| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Richter, U Ebert, J N Nobrega, J J Vallbacka, M Fedrowitz, W Lösche. Immunohistochemical and neurochemical studies on nigral and striatal functions in the circling (ci) rat, a genetic animal model with spontaneous rotational behavior. Neuroscience. vol 89. issue 2. 1999-05-07. PMID:10077328. |
immunohistochemical labeling of dopaminergic neurons and fibers in substantia nigra pars compacta, ventral tegmental area, and striatum did not indicate any significant neurodegeneration or asymmetry that could explain the lateralization in dopamine levels in striatum of ci rats. |
1999-05-07 |
2023-08-12 |
rat |
| A Richter, U Ebert, J N Nobrega, J J Vallbacka, M Fedrowitz, W Lösche. Immunohistochemical and neurochemical studies on nigral and striatal functions in the circling (ci) rat, a genetic animal model with spontaneous rotational behavior. Neuroscience. vol 89. issue 2. 1999-05-07. PMID:10077328. |
taken together, ci mutant rats of both genders exhibit an asymmetry in striatal dopamine and metabolite levels and an enhanced dopamine transporter and receptor binding, but the link of these differences in dopaminergic parameters with the rotational behavior of the animals is not clear yet. |
1999-05-07 |
2023-08-12 |
rat |
| A I Brooks, C A Chadwick, H A Gelbard, D A Cory-Slechta, H J Federof. Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss. Brain research. vol 823. issue 1-2. 1999-05-07. PMID:10095006. |
the data indicate that paraquat like mptp elicits a dose-dependent decrease in substantia nigra dopaminergic neurons assessed by a fluoro-gold prelabeling method, a decline in striatal dopamine nerve terminal density assessed by measurement of tyrosine hydroxylase immunoreactivity; and neurobehavioral syndrome characterized by reduced ambulatory activity. |
1999-05-07 |
2023-08-12 |
mouse |
| A I Brooks, C A Chadwick, H A Gelbard, D A Cory-Slechta, H J Federof. Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss. Brain research. vol 823. issue 1-2. 1999-05-07. PMID:10095006. |
taken together, these data suggest that systemically absorbed paraquat crosses the blood-brain barrier to cause destruction of dopamine neurons in the substantia nigra, consequent reduction of dopaminergic innervation of the striatum and a neurobehavioral syndrome similar to the well characterized and bona fide dopaminergic toxin mptp. |
1999-05-07 |
2023-08-12 |
mouse |
| D M Nielsen, K J Crosley, R W Keller, S D Glick, J N Carlso. Left and right 6-hydroxydopamine lesions of the medial prefrontal cortex differentially affect voluntary ethanol consumption. Brain research. vol 823. issue 1-2. 1999-05-07. PMID:10095012. |
dopaminergic projections to the medial prefrontal cortex (mpfc) were unilaterally lesioned with 6-hydroxydopamine (6-ohda) to examine how dopamine (da) asymmetry in the mpfc influences voluntary ethanol consumption. |
1999-05-07 |
2023-08-12 |
rat |
| D A Loeffler, P A LeWitt, P L Juneau, D M Camp, L A Arnold, K Hylan. Time-dependent effects of levodopa on regional brain dopamine metabolism and lipid peroxidation. Brain research bulletin. vol 47. issue 6. 1999-05-06. PMID:10078623. |
we compared the time course of levodopa-induced dopamine metabolism, and the resulting oxidative stress, between rat brain regions with varying dopaminergic innervation. |
1999-05-06 |
2023-08-12 |
rat |
| D A Loeffler, P A LeWitt, P L Juneau, D M Camp, L A Arnold, K Hylan. Time-dependent effects of levodopa on regional brain dopamine metabolism and lipid peroxidation. Brain research bulletin. vol 47. issue 6. 1999-05-06. PMID:10078623. |
at 1, 4, 8, and 12 h after levodopa administration (100 mg/kg), dopamine, dihydroxyphenylacetic acid, and homovanillic acid were measured in striatum and ventral midbrain, regions containing marked dopaminergic innervation, and in prefrontal cortex and cerebellum, which possess little dopaminergic innervation. |
1999-05-06 |
2023-08-12 |
rat |
| D A Loeffler, P A LeWitt, P L Juneau, D M Camp, L A Arnold, K Hylan. Time-dependent effects of levodopa on regional brain dopamine metabolism and lipid peroxidation. Brain research bulletin. vol 47. issue 6. 1999-05-06. PMID:10078623. |
the return of dopamine and its metabolites to control concentrations tended to be slower (by 3-8 h) in cerebellum and prefrontal cortex than in dopaminergic regions. |
1999-05-06 |
2023-08-12 |
rat |
| D A Loeffler, P A LeWitt, P L Juneau, D M Camp, L A Arnold, K Hylan. Time-dependent effects of levodopa on regional brain dopamine metabolism and lipid peroxidation. Brain research bulletin. vol 47. issue 6. 1999-05-06. PMID:10078623. |
we concluded that levodopa increases dopamine metabolism in nondopaminergic as well as dopaminergic regions, with delayed clearance of dopamine and its metabolites in nondopaminergic regions. |
1999-05-06 |
2023-08-12 |
rat |
| N S Magoski, A G Bulloc. Dopamine activates two different receptors to produce variability in sign at an identified synapse. Journal of neurophysiology. vol 81. issue 3. 1999-05-06. PMID:10085359. |
