| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Louise C Parr-Brownlie, Christy A Itoga, Judith R Walters, Conor F Underwoo. Oscillatory waveform sharpness asymmetry changes in motor thalamus and motor cortex in a rat model of Parkinson's disease. Experimental neurology. 2022-04-24. PMID:35461830. |
hypoactive layer v pyramidal neuron firing in dopamine lesioned rats is unlikely to be driven by vavl thalamus and may, therefore, reflect the loss of mesocortical dopaminergic afferents and/or changes in intrinsic excitability. |
2022-04-24 |
2023-08-13 |
rat |
| Karl Ebner, Simone B Sartori, Rita Murau, Fabian Kopel, Predrag Kalaba, Vladimir Dragačević, Johann J Leban, Nicolas Singewald, Mario Engelmann, Gert Lube. The Novel Analogue of Modafinil CE-158 Protects Social Memory against Interference and Triggers the Release of Dopamine in the Nucleus Accumbens of Mice. Biomolecules. vol 12. issue 4. 2022-04-23. PMID:35454095. |
paralleling these behavioral effects, the systemic administration of 10 mg/kg ce-158 caused a rapid and sustained elevation of extracellular dopamine in the nucleus accumbens, a brain area where dopaminergic signaling plays a key role in learning and memory function, of freely moving mice, while 1 mg/kg was not sufficient for altering dopamine levels. |
2022-04-23 |
2023-08-13 |
mouse |
| R Pivonello, C Pivonello, C Simeoli, M C De Martino, A Cola. The dopaminergic control of Cushing's syndrome. Journal of endocrinological investigation. 2022-04-23. PMID:35460460. |
corticotroph pituitary and extra-pituitary tumours, as well as adrenal tumours and lesions responsible for cs express dopamine receptors (drs), which have been found to mediate inhibition of hormone secretion and/or cell proliferation in experimental setting, suggesting that dopaminergic system, particularly drs, might represent a target for the treatment of cs. |
2022-04-23 |
2023-08-13 |
Not clear |
| Andrew B Hawkey, Erica Pippen, Bruny Kenou, Zade Holloway, Theodore A Slotkin, Frederic J Seidler, Edward D Levi. Persistent Neurobehavioral and Neurochemical Anomalies in Middle-Aged Rats after Maternal Diazinon Exposure. Toxicology. 2022-04-22. PMID:35452779. |
across adulthood, the continued potential for behavioral defects was associated with altered dopaminergic function, characterized by enhanced dopamine utilization that was regionally-selective (striatum but not frontal/parietal cortex). |
2022-04-22 |
2023-08-13 |
rat |
| Koji Furukawa, Atsushi Shima, Daisuke Kambe, Akira Nishida, Ikko Wada, Haruhi Sakamaki, Kenji Yoshimura, Yuta Terada, Yusuke Sakato, Masahiro Mitsuhashi, Masanori Sawamura, Etsuro Nakanishi, Yosuke Taruno, Hodaka Yamakado, Yasutaka Fushimi, Tomohisa Okada, Yuji Nakamoto, Ryosuke Takahashi, Nobukatsu Sawamot. Motor progression and nigrostriatal neurodegeneration in Parkinson's disease. Annals of neurology. 2022-04-16. PMID:35428994. |
here, we aimed to clarify the correlation between motor impairments and striatal dopaminergic terminal degeneration and nigral neuromelanin-laden dopamine neuron loss at early to advanced stages of pd. |
2022-04-16 |
2023-08-13 |
Not clear |
| Amanda R Burmeister, Juozas Gordevicius, Emmanuel N Paul, Christina Houck, Sonia George, Martha L Escobar Galvis, Qiong Sha, Patrik Brundin, J Andrew Pospisilik, Karen Racicot, Lena Brundi. Maternal Herpesviridae infection during pregnancy alters midbrain dopaminergic signatures in adult offspring. Neurobiology of disease. 2022-04-13. PMID:35417751. |
adults exhibit great variability in the numbers of nigral dopamine neurons, suggesting that factors during embryonic or early life regulate the development and physiology of dopaminergic neurons. |
