| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aleksandra Pytel, Jan Aleksander Beszlej, Monika Biercewicz, Anna Roszmann, Dorota Krówczyńska, Aleksandra Kołtuniu. The Effect of Frailty Syndrome on the Quality of Life of Individuals with Parkinson's Disease: A Pilot Observational and Multicenter Study on the Polish Population. International journal of environmental research and public health. vol 19. issue 22. 2022-11-26. PMID:36429942. |
parkinson's disease (pd) is a neurodegenerative disorder involving decreased dopamine release and atrophy of dopaminergic neurons of the substantia nigra. |
2022-11-26 |
2023-08-14 |
Not clear |
| Laura A Struzyna, Kevin D Browne, Justin C Burrell, Wisberty J Gordián Vélez, Kathryn L Wofford, Hilton M Kaplan, N Sanjeeva Murthy, H Isaac Chen, John E Duda, Rodrigo A España, D Kacy Culle. Axonal Tract Reconstruction Using a Tissue-Engineered Nigrostriatal Pathway in a Rat Model of Parkinson's Disease. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430464. |
immunohistochemistry and fscv established that transplanted te-nsps survived, maintained their axonal tract projections, extended dopaminergic neurites into host tissue, and released dopamine in the striatum. |
2022-11-26 |
2023-08-14 |
rat |
| Carmen Costas-Ferreira, Társila Romero, Rafael Durán, Lilian R F Far. Role of voltage-sensitive Ca Toxicology letters. 2022-11-25. PMID:36427774. |
these results show that gla-induced dopamine release could be produced by the activation of a wide range of striatal vscc located at the synaptic terminals and axons of striatal dopaminergic neurons, especially n-type vscc. |
2022-11-25 |
2023-08-14 |
Not clear |
| Gurvir S Virdi, Minee L Choi, James R Evans, Zhi Yao, Dilan Athauda, Stephanie Strohbuecker, Raja S Nirujogi, Anna I Wernick, Noelia Pelegrina-Hidalgo, Craig Leighton, Rebecca S Saleeb, Olga Kopach, Haya Alrashidi, Daniela Melandri, Jimena Perez-Lloret, Plamena R Angelova, Sergiy Sylantyev, Simon Eaton, Simon Heales, Dmitri A Rusakov, Dario R Alessi, Tilo Kunath, Mathew H Horrocks, Andrey Y Abramov, Rickie Patani, Sonia Gandh. Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons. NPJ Parkinson's disease. vol 8. issue 1. 2022-11-24. PMID:36424392. |
our small molecule-based protocol generates highly enriched midbrain dopaminergic (mda) neurons: molecular identity was confirmed using single-cell rna sequencing and proteomics, and functional identity was established through dopamine synthesis, and measures of electrophysiological activity. |
2022-11-24 |
2023-08-14 |
human |
| Ganesh R Pawar, Yogeeta O Agrawal, Kartik T Nakhate, Chandragouda R Patil, Charu Sharma, Shreesh Ojha, Umesh B Mahajan, Sameer N Goya. Ghrelin alleviates depression-like behaviour in rats subjected to high-fat diet and diurnal rhythm disturbance. American journal of translational research. vol 14. issue 10. 2022-11-18. PMID:36398212. |
while depression is associated with dopamine dysfunction in the ventral tegmental area (vta), ghrelin enhances the dopaminergic activity in the vta. |
2022-11-18 |
2023-08-14 |
rat |
| Zachary Gaertner, Maite Azcorra, Daniel A Dombeck, Rajeshwar Awatraman. Molecular heterogeneity in the substantia nigra: A roadmap for understanding PD motor pathophysiology. Neurobiology of disease. 2022-11-13. PMID:36372290. |
recently, dopamine (da) neurons of the substantia nigra pars compacta (snc) and adjacent ventral tegmental area (vta) have been revealed to be diverse not only when comparing between these two dopaminergic nuclei, but within them, and with the distribution of identified subtypes often agnostic to traditional neuroanatomical boundaries (saunders et al., 2018a; hook et al., 2018; kramer et al., 2018; la manno et al., 2016; poulin et al., 2014; tiklova et al., 2019; poulin et al., 2018). |
2022-11-13 |
2023-08-14 |
human |