the hyperpolarizing but not the depolarizing phase of the bpsp and the biphasic dopamine response was blocked by the d-2 dopaminergic antagonist (+/-) sulpiride. |
1999-05-06 |
2023-08-12 |
Not clear |
| N I Bohnen, R L Albin, K A Frey, J K Fin. (+)-alpha-[11C]Dihydrotetrabenazine PET imaging in familial paroxysmal dystonic choreoathetosis. Neurology. vol 52. issue 5. 1999-05-06. PMID:10102431. |
this suggests that dopaminergic abnormalities, if present, may be due to altered regulation of dopamine release or to postsynaptic mechanisms, rather than to an altered density of nigrostriatal innervation. |
1999-05-06 |
2023-08-12 |
Not clear |
| C Gambarana, F Masi, A Tagliamonte, S Scheggi, O Ghiglieri, M G De Monti. A chronic stress that impairs reactivity in rats also decreases dopaminergic transmission in the nucleus accumbens: a microdialysis study. Journal of neurochemistry. vol 72. issue 5. 1999-05-06. PMID:10217282. |
these data suggest a reduced activity of dopaminergic neurons as the possible mechanism underlying dopamine basal level reduction in stressed animals. |
1999-05-06 |
2023-08-12 |
rat |
| J Booij, G Tissingh, A Winogrodzka, E A van Roye. Imaging of the dopaminergic neurotransmission system using single-photon emission tomography and positron emission tomography in patients with parkinsonism. European journal of nuclear medicine. vol 26. issue 2. 1999-04-27. PMID:9933352. |
nowadays, by using single-photon emission tomography (spet) and positron emission tomography (pet) it is possible to visualise both the nigrostriatal dopaminergic neurons and the striatal dopamine d2 receptors in vivo. |
1999-04-27 |
2023-08-12 |
Not clear |
| V Melnikova, M Orosco, A Calas, A Sapronova, R Gainetdinov, N Delhaye-Bouchaud, S Nicolaidis, K Rayevsky, M Ugrumo. Dopamine turnover in the mediobasal hypothalamus in rat fetuses. Neuroscience. vol 89. issue 1. 1999-04-26. PMID:10051232. |
the dopaminergic activity in the developing mediobasal hypothalamus showed sexual dimorphism that was manifested in a greater concentration of 3,4-dihydroxyphenylalanine and dopamine, at least in cell extracts of cultures, as well as in a higher rate of dopamine release, both in the perifusion system and in culture in males compared to females. |
1999-04-26 |
2023-08-12 |
rat |
| M V Ugriumo. [Differentiation of dopaminergic neurones in situ, in vitro, and in the transplant]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 84. issue 10. 1999-04-26. PMID:10097269. |
four stages were distinguished in differentiation of the hypothalamic dopaminergic (da) neurones: a) origin of the neurone, b) expression of enzymes and dopamine specific synthesis and of the dopamine transmembrane transportation mechanisms, c) development of permanent and transient efferent connections, d) forming of afferent innervation and synaptogenesis. |
1999-04-26 |
2023-08-12 |
Not clear |
| F Georges, L Stinus, B Bloch, C Le Moin. Chronic morphine exposure and spontaneous withdrawal are associated with modifications of dopamine receptor and neuropeptide gene expression in the rat striatum. The European journal of neuroscience. vol 11. issue 2. 1999-04-21. PMID:10051749. |
our results suggest that during morphine dependence, dopamine and morphine exert opposite effects on striatonigral neurons, and that effects occurring on striatopallidal neurons are under dopaminergic control. |
1999-04-21 |
2023-08-12 |
rat |
| E V Gurevich, J W Himes, J N Joyc. Developmental regulation of expression of the D3 dopamine receptor in rat nucleus accumbens and islands of Calleja. The Journal of pharmacology and experimental therapeutics. vol 289. issue 1. 1999-04-21. PMID:10087054. |
the dopamine d3 receptor (d3r) belongs to the d2 subfamily and is expressed in the rat brain in targets of the mesolimbic dopaminergic system. |
1999-04-21 |
2023-08-12 |
rat |
| P E Batchelor, G T Liberatore, J Y Wong, M J Porritt, F Frerichs, G A Donnan, D W Howell. Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 5. 1999-04-20. PMID:10024357. |
moreover, dopamine transporter-positive dopaminergic neurites can be seen growing toward and embracing hemosiderin-filled wound macrophages. |
1999-04-20 |
2023-08-12 |
Not clear |
| W Haube. Blockade of subthalamic dopamine D1 receptors elicits akinesia in rats. Neuroreport. vol 9. issue 18. 1999-04-13. PMID:9926857. |
furthermore, the data point to the possibility that a reduced dopaminergic tone at subthalamic dopamine d1 receptors might contribute to akinesia in parkinson's disease. |
1999-04-13 |
2023-08-12 |
rat |
| B A Baldo, A Markou, G F Koo. Increased sensitivity to the locomotor depressant effect of a dopamine receptor antagonist during cocaine withdrawal in the rat. Psychopharmacology. vol 141. issue 2. 1999-04-13. PMID:9952037. |
the results of this study support clinical observations of dopamine antagonist-precipitated motor dysfunction in abstinent cocaine abusers, and lend further support to the hypothesis that alterations in dopaminergic neurotransmission consequent to prolonged cocaine exposure are partly responsible for some of the symptoms of cocaine withdrawal. |
1999-04-13 |
2023-08-12 |
rat |