| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guillermo Fernández, Favio Krapacher, Soledad Ferreras, Gonzalo Quassollo, Macarena Mariel Mari, María Victoria Pisano, Antonella Montemerlo, María Dolores Rubianes, Claudia Bregonzio, Carlos Arias, María Gabriela Paglin. Lack of Cdk5 activity is involved on Dopamine Transporter expression and function: Evidences from an animal model of Attention-Deficit Hyperactivity Disorder. Experimental neurology. vol 346. 2021-10-04. PMID:34537209. |
interestingly, dopaminergic neurotransmission is altered in these mice as they have an increased dopamine (da) content together with a low da turnover. |
2021-10-04 |
2023-08-13 |
mouse |
| Anthony M Downs, Xueliang Fan, Radhika F Kadakia, Yuping Donsante, H A Jinnah, Ellen J Hes. Cell-intrinsic effects of TorsinA(ΔE) disrupt dopamine release in a mouse model of TOR1A dystonia. Neurobiology of disease. vol 155. 2021-10-02. PMID:33894367. |
because striatal cholinergic neurotransmission mediates dopamine release, it is not known if the dopamine release deficit is mediated indirectly by abnormal acetylcholine neurotransmission or if tor1a(Δe) acts directly within dopaminergic neurons to attenuate release. |
2021-10-02 |
2023-08-13 |
mouse |
| Sara Dominguez, Eugene Varfolomeev, Robert Brendza, Kim Stark, Joy Tea, Jose Imperio, Hai Ngu, Timothy Earr, Oded Foreman, Joshua D Webster, Amy Easton, Domagoj Vucic, Baris Bingo. Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS. Cell death and differentiation. vol 28. issue 3. 2021-10-01. PMID:32994544. |
on the other hand, genetic inactivation of rip1 kinase activity ameliorated the depletion of the neurotransmitter dopamine in a toxin model of dopaminergic neurodegeneration. |
2021-10-01 |
2023-08-13 |
mouse |
| Adriano Lama, Claudio Pirozzi, Carmen Avagliano, Chiara Annunziata, Maria Pina Mollica, Antonio Calignano, Rosaria Meli, Giuseppina Mattace Ras. Nutraceuticals: An integrative approach to starve Parkinson's disease. Brain, behavior, & immunity - health. vol 2. 2021-10-01. PMID:34589828. |
current treatment approaches include mainly dopamine replacement therapy or optimizing dopaminergic transmission; however, these strategies that do not counteract the pathogenic mechanisms underlying pd symptoms and often are less effective over time. |
2021-10-01 |
2023-08-13 |
Not clear |
| Taruna Pandey, Aparna Shukla, Mashu Trivedi, Feroz Khan, Rakesh Pande. Swertiamarin from Enicostemma littorale, counteracts PD associated neurotoxicity via enhancement α-synuclein suppressive genes and SKN-1/NRF-2 activation through MAPK pathway. Bioorganic chemistry. vol 108. 2021-09-30. PMID:33548732. |
the neuroprotective effect of sw was evident from the robust reduction of 6-hydroxydopamine (6-ohda) induced dopaminergic neurodegeneration independent of dopamine transporter (dat-1). |
2021-09-30 |
2023-08-13 |
caenorhabditis_elegans |
| R A Nolan, K L Reeb, Y Rong, S M Matt, H S Johnson, K Runner, P J Gaskil. Dopamine activates NF-κB and primes the NLRP3 inflammasome in primary human macrophages. Brain, behavior, & immunity - health. vol 2. 2021-09-29. PMID:33665636. |
all addictive drugs modulate the dopaminergic system and our previous studies have identified dopamine as a pro-inflammatory modulator of macrophage function. |
2021-09-29 |
2023-08-13 |
human |
| Federica Bono, Veronica Mutti, Paola Devoto, Silvia Bolognin, Jens C Schwamborn, Cristina Missale, Chiara Fiorentin. Impaired dopamine D3 and nicotinic acetylcholine receptor membrane localization in iPSCs-derived dopaminergic neurons from two Parkinson's disease patients carrying the LRRK2 G2019S mutation. Neurobiology of aging. vol 99. 2021-09-28. PMID:33422895. |