2022-04-13 |
2023-08-13 |
mouse |
| Lingfei Li, Philip Wing-Lok Ho, Huifang Liu, Shirley Yin-Yu Pang, Eunice Eun-Seo Chang, Zoe Yuen-Kiu Choi, Yasine Malki, Michelle Hiu-Wai Kung, David Boyer Ramsden, Shu-Leong H. Transcriptional Regulation of the Synaptic Vesicle Protein Synaptogyrin-3 ( International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35409005. |
syngr3 interacts with the dopamine transporter (dat) to facilitate dopamine (da) uptake and synaptic da turnover in dopaminergic transmission. |
2022-04-12 |
2023-08-13 |
human |
| Victor Blokhin, Alina V Lavrova, Sergey A Surkov, Eduard R Mingazov, Natalia M Gretskaya, Vladimir V Bezuglov, Michael V Ugrumo. A New Method for the Visualization of Living Dopaminergic Neurons and Prospects for Using It to Develop Targeted Drug Delivery to These Cells. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35409040. |
this is the first study aiming to develop a method for the long-term visualization of living nigrostriatal dopaminergic neurons using 1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine-bodipy (gbr-bp), the original fluorescent substance, which is a derivative of gbr-12909, a dopamine uptake inhibitor. |
2022-04-12 |
2023-08-13 |
mouse |
| Victor Blokhin, Alina V Lavrova, Sergey A Surkov, Eduard R Mingazov, Natalia M Gretskaya, Vladimir V Bezuglov, Michael V Ugrumo. A New Method for the Visualization of Living Dopaminergic Neurons and Prospects for Using It to Develop Targeted Drug Delivery to These Cells. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35409040. |
this method is based on the authors' hypothesis about the possibility of specifically internalizing into dopaminergic neurons substances with a high affinity for the dopamine transporter (dat). |
2022-04-12 |
2023-08-13 |
mouse |
| Kenneth Blum, Diwanshu Soni, Rajendra D Badgaiyan, David Baro. Overcoming reward deficiency syndrome by the induction of "dopamine homeostasis" instead of opioids for addiction: illusion or reality? Journal of osteopathic medicine. 2022-04-12. PMID:35411759. |
the article discusses various potential therapeutic modalities that can provide dopamine homeostasis via activation of dopaminergic pathways. |
2022-04-12 |
2023-08-13 |
Not clear |
| Hairong Peng, Shui Yu, Yukai Zhang, Yanqing Yin, Jiawei Zho. Intestinal Dopamine Receptor D2 is Required for Neuroprotection Against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Dopaminergic Neurodegeneration. Neuroscience bulletin. 2022-04-11. PMID:35399136. |
here, we investigated the impact of deregulation of intestinal dopamine d2 receptor (drd2) signaling in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced dopaminergic neurodegeneration. |
2022-04-11 |
2023-08-13 |
mouse |
| Béla Kiss, Balázs Krámos, István Laszlovszk. Potential Mechanisms for Why Not All Antipsychotics Are Able to Occupy Dopamine D Frontiers in psychiatry. vol 13. 2022-04-11. PMID:35401257. |
potential mechanisms for why not all antipsychotics are able to occupy dopamine d dysfunctions of the dopaminergic system are believed to play a major role in the core symptoms of schizophrenia such as positive, negative, and cognitive symptoms. |
2022-04-11 |
2023-08-13 |
Not clear |
| Georgia Richard, Aine Redmond, Maitreyi Penugonda, David Bradle. Parkinson's Disease Medication Prescribing and Administration During Unplanned Hospital Admissions. Movement disorders clinical practice. vol 9. issue 3. 2022-04-11. PMID:35402654. |
treatment includes supplementation of central dopaminergic neurotransmission with levodopa preparations and dopamine agonists. |
