| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Merino, M L Vizuete, J Cano, A Machad. The non-NMDA glutamate receptor antagonists 6-cyano-7-nitroquinoxaline-2,3-dione and 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline, but not NMDA antagonists, block the intrastriatal neurotoxic effect of MPP+. Journal of neurochemistry. vol 73. issue 2. 1999-08-13. PMID:10428073. |
different doses of glutamate receptor antagonists were coinfused with 1.5 microg of mpp+ into the striatum; kynurenic acid, a nonselective antagonist of glutamate receptors (30 and 60 nmol), partially protected dopaminergic terminal degeneration in terms of rescue of dopamine levels and tyrosine hydroxylase immunohistochemistry. |
1999-08-13 |
2023-08-12 |
rat |
| S Cho, A M Duchemin, N H Neff, M Hadjiconstantino. Tyrosine hydroxylase, aromatic L-amino acid decarboxylase and dopamine metabolism after chronic treatment with dopaminergic drugs. Brain research. vol 830. issue 2. 1999-08-11. PMID:10366680. |
tyrosine hydroxylase, aromatic l-amino acid decarboxylase and dopamine metabolism after chronic treatment with dopaminergic drugs. |
1999-08-11 |
2023-08-12 |
mouse |
| A Shane. Delusions, superstitious conditioning and chaotic dopamine neurodynamics. Medical hypotheses. vol 52. issue 2. 1999-08-09. PMID:10340292. |
a mathematical model of dopamine neuron firing rates, developed by king and others, suggests a mechanism by which excessive dopaminergic transmission could produce psychotic symptoms, especially delusions. |
1999-08-09 |
2023-08-12 |
rat |
| M Scarselli, P Barbier, F Salvadori, M Armogida, P Collecchi, C Pardini, F Vaglini, R Maggio, G U Corsin. Apomorphine has a potent antiproliferative effect on Chinese hamster ovary cells. Journal of neural transmission. Supplementum. vol 55. 1999-08-03. PMID:10335492. |
the dopaminergic antagonists sch23390 and spiperone at a concentration of 10 microm (well beyond their kd values for the dopamine d1- and d2-like receptors respectively) were not able to antagonize the effect of apomorphine on cho-k1 cell proliferation. |
1999-08-03 |
2023-08-12 |
Not clear |
| R M Moresco, C Loc'h, M Ottaviani, B Guibert, V Leviel, M Maziere, F Fazio, B Mazier. Effects of dopamine on the in vivo binding of dopamine D2 receptor radioligands in rat striatum. Nuclear medicine and biology. vol 26. issue 1. 1999-08-02. PMID:10096507. |
the effects of moderate changes in extracellular dopamine concentrations on the in vivo binding of specific dopaminergic d2 radioligands with different affinities and kinetics were investigated in rats. |
1999-08-02 |
2023-08-12 |
rat |
| H Araki, N Hino, Y Karasawa, H Kawasaki, Y Gomit. Effect of dopamine blockers on cerebral ischemia-induced hyperactivity in gerbils. Physiology & behavior. vol 66. issue 2. 1999-08-02. PMID:10336152. |
thus, the ischemia-induced hyperactivity is apparently related to abnormalities in dopaminergic functions, particularly the dopamine d2 receptor. |
1999-08-02 |
2023-08-12 |
Not clear |
| K A Jellinge. Post mortem studies in Parkinson's disease--is it possible to detect brain areas for specific symptoms? Journal of neural transmission. Supplementum. vol 56. 1999-08-02. PMID:10370901. |
parkinson's disease (pd) is characterized by progressive degeneration of the nigrostriatal dopaminergic system and other subcortical neuronal systems leading to striatal dopamine deficiency and other biochemical deficits related to the variable clinical signs and symptoms of the disorder. |
1999-08-02 |
2023-08-12 |
Not clear |
| H Przuntek, T Mülle. Clinical efficacy of budipine in Parkinson's disease. Journal of neural transmission. Supplementum. vol 56. 1999-08-02. PMID:10370903. |
budipine induced a relevant additional positive effect in patients with an optimal dopaminergic therapy based on levodopa and dopamine agonists, such as bromocriptine. |
1999-08-02 |
2023-08-12 |
mouse |
| M Eltz. Multiple mechanisms of action: the pharmacological profile of budipine. Journal of neural transmission. Supplementum. vol 56. 1999-08-02. PMID:10370904. |
1) the primary action of budipine is an indirect dopaminergic effect as shown by facilitation of dopamine (da) release, inhibition of monoamine oxidase type b (mao-b) and of da (re) up-take and stimulation of aromatic l-amino acid decarboxylase (aadc), which in sum might be responsible for enhancing the endogenous dopaminergic activity. |
1999-08-02 |
2023-08-12 |
human |
| D B Caln. Differentiation of dopamine agonists and their role in the treatment of Parkinson's disease. Journal of neural transmission. Supplementum. vol 56. 1999-08-02. PMID:10370912. |
since the pioneering work of hornykiewicz and his colleagues, it has been recognized that dopaminergic cells die selectively in parkinson's disease, and considerable improvement in symptoms can be achieved by administering levodopa, so that it may be converted to dopamine. |
1999-08-02 |
2023-08-12 |
Not clear |