impaired dopamine d3 and nicotinic acetylcholine receptor membrane localization in ipscs-derived dopaminergic neurons from two parkinson's disease patients carrying the lrrk2 g2019s mutation. |
2021-09-28 |
2023-08-13 |
Not clear |
| Huimin Zheng, Changhe Shi, Haiyang Luo, Liyuan Fan, Zhihua Yang, Xinchao Hu, Zhongxian Zhang, Shuo Zhang, Zhengwei Hu, Yu Fan, Jing Yang, Chengyuan Mao, Yuming X. α-Synuclein in Parkinson's Disease: Does a Prion-Like Mechanism of Propagation from Periphery to the Brain Play a Role? The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 27. issue 4. 2021-09-24. PMID:32729773. |
parkinson's disease (pd) is one of the most common neurodegenerative diseases, defined as motor and non-motor symptoms associated with the loss of dopaminergic neurons and a decreased release of dopamine (da). |
2021-09-24 |
2023-08-13 |
Not clear |
| Ece Bayram, Irene Litvan, Brenton A Wright, Cailey Grembowski, Qian Shen, Deborah L Harringto. Dopamine effects on memory load and distraction during visuospatial working memory in cognitively normal Parkinson's disease. Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition. vol 28. issue 6. 2021-09-23. PMID:33021874. |
wm is regulated by dopaminergic neurotransmission in the prefrontal cortex, but the effect of dopamine on specific processes supporting visuospatial wm are not well understood. |
2021-09-23 |
2023-08-13 |
human |
| Sanne K Meles, Wolfgang H Oertel, Klaus L Leender. Circuit imaging biomarkers in preclinical and prodromal Parkinson's disease. Molecular medicine (Cambridge, Mass.). vol 27. issue 1. 2021-09-23. PMID:34530732. |
studies have focused on radiotracer imaging of the dopaminergic nigrostriatal system, which can be assessed with dopamine transporter (dat) single photon emission computed tomography (spect). |
2021-09-23 |
2023-08-13 |
human |
| José Ángel García-Pedraza, Asunción Morán, María Luisa Martín, Claudia Ollauri-Ibáñez, Alicia Rodríguez-Barbero, Carlos M Villalón, Mónica García-Doming. Dopamine D Pflugers Archiv : European journal of physiology. vol 472. issue 12. 2021-09-22. PMID:32820344. |
dopamine d the dopaminergic system influences the heart rhythm by inhibiting the rat cardiac sympathetic and parasympathetic neurotransmissions through activation of d |
2021-09-22 |
2023-08-13 |
rat |
| Sven R Suwijn, Hamdia Samim, Carsten Eggers, Alberto J Espay, Susan Fox, Anthony E Lang, Mike Samuel, Monty Silverdale, Constant V M Verschuur, Joke M Dijk, Hein J Verberne, Jan Booij, Rob M A de Bi. Value of Clinical Signs in Identifying Patients with Scans without Evidence of Dopaminergic Deficit (SWEDD). Journal of Parkinson's disease. vol 10. issue 4. 2021-09-17. PMID:32597819. |
in clinical trials that recruited patients with early parkinson's disease (pd), 4-15% of the participants with a clinical diagnosis of pd had normal dopamine transporter single photon emission computed tomography (dat spect) scans, also called "scans without evidence of dopaminergic deficit" (swedd). |
2021-09-17 |
2023-08-13 |
human |
| Richard L Jayaraj, Rami Beiram, Sheikh Azimullah, Nagoor Meeran M F, Shreesh K Ojha, Abdu Adem, Fakhreya Yousuf Jala. Noscapine Prevents Rotenone-Induced Neurotoxicity: Involvement of Oxidative Stress, Neuroinflammation and Autophagy Pathways. Molecules (Basel, Switzerland). vol 26. issue 15. 2021-09-17. PMID:34361780. |
