| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E C Hirsc. Biochemistry of Parkinson's disease with special reference to the dopaminergic systems. Molecular neurobiology. vol 9. issue 1-3. 1995-04-18. PMID:7888089. |
the cardinal neurochemical abnormality in parkinson's disease is the decreased dopamine content in the striatum, resulting from the loss of dopaminergic neurons in the mesencephalon. |
1995-04-18 |
2023-08-12 |
Not clear |
| C G Charlton, J Mac. Substantia nigra degeneration and tyrosine hydroxylase depletion caused by excess S-adenosylmethionine in the rat brain. Support for an excess methylation hypothesis for parkinsonism. Molecular neurobiology. vol 9. issue 1-3. 1995-04-18. PMID:7888091. |
the major symptoms of parkinson's disease (pd) are tremors, hypokinesia, rigidity, and abnormal posture, caused by degeneration of dopamine (da) neurons in the substantia nigra (sn) and deficiency of da in the neostriatal dopaminergic terminals. |
1995-04-18 |
2023-08-12 |
rat |
| J R Simon, B Ghett. The weaver mutant mouse as a model of nigrostriatal dysfunction. Molecular neurobiology. vol 9. issue 1-3. 1995-04-18. PMID:7888095. |
in summary, the weaver mutant mouse has dramatic deficits in the nigrostriatal pathway, but also seems to develop certain adaptive mechanisms in dopaminergic and other transmitter systems that may compensate functionally for the dopamine deficit. |
1995-04-18 |
2023-08-12 |
mouse |
| M B Mattammal, R Strong, V M Lakshmi, H D Chung, A H Stephenso. Prostaglandin H synthetase-mediated metabolism of dopamine: implication for Parkinson's disease. Journal of neurochemistry. vol 64. issue 4. 1995-04-18. PMID:7891092. |
phs catalyzed cooxidation of dopamine in dopaminergic neuronal degeneration is discussed. |
1995-04-18 |
2023-08-12 |
cattle |
| P M Iuvone, J Ga. Functional interaction of melatonin receptors and D1 dopamine receptors in cultured chick retinal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 3 Pt 2. 1995-04-17. PMID:7534345. |
these results suggest that melatonin receptors are coupled to dopamine receptor-regulated adenylate cyclase via an inhibitory g protein, and demonstrate another mechanism, in addition to inhibition of dopamine release, through which melatonin can modulate dopaminergic neurotransmission. |
1995-04-17 |
2023-08-12 |
chicken |
| E M Frodl, N Nakao, P Brundi. Lazaroids improve the survival of cultured rat embryonic mesencephalic neurones. Neuroreport. vol 5. issue 17. 1995-04-13. PMID:7881066. |
these findings suggest that oxidative stress plays an important role in the death of cultured embryonic dopamine neurones and that lazaroids may be potent neuroprotective agents in situations where dopaminergic neurones degenerate. |
1995-04-13 |
2023-08-12 |
rat |
| T Willemse, J A Mo. Comparison of in vivo and in vitro corticotropin-releasing hormone-stimulated release of proopiomelanocortin-derived peptides in cats. American journal of veterinary research. vol 55. issue 12. 1995-04-13. PMID:7887510. |
the msh release from the pars intermedia is sensitive to dopaminergic inhibition, indicating that dopamine may have a central role in regulation of msh secretion in cats. |
1995-04-13 |
2023-08-12 |
Not clear |
| H Onoe, O Inoue, K Suzuki, H Tsukada, T Itoh, N Mataga, Y Watanab. Ketamine increases the striatal N-[11C]methylspiperone binding in vivo: positron emission tomography study using conscious rhesus monkey. Brain research. vol 663. issue 2. 1995-04-06. PMID:7874501. |
these results indicate that ketamine facilitates striatal dopaminergic neurotransmission through increasing the binding activity of dopamine d2 receptors in the striatum, and suggest that these changes may be related to the psychotomimetic behavioral symptoms of this drug. |
1995-04-06 |
2023-08-12 |
monkey |
| D Lévesque, M P Martres, J Diaz, N Griffon, C H Lammers, P Sokoloff, J C Schwart. A paradoxical regulation of the dopamine D3 receptor expression suggests the involvement of an anterograde factor from dopamine neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 5. 1995-04-04. PMID:7878047. |
the effects of interruption of dopaminergic transmission or sustained blockade of dopamine receptors by neuroleptics on the dopamine d3 receptor in the shell of the nucleus accumbens were investigated in rats. |
1995-04-04 |
2023-08-12 |
rat |
| D Lévesque, M P Martres, J Diaz, N Griffon, C H Lammers, P Sokoloff, J C Schwart. A paradoxical regulation of the dopamine D3 receptor expression suggests the involvement of an anterograde factor from dopamine neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 5. 1995-04-04. PMID:7878047. |
we therefore propose that an anterograde factor present in mesolimbic dopaminergic neurons, but distinct from dopamine and known peptide cotransmitters, plays a positive role on transcription of the d3 receptor gene. |
1995-04-04 |
2023-08-12 |
rat |
| J M Rivet, V Audinot, A Gobert, J L Peglion, M J Milla. Modulation of mesolimbic dopamine release by the selective dopamine D3 receptor antagonist, (+)-S 14297. European journal of pharmacology. vol 265. issue 3. 1995-04-03. PMID:7875234. |
