| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J F Chen, V J Aloyo, Z H Qin, B Weis. Irreversible blockade of D2 dopamine receptors by fluphenazine-N-mustard increases D2 dopamine receptor mRNA and proenkephalin mRNA and decreases D1 dopamine receptor mRNA and mu and delta opioid receptors in rat striatum. Neurochemistry international. vol 25. issue 4. 1995-02-16. PMID:7820070. |
these results suggest that persistent inhibition of d2 dopamine receptors differentially regulates the expression of d1 and d2 dopamine receptor mrna in striatum, and that the magnitude, duration and interval of inhibiting dopaminergic transmission may be important factors in regulating dopamine receptor mrna expression. |
1995-02-16 |
2023-08-12 |
rat |
| N Ogaw. Levodopa and dopamine agonists in the treatment of Parkinson's disease: advantages and disadvantages. European neurology. vol 34 Suppl 3. 1995-02-16. PMID:7821332. |
we then evaluated the protective effects of bromocriptine on striatal dopaminergic neurons, with determination of dopamine (da) and its metabolites as markers. |
1995-02-16 |
2023-08-12 |
mouse |
| S D Glick, M E Kuehne, J Raucci, T E Wilson, D Larson, R W Keller, J N Carlso. Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Brain research. vol 657. issue 1-2. 1995-02-14. PMID:7820611. |
lastly, in view of the involvement of the dopaminergic mesolimbic system in the actions of drugs of abuse, the effects of some of the iboga alkaloids on extracellular levels of dopamine and its metabolites in the nucleus accumbens and striatum were determined. |
1995-02-14 |
2023-08-12 |
rat |
| M K Sanghera, K F Manaye, C L Liang, A M Lacopino, M J Bannon, D C Germa. Low dopamine transporter mRNA levels in midbrain regions containing calbindin. Neuroreport. vol 5. issue 13. 1995-02-10. PMID:7819538. |
the dopamine transporter (dat) is the site at which the neurotoxic metabolite of mptp gains access to midbrain dopaminergic (da) neurons. |
1995-02-10 |
2023-08-12 |
mouse |
| M Hankins, H Iked. Early abnormalities of retinal dopamine pathways in rats with hereditary retinal dystrophy. Documenta ophthalmologica. Advances in ophthalmology. vol 86. issue 3. 1995-02-09. PMID:7813383. |
in the period preceding degeneration, the rcs retina thus displays a discrete abnormality in dopaminergic pathways, such that there is a gross reduction in endogenous dopamine release below that required to activate d1 receptors. |
1995-02-09 |
2023-08-12 |
rat |
| J Kornhuber, M Welle. [Current status of biochemical hypotheses in the pathogenesis of schizophrenia]. Der Nervenarzt. vol 65. issue 11. 1995-02-09. PMID:7816150. |
the main focus of interest has shifted in recent years from the classical dopamine hypothesis to an increasing set of various neurotransmitter imbalance models of schizophrenic psychoses involving not only the dopaminergic system but also glutamatergic, serotonergic, cholinergic, gabaergic or peptidergic neuron systems. |
1995-02-09 |
2023-08-12 |
human |
| R Spanagel, B Eilbacher, R Wilk. Memantine-induced dopamine release in the prefrontal cortex and striatum of the rat--a pharmacokinetic microdialysis study. European journal of pharmacology. vol 262. issue 1-2. 1995-02-08. PMID:7813574. |
these data demonstrate enhanced dopamine release and metabolism after memantine treatment and support the assumption of an interaction between noncompetitive nmda-receptor antagonists and dopaminergic systems. |
1995-02-08 |
2023-08-12 |
rat |
| G V Rebec, R C Pierc. A vitamin as neuromodulator: ascorbate release into the extracellular fluid of the brain regulates dopaminergic and glutamatergic transmission. Progress in neurobiology. vol 43. issue 6. 1995-02-07. PMID:7816935. |
ascorbate release is regulated, at least in part, by dopaminergic mechanisms, which appear to involve both the d1 and d2 family of dopamine receptors. |
1995-02-07 |
2023-08-12 |
Not clear |
| S Nanko, R Fukuda, M Hattori, T Sasaki, X Y Dai, K Yamaguchi, H Kazamatsur. Further evidence of no linkage between schizophrenia and the dopamine D3 receptor gene locus. American journal of medical genetics. vol 54. issue 3. 1995-02-01. PMID:7810586. |
the dopamine hypothesis of schizophrenia proposed that dopaminergic pathways are involved in the etiology of the disease. |
1995-02-01 |
2023-08-12 |
Not clear |
| E Melame. Biochemical and functional differences between dopamine formed from endogenous tyrosine and exogenous L-dopa in nigrostriatal dopaminergic neurons. Neurochemistry international. vol 20 Suppl. 1995-01-30. PMID:1365408. |
biochemical and functional differences between dopamine formed from endogenous tyrosine and exogenous l-dopa in nigrostriatal dopaminergic neurons. |
1995-01-30 |
2023-08-11 |
Not clear |
| G Mengod, M T Villaró, G B Landwehrmeyer, M I Martinez-Mir, H B Niznik, R K Sunahara, P Seeman, B F O'Dowd, A Probst, J M Palacio. Visualization of dopamine D1, D2 and D3 receptor mRNAs in human and rat brain. Neurochemistry international. vol 20 Suppl. 1995-01-30. PMID:1365451. |