| Stephanie T Hirschbichler, John C Rothwell, Sanjay G Manoha. Dopamine increases risky choice while D2 blockade shortens decision time. Experimental brain research. 2022-11-09. PMID:36350356. |
dopamine is crucially involved in decision-making and overstimulation within dopaminergic pathways can lead to impulsive behaviour, including a desire to take risks and reduced deliberation before acting. |
2022-11-09 |
2023-08-14 |
human |
| Stephanie T Hirschbichler, John C Rothwell, Sanjay G Manoha. Dopamine increases risky choice while D2 blockade shortens decision time. Experimental brain research. 2022-11-09. PMID:36350356. |
these behavioural changes are side effects of treatment with dopaminergic drugs in parkinson disease, but their likelihood of occurrence is difficult to predict and may be influenced by the individual's baseline endogenous dopamine state, and indeed correlate with sensation-seeking personality traits. |
2022-11-09 |
2023-08-14 |
human |
| Stephanie T Hirschbichler, John C Rothwell, Sanjay G Manoha. Dopamine increases risky choice while D2 blockade shortens decision time. Experimental brain research. 2022-11-09. PMID:36350356. |
furthermore, our data suggest that the actual dopaminergic drug effect may be dependent on the individual's baseline dopamine state, which may influence our therapeutic decision as clinicians in the future. |
2022-11-09 |
2023-08-14 |
human |
| Shu-Mei Wang, Bess Yin-Hung Lam, Li-Chieh Kuo, Hsiao-Man Hsu, Wen-Chen Ouyan. Facial and upper-limb movement abnormalities in individuals with psychotic-like experiences: a motion analysis study. European archives of psychiatry and clinical neuroscience. 2022-11-09. PMID:36350375. |
compensatory changes in dopaminergic neural pathways in response to elevated dopamine might explain connection between slow movements and irregular muscle contraction. |
2022-11-09 |
2023-08-14 |
Not clear |
| Rachel M Wise, Annika Wagener, Urban M Fietzek, Thomas Klopstock, Eugene V Mosharov, Fabio A Zucca, David Sulzer, Luigi Zecca, Lena F Burbull. Interactions of dopamine, iron, and alpha-synuclein linked to dopaminergic neuron vulnerability in Parkinson's disease and neurodegeneration with brain iron accumulation disorders. Neurobiology of disease. 2022-11-09. PMID:36351559. |
dopamine metabolism, alpha-synuclein pathology, and iron homeostasis have all been implicated as potential contributors to the unique vulnerability of substantia nigra dopaminergic neurons which preferentially decline in parkinson's disease and some rare neurodegenerative disorders with shared pathological features. |
2022-11-09 |
2023-08-14 |
Not clear |
| Shashank Vasudevan, Andrea Dotti, Janko Kajtez, Alberto Martínez-Serrano, Carsten Gundlach, Sandrina Campos Maçãs, Karin Lauschke, Anne-Marie Vinngaard, Silvia García López, Marta Pereira, Arto Heiskanen, Stephan S Keller, Jenny Emnéu. Omnidirectional leaky opto-electrical fiber for optogenetic control of neurons in cell replacement therapy. Bioelectrochemistry (Amsterdam, Netherlands). vol 149. 2022-11-08. PMID:36345111. |
the pathophysiological progress of parkinson's disease leads through degeneration of dopaminergic neurons in the substantia nigra to complete cell death and lack of dopamine in the striatum where it modulates motor functions. |
2022-11-08 |
2023-08-14 |
Not clear |
| Shashank Vasudevan, Andrea Dotti, Janko Kajtez, Alberto Martínez-Serrano, Carsten Gundlach, Sandrina Campos Maçãs, Karin Lauschke, Anne-Marie Vinngaard, Silvia García López, Marta Pereira, Arto Heiskanen, Stephan S Keller, Jenny Emnéu. Omnidirectional leaky opto-electrical fiber for optogenetic control of neurons in cell replacement therapy. Bioelectrochemistry (Amsterdam, Netherlands). vol 149. 2022-11-08. PMID:36345111. |
transplantation of dopaminergic stem cell-derived neurons is a possible therapy to restore dopamine levels. |
2022-11-08 |
