| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Iro Boura, Kallol Ray Chaudhur. Coronavirus Disease 2019 and Related Parkinsonism: The Clinical Evidence Thus Far. Movement disorders clinical practice. 2022-05-23. PMID:35601258. |
this theory is further augmented by reports of a pathogenic effect of the severe acute respiratory syndrome coronavirus-2 (sars-cov-2) on the central nervous system with specific impact on the dopaminergic pathway, as well as the possibility of the virus to selectively bind to angiotensin-converting enzyme-2 (ace-2); these molecules are expressed abundantly in the midbrain dopamine neurons and, are likely involved in several cellular mechanisms cited in parkinson's disease (pd) pathophysiology. |
2022-05-23 |
2023-08-13 |
Not clear |
| Tomoyo Shimada, Ryota Kamo, Kensuke Daida, Kenya Nishioka, Nobutaka Hattori, Taiji Tsunem. Radiation-induced Brain Calcification Leads to L-dopa-resistant Parkinsonism and Cerebellar Ataxia. Internal medicine (Tokyo, Japan). 2022-05-22. PMID:35598989. |
while dopamine transporter-single photon emission computed tomography revealed only slight damage to the dopaminergic striatal pathway, the extension of calcification to the periventricular white matter was likely responsible for her parkinsonism. |
2022-05-22 |
2023-08-13 |
Not clear |
| Pooriya Ghanbari Merdasi, Ramin Abdi Dezfouli, Sajad Mazaheri, Abbas Haghparas. Blocking the dopaminergic receptors in the hippocampal dentate gyrus reduced the stress-induced analgesia in persistent inflammatory pain in the rat. Physiology & behavior. 2022-05-21. PMID:35597308. |
this study aimed to investigate the role of dg dopaminergic receptors (d1- and d2-like dopamine receptors) in stress-induced analgesia (sia) using the formalin test as a persistent inflammatory pain model. |
2022-05-21 |
2023-08-13 |
rat |
| Francesca Montarolo, Serena Martire, Francesco Chiara, Sarah Allegra, Silvia De Francia, Eriola Hoxha, Filippo Tempia, Marco Alfonso Capobianco, Antonio Bertolott. NURR1-deficient mice have age- and sex-specific behavioral phenotypes. Journal of neuroscience research. 2022-05-20. PMID:35593070. |
the transcription factor nurr1 is essential to the generation and maintenance of midbrain dopaminergic (mda) neurons and its deregulation is involved in the development of dopamine (da)-associated brain disorders, such as parkinson's disease (pd). |
2022-05-20 |
2023-08-13 |
mouse |
| Giovanni Palermo, Sara Giannoni, Tommaso Depalo, Daniela Frosini, Duccio Volterrani, Gabriele Siciliano, Ubaldo Bonuccelli, Roberto Ceravol. Negative DAT-SPECT in Old Onset Parkinson's Disease: An Additional Pitfall? Movement disorders clinical practice. vol 9. issue 4. 2022-05-18. PMID:35582312. |
scans without evidence of dopaminergic deficit (swedds) refer to patients clinically diagnosed with parkinson's disease (pd), but showing normal findings on dopamine transporter single-photon emission computed tomography (dat-spect). |
2022-05-18 |
2023-08-13 |
Not clear |
| Ada Sinani, Andriana Vassi, Giota Tsotsokou, Maria Nikolakopoulou, Elias D Kouvelas, Ada Mitsaco. Early life stress influences basal ganglia dopamine receptors and novel object recognition of adolescent and adult rats. IBRO neuroscience reports. vol 12. 2022-05-16. PMID:35572456. |
it is known that the dopaminergic system undergoes significant reorganization during adolescence and that dopamine receptors are involved in recognition memory. |
2022-05-16 |
2023-08-13 |
rat |
| Subhamita Maitra, Mahasweta Chatterjee, Anirban Roychowdhury, Chinmay Kumar Panda, Swagata Sinha, Kanchan Mukhopadhya. Specific dopaminergic genetic variants influence impulsivity, cognitive deficit, and disease severity of Indian ADHD probands. Molecular biology reports. 2022-05-13. PMID:35553330. |
