon, Bong Hyo Lee, Seong Ho Lee, Seong Hun Choi, Seon-Ju Jeong, Sang Chan Kim, Chae Ha Yan. Effects of isoflurane anesthesia on addictive behaviors in rats. Psychopharmacology. 2022-09-15. PMID:36109391. |
recently, it has been suggested that isoflurane might reduce dopamine release from rat midbrain dopaminergic neurons, the neurobiological substrate implicated in the reinforcing effects of abused drugs and nondrug rewards. |
2022-09-15 |
2023-08-14 |
rat |
| Janaína K Barbiero, Daniele C Ramos, Suelen Boschen, Taysa Bassani, Cláudio Da Cunha, Maria A B F Vita. Fenofibrate promotes neuroprotection in a model of rotenone-induced Parkinson's disease. Behavioural pharmacology. 2022-09-12. PMID:36094044. |
moreover, fenofibrate diminished the depletion of striatal dopamine and protected against dopaminergic neuronal death in the snpc. |
2022-09-12 |
2023-08-14 |
rat |
| Carlo Matera, Pablo Calvé, Verònica Casadó-Anguera, Rosalba Sortino, Alexandre M J Gomila, Estefanía Moreno, Thomas Gener, Cristina Delgado-Sallent, Pau Nebot, Davide Costazza, Sara Conde-Berriozabal, Mercè Masana, Jordi Hernando, Vicent Casadó, M Victoria Puig, Pau Gorostiz. Reversible Photocontrol of Dopaminergic Transmission in Wild-Type Animals. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077512. |
dopamine receptors are involved in the modulation of fundamental physiological functions, and dysregulation of dopaminergic transmission is associated with major neurological disorders. |
2022-09-09 |
2023-08-14 |
Not clear |
| Federica Ferrari, Antonio Moretti, Roberto Federico Vill. Incretin-based drugs as potential therapy for neurodegenerative diseases: Current status and perspectives. Pharmacology & therapeutics. 2022-09-05. PMID:36064147. |
for pd, both glp-1ras and of dpp-ivis reversed the nigrostriatal dopaminergic cell loss progression, restored dopamine synthesis, exerted anti-inflammatory activity and improved motor functions. |
2022-09-05 |
2023-08-14 |
Not clear |
| Megan A McWain, Rachel L Pace, Patricia A Nalan, Deranda B Leste. Age-dependent effects of social isolation on mesolimbic dopamine release. Experimental brain research. 2022-09-03. PMID:36057752. |
mice were socially isolated for 6 weeks during these developmental stages, then in vivo fixed potential amperometry with recording electrodes in the nucleus accumbens was used to measure stimulation-evoked dopamine release, the synaptic half-life of dopamine, dopamine autoreceptor functioning, and the dopaminergic response to cocaine. |
2022-09-03 |
2023-08-14 |
mouse |
| Milca Abda Morais, Beatriz Silva Franco, Alessandro Spencer Souza Holanda, Laís Angélica de Paula Simino, Alana Carolina Costa Veras, Marcio Alberto Torsoni, Mauro Manconi, Adriana Souza Torsoni, Andrea Maculano Esteve. Protein tyrosine phosphatase receptor type delta (PTPRD) gene in an animal model of restless legs syndrome. Journal of sleep research. 2022-09-02. PMID:36053904. |
to evaluate the tyrosine hydroxylase enzyme, dopamine transporter (dat) and type 2 dopaminergic receptor, qpcr and western blotting techniques were used. |
2022-09-02 |
2023-08-14 |
rat |
| Jacqueline M Garrick, Khoi Dao, Lucio G Costa, Judit Marsillach, Clement E Furlon. Examining the role of paraoxonase 2 in the dopaminergic system of the mouse brain. BMC neuroscience. vol 23. issue 1. 2022-09-02. PMID:36056313. |
dopamine metabolism generates considerable oxidative stress and antioxidant function is critical to the survival of dopaminergic neurons, providing a potential mechanism for pon2 in the dopaminergic system. |
2022-09-02 |
2023-08-14 |
mouse |
| Javier García-Cárceles, Henar Vázquez-Villa, José Brea, David Ladron de Guevara-Miranda, Giovanni Cincilla, Melchor Sánchez-Martínez, Anabel Sánchez-Merino, Sergio Algar, María Teresa de Los Frailes, Richard S Roberts, Juan A Ballesteros, Fernando Rodríguez de Fonseca, Bellinda Benhamú, María I Loza, María L López-Rodrígue. 2-(Fluoromethoxy)-4'-( Journal of medicinal chemistry. 2022-08-31. PMID:36044544. |
