| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kristina Sabaroedin, Jeggan Tiego, Alex Fornit. Circuit-Based Approaches to Understanding Corticostriatothalamic Dysfunction Across the Psychosis Continuum. Biological psychiatry. 2022-10-17. PMID:36253195. |
dopamine is known to play a role in the pathogenesis of psychotic symptoms, but the mechanisms driving dopaminergic dysfunction in psychosis remain unclear. |
2022-10-17 |
2023-08-14 |
human |
| Dmitry Troshev, Alyona Bannikova, Victor Blokhin, Anna Kolacheva, Tatiana Pronina, Michael Ugrumo. Striatal Neurons Partially Expressing a Dopaminergic Phenotype: Functional Significance and Regulation. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232359. |
in this study, it was shown that in transgenic mice expressing green fluorescent protein (gfp) under the tyrosine hydroxylase (th) gene promoter, (i) there are striatal neurons expressing only th, only aromatic l-amino acid decarboxylase (aadc), or both enzymes of dopamine synthesis; (ii) striatal neurons expressing dopamine-synthesizing enzymes are not dopaminergic since they lack a dopamine transporter; (iii) monoenzymatic neurons expressing individual complementary dopamine-synthesizing enzymes produce this neurotransmitter in cooperation; (iv) striatal nerve fibers containing only th, only aadc, or both enzymes project into the lateral ventricles, providing delivery pathways for l-3,4-dihydroxyphenylalanine and dopamine to the cerebrospinal fluid; and (v) striatal gfp neurons express receptor genes for various signaling molecules, i.e., classical neurotransmitters, neuropeptides, and steroids, indicating fine regulation of these neurons. |
2022-10-14 |
2023-08-14 |
mouse |
| Dmitry Troshev, Alyona Bannikova, Victor Blokhin, Anna Kolacheva, Tatiana Pronina, Michael Ugrumo. Striatal Neurons Partially Expressing a Dopaminergic Phenotype: Functional Significance and Regulation. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232359. |
based on our data, it is assumed that the synthesis of dopamine by striatal neurons is a compensatory response to the death of nigral dopaminergic neurons in parkinson's disease, which opens broad prospects for the development of a fundamentally novel antiparkinsonian therapy. |
2022-10-14 |
2023-08-14 |
mouse |
| Xinjian Zhang, Daisuke Tsuboi, Yasuhiro Funahashi, Yukie Yamahashi, Kozo Kaibuchi, Taku Naga. Phosphorylation Signals Downstream of Dopamine Receptors in Emotional Behaviors: Association with Preference and Avoidance. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232945. |
dopamine regulates emotional behaviors, including rewarding and aversive behaviors, through the mesolimbic dopaminergic pathway, which projects dopamine neurons from the ventral tegmental area to the nucleus accumbens (nac). |
2022-10-14 |
2023-08-14 |
Not clear |
| Allen P F Chen, Jeffrey M Malgady, Lu Chen, Kaiyo W Shi, Eileen Cheng, Joshua L Plotkin, Shaoyu Ge, Qiaojie Xion. Nigrostriatal dopamine pathway regulates auditory discrimination behavior. Nature communications. vol 13. issue 1. 2022-10-08. PMID:36209150. |
in vivo dopamine and calcium imaging in freely behaving mice revealed that this dopaminergic projection modulates striatal tone representations, and tone-evoked striatal dopamine release inversely correlated with the evidence strength of tones. |
2022-10-08 |
2023-08-14 |
mouse |
| Paweł Napora, Anna Kobrzycka, Krystyna Pierzchała-Koziec, Marek Wieczore. Effect of Selective Cyclooxygenase Inhibitors on Animal Behaviour and Monoaminergic Systems of the Rat Brain. Behavioural brain research. 2022-10-07. PMID:36206821. |
we suggest that the effect of used inhibitors on the dopaminergic system is associated with a possible increase in anandamide concentration and its effect on dopamine reuptake in synaptic clefts. |
2022-10-07 |
2023-08-14 |
rat |