since the dopaminergic system is the primary target for pharmaceutical intervention in adhd, we investigated the association between adhd-related imp and functional gene variants of the dopamine transporter (slc6a3) and catechol-o-methyltransferase involved in dopamine clearance. |
2022-05-13 |
2023-08-13 |
Not clear |
| Ashley Y Gao, Patrick A Link, Sophie J Bakri, Andrew J Haa. Dopamine Receptor Signaling Regulates Fibrotic Activation of Retinal Pigmented Epithelial Cells. American journal of physiology. Cell physiology. 2022-05-11. PMID:35544697. |
drd2 and drd5 are the dominant dopaminergic receptors expressed in arpe-19 cells and tgfβ stimulates enhances autocrine release of dopamine which we show further exasperates fibrotic activation. |
2022-05-11 |
2023-08-13 |
human |
| Björn Falkenburger, Theodoros Kalliakoudas, Heinz Reichman. Adaptive changes in striatal projection neurons explain the long duration response and the emergence of dyskinesias in patients with Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2022-05-10. PMID:35538324. |
moreover, dyskinesias are considered signs of excessive dopaminergic neurotransmission in parkinson's disease, but they are typically more severe on the body side that is more strongly affected by dopamine depletion. |
2022-05-10 |
2023-08-13 |
Not clear |
| Shivangi Gupta, Virendra Tiwari, Priya Tiwari, Parul, Akanksha Mishra, Kashif Hanif, Shubha Shukl. Angiotensin-Converting Enzyme 2 Activation Mitigates Behavioral Deficits and Neuroinflammatory Burden in 6-OHDA Induced Experimental Models of Parkinson's Disease. ACS chemical neuroscience. 2022-05-09. PMID:35533351. |
further, the dize-mediated activation of ace2 led to increased tyrosine hydroxylase (th) and dopamine transporters (dat) expression in the rat brain, indicating the protection of dopaminergic (daergic) neurons from 6-ohda induced neurotoxicity. |
2022-05-09 |
2023-08-13 |
rat |
| Joseph P Schacht, Yeongbin Im, Michaela Hoffman, Konstantin E Voronin, Sarah W Book, Raymond F Anto. Effects of pharmacological and genetic regulation of COMT activity in alcohol use disorder: a randomized, placebo-controlled trial of tolcapone. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-05-06. PMID:35523943. |
inhibition of catechol-o-methyltransferase (comt), the enzyme primarily responsible for cortical dopamine inactivation, may increase cortical dopamine, especially among individuals with genetically mediated lower dopaminergic tone, such as comt rs4680 (val158met) val-allele homozygotes. |
2022-05-06 |
2023-08-13 |
human |
| Arata Oh-Nishi, Yuji Nagai, Chie Seki, Tetsuya Suhara, Takafumi Minamimoto, Makoto Higuch. Imaging extra-striatal dopamine D2 receptors in a maternal immune activation rat model. Brain, behavior, & immunity - health. vol 22. 2022-05-02. PMID:35496774. |
mia in pregnant rodents can be induced by injection of synthetic polyriboinosinic-polyribocytidilic acid (poly i:c), which causes decreased striatal dopamine d2 receptor (d2r) expression and behavioral dysfunction mediated by the dopaminergic system in the offspring. |
2022-05-02 |
2023-08-13 |
rat |
| B A Schuster, S Sowden, A J Rybicki, D S Fraser, C Press, P Holland, J L Coo. Dopaminergic modulation of dynamic emotion perception. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-05-02. PMID:35501156. |
interestingly, whilst a dependence of dopaminergic drug effects on individual baseline dopamine function has been well established in other cognitive domains, the emotion recognition literature so far has failed to account for these possible interindividual differences. |
