| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R L Watt. The role of dopamine agonists in early Parkinson's disease. Neurology. vol 49. issue 1 Suppl 1. 1997-08-04. PMID:9222273. |
because they act on postsynaptic dopamine receptors of the striatum, dopamine agonists act independent of the synthetic dopaminergic enzyme system and are not dependent on degenerating presynaptic neurons in the substantia nigra. |
1997-08-04 |
2023-08-12 |
Not clear |
| K Blum, E R Braverman, S Wu, J G Cull, T J Chen, J Gill, R Wood, A Eisenberg, M Sherman, K R Davis, D Matthews, L Fischer, N Schnautz, W Walsh, A A Pontius, M Zedar, G Kaats, D E Coming. Association of polymorphisms of dopamine D2 receptor (DRD2), and dopamine transporter (DAT1) genes with schizoid/avoidant behaviors (SAB). Molecular psychiatry. vol 2. issue 3. 1997-07-30. PMID:9152988. |
the dopaminergic system, and in particular the dopamine d2 receptor, has been implicated in reward mechanisms in the brain. |
1997-07-30 |
2023-08-12 |
Not clear |
| M Kotler, H Cohen, R Segman, I Gritsenko, L Nemanov, B Lerer, I Kramer, M Zer-Zion, I Kletz, R P Ebstei. Excess dopamine D4 receptor (D4DR) exon III seven repeat allele in opioid-dependent subjects. Molecular psychiatry. vol 2. issue 3. 1997-07-30. PMID:9152990. |
central dopaminergic pathways figure prominently in drug-mediated reinforcement suggesting that dopamine receptors are likely candiadates for association with substance abuse in man. |
1997-07-30 |
2023-08-12 |
mouse |
| Z Walker, D C Costa, A G Janssen, R W Walker, G Livingstone, C L Katon. Dementia with lewy bodies: a study of post-synaptic dopaminergic receptors with iodine-123 iodobenzamide single-photon emission tomography. European journal of nuclear medicine. vol 24. issue 6. 1997-07-30. PMID:9169566. |
iodine-123 iodobenzamide single-photon emission tomography (ibzm-spet) measures post-synaptic dopamine d2 neuroreceptor availability in the corpus striatum, but is nevertheless a method for assessing the integrity of the nigrostriatal dopaminergic pathway. |
1997-07-30 |
2023-08-12 |
human |
| J B Zawilska, T Derbiszewska, J Z Nowa. Prolonged exposure of chicks to light or darkness differentially affects the quinpirole-evoked suppression of serotonin N-acetyltransferase activity in chick retina: an impact on dopamine D4-like receptor. Journal of pineal research. vol 22. issue 2. 1997-07-30. PMID:9181516. |
it is suggested that prolonged exposure to light or darkness, by altering the level of the retinal dopaminergic neurotransmission, may modify the reactivity of the d4-like dopamine receptors regulating nat activity of the chick retina. |
1997-07-30 |
2023-08-12 |
chicken |
| M Naumann, W Pirker, K Reiners, K Lange, G Becker, T Brück. [123I]beta-CIT single-photon emission tomography in DOPA-responsive dystonia. Movement disorders : official journal of the Movement Disorder Society. vol 12. issue 3. 1997-07-28. PMID:9159746. |
the radiotracer [123i]beta-cit is a sensitive marker of dopamine uptake sites that can be used to visualize dopaminergic nerve endings in vivo in the human brain. |
1997-07-28 |
2023-08-12 |
human |
| M E Reith, C Xu, N H Che. Pharmacology and regulation of the neuronal dopamine transporter. European journal of pharmacology. vol 324. issue 1. 1997-07-24. PMID:9137907. |
the dopamine transporter, a member of the family of na+,cl(-)-dependent transporters, mediates uptake of dopamine into dopaminergic neurons by an electrogenic, na(+)- and cl(-)-transport-coupled mechanism. |
1997-07-24 |
2023-08-12 |
Not clear |
| N Gorelova, C R Yan. The course of neural projection from the prefrontal cortex to the nucleus accumbens in the rat. Neuroscience. vol 76. issue 3. 1997-07-21. PMID:9135043. |
corticostriatal neurons linking the prefrontal cortex and the nucleus accumbens connect the terminal fields of the ascending mesotelencephalic dopamine neurons and may potentially mediate cortical dopaminergic modulation of subcortical dopamine transmission. |
1997-07-21 |
2023-08-12 |
rat |
| M L Veruk. Dopaminergic neurons in the rat retina express dopamine D2/3 receptors. The European journal of neuroscience. vol 9. issue 5. 1997-07-21. PMID:9182963. |
dopaminergic neurons in the rat retina express dopamine d2/3 receptors. |
1997-07-21 |
2023-08-12 |
rat |
| M L Veruk. Dopaminergic neurons in the rat retina express dopamine D2/3 receptors. The European journal of neuroscience. vol 9. issue 5. 1997-07-21. PMID:9182963. |
as previous biochemical and physiological studies have demonstrated that activation of d2-like receptors inhibits the release of dopamine in the retina, the present results suggest that the d2/3 receptors on dopaminergic neurons function as autoreceptors. |
1997-07-21 |
2023-08-12 |
rat |
| M J Nirenberg, J Chan, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 14. 1997-07-21. PMID:9204909. |
