| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Donato A Di Monte, Mitra Lavasani, Amy B Manning-Bo. Environmental factors in Parkinson's disease. Neurotoxicology. vol 23. issue 4-5. 2002-12-16. PMID:12428721. |
relevant examples are (i) the role of the plasma membrane dopamine transporter in facilitating the access of potentially toxic species into dopaminergic neurons; (ii) the vulnerability of the nigrostriatal system to failure of mitochondrial energy metabolism; and (iii) the contribution of inflammatory processes to tissue lesioning. |
2002-12-16 |
2023-08-12 |
Not clear |
| Estelle Rousselet, Jacques Callebert, Karine Parain, Chantal Joubert, Stéphane Hunot, Andreas Hartmann, Claude Jacque, Fernando Perez-Diaz, Charles Cohen-Salmon, Jean-Marie Launay, Etienne C Hirsc. Role of TNF-alpha receptors in mice intoxicated with the parkinsonian toxin MPTP. Experimental neurology. vol 177. issue 1. 2002-12-09. PMID:12429221. |
these data suggest that tnf-alpha does not participate in the death of dopaminergic neurons in parkinsonism but that it slightly alters dopamine metabolism or the survival of dopaminergic terminals by a mechanism involving both receptors. |
2002-12-09 |
2023-08-12 |
mouse |
| Wenzhen Duan, Xiaoxiang Zhu, Bruce Ladenheim, Qian-sheng Yu, Zhihong Guo, Jon Oyler, Roy G Cutler, Jean Lud Cadet, Nigel H Greig, Mark P Mattso. p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism. Annals of neurology. vol 52. issue 5. 2002-12-03. PMID:12402257. |
mice given intraperitoneal injections of pft-alpha or z-1-117 exhibited improved motor function, reduced damage to nigrostriatal dopaminergic neurons and reduced depletion of dopamine and its metabolites after exposure to the toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
2002-12-03 |
2023-08-12 |
mouse |
| Yilong Ma, Andrew Feigin, Vijay Dhawan, Masafumi Fukuda, Qiuhu Shi, Paul Greene, Robert Breeze, Stanley Fahn, Curt Freed, David Eidelber. Dyskinesia after fetal cell transplantation for parkinsonism: a PET study. Annals of neurology. vol 52. issue 5. 2002-12-03. PMID:12402261. |
persistent dyskinesias in the absence of or with only minimal amounts of dopaminergic medication have been reported after dopamine cell implantation for parkinson's disease. |
2002-12-03 |
2023-08-12 |
Not clear |
| R M Moresco, M A Volonte, C Messa, C Gobbo, L Galli, A Carpinelli, G Rizzo, A Panzacchi, M Franceschi, F Fazi. New perspectives on neurochemical effects of amantadine in the brain of parkinsonian patients: a PET - [(11)C]raclopride study. Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 10. 2002-11-27. PMID:12373560. |
aim of this study was to evaluate the effect of repeated administration of amantadine on striatal dopaminergic system by measuring [(11)c]raclopride binding to striatal d(2) dopamine receptors, in patients with moderate idiopathic parkinson's disease. |
2002-11-27 |
2023-08-12 |
rat |
| Kristin E Larsen, Edward A Fon, Teresa G Hastings, Robert H Edwards, David Sulze. Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 20. 2002-11-25. PMID:12388602. |
methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis. |
2002-11-25 |
2023-08-12 |
mouse |
| Stanislav R Vorel, Charles R Ashby, Mousumi Paul, Xinhe Liu, Robert Hayes, Jim J Hagan, Derek N Middlemiss, Geoffrey Stemp, Eliot L Gardne. Dopamine D3 receptor antagonism inhibits cocaine-seeking and cocaine-enhanced brain reward in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 21. 2002-11-25. PMID:12417684. |
dopamine d3 receptor is preferentially localized to the mesocorticolimbic dopaminergic system and has been hypothesized to play a role in cocaine addiction. |
2002-11-25 |
2023-08-12 |
rat |
| Gilberto Gerra, Amir Zaimovic, Gabriele Moi, Francesca Giusti, Simona Gardini, Roberto Delsignore, Gianni Laviola, Teodora Macchia, Francesca Brambill. Effects of (+/-) 3,4-methylene-dioxymethamphetamine (ecstasy) on dopamine system function in humans. Behavioural brain research. vol 134. issue 1-2. 2002-11-19. PMID:12191827. |
although the hypothesis of dopaminergic changes associated with a premorbid condition cannot be completely excluded, the inverse correlation between da receptors sensitivity and the extent of ecstasy exposure may suggest a direct pharmacological action of mdma on brain dopamine function in humans. |
2002-11-19 |
2023-08-12 |
human |
| Zhizhong Dong, Boris Ferger, Joram Feldon, Hansruedi Büele. Overexpression of Parkinson's disease-associated alpha-synucleinA53T by recombinant adeno-associated virus in mice does not increase the vulnerability of dopaminergic neurons to MPTP. Journal of neurobiology. vol 53. issue 1. 2002-11-19. PMID:12360578. |
determination of dopaminergic neuron survival, striatal tyrosine hydroxylase fiber density, and striatal content of dopamine and its metabolites in raav-injected and uninjected hemispheres demonstrated that alpha-synuclein(a53t) does not increase the susceptibility of dopaminergic neurons to mptp. |
2002-11-19 |
2023-08-12 |
mouse |
| Douglas S Kim, Glenda J Froelick, Richard D Palmite. Dopamine-dependent desensitization of dopaminergic signaling in the developing mouse striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 22. 2002-11-18. PMID:12427840. |
control mice and mutant mice, in which dopamine production is inactivated in dopaminergic neurons by gene targeting, were treated with saline; a synthetic dopamine precursor, l-3,4-dihydroxyphenylalanine (l-dopa) methyl ester; a direct dopamine d(1) receptor agonist, n-allyl-skf 38393; or a dopamine reuptake inhibitor, cocaine. |