2023-08-14 |
Not clear |
| Laísa Aliandro Dos Santos, Gabriela Salles Dos Santos, Gustavo Ariel Borges Fernandes, Michelle Fidelis Corrêa, Carolina Aparecida de Faria Almeida, Liliam Fernandes, Tania Marcourakis, João Paulo S Fernandes, Raphael Caio Tamborelli Garci. Neurotoxicity Assessment of 1-[(2,3-Dihydro-1-Benzofuran-2-yl)Methyl]Piperazine (LINS01 Series) Derivatives and their Protective Effect on Cocaine-Induced Neurotoxicity Model in SH-SY5Y Cell Culture. Neurotoxicity research. 2022-11-07. PMID:36342586. |
excessive levels of dopamine in the synaptic cleft, induced by cocaine for example, activates dopaminergic receptors, mainly d |
2022-11-07 |
2023-08-14 |
Not clear |
| Yingliang Xie, Peizhen Wang, Xiaoyan Cui, Lei Liu, Pengcheng Wang, Shimei Jing, Qi Liu, Yuting Wang, Shiqiang Wan. Retraction notice to "Dopaminergic neurons project to the nucleus accumbens regulates anxiety-like behaviors through dopamine D Behavioural brain research. vol 438. 2022-11-06. PMID:36335880. |
retraction notice to "dopaminergic neurons project to the nucleus accumbens regulates anxiety-like behaviors through dopamine d |
2022-11-06 |
2023-08-14 |
Not clear |
| Shima Tavakol, Elham Hoveizi, Hani Tavakol, Amin Almasi, Mansoureh Soleimani, Shadi Rabiee Motmaen, Fereshteh Azedi, Mohammad Taghi Joghatae. Strong binding of phytochemicals to the catalytic domain of tyrosine hydroxylase as a Trojan horse decreases dopamine in dopaminergic cells: Pharmaceutical considerations in schizophrenia and Parkinson's disease. Current pharmaceutical design. 2022-11-04. PMID:36330626. |
strong binding of phytochemicals to the catalytic domain of tyrosine hydroxylase as a trojan horse decreases dopamine in dopaminergic cells: pharmaceutical considerations in schizophrenia and parkinson's disease. |
2022-11-04 |
2023-08-14 |
Not clear |
| Ichiro Kawahata, Kohji Fukunag. [Development of therapeutic peptides for Lewy body diseases preventing α-synuclein propagation]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 157. issue 6. 2022-11-03. PMID:36328546. |
type 3 fatty acid-binding protein (fabp3) is highly expressed in dopaminergic neurons and has the ability to bind dopamine receptors, particularly dopamine d2 long type (d2l) receptors, which are abundantly localized on caveolae structures in the plasma membrane. |
2022-11-03 |
2023-08-14 |
mouse |
| Lakshmi N Yatham, Peter F Liddle, Marjorie Gonzalez, Gayatri Saraf, Nasim Vafai, Raymond W Lam, Vesna Soss. A Positron Emission Tomography Study of Dopamine Transporter Density in Patients With Bipolar Disorder With Current Mania and Those With Recently Remitted Mania. JAMA psychiatry. 2022-11-02. PMID:36322065. |
although dopamine is implicated in the pathophysiology of bipolar disorder (bd), the precise alterations in the dopaminergic system remain unknown. |
2022-11-02 |
2023-08-14 |
Not clear |
| Eva M Szego, Laura Malz, Nadine Bernhardt, Angela Rösen-Wolff, Björn H Falkenburger, Hella Luksc. Constitutively active STING causes neuroinflammation and degeneration of dopaminergic neurons in mice. eLife. vol 11. 2022-10-31. PMID:36314770. |
in adult mice expressing n153s sting, the number of dopaminergic neurons was smaller than in controls, as was the density of dopaminergic axon terminals and the concentration of dopamine in the striatum. |
2022-10-31 |
2023-08-14 |
mouse |
| Marit F L Ruitenberg, Elger L Abrahamse, Patrick Santens, Wim Notebaer. Testing the dopamine overdose hypothesis in action control: A study in people with Parkinson's disease. Journal of neuropsychology. 2022-10-28. PMID:36303524. |
our findings do not support the notion that dopaminergic medication modulates action control processes, suggesting that the dopamine overdose hypothesis may only apply to a specific set of cognitive processes and should potentially be refined. |
2022-10-28 |
2023-08-14 |
Not clear |