2-(fluoromethoxy)-4'-( tolerance development caused by dopamine replacement with l-dopa and therapeutic drawbacks upon activation of dopaminergic receptors with orthosteric agonists reveal a significant unmet need for safe and effective treatment of parkinson's disease. |
2022-08-31 |
2023-08-14 |
Not clear |
| Han-Kyeol Kim, Myung Jun Lee, Han Soo Yoo, Jae Hoon Lee, Young Hoon Ryu, Chul Hyoung Lyo. Temporal trajectory model for dopaminergic input to the striatal subregions in Parkinson's disease. Parkinsonism & related disorders. vol 103. 2022-08-29. PMID:36037782. |
we sought to establish long-term temporal trajectory models for the dopaminergic input to the striatal subregions and a 4d-temporal trajectory model for the dopamine transporter positron emission tomography (pet). |
2022-08-29 |
2023-08-14 |
Not clear |
| Xiaosan Tang, Heng Li, Baozeng An, Haibo Ma, Nana Huang, Xiaohong L. Transplantation of human cord blood-derived multipotent stem cells (CB-SCs) enhances the recovery of Parkinson in rats. Transplant immunology. 2022-08-29. PMID:36038047. |
after being transplanted into the striatum and substantia nigra of pd rats, most of cb-scs (>90%) developed a fate commitment to dopaminergic differentiation, expressed as the expression of tyrosine hydroxylase (th) and dopamine transporter (dat). |
2022-08-29 |
2023-08-14 |
human |
| Thayssa Tavares da Silva Cunha, Rafaela Ribeiro Silva, Daniel Alencar Rodrigues, Pedro de Sena Murteira Pinheiro, Thales Kronenberger, Carlos Maurício R Sant'Anna, François Noël, Carlos Alberto Manssour Frag. Design, Synthesis and Pharmacological Evaluation of Novel Conformationally Restricted Biomolecules. vol 12. issue 8. 2022-08-26. PMID:36009006. |
dopamine and dopaminergic receptor subtypes are involved in the pathophysiology of several neurological disorders, such as schizophrenia, depression and drug addiction. |
2022-08-26 |
2023-08-14 |
Not clear |
| Jannette Rodríguez-Pallares, María García-Garrote, Juan A Parga, José Luis Labandeira-Garcí. Combined cell-based therapy strategies for the treatment of Parkinson's disease: focus on mesenchymal stromal cells. Neural regeneration research. vol 18. issue 3. 2022-08-26. PMID:36018150. |
clinical studies of transplantation of human fetal ventral mesencephalic tissue have provided evidence that the grafted dopaminergic neurons can reinnervate the striatum, release dopamine, integrate into the host neural circuits, and improve motor functions. |
2022-08-26 |
2023-08-14 |
human |
| Oliver D Howes, Ekaterina Shatalin. Integrating the Neurodevelopmental and Dopamine Hypotheses of Schizophrenia and the Role of Cortical Excitation-Inhibition Balance. Biological psychiatry. vol 92. issue 6. 2022-08-25. PMID:36008036. |
we discuss mechanisms through which frontal cortex circuitry may regulate striatal dopamine and consider how frontal e/i imbalance may cause dopaminergic dysregulation to result in psychotic symptoms. |
2022-08-25 |
2023-08-14 |
Not clear |
| Mimi Shin, B Jill Vento. Fast-Scan Cyclic Voltammetry (FSCV) Reveals Behaviorally-Evoked Dopamine Release by Sugar Feeding in Adult Drosophila Mushroom Body. Angewandte Chemie (International ed. in English). 2022-08-22. PMID:35989453. |
drosophila melanogaster , the fruit fly, is an excellent model organism for studying dopaminergic mechanisms and simple behaviors, but methods to measure dopamine during behavior are needed. |
2022-08-22 |
2023-08-14 |
drosophila_melanogaster |
| Ranjithkumar Chellian, Azin Behnood-Rod, Ryann Wilson, Karen Lin, Grace Wing-Yan King, Marcella Ruppert-Gomez, Alexandria Nicole Teter, Marcelo Febo, Adriaan W Bruijnzee. Dopamine D1-like receptor blockade and stimulation decreases operant responding for nicotine and food in male and female rats. Scientific reports. vol 12. issue 1. 2022-08-19. PMID:35986048. |
however, there remains a need for a better understanding of the effects of dopamine d1-like receptor agonists on nicotine intake and the role of sex differences in the effects of dopaminergic drugs on behavior. |
2022-08-19 |
2023-08-14 |
rat |