| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Revuelta, M Romero-Ramos, J L Venero, F Millan, A Machado, J Can. Less induced 1-methyl-4-phenylpyridinium ion neurotoxicity on striatal slices from guinea-pigs fed with a vitamin C-deficient diet. Neuroscience. vol 77. issue 1. 1997-05-02. PMID:9044384. |
in view of the higher resistance of the ascorbic acid-deficient animals to the neurotoxicity elicited by mpp+, additional dopaminergic parameters were also measured in striatal tissue from ascorbic acid-deficient animals in the absence of mpp+, including levels of dopamine and its metabolites, tyrosine hydroxylase activity and dopamine uptake, with the aim of finding an explanation for this unexpected result. |
1997-05-02 |
2023-08-12 |
Not clear |
| M Revuelta, M Romero-Ramos, J L Venero, F Millan, A Machado, J Can. Less induced 1-methyl-4-phenylpyridinium ion neurotoxicity on striatal slices from guinea-pigs fed with a vitamin C-deficient diet. Neuroscience. vol 77. issue 1. 1997-05-02. PMID:9044384. |
since mpp+ is actively accumulated into dopaminergic nerve terminals via the high-affinity dopamine uptake system, this finding could explain the higher resistance of ascorbic acid-deficient animals to the dopamine-depleting effect induced by mpp+ toxicity assayed in striatal slices. |
1997-05-02 |
2023-08-12 |
Not clear |
| T Hussain, M F Lokhandwal. Dopamine-1 receptor G-protein coupling and the involvement of phospholipase A2 in dopamine-1 receptor mediated cellular signaling mechanisms in the proximal tubules of SHR. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 19. issue 1-2. 1997-04-30. PMID:9028641. |
these data suggest that (i) the reduced activation of g proteins following da1 receptor stimulation, (ii) reduced amount of gq/11 alpha and (iii) a defect in the aa metabolism may be responsible for the reduced dopaminergic inhibition of sodium pump activity and a diminished natriuretic response to dopamine in shr. |
1997-04-30 |
2023-08-12 |
rat |
| J Nguyen-Legros, C Versaux-Botteri, C Sav. Dopaminergic and GABAergic retinal cell populations in mammals. Microscopy research and technique. vol 36. issue 1. 1997-04-30. PMID:9031259. |
gaba antagonizes a number of dopaminergic actions by inhibiting both the release and synthesis of dopamine. |
1997-04-30 |
2023-08-12 |
Not clear |
| F M Chang, H C Ko, R B Lu, A J Pakstis, K K Kid. The dopamine D4 receptor gene (DRD4) is not associated with alcoholism in three Taiwanese populations: six polymorphisms tested separately and as haplotypes. Biological psychiatry. vol 41. issue 4. 1997-04-30. PMID:9034534. |
the dopaminergic system has been implicated in alcoholism but studies at the dopamine d2 receptor gene (drd2), one of the five dopamine receptors, have not given a consistent picture of an association with alcoholism. |
1997-04-30 |
2023-08-12 |
Not clear |
| T Sander, H Harms, J Podschus, U Finckh, B Nickel, A Rolfs, H Rommelspacher, L G Schmid. Allelic association of a dopamine transporter gene polymorphism in alcohol dependence with withdrawal seizures or delirium. Biological psychiatry. vol 41. issue 3. 1997-04-29. PMID:9024952. |
the role of the dopamine transporter in terminating dopaminergic activity in synaptic neurotransmission suggests that variants of the dopamine transporter gene (dat1) might contribute to individual differences in vulnerability to addictive behavior. |
1997-04-29 |
2023-08-12 |
Not clear |
| H Moukhles, O Bosler, J P Bolam, A Vallée, D Umbriaco, M Geffard, G Douce. Quantitative and morphometric data indicate precise cellular interactions between serotonin terminals and postsynaptic targets in rat substantia nigra. Neuroscience. vol 76. issue 4. 1997-04-29. PMID:9027876. |
they indicate that this dense serotonin input to the substantia nigra is very precisely organized, acting through both "non-junctional" and "junctional" modes of neurotransmission in the pars compacta, which projects to the neostriatum and the limbic system, whereas the predominant mode of serotonin transmission appears to be of the "junctional" type in the pars reticulata, where serotonin can finely control the motor output of the basal ganglia by acting on the gaba projection neurons either directly or through the local release of dopamine by dopaminergic dendrites. |
1997-04-29 |
2023-08-12 |
rat |
| S K Hore, V K Dumka, D Kumar, H C Tripathi, S K Tanda. Central noradrenergic & dopaminergic modulation of brewer's yeast-induced inflammation & nociception in rats. The Indian journal of medical research. vol 105. 1997-04-29. PMID:9055502. |
conversely, the beta-adrenoceptor blocker, propranolol, catecholaminergic neuron degenerator, 6-hydroxydopamine (6-ohda), dopaminergic antagonist, haloperidol and dopamine synthesis inhibitor, alpha-methyl para tyrosine (ampt) augmented paw oedema. |
1997-04-29 |
2023-08-12 |
rat |
| K Thermos, J Radke, A Kastellakis, Y Anagnostakis, C Spyrak. Dopamine-somatostatin interactions in the rat striatum: an in vivo microdialysis study. Synapse (New York, N.Y.). vol 22. issue 3. 1997-04-29. PMID:9132988. |
to assess the effect of dopamine on somatostatinergic neurons, dopaminergic agents were administered and somatostatin levels measured using a radioimmunoassay. |
1997-04-29 |
2023-08-12 |
rat |
| K Thermos, J Radke, A Kastellakis, Y Anagnostakis, C Spyrak. Dopamine-somatostatin interactions in the rat striatum: an in vivo microdialysis study. Synapse (New York, N.Y.). vol 22. issue 3. 1997-04-29. PMID:9132988. |