the dopamine transporter (dat) plays an important role in the plasmalemmal reuptake of dopamine and, thus, in the termination of normal dopaminergic neurotransmission. |
1997-07-21 |
2023-08-12 |
rat |
| M J Nirenberg, J Chan, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 14. 1997-07-21. PMID:9204909. |
dat is also a major binding site for cocaine and other stimulants, the psychoactive effects of which are associated primarily with the inhibition of dopamine reuptake within mesocorticolimbic dopaminergic neurons. |
1997-07-21 |
2023-08-12 |
rat |
| M J Nirenberg, J Chan, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 14. 1997-07-21. PMID:9204909. |
these findings suggest that intermediate and distal dendrites are both the primary sites of dopamine reuptake and the principal targets of cocaine and related psychostimulants within dopaminergic neurons in the vta. |
1997-07-21 |
2023-08-12 |
rat |
| M I Gonzalez, V Kalia, D R Hole, C A Wilso. alpha-Melanocyte-stimulating hormone (alpha-MSH) and melanin-concentrating hormone (MCH) modify monoaminergic levels in the preoptic area of the rat. Peptides. vol 18. issue 3. 1997-07-17. PMID:9145425. |
dopamine may mediate the similar effects of the two peptides, because alpha-msh inhibits dopaminergic release in the mpoa (but not vmn) and mch tends to follow the same pattern. |
1997-07-17 |
2023-08-12 |
rat |
| W Y Chang, R A Webste. Effect of L-dopa alone and with benserazide on the spontaneous activity of striatal neurones in normal and 6-hydroxydopamine-lesioned rats. British journal of pharmacology. vol 121. issue 2. 1997-07-16. PMID:9154345. |
this study also shows the chronic levodopa/pdi treatment reduces the compensating increased activity of surviving dopaminergic neurones and the functional supersensitivity to dopamine and suggests that the long term administration of levodopa may reduce its own utilization and activity in the striatum and in the treatment of parkinson's disease [corrected]. |
1997-07-16 |
2023-08-12 |
rat |
| M D Lindner, M A Plone, J M Francis, T J Blaney, J D Salamone, D F Emeric. Rats with partial striatal dopamine depletions exhibit robust and long-lasting behavioral deficits in a simple fixed-ratio bar-pressing task. Behavioural brain research. vol 86. issue 1. 1997-07-15. PMID:9105579. |
it is widely accepted that enduring parkinsonian symptoms are only evident if there are few remaining dopaminergic neurons in the substantia nigra and dopamine levels in the basal ganglia are very low [26,41]. |
1997-07-15 |
2023-08-12 |
rat |
| Y Lecrubier, P Boyer, S Turjanski, W Rei. Amisulpride versus imipramine and placebo in dysthymia and major depression. Amisulpride Study Group. Journal of affective disorders. vol 43. issue 2. 1997-07-15. PMID:9165379. |
amisulpride, a selective antagonist of d2 and d3 dopamine receptors, acts preferentially on presynaptic receptors increasing dopaminergic transmission at low doses. |
1997-07-15 |
2023-08-12 |
Not clear |
| M Guttman, J Burkholder, S J Kish, D Hussey, A Wilson, J DaSilva, S Houl. [11C]RTI-32 PET studies of the dopamine transporter in early dopa-naive Parkinson's disease: implications for the symptomatic threshold. Neurology. vol 48. issue 6. 1997-07-10. PMID:9191769. |
to the extent that dopamine transporter binding accurately reflects the number of nigrostriatal dopamine nerve terminals, these findings suggest that the clinical threshold for pd in the middle-age human is approximately 50% loss of dopaminergic innervation to the posterior putamen. |
1997-07-10 |
2023-08-12 |
human |
| V Planté-Bordeneuve, D Taussig, F Thomas, G Said, N W Wood, C D Marsden, A E Hardin. Evaluation of four candidate genes encoding proteins of the dopamine pathway in familial and sporadic Parkinson's disease: evidence for association of a DRD2 allele. Neurology. vol 48. issue 6. 1997-07-10. PMID:9191771. |
we assessed the role of four candidate genes encoding proteins involved in dopaminergic transmission, the dopamine transporter (dat), the dopamine receptor d2 (drd2), and the main catabolic enzymes of dopamine, monoamine oxidase a (maoa) and b (maob), through allelic association studies in a population of familial and sporadic parkinson's disease (pd). |
1997-07-10 |
2023-08-12 |
human |
| D J Autelitano, M van den Buus. Concomitant up-regulation of proopiomelanocortin and dopamine D2-receptor gene expression in the pituitary intermediate lobe of the spontaneously hypertensive rat. Journal of neuroendocrinology. vol 9. issue 4. 1997-07-07. PMID:9147288. |
the current data demonstrate changes in expression of both pomc and d2-r mrna in the shr nil which may be a consequence of altered dopaminergic input and/or alterations in d2-r regulation in this tissue, possibly enabling other factors in addition to dopamine to maintain the nil of the shr in a relatively hyperactive state. |
1997-07-07 |
2023-08-12 |
rat |