in conclusion, data obtained with the novel, selective dopamine d3 receptor antagonist, (+)-s 14297 suggest that dopamine d3 autoreceptors modulate the release of dopamine from mesolimbic dopaminergic neurones. |
1995-04-03 |
2023-08-12 |
rat |
| O Lingjaerd. New perspectives on biological treatment of schizophrenia. Acta psychiatrica Scandinavica. Supplementum. vol 384. 1995-03-31. PMID:7879631. |
to obtain such improvement, it seems necessary, in addition to blocking dopamine d2 receptors, to influence other receptor systems, as for instance serotonergic 5ht-2 and possibly dopaminergic d1 and/or d4 receptors. |
1995-03-31 |
2023-08-12 |
Not clear |
| J Reiriz, S Ambrosio, A Cobos, M Ballarín, E Tolosa, N Mah. Dopaminergic function in rat brain after oral administration of calcium-channel blockers or haloperidol. A microdialysis study. Journal of neural transmission. General section. vol 95. issue 3. 1995-03-30. PMID:7865175. |
a neuroleptic-like mechanism of action together with a decrease in firing activity and/or a reduced dopamine re-uptake of dopaminergic neurons are considered. |
1995-03-30 |
2023-08-12 |
rat |
| K Chergui, M F Suaud-Chagny, F Gono. Nonlinear relationship between impulse flow, dopamine release and dopamine elimination in the rat brain in vivo. Neuroscience. vol 62. issue 3. 1995-03-30. PMID:7870295. |
in the present study the dopamine overflow evoked by electrical stimulation of the dopaminergic pathway was measured in vivo by carbon fibre electrodes combined with continuous amperometry. |
1995-03-30 |
2023-08-12 |
rat |
| C Dugast, M F Suaud-Chagny, F Gono. Continuous in vivo monitoring of evoked dopamine release in the rat nucleus accumbens by amperometry. Neuroscience. vol 62. issue 3. 1995-03-30. PMID:7870296. |
the release of dopamine in the nucleus accumbens of anaesthetized rats was evoked either by electrical stimulation of the mesolimbic dopaminergic pathway or by local ejection of n-methyl-d-aspartate in the ventral tegmental area. |
1995-03-30 |
2023-08-12 |
rat |
| J L Evenden, M Turpin, L Oliver, C Jenning. Caffeine and nicotine improve visual tracking by rats: a comparison with amphetamine, cocaine and apomorphine. Psychopharmacology. vol 110. issue 1-2. 1995-03-29. PMID:7870879. |
the present study was undertaken to determine whether these performance enhancing effects of amphetamine could also be obtained with cocaine and apomorphine, which both have psychomotor stimulant effects through their actions as, respectively, indirect and direct dopamine agonists, and by caffeine and nicotine, which do not have a direct dopaminergic mechanism of action. |
1995-03-29 |
2023-08-12 |
rat |
| F Duval, M C Mokrani, J P Macher, M A Crocq, J O Castro, P Bailey, X Latast. Neuroendocrine profile of SDZ HDC-912 and OPC-4392, two new atypical antipsychotic drugs, in schizophrenic patients. Psychopharmacology. vol 110. issue 1-2. 1995-03-29. PMID:7870880. |
the aim of this study was to evaluate the effect on the activity of the hypothalamic-pituitary dopaminergic system of two new atypical antipsychotic drugs: the ergoline derivative sdz hdc-912, which is a dopamine (da) d2 receptor partial agonist; and the quinolinone derivative opc-4392, which acts as an agonist at presynaptic da autoreceptors and as an antagonist at post-synaptic d2 receptors. |
1995-03-29 |
2023-08-12 |
Not clear |
| C N Ryan, J L Evenden, M Petterso. Effects of buspirone and ipsapirone on schedule induced polydipsia: comparison with 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and raclopride. Psychopharmacology. vol 112. issue 1. 1995-03-29. PMID:7871008. |
because buspirone is known to block dopamine receptors and both buspirone and ipsapirone act as agonists at the 5-ht1a receptor, their effects on polydipsia were compared to raclopride, an antagonist at d2 receptors, and 8-oh-dpat, an agonist at the 5-ht1a receptor, thus providing information about the relative importance of the serotonergic and/or dopaminergic systems for the maintenance of polydipsia. |
1995-03-29 |
2023-08-12 |
Not clear |
| Y Uchihashi, H Kuribara, Y Isa, T Morita, T Sat. The disruptive effects of ketamine on passive avoidance learning in mice: involvement of dopaminergic mechanism. Psychopharmacology. vol 116. issue 1. 1995-03-23. PMID:7862929. |
the involvement of dopaminergic mechanisms in ketamine-induced disruption of one trial step-through passive avoidance performance was assessed through the coadministration with the dopamine d1 antagonist sch 23390, the dopamine d2 antagonist ym-091512 and the dopamine autoreceptor agonist at low doses, apomorphine, in mice. |
1995-03-23 |
2023-08-12 |
mouse |
| E Tirelli, J M Witki. Verticalization of behavior elicited by dopaminergic mobilization is qualitatively different between C57BL/6J and DBA/2J mice. Psychopharmacology. vol 116. issue 2. 1995-03-22. PMID:7862948. |
behavioral effects of dopaminergic stimulation were evaluated in c57bl/6j mice and compared to the effects occurring in dba/2j mice, an inbred strain with reduced densities of striatal dopamine receptors. |
1995-03-22 |
2023-08-12 |
mouse |