| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Maeda, K Kannari, T Suda, M Matsunag. Loss of regulation by presynaptic dopamine D2 receptors of exogenous L-DOPA-derived dopamine release in the dopaminergic denervated striatum. Brain research. vol 817. issue 1-2. 1999-03-12. PMID:9889362. |
loss of regulation by presynaptic dopamine d2 receptors of exogenous l-dopa-derived dopamine release in the dopaminergic denervated striatum. |
1999-03-12 |
2023-08-12 |
rat |
| T Maeda, K Kannari, T Suda, M Matsunag. Loss of regulation by presynaptic dopamine D2 receptors of exogenous L-DOPA-derived dopamine release in the dopaminergic denervated striatum. Brain research. vol 817. issue 1-2. 1999-03-12. PMID:9889362. |
to determine whether dopamine release derived from exogenous l-dopa is under inhibitory control of presynaptic dopamine d2 receptors in the dopaminergic denervated striatum, extracellular dopamine levels were measured in the striatum of 6-hydroxydopamine-lesioned rats using in vivo brain microdialysis. |
1999-03-12 |
2023-08-12 |
rat |
| T Maeda, K Kannari, T Suda, M Matsunag. Loss of regulation by presynaptic dopamine D2 receptors of exogenous L-DOPA-derived dopamine release in the dopaminergic denervated striatum. Brain research. vol 817. issue 1-2. 1999-03-12. PMID:9889362. |
quinpirole, a d2 agonist, dose-dependently (0.01-3 mg/kg s.c.) inhibited endogenous dopamine release both in the intact and dopaminergic denervated striatum. |
1999-03-12 |
2023-08-12 |
rat |
| T Maeda, K Kannari, T Suda, M Matsunag. Loss of regulation by presynaptic dopamine D2 receptors of exogenous L-DOPA-derived dopamine release in the dopaminergic denervated striatum. Brain research. vol 817. issue 1-2. 1999-03-12. PMID:9889362. |
these results suggest that, in the striatum with dopaminergic denervation, regulation by presynaptic d2 receptors is still operative on endogenous dopamine release but it does not work on dopamine release derived from exogenously administered l-dopa. |
1999-03-12 |
2023-08-12 |
rat |
| T Kouki, K Kawamura, S Kikuyam. Developmental studies for identification of the inhibitory center of melanotropes in the toad, Bufo japonicus. Development, growth & differentiation. vol 40. issue 6. 1999-03-08. PMID:9865975. |
first, developmental changes in the distribution of dopaminergic neurons were examined from hatching stage to postmetamorphosis using an antiserum against dopamine synthase (tyrosine hydroxylase, th). |
1999-03-08 |
2023-08-12 |
Not clear |
| M Nanri, N Kasahara, J Yamamoto, H Miyake, H Watanab. A comparative study on the effects of nicotine and GTS-21, a new nicotinic agonist, on the locomotor activity and brain monoamine level. Japanese journal of pharmacology. vol 78. issue 3. 1999-03-03. PMID:9869274. |
it also enhanced dopamine turnover rates in the striatum and cerebral cortex, suggesting the involvement of dopaminergic systems in the nicotine-induced changes in locomotor activity. |
1999-03-03 |
2023-08-12 |
mouse |
| R Karler, L D Calder, D K Thai, J B Bedingfiel. The role of dopamine in the mouse frontal cortex: a new hypothesis of behavioral sensitization to amphetamine and cocaine. Pharmacology, biochemistry, and behavior. vol 61. issue 4. 1999-03-01. PMID:9802839. |
in previous studies we demonstrated that dopamine, specifically a d2-receptor system, in the frontal cortex of the mouse functions to inhibit the motor response elicited by systemically administered amphetamine or cocaine; the inhibition appears to be the result of the dopaminergic activation of a gabaergic system. |
1999-03-01 |
2023-08-12 |
mouse |
| R Torstenson, P Hartvig, B Långström, S Bastami, G Antoni, J Tedrof. Effect of apomorphine infusion on dopamine synthesis rate relates to dopaminergic tone. Neuropharmacology. vol 37. issue 8. 1999-02-26. PMID:9833628. |
effect of apomorphine infusion on dopamine synthesis rate relates to dopaminergic tone. |
1999-02-26 |
2023-08-12 |
monkey |
| K Grasing, S Ghos. Selegiline prevents long-term changes in dopamine efflux and stress immobility during the second and third weeks of abstinence following opiate withdrawal. Neuropharmacology. vol 37. issue 8. 1999-02-26. PMID:9833630. |
because of evidence for decreased dopaminergic function during the withdrawal syndromes associated with opiates and other medications with potential for abuse, we investigated effects of treatment with selegiline on in vitro measures of dopamine efflux following opiate withdrawal. |
1999-02-26 |
2023-08-12 |
human |
| D S Fan, M Ogawa, K I Fujimoto, K Ikeguchi, Y Ogasawara, M Urabe, M Nishizawa, I Nakano, M Yoshida, I Nagatsu, H Ichinose, T Nagatsu, G J Kurtzman, K Ozaw. Behavioral recovery in 6-hydroxydopamine-lesioned rats by cotransduction of striatum with tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes using two separate adeno-associated virus vectors. Human gene therapy. vol 9. issue 17. 1999-02-26. PMID:9853519. |
parkinson's disease (pd) is characterized by the progressive loss of the dopaminergic neurons in the substantia nigra and a severe decrease in dopamine in the striatum. |