| In-Cheol Chae, Jung-Hee Jang, In-Chan Seol, Yoon-Sik Kim, Gunhyuk Park, Ho-Ryong Yo. Ukgansan Protects Dopaminergic Neurons against MPTP-Induced Neurotoxicity via the Nurr1 Signaling Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-10-04. PMID:36193151. |
parkinson's disease is a neurodegenerative disorder caused by the destruction of dopaminergic neurons in the substantia nigra pars compacta (snpc), and the long-term use of conventional dopamine replacement therapies causes many side effects, highlighting the need for new treatments such as complementary and alternative medicine. |
2022-10-04 |
2023-08-14 |
mouse |
| In-Cheol Chae, Jung-Hee Jang, In-Chan Seol, Yoon-Sik Kim, Gunhyuk Park, Ho-Ryong Yo. Ukgansan Protects Dopaminergic Neurons against MPTP-Induced Neurotoxicity via the Nurr1 Signaling Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-10-04. PMID:36193151. |
specifically, this study demonstrated the effect of ukgansan in protecting dopaminergic neurons and increasing nurr1 involved in maintaining dopamine levels by activating nurr1 expression in mptp-induced pc12 cells and a mouse model of pd. |
2022-10-04 |
2023-08-14 |
mouse |
| In-Cheol Chae, Jung-Hee Jang, In-Chan Seol, Yoon-Sik Kim, Gunhyuk Park, Ho-Ryong Yo. Ukgansan Protects Dopaminergic Neurons against MPTP-Induced Neurotoxicity via the Nurr1 Signaling Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-10-04. PMID:36193151. |
in this mechanism, the loss of dopaminergic neurons and dopamine depletion were suppressed, and motor impairment caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity was improved. |
2022-10-04 |
2023-08-14 |
mouse |
| Song-Yu Guo, Rong-Xiao Guan, Xiao-Dong Chi, Yue-Zhang, Ao-Ran Sui, Wei Zhao, Supratik Kundu, Jin-Yi Yang, Jie Zhao, Shao L. Scorpion venom heat-resistant synthetic peptide protects dopamine neurons against 6-hydroxydopamine neurotoxicity in C. elegans. Brain research bulletin. 2022-10-03. PMID:36191729. |
the main pathological feature is the degeneration and loss of dopaminergic neurons in the substantia nigra, which leads to the significant decrease of dopamine content in the striatum. |
2022-10-03 |
2023-08-14 |
caenorhabditis_elegans |
| Yang Liu, Nanshan Song, Hang Yao, Siyuan Jiang, Yueping Wang, Ying Zheng, Yuanzhang Zhou, Jianhua Ding, Gang Hu, Ming L. β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression. Journal of neuroinflammation. vol 19. issue 1. 2022-10-01. PMID:36183107. |
multiple evidence suggests that dopamine (da) and dopaminergic signals associated with neuroinflammation are highly involved in the pathophysiology of depression as well as in the mechanism of antidepressant drugs, which is still in the early stage of study and well worthy of investigation. |
2022-10-01 |
2023-08-14 |
mouse |
| Thanh-Van Le, Sang-Wha Le. Core-shell Au-Ag nanoparticles as colorimetric sensing probes for highly selective detection of a dopamine neurotransmitter under different pH conditions. Dalton transactions (Cambridge, England : 2003). 2022-09-29. PMID:36172825. |
dopamine (da) is a vital biomarker for the early diagnosis of dopaminergic dysfunction; therefore, it is important to establish a direct and selective detection tool for da neurotransmitters. |
2022-09-29 |
2023-08-14 |
human |
| Kevin Butler, Bernard Le Foll, Patricia Di Cian. The Role of Dopamine D3 Receptors in Tobacco Use Disorder: A Synthesis of the Preclinical and Clinical Literature. Current topics in behavioral neurosciences. 2022-09-29. PMID:36173599. |
dopamine has a well-established role in substance use disorders, including tud, and there has been a long-standing interest in developing agents that target the dopaminergic system to treat substance use disorders. |
2022-09-29 |
2023-08-14 |
human |