in contrast, dopamine d2 receptor mrna was found in dopaminergic neurons of the substantia nigra pars compacta and of the ventral tegmental area. |
1995-01-30 |
2023-08-11 |
human |
| P Onali, E Mosca, M C Oliana. Presynaptic dopamine autoreceptors and second messengers controlling tyrosine hydroxylase activity in rat brain. Neurochemistry international. vol 20 Suppl. 1995-01-30. PMID:1365463. |
in brain areas enriched of dopaminergic nerve terminals presynaptic dopamine (da) autoreceptors control the state of activation of tyrosine hydroxylase (th) by regulating the extent of phosphorylation of the enzyme. |
1995-01-30 |
2023-08-11 |
rat |
| J H Meador-Woodruf. Update on dopamine receptors. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists. vol 6. issue 2. 1995-01-30. PMID:7804392. |
the distinct distributions of each of the dopamine receptors in brain facilitates a new understanding of potential neurochemical and neuroanatomical substrates of psychiatric illnesses such as schizophrenia, permits an understanding of observed actions and side effects of psychotropic agents, and provides clues for the rational development of new drugs with effects in the dopaminergic system. |
1995-01-30 |
2023-08-12 |
Not clear |
| A M Persico, Z W Wang, D W Black, N C Andreasen, G R Uhl, R R Crow. Exclusion of close linkage of the dopamine transporter gene with schizophrenia spectrum disorders. The American journal of psychiatry. vol 152. issue 1. 1995-01-25. PMID:7802105. |
involvement of genetic factors in the pathogenesis of schizophrenia spectrum disorders has been indicated in twin, adoption, and familial aggregation studies; the pivotal role played by the dopamine transporter in dopaminergic neurotransmission makes it a candidate gene for these disorders. |
1995-01-25 |
2023-08-12 |
Not clear |
| M Amalric, A Ouagazzal, C Baunez, A Nieoullo. Functional interactions between glutamate and dopamine in the rat striatum. Neurochemistry international. vol 25. issue 2. 1995-01-19. PMID:7994193. |
dopamine injected in the same striatal locations induced effects similar to apv on locomotion and reaction-time performance, in agreement with the proposal for a functional antagonism between the glutamatergic and the dopaminergic transmission at striatal level. |
1995-01-19 |
2023-08-12 |
rat |
| K W Lange, P Riederer, M B Youdi. Biochemical actions of l-deprenyl (selegiline). Clinical pharmacology and therapeutics. vol 56. issue 6 Pt 2. 1995-01-18. PMID:7995015. |
because parkinson's disease is characterized by a decrease in dopaminergic neurotransmission in the basal ganglia, the selective inhibition of mao-b should lead to diminished metabolism of dopamine in the nigrostriatal system and a significant increase in the concentration of the neurotransmitter. |
1995-01-18 |
2023-08-12 |
human |
| R K Støving, J Hangaard, K K Pedersen, C Hage. [Menstruation disorders in insulin-dependent diabetes mellitus--epidemiology and causes]. Ugeskrift for laeger. vol 156. issue 42. 1995-01-18. PMID:7998353. |
dopamine and opiates exert an inhibitory effect, and there is evidence for an abnormally high dopaminergic hypothalamic activity among women with iddm. |
1995-01-18 |
2023-08-12 |
Not clear |
| A Björk, E Christensson, A Albinsson, B Gustafsson, E Pettersson, G Pettersson, J Svartengren, G Andersso. In the search for a novel class of antipsychotic drugs: preclinical pharmacology of FG5803, a 1-piperazinecarboxamide derivative. The Journal of pharmacology and experimental therapeutics. vol 271. issue 3. 1995-01-17. PMID:7996444. |
in behavioral studies in rats, fg5803 showed strong antagonistic action on presynaptic dopaminergic autoreceptors but only weak postsynaptic dopamine d2 blockade. |
1995-01-17 |
2023-08-12 |
mouse |
| K X Huang, J R Walter. Electrophysiological effects of SKF 38393 in rats with reserpine treatment and 6-hydroxydopamine-induced nigrostriatal lesions reveal two types of plasticity in D1 dopamine receptor modulation of basal ganglia output. The Journal of pharmacology and experimental therapeutics. vol 271. issue 3. 1995-01-17. PMID:7996456. |
to examine the role of d1 dopamine receptors in modulating basal ganglia output and how this role may be altered by changes in dopaminergic transmission, the effects of a d1 dopamine agonist on firing rates of substantia nigra pars reticulata (snpr) neurons were determined in reserpine-treated rats and compared with effects observed in nigrostriatal-lesioned and normal rats. |
1995-01-17 |
2023-08-12 |
rat |
| M J Andreu, J C Dávila, A de la Calle, S Guirad. Monoaminergic innervation patterns in the anterior dorsal ventricular ridge of a lacertid lizard, Psammodromus algirus. Brain, behavior and evolution. vol 44. issue 3. 1995-01-09. PMID:7987666. |
with regard to regional patterns, dopamine exhibited major differences in the mediolateral axis of the anterior dorsal ventricular ridge: dopaminergic innervation was densest in the lateral region, which in other reptiles is described as a target of visual thalamic projections. |
1995-01-09 |
2023-08-12 |
Not clear |