| E Melamed, J Zoldan, R Galili-Mosberg, I Ziv, R Djaldett. Current management of motor fluctuations in patients with advanced Parkinson's disease treated chronically with levodopa. Journal of neural transmission. Supplementum. vol 56. 1999-08-02. PMID:10370911. |
motor fluctuations after long-term administration of levodopa may be due to central pharmacodynamic mechanisms such as reduced striatal synthesis and storage of dopamine from exogenous levodopa and subsensitization of postsynaptic dopaminergic receptors. |
1999-08-02 |
2023-08-12 |
Not clear |
| M P Muriel, V Bernard, A I Levey, O Laribi, D N Abrous, Y Agid, B Bloch, E C Hirsc. Levodopa induces a cytoplasmic localization of D1 dopamine receptors in striatal neurons in Parkinson's disease. Annals of neurology. vol 46. issue 1. 1999-08-02. PMID:10401786. |
this effect was likely the result of the treatment rather than the dopaminergic denervation, as such changes were not observed in the striatum of rats with a unilateral 6-hydroxydopamine nigrostriatal lesion, but were present in normal or lesioned rats treated with a d1 dopamine agonist. |
1999-08-02 |
2023-08-12 |
human |
| A Adell, F Artiga. Regulation of the release of 5-hydroxytryptamine in the median raphe nucleus of the rat by catecholaminergic afferents. The European journal of neuroscience. vol 11. issue 7. 1999-07-30. PMID:10383619. |
these results indicate that the release of serotonin in the median raphe nucleus does not appear to be regulated by dopaminergic afferents through the activation of dopamine d1 or d2 receptors. |
1999-07-30 |
2023-08-12 |
rat |
| F Rougé-Pont, D N Abrous, M Le Moal, P V Piazz. Release of endogenous dopamine in cultured mesencephalic neurons: influence of dopaminergic agonists and glucocorticoid antagonists. The European journal of neuroscience. vol 11. issue 7. 1999-07-30. PMID:10383623. |
release of endogenous dopamine in cultured mesencephalic neurons: influence of dopaminergic agonists and glucocorticoid antagonists. |
1999-07-30 |
2023-08-12 |
Not clear |
| F Rougé-Pont, D N Abrous, M Le Moal, P V Piazz. Release of endogenous dopamine in cultured mesencephalic neurons: influence of dopaminergic agonists and glucocorticoid antagonists. The European journal of neuroscience. vol 11. issue 7. 1999-07-30. PMID:10383623. |
in this report, we applied one of these techniques, coulometry, coupled to high-performance liquid chromatography (hplc), to the study of dopamine release in primary cultures of embryonic mesencephalic dopaminergic neurons. |
1999-07-30 |
2023-08-12 |
Not clear |
| R Sandy. Treatment with AC pulsed electromagnetic fields improves olfactory function in Parkinson's disease. The International journal of neuroscience. vol 97. issue 3-4. 1999-07-29. PMID:10372649. |
since dopaminergic drugs do not affect olfactory threshold in pd patients, it has been suggested that olfactory dysfunction in these patients is not dependent on dopamine deficiency. |
1999-07-29 |
2023-08-12 |
Not clear |
| R Sandy. Treatment with AC pulsed electromagnetic fields improves olfactory function in Parkinson's disease. The International journal of neuroscience. vol 97. issue 3-4. 1999-07-29. PMID:10372649. |
degeneration of olfactory dopaminergic neurons may lead to upregulation (i.e., supersensitivity) of postsynaptic dopamine d2 receptors. |
1999-07-29 |
2023-08-12 |
Not clear |
| H S Kim, G S Rhee, S Oh, W K Par. NMDA receptor antagonists inhibit apomorphine-induced climbing behavior not only in intact mice but also in reserpine-treated mice. Behavioural brain research. vol 100. issue 1-2. 1999-07-28. PMID:10212060. |
previous work in our laboratory had shown that the noncompetitive nmda receptor antagonists, mk-801, ketamine, dextrorphan and dextromethorphan cause a pronounced inhibition of apomorphine-induced cage climbing behavior in intact mice, suggesting the involvement of nmda receptors in the glutamatergic modulation of dopaminergic function at the postsynaptic dopamine (da) receptors. |
1999-07-28 |
2023-08-12 |
mouse |
| B J Ciliax, G W Drash, J K Staley, S Haber, C J Mobley, G W Miller, E J Mufson, D C Mash, A I Leve. Immunocytochemical localization of the dopamine transporter in human brain. The Journal of comparative neurology. vol 409. issue 1. 1999-07-20. PMID:10363710. |
these data indicate that different subpopulations of dopaminergic neurons use different mechanisms to regulate their extracellular dopamine levels. |
1999-07-20 |
2023-08-12 |
human |
| E A Budygin, R R Gainetdinov, M R Kilpatrick, K S Rayevsky, P T Männistö, R M Wightma. Effect of tolcapone, a catechol-O-methyltransferase inhibitor, on striatal dopaminergic transmission during blockade of dopamine uptake. European journal of pharmacology. vol 370. issue 2. 1999-07-16. PMID:10323260. |
effect of tolcapone, a catechol-o-methyltransferase inhibitor, on striatal dopaminergic transmission during blockade of dopamine uptake. |
1999-07-16 |
2023-08-12 |
rat |