2022-05-02 |
2023-08-13 |
human |
| B A Schuster, S Sowden, A J Rybicki, D S Fraser, C Press, P Holland, J L Coo. Dopaminergic modulation of dynamic emotion perception. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-05-02. PMID:35501156. |
results highlight the need for future studies to account for baseline dopamine and suggest putative mechanisms underlying the dopaminergic modulation of emotion recognition. |
2022-05-02 |
2023-08-13 |
human |
| Hye-Sun Lim, Gunhyuk Par. Resilin, an insect-derived elastomeric protein, protects dopaminergic neurons in Parkinson disease models. Neuroscience letters. 2022-05-01. PMID:35490904. |
the primary cause of pd is the degeneration of dopaminergic neurons in the substantia nigra pars compacta (snpc) region that subsequently reduces the dopamine content in the striatum (st); this is a promising therapeutic target for pd. |
2022-05-01 |
2023-08-13 |
mouse |
| Enhui He, You Zhou, Jinping Luo, Shihong Xu, Kui Zhang, Yilin Song, Mixia Wang, Shengwei Xu, Yuchuan Dai, Gucheng Yang, Jingyu Xie, Zhaojie Xu, Wanwan Zhu, Yu Deng, Qi Xu, Xinxia Ca. Sensitive detection of electrophysiology and dopamine vesicular exocytosis of hESC-derived dopaminergic neurons using multifunctional microelectrode array. Biosensors & bioelectronics. vol 209. 2022-04-28. PMID:35483214. |
sensitive detection of electrophysiology and dopamine vesicular exocytosis of hesc-derived dopaminergic neurons using multifunctional microelectrode array. |
2022-04-28 |
2023-08-13 |
human |
| Jochem van Kempen, Christian Brandt, Claudia Distler, Mark A Bellgrove, Alexander Thiel. Dopamine influences attentional rate modulation in Macaque posterior parietal cortex. Scientific reports. vol 12. issue 1. 2022-04-28. PMID:35484302. |
although dopamine has historically been studied in relation to frontal functioning, emerging evidence suggests important dopaminergic influences in parietal cortex. |
2022-04-28 |
2023-08-13 |
monkey |
| Beth Fairfield, Caterina Padulo, Nicola Mammarella, Sara Fontanella, Annalina Sarra, Fani Konstantinidou, Liborio Stuppia, Valentina Gatt. Dopamine-related polymorphisms and Affective Working Memory in aging. Neurobiology of learning and memory. 2022-04-26. PMID:35472439. |
the neurotransmitter dopamine (da) is a key regulatory component of executive functioning and dysfunction in dopaminergic circuity has been shown to result in impaired working memory. |
2022-04-26 |
2023-08-13 |
human |
| Xian-Guo Zou, Meng-Ting Xu, Xiao-Li Dong, You-Min Ying, Rong-Fa Guan, Wei-Cheng Wu, Kai Yang, Pei-Long Su. Solid-state-cultured mycelium of Antrodia camphorata exerts potential neuroprotective activities against 6-hydroxydopamine-induced toxicity in PC12 cells. Journal of food biochemistry. 2022-04-25. PMID:35467031. |
the results showed that scmac extracts alleviated cell toxicity induced by 6-ohda and the loss of dopaminergic neurons, which was confirmed by the increase of cell viabilities, inhibition of cell apoptosis, the upregulation of tyrosine hydroxylase (th) and dopamine transporter (dat) levels and the downregulation of α-synuclein level. |
2022-04-25 |
2023-08-13 |
Not clear |
| Natasha M Puri, Giovanna R Romano, Ting-Yu Lin, Quynh N Mai, Roshanak Iranneja. The organic cation Transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus. eLife. vol 11. 2022-04-25. PMID:35467530. |
here, using novel nanobody-based biosensors, we demonstrate for the first time that the dopamine d1 receptor (d1dr), the primary mediator of dopaminergic signaling in the brain and kidney, not only functions on the plasma membrane but becomes activated at the golgi apparatus in the presence of its ligand. |
2022-04-25 |
2023-08-13 |
Not clear |