the results confirm that somatostatin modulates the function of dopaminergic neurons in the striatum and provide new evidence that somatostatin-14 may differentially regulate dopamine release. |
1997-04-29 |
2023-08-12 |
rat |
| A N Gifford, S J Gatley, C R Ashb. Endogenously released dopamine inhibits the binding of dopaminergic PET and SPECT ligands in superfused rat striatal slices. Synapse (New York, N.Y.). vol 22. issue 3. 1997-04-29. PMID:9132991. |
endogenously released dopamine inhibits the binding of dopaminergic pet and spect ligands in superfused rat striatal slices. |
1997-04-29 |
2023-08-12 |
rat |
| A N Gifford, S J Gatley, C R Ashb. Endogenously released dopamine inhibits the binding of dopaminergic PET and SPECT ligands in superfused rat striatal slices. Synapse (New York, N.Y.). vol 22. issue 3. 1997-04-29. PMID:9132991. |
pharmacologically induced changes in synaptic levels of dopamine (da) have been found, in some studies, to affect the in vivo binding of dopaminergic radioligands. |
1997-04-29 |
2023-08-12 |
rat |
| S M Brudzynski, C J Gibso. Release of dopamine in the nucleus accumbens caused by stimulation of the subiculum in freely moving rats. Brain research bulletin. vol 42. issue 4. 1997-04-28. PMID:9043717. |
dopaminergic terminals in the nucleus accumbens have also been implicated in initiation of locomotor activity, and the release of dopamine in the nucleus accumbens is critical for locomotor responses initiated from the subiculum to occur. |
1997-04-28 |
2023-08-12 |
rat |
| D L Marshall, P H Redfern, S Wonnacot. Presynaptic nicotinic modulation of dopamine release in the three ascending pathways studied by in vivo microdialysis: comparison of naive and chronic nicotine-treated rats. Journal of neurochemistry. vol 68. issue 4. 1997-04-28. PMID:9084421. |
we have characterised the effect of nicotine, locally applied via a microdialysis probe, on dopamine release from the terminal regions of three ascending dopaminergic pathways in conscious, freely moving rats. |
1997-04-28 |
2023-08-12 |
rat |
| D C German, E L Nelson, C L Liang, S G Speciale, C M Sinton, P K Sonsall. The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117541. |
seven days later, dopamine concentrations were measured in the striatum using high performance liquid chromatography, and midbrain dopaminergic neurons were identified using an antibody against tyrosine hydroxylase. |
1997-04-24 |
2023-08-12 |
mouse |
| D C German, E L Nelson, C L Liang, S G Speciale, C M Sinton, P K Sonsall. The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117541. |
although the highest dose (300 mg/kg) caused an 86% reduction in striatal dopamine concentrations, there was only a moderate and non-significant loss of midbrain dopaminergic neurons. |
1997-04-24 |
2023-08-12 |
mouse |
| D C German, E L Nelson, C L Liang, S G Speciale, C M Sinton, P K Sonsall. The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117541. |
in the c57bl/6 strain, however, a high dose of mptp (240 mg/kg) caused a significant reduction in both striatal dopamine concentrations (95%), and midbrain dopaminergic cells; 69% loss of nucleus a8 cells, 75% loss of nucleus a9 cells, and in nucleus a10 subnuclei there was 42% loss of ventral tegmental area cells, 55% loss of interfascicular nucleus cells, and no loss of cells in the central linear nucleus. |
1997-04-24 |
2023-08-12 |
mouse |
| D C German, E L Nelson, C L Liang, S G Speciale, C M Sinton, P K Sonsall. The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117541. |
these data (1) provide further evidence for differential susceptibility to mptp toxicity among different mouse strains, (2) indicate that a significant depletion of striatal dopamine is not necessarily due to degeneration of midbrain dopaminergic neurons, (3) provide the precise locations of midbrain dopaminergic cells that are vulnerable to mptp, which will aid future studies that seek to determine the mechanism/s by which-mptp selectively destroys only certain midbrain dopaminergic neurons, and (4) indicate that mptp produces midbrain dopaminergic neuronal degeneration in the same nuclei in the c57bl16 mouse that degenerate in humans with parkinson's disease. |
1997-04-24 |
2023-08-12 |
mouse |
| M Naoi, W Maruyama, P Dostert, Y Hashizum. N-methyl-(R)salsolinol as a dopaminergic neurotoxin: from an animal model to an early marker of Parkinson's disease. Journal of neural transmission. Supplementum. vol 50. 1997-04-24. PMID:9120428. |
n-methyl-(r)salsolinol depleted dopamine neurons in the rat substantia nigra without necrotic tissue reaction, which may be due to the apoptotic death process, as proved by its induction of dna damage in dopaminergic neuroblastoma sh-sy5y cells. |
1997-04-24 |
2023-08-12 |
human |
| T Brücke, S Asenbaum, W Pirker, S Djamshidian, S Wenger, C Wöber, C Müller, I Podrek. Measurement of the dopaminergic degeneration in Parkinson's disease with [123I] beta-CIT and SPECT. Correlation with clinical findings and comparison with multiple system atrophy and progressive supranuclear palsy. Journal of neural transmission. Supplementum. vol 50. 1997-04-24. PMID:9120429. |
the cocaine derivative [123i] beta-cit binds with high affinity to dopamine uptake sites in the striatum and can be used to visualize dopaminergic nerve terminals in vivo in the human brain with spect. |
1997-04-24 |
2023-08-12 |
human |