parkinson's disease is characterized by the loss of dopaminergic neurons in substantia nigra pars compacta (snpc) and the resultant loss of dopamine in the striatum. |
2021-09-17 |
2023-08-13 |
rat |
| Rita R Fagan, Patrick J Kearney, Dino Luethi, Nicholas C Bolden, Harald H Sitte, Patrick Emery, Haley E Melikia. Dopaminergic Ric GTPase activity impacts amphetamine sensitivity and sleep quality in a dopamine transporter-dependent manner in Drosophila melanogaster. Molecular psychiatry. 2021-09-17. PMID:34471250. |
dopaminergic ric gtpase activity impacts amphetamine sensitivity and sleep quality in a dopamine transporter-dependent manner in drosophila melanogaster. |
2021-09-17 |
2023-08-13 |
mouse |
| Loredana Leggio, Greta Paternò, Silvia Vivarelli, Giovanna G Falzone, Carmela Giachino, Bianca Marchetti, Nunzio Irac. Extracellular Vesicles as Novel Diagnostic and Prognostic Biomarkers for Parkinson's Disease. Aging and disease. vol 12. issue 6. 2021-09-17. PMID:34527424. |
pd is characterized by the progressive degeneration of dopaminergic neurons, with consequent dopamine depletion, and the accumulation of misfolded α-synuclein aggregates. |
2021-09-17 |
2023-08-13 |
Not clear |
| Tomasz Maciej Stepniewski, Arturo Mancini, Richard Ågren, Mariona Torrens-Fontanals, Meriem Semache, Michel Bouvier, Kristoffer Sahlholm, Billy Breton, Jana Selen. Mechanistic insights into dopaminergic and serotonergic neurotransmission - concerted interactions with helices 5 and 6 drive the functional outcome. Chemical science. vol 12. issue 33. 2021-09-16. PMID:34522296. |
in this work, we combine molecular dynamics simulations, live-cell biosensor and electrophysiological assays to investigate the action of the neurotransmitter dopamine at the dopaminergic d |
2021-09-16 |
2023-08-13 |
Not clear |
| Seok Jong Chung, Sangwon Lee, Han Soo Yoo, Yang Hyun Lee, Hye Sun Lee, Yonghoon Choi, Phil Hyu Lee, Mijin Yun, Young H Soh. Association of the Non-Motor Burden with Patterns of Striatal Dopamine Loss in de novo Parkinson's Disease. Journal of Parkinson's disease. vol 10. issue 4. 2021-09-15. PMID:32925098. |
striatal dopamine deficits play a key role in the pathogenesis of parkinson's disease (pd), and several non-motor symptoms (nmss) have a dopaminergic component. |
2021-09-15 |
2023-08-13 |
Not clear |
| Yue Yu, Richard P S de Campos, Seolim Hong, Dimitar L Krastev, Siddharth Sadanand, Yen Leung, Aaron R Wheele. A microfluidic platform for continuous monitoring of dopamine homeostasis in dopaminergic cells. Microsystems & nanoengineering. vol 5. 2021-09-14. PMID:31057937. |
a microfluidic platform for continuous monitoring of dopamine homeostasis in dopaminergic cells. |
2021-09-14 |
2023-08-13 |
Not clear |
| Yue Yu, Richard P S de Campos, Seolim Hong, Dimitar L Krastev, Siddharth Sadanand, Yen Leung, Aaron R Wheele. A microfluidic platform for continuous monitoring of dopamine homeostasis in dopaminergic cells. Microsystems & nanoengineering. vol 5. 2021-09-14. PMID:31057937. |
in response to this challenge, we introduce an integrated microfluidic system that combines dopaminergic cell culture and differentiation with electroanalytical measurements of extracellular dopamine in real |
2021-09-14 |
2023-08-13 |
Not clear |
| Peter A Kempster, Laura Perju-Dumbrav. The Thermodynamic Consequences of Parkinson's Disease. Frontiers in neurology. vol 12. 2021-09-14. PMID:34512508. |
that the dopaminergic deficit of pd creates a problem with energy efficiency highlights the role played by the basal ganglia, and by dopamine, in thermodynamic governance. |
2021-09-14 |
2023-08-13 |
Not clear |