| Claudette Barreto, Ana Vila Irigoyen, Olga Lopez, Leonard Gralni. Psychostimulants for the Treatment of Comorbid Post-traumatic Stress Disorder (PTSD) in a Patient With Attention-Deficit/Hyperactivity Disorder (ADHD): A Case Report and Literature Summary. Cureus. vol 14. issue 8. 2022-09-26. PMID:36158332. |
decreased dopaminergic receptors are associated with developing ptsd and psychostimulants are known to have an effect of increasing dopamine release. |
2022-09-26 |
2023-08-14 |
Not clear |
| Meijun Pang, Rui Peng, Yiwen Wang, Yi Zhu, Peng Wang, Bernard Moussian, Yanfang Su, Xiuyun Liu, Dong Min. Molecular understanding of the translational models and the therapeutic potential natural products of Parkinson's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 155. 2022-09-24. PMID:36152409. |
the mechanism of parkinson's disease still remains unknown, however, studies already proved that the damage or absence of dopaminergic neurons located in the substantia nigra and the decreased dopamine in the striatum are significantly related to parkinson's disease. |
2022-09-24 |
2023-08-14 |
Not clear |
| Alexander N Rodichkin, Melissa K Edler, Jennifer L McGlothan, Tomás R Guilart. Pathophysiological studies of aging Slc39a14 knockout mice to assess the progression of Manganese-Induced Dystonia-Parkinsonism. Neurotoxicology. 2022-09-24. PMID:36152728. |
neurochemical, neuropathological, and functional assessment of the dopaminergic system of the basal ganglia revealed absence of neurodegenerative changes of dopamine (da) neurons in the substantia nigra pars compacta (snc), with no changes in da or metabolite concentrations in the striatum of slc39a14-ko mice relative to wildtype (wt). |
2022-09-24 |
2023-08-14 |
mouse |
| Emma Veronica Carsana, Matteo Audano, Silvia Breviario, Silvia Pedretti, Massimo Aureli, Giulia Lunghi, Nico Mitr. Metabolic Profile Variations along the Differentiation of Human-Induced Pluripotent Stem Cells to Dopaminergic Neurons. Biomedicines. vol 10. issue 9. 2022-09-23. PMID:36140170. |
interestingly, in neuronal precursors, we observed an increase in amino acids that are likely the result of increased uptake or synthesis, while in mature dopaminergic neurons, we also observed an augmented content of those amino acids needed for dopamine synthesis. |
2022-09-23 |
2023-08-14 |
Not clear |
| Valeria V Goloborshcheva, Valerian G Kucheryanu, Natalia A Voronina, Ekaterina V Teterina, Aleksey A Ustyugov, Sergei G Morozo. Synuclein Proteins in MPTP-Induced Death of Substantia Nigra Pars Compacta Dopaminergic Neurons. Biomedicines. vol 10. issue 9. 2022-09-23. PMID:36140378. |
parkinson's disease (pd) is one of the key neurodegenerative disorders caused by a dopamine deficiency in the striatum due to the death of dopaminergic (da) neurons of the substantia nigra pars compacta. |
2022-09-23 |
2023-08-14 |
Not clear |
| Luoyi Huang, Chiara Palmieri, François-René Berti. Correlation of pituitary histomorphometry with dopamine and dopamine D2 receptor expression in horses with pituitary pars intermedia dysfunction. Research in veterinary science. vol 152. 2022-09-20. PMID:36126509. |
previous studies have observed neurodegeneration of the dopaminergic inhibition of melanotrophs, which leads to decreased dopamine (da) in the pars intermedia (pi) and increased pro-opiomelanocortin-derived peptides circulating in plasma. |
2022-09-20 |
2023-08-14 |
rat |
| Soomin Jeong, Soogyeong Jang, Seong Soon Kim, Myung Ae Bae, Junnyung Shin, Ki-Baek Lee, Ki-Tae Ki. Size-dependent seizurogenic effect of polystyrene microplastics in zebrafish embryos. Journal of hazardous materials. vol 439. 2022-09-15. PMID:36104895. |
additionally, an increase in the levels of neurochemicals choline, betaine, dopamine, 3-methoxytyramine, and gamma-aminobutyric acid indicated that the observed hypoactivity and seizure-like behavior were associated with the dysregulation of the cholinergic, dopaminergic, and gabaergic systems. |
2022-09-15 |
2023-08-14 |
zebrafish |