2002-11-18 |
2023-08-12 |
mouse |
| Douglas S Kim, Glenda J Froelick, Richard D Palmite. Dopamine-dependent desensitization of dopaminergic signaling in the developing mouse striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 22. 2002-11-18. PMID:12427840. |
the results suggest that striatal dopamine receptors are capable of transducing extracellular signals at p4 and p6, but dopaminergic neurotransmission begins thereafter. |
2002-11-18 |
2023-08-12 |
mouse |
| Douglas S Kim, Glenda J Froelick, Richard D Palmite. Dopamine-dependent desensitization of dopaminergic signaling in the developing mouse striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 22. 2002-11-18. PMID:12427840. |
dopaminoceptive neurons appear to reduce their sensitivity to dopamine as dopaminergic terminals innervate the striatum and functional neurotransmission begins. |
2002-11-18 |
2023-08-12 |
mouse |
| Jenny L Wiley, Kari L Lavecchia, Billy R Martin, M Imad Dama. Nicotine-like discriminative stimulus effects of bupropion in rats. Experimental and clinical psychopharmacology. vol 10. issue 2. 2002-11-13. PMID:12022798. |
given bupropion's shared pharmacology with dopamine transport inhibitors, these effects may be produced in part through bupropion's actions on dopaminergic neurotransmission. |
2002-11-13 |
2023-08-12 |
rat |
| Nicholas H Caskey, Murray E Jarvik, William C Wirshing, Damian C Madsen, Paula N Iwamoto-Schaap, Naomi I Eisenberger, Lorena Huerta, Scott M Terrace, Richard E Olmstea. Modulating tobacco smoking rates by dopaminergic stimulation and blockade. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 4. issue 3. 2002-11-07. PMID:12215234. |
in prior human studies, a dopaminergic antagonist, haloperidol, increased smoking and/or nicotine intake, and a dopamine agonist, bromocriptine, decreased smoking. |
2002-11-07 |
2023-08-12 |
human |
| Wim Vleeming, Bisoen Rambali, Antoon Opperhuize. The role of nitric oxide in cigarette smoking and nicotine addiction. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 4. issue 3. 2002-11-07. PMID:12215243. |
this second form of exposure to no also inhibits the re-uptake of dopamine, which may contribute to dopaminergic receptor stimulation and thus to the acute rewarding effects of nicotine. |
2002-11-07 |
2023-08-12 |
Not clear |
| T Mülle. Non-dopaminergic drug treatment of Parkinson's disease. Expert opinion on pharmacotherapy. vol 2. issue 4. 2002-11-06. PMID:11336607. |
the interesting field of non-dopaminergic drug therapy is emerging and will hopefully lead to a better understanding of pd and subsequently improve drug therapy of parkinsonian symptoms, which do not respond to dopaminergic substitution or are long-term complications of dopamine substitution. |
2002-11-06 |
2023-08-12 |
Not clear |
| David J Gracey, Robert Bell, David J Kin. Differential effects of the CCKA receptor ligands PD-140,548 and A-71623 on latent inhibition in the rat. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 3. 2002-11-05. PMID:11999900. |
the antipsychotic potential of cholecystokinin (cck) stems from its colocalization with dopamine (da) in the mesolimbic pathway, where it demonstrates both excitatory and inhibitory effects on dopaminergic activity. |
2002-11-05 |
2023-08-12 |
rat |
| Frédéric Canini, Nadine Simler, Lionel Bourdo. MK801 impairs thermoregulation in the heat. Canadian journal of physiology and pharmacology. vol 80. issue 3. 2002-11-04. PMID:11991234. |
the effects of mk801 (dizocilpine), a glutamate nmda receptor antagonist, on thermoregulation in the heat were studied in awake rats exposed to 40 degrees c ambient temperature until their body core temperature reached 43 degrees c. under these conditions, mk801-treated rats exhibited enhanced locomotor activity and a steady rise in body core temperature, which reduced the heat exposure duration required to reach 43 degrees c. since mk801-treated rats also showed increased striatal dopaminergic metabolism at thermoneutrality, the role of dopamine in the mk801-induced impairment of thermoregulation in the heat was determined using co-treatment with sch23390, a dopamine d1 receptor antagonist. |
2002-11-04 |
2023-08-12 |
rat |
| Maria Antonietta Casu, Dinuccio Dinucci, Giancarlo Colombo, Gian Luigi Gessa, Luca Pan. Reduced DAT- and DBH-immunostaining in the limbic system of Sardinian alcohol-preferring rats. Brain research. vol 948. issue 1-2. 2002-10-30. PMID:12383975. |
since these regions contain both dopamine and noradrenaline (na) fibers, clarification of the dopaminergic and noradrenergic contribution to the decreased th-immunoreactivity was needed. |
2002-10-30 |
2023-08-12 |
rat |
| Maria Antonietta Casu, Dinuccio Dinucci, Giancarlo Colombo, Gian Luigi Gessa, Luca Pan. Reduced DAT- and DBH-immunostaining in the limbic system of Sardinian alcohol-preferring rats. Brain research. vol 948. issue 1-2. 2002-10-30. PMID:12383975. |
to this aim, we carried out the present immunohistochemistry study using two antibodies raised against dopamine beta-hydroxylase (dbh), the enzyme responsible for the conversion of dopamine into noradrenaline, and against the dopamine transporter (dat), as markers for noradrenergic and dopaminergic fibers, respectively. |
2002-10-30 |
2023-08-12 |
rat |