2022-04-11 |
2023-08-13 |
Not clear |
| Karolin Wieber, Leonie Fleige, Styliani Tsiami, Jörg Reinders, Jürgen Braun, Xenofon Baraliakos, Silvia Capellin. Dopamine receptor 1 expressing B cells exert a proinflammatory role in female patients with rheumatoid arthritis. Scientific reports. vol 12. issue 1. 2022-04-09. PMID:35396380. |
recent data indicated a role for dopamine in ra pathogenesis, while dopaminergic pathways can be modulated by estrogens. |
2022-04-09 |
2023-08-13 |
Not clear |
| Emiliano De Santis, Velia Minicozzi, Giancarlo Rossi, Francesco Stellato, Silvia Morant. Is styrene competitive for dopamine receptor binding? Biomolecular concepts. vol 13. issue 1. 2022-04-08. PMID:35394712. |
we estimate the binding affinity of both styrene oxide and dopamine to the dopaminergic receptor drd2 by computing the free-energy difference, ∆ |
2022-04-08 |
2023-08-13 |
Not clear |
| Elena Contaldi, Luca Magistrelli, Silvia Gallo, Cristoforo Com. Striatal dopamine transporter imaging in Parkinson's disease drug-naïve patients: focus on sexual dysfunction. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2022-04-07. PMID:35386018. |
dopamine is involved in sexual behavior, but dopaminergic imaging studies establishing the relationship between nigrostriatal dopaminergic degeneration and sexual dysfunction (sd) in parkinson's disease (pd) are lacking. |
2022-04-07 |
2023-08-13 |
Not clear |
| Matthew A Weber, Mackenzie M Conlon, Hannah R Stutt, Linder Wendt, Patrick Ten Eyck, Nandakumar S Narayana. Quantifying the inverted U: A meta-analysis of prefrontal dopamine, D1 receptors, and working memory. Behavioral neuroscience. 2022-04-07. PMID:35389678. |
our results provide insight into the fundamental dynamics of prefrontal dopamine, which could be useful for pharmacological interventions targeting prefrontal dopaminergic circuits, and into the pathophysiology of human brain disease. |
2022-04-07 |
2023-08-13 |
human |
| Xiaodong Wang, Yinhao Wang, Jian Chen, Juan Li, Yang Liu, Wei Che. Aerobic exercise improves motor function and striatal MSNs-Erk/MAPK signaling in mice with 6-OHDA-induced Parkinson's disease. Experimental brain research. 2022-04-06. PMID:35384454. |
in parkinson's disease (pd) state, with progressive loss of dopaminergic neurons in the substantia nigra, the striatal dopamine (da) and glutamate (glu) levels change, resulting in dysfunction of basal ganglia motor regulation. |
2022-04-06 |
2023-08-13 |
mouse |
| Elvi Gil-Lievana, Gerardo Ramírez-Mejía, Oscar Urrego-Morales, Jorge Luis-Islas, Ranier Gutierrez, Federico Bermúdez-Ratton. Photostimulation of Ventral Tegmental Area-Insular Cortex Dopaminergic Inputs Enhances the Salience to Consolidate Aversive Taste Recognition Memory Frontiers in cellular neuroscience. vol 16. 2022-04-01. PMID:35360496. |
photostimulation of ventral tegmental area-insular cortex dopaminergic inputs enhances the salience to consolidate aversive taste recognition memory taste memory involves storing information through plasticity changes in the neural network of taste, including the insular cortex (ic) and ventral tegmental area (vta), a critical provider of dopamine. |
2022-04-01 |
2023-08-13 |
mouse |
| Hyunbin Kim, Min-Ho Nam, Sohyeon Jeong, Hyowon Lee, Soo-Jin Oh, Jeongjin Kim, Nakwon Choi, Jihye Seon. Visualization of differential GPCR crosstalk in DRD1-DRD2 heterodimer upon different dopamine levels. Progress in neurobiology. 2022-04-01. PMID:35364139. |
dopaminergic signaling is regulated by transient micromolar (phasic) and background nanomolar (tonic) dopamine releases in the brain. |
2022-04-01 |
2023-08-13 |
Not clear |