1999-02-26 |
2023-08-12 |
rat |
| N B Mercuri, M Scarponi, A Bonci, A Siniscalchi, G Bernard. Monoamine oxidase inhibition causes a long-term prolongation of the dopamine-induced responses in rat midbrain dopaminergic cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 7. 1999-02-25. PMID:9065488. |
the way monoamine oxidase (mao) modulates the depression of the firing rate and the hyperpolarization of the membrane caused by dopamine (da) on rat midbrain dopaminergic cells was investigated by means of intracellular recordings in vitro. |
1999-02-25 |
2023-08-12 |
rat |
| J M Tepper, B C Sun, L P Martin, I Crees. Functional roles of dopamine D2 and D3 autoreceptors on nigrostriatal neurons analyzed by antisense knockdown in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 7. 1999-02-25. PMID:9065512. |
two different 19-mer antisense oligodeoxynucleotides complementary to the initial coding regions of dopamine d2 or d3 receptor mrna were infused unilaterally into the substantia nigra of rats for 3-6 d to suppress synthesis of d2 and/or d3 receptors on substantia nigra dopaminergic neurons, thereby producing specific reductions of d2 and/or d3 receptors. |
1999-02-25 |
2023-08-12 |
rat |
| M Batchelor, J O Schen. Protein kinase A activity may kinetically upregulate the striatal transporter for dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 24. 1999-02-25. PMID:9852568. |
the neuronal dopamine transporter (dat) plays a key role in terminating dopaminergic chemical neurotransmission; thus, the study of the regulation of dat activity is important in defining parameters relevant to the control of dopaminergic neurotransmission. |
1999-02-25 |
2023-08-12 |
Not clear |
| M S Saporito, E M Brown, M S Miller, S Carswel. CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivo. The Journal of pharmacology and experimental therapeutics. vol 288. issue 2. 1999-02-22. PMID:9918541. |
cep-1347/kt-7515 did not inhibit monoamine oxidase b or the dopamine transporter, suggesting that the neuroprotective effects of cep-1347/kt-7515 occur downstream of the metabolic conversion of mptp to mpp+ and accumulation of mpp+ into dopaminergic neurons. |
1999-02-22 |
2023-08-12 |
mouse |
| P Chopin, F C Colpaert, M Marie. Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. The Journal of pharmacology and experimental therapeutics. vol 288. issue 2. 1999-02-22. PMID:9918591. |
although a modulation of dopamine release may be involved in some of these drug effects, the effects on apomorphine-induced circling indicate an influence of alpha-2 adrenoceptor compounds on nigrostriatal neurotransmission at sites downstream from the dopaminergic neurons themselves. |
1999-02-22 |
2023-08-12 |
rat |
| K W Lang. Clinical pharmacology of dopamine agonists in Parkinson's disease. Drugs & aging. vol 13. issue 5. 1999-02-12. PMID:9829165. |
continuous dopaminergic stimulation by parenteral infusion of water-soluble dopamine agonists such as apomorphine and lisuride can overcome motor fluctuations in advanced parkinson's disease. |
1999-02-12 |
2023-08-12 |
Not clear |
| C Infante, M Monari, E Motle. Effects of bilateral ablation or 6-OHDA lesion of the frontal cortex upon the behaviors induced by apomorphine and amphetamine in adult cats. Archives italiennes de biologie. vol 136. issue 4. 1999-02-12. PMID:9834836. |
these results show the importance of the interplay between dopamine and the target tissue that receive the dopaminergic fibers in the production of the behaviors evoked by parenteral injection of apomorphine and amphetamine. |
1999-02-12 |
2023-08-12 |
Not clear |
| P J Blanchet, J Fang, M Gillespie, L Sabounjian, K W Locke, R Gammans, M M Mouradian, T N Chas. Effects of the full dopamine D1 receptor agonist dihydrexidine in Parkinson's disease. Clinical neuropharmacology. vol 21. issue 6. 1999-02-12. PMID:9844789. |
the contribution of dopamine d1 receptor stimulation to the motor effects of dopaminergic drugs in patients with parkinson's disease remains undetermined. |
1999-02-12 |
2023-08-12 |
Not clear |
| M Madsen, H Lubli. MK-801-induced dystonia in cebus monkeys. Clinical neuropharmacology. vol 21. issue 6. 1999-02-12. PMID:9844788. |
this syndrome was tested with the dopamine d1 receptor antagonist nnc 756, the da d2 receptor antagonist raclopride, the atypical antipsychotic clozapine, the dopamine d1 receptor agonist skf 81297, the dopamine d2/d3 receptor agonist quinpirole, the anticholinergic biperiden, amphetamine, and the benzodiazepine midazolam in 7 cebus apella monkeys previously treated with dopaminergic agents. |
1999-02-12 |
2023-08-12 |
monkey |
| H S Kim, Y H Zhang, L H Fang, M K Le. Effect of ginseng total saponin on bovine adrenal tyrosine hydroxylase. Archives of pharmacal research. vol 21. issue 6. 1999-02-11. PMID:9868557. |
ginseng total saponin (gts) can modulate dopaminergic activity at both presynaptic and postsynaptic dopamine receptors (kim et al., 1998). |
1999-02-11 |
2023-08-12 |
cattle |