| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marie-Thérèse Armentero, Roberto Fancellu, Giuseppe Nappi, Fabio Blandin. Dopamine receptor agonists mediate neuroprotection in malonate-induced striatal lesion in the rat. Experimental neurology. vol 178. issue 2. 2003-01-21. PMID:12504889. |
recent studies have shown that dopamine agonists may exert neuroprotective effects via multiple mechanisms, including modulation of dopamine release from nigrostriatal dopaminergic terminals. |
2003-01-21 |
2023-08-12 |
rat |
| Regina Katzenschlager, Andrew J Lee. Treatment of Parkinson's disease: levodopa as the first choice. Journal of neurology. vol 249 Suppl 2. 2003-01-17. PMID:12375059. |
studies in animal models and in humans show that these motor complications are not specific to a particular dopaminergic agent, but that they are related both to the extent of the striatal lesion and to the mode of application of dopaminergic agents: pulsatile administration of l-dopa and of the dopamine agonist apomorphine causes more motor complications than continuous striatal dopaminergic receptor stimulation, and continuous administration can alleviate existing dyskinesias and fluctuations. |
2003-01-17 |
2023-08-12 |
Not clear |
| Brandon J Aragona, J Thomas Curtis, Alec J Davidson, Zuoxin Wang, Friedrich K Stepha. Behavioral and neurochemical investigation of circadian time-place learning in the rat. Journal of biological rhythms. vol 17. issue 4. 2003-01-16. PMID:12164249. |
these rats also showed significant correlations between the level of faa and the amount of dopamine turnover (the dihydroxyphenylacetic acid/dopamine ratio) in the nucleus accumbens and paraventricular nucleus of the hypothalamus, indicating possible involvement of regional dopaminergic activity in time-place behavior. |
2003-01-16 |
2023-08-12 |
rat |
| P O Fernagut, E Diguet, N Stefanova, M Biran, G K Wenning, P Canioni, B Bioulac, F Tiso. Subacute systemic 3-nitropropionic acid intoxication induces a distinct motor disorder in adult C57Bl/6 mice: behavioural and histopathological characterisation. Neuroscience. vol 114. issue 4. 2003-01-10. PMID:12379255. |
the scale correlated with the striatal volume reduction (r(2)=0.57) and striatal cell loss (r(2)=0.87) but not with the loss of striatal dopaminergic terminals (dopamine transporter binding). |
2003-01-10 |
2023-08-12 |
mouse |
| Jennifer L Tillerson, W Michael Caudle, Maria E Reverón, Gary W Mille. Detection of behavioral impairments correlated to neurochemical deficits in mice treated with moderate doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Experimental neurology. vol 178. issue 1. 2003-01-08. PMID:12460610. |
in this paper, we demonstrate that mice treated with moderate doses of the dopaminergic toxin mptp display deficits in behavioral parameters that are significantly correlated with the loss of striatal dopamine. |
2003-01-08 |
2023-08-12 |
mouse |
| Choon-Gon Jang, Seok-Yong Lee, Han-Kyu Lee, Hong-Won Suh, Dong-Keun Son. Time courses of pCREB expression after dopaminergic stimulation by apomorphine in mouse brain. Archives of pharmacal research. vol 25. issue 3. 2003-01-07. PMID:12135112. |
administration of dopamine agonist, apomorphine (2 mg/kg, s.c.), produces cage climbing behavior in mice that exhibit typical dopaminergic stimulation. |
2003-01-07 |
2023-08-12 |
mouse |
| N A Denisova, B Shukitt-Hale, B M Rabin, J A Josep. Brain signaling and behavioral responses induced by exposure to (56)Fe-particle radiation. Radiation research. vol 158. issue 6. 2003-01-03. PMID:12452775. |
overall, our findings suggest that radiation-induced pre-synaptic facilitation may contribute to some previously reported radiation-induced decrease in striatal dopamine release and for the disruption of the central dopaminergic system integrity and dopamine-mediated behavior. |
2003-01-03 |
2023-08-12 |
Not clear |
| Barbara Picconi, Antonio Pisani, Diego Centonze, Giuseppe Battaglia, Marianna Storto, Ferdinando Nicoletti, Giorgio Bernardi, Paolo Calabres. Striatal metabotropic glutamate receptor function following experimental parkinsonism and chronic levodopa treatment. Brain : a journal of neurology. vol 125. issue Pt 12. 2002-12-31. PMID:12429591. |
corticostriatal glutamatergic transmission was examined in striatal slices obtained from rats unilaterally denervated with the dopaminergic neurotoxin, 6-hydroxy dopamine (6-ohda), and from denervated rats chronically treated with l-dopa plus benserazide (25 + 6.25 mg/kg, intraperitoneally, twice daily for 21 days). |
2002-12-31 |
2023-08-12 |
rat |
| José Segovi. Gene therapy for Parkinson's disease: current status and future potential. American journal of pharmacogenomics : genomics-related research in drug development and clinical practice. vol 2. issue 2. 2002-12-26. PMID:12083948. |
the first, and most explored strategy so far, consists in engineering cells to produce levodopa or dopamine so they will replace dopaminergic neurotransmission. |
2002-12-26 |
2023-08-12 |
Not clear |
| Diego Centonze, Alessandro Usiello, Paolo Gubellini, Antonio Pisani, Emiliana Borrelli, Giorgio Bernardi, Paolo Calabres. Dopamine D2 receptor-mediated inhibition of dopaminergic neurons in mice lacking D2L receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 5. 2002-12-26. PMID:12431847. |
dopamine d2 receptor-mediated inhibition of dopaminergic neurons in mice lacking d2l receptors. |
2002-12-26 |
2023-08-12 |
mouse |
| b' Marko Huotari, Miklos Santha, Louis R Lucas, Maria Karayiorgou, Joseph A Gogos, Pekka T M\\xc3\\xa4nnist\\xc3\\xb. Effect of dopamine uptake inhibition on brain catecholamine levels and locomotion in catechol-O-methyltransferase-disrupted mice. The Journal of pharmacology and experimental therapeutics. vol 303. issue 3. 2002-12-24. PMID:12438556.' |
for dopaminergic neurons, uptake by the high-affinity dopamine transporter (dat) is the most effective mechanism, and the contribution of glial comt remains secondary under normal conditions. |
2002-12-24 |
2023-08-12 |
mouse |
| Gustavo Pastelín Hernánde. [Pharmacology of inotropic agents]. Archivos de cardiologia de Mexico. vol 72 Suppl 1. 2002-12-23. PMID:12001837. |
adrenergic agents are the catecholamines, adrenaline (a), noradrenaline (na) and dopamine (d), plus dopaminergic agonists as dobutamine and pirbuterol. |
2002-12-23 |
2023-08-12 |
Not clear |
| Patrik Munzar, Zuzana Justinova, Scott W Kutkat, Sergi Ferré, Steven R Goldber. Adenosinergic modulation of the discriminative-stimulus effects of methamphetamine in rats. Psychopharmacology. vol 161. issue 4. 2002-12-23. PMID:12073161. |
a(1) and a(2a) adenosine receptors are co-localized with dopamine d(1) and d(2) receptors, respectively, and their stimulation attenuates dopaminergic functioning. |
2002-12-23 |
2023-08-12 |
rat |
| J P Guignar. [Aggression to the immature kidney]. La Pediatria medica e chirurgica : Medical and surgical pediatrics. vol 24. issue 2. 2002-12-20. PMID:11987507. |
moreover, in order to protect the kidney, different compounds have been proposed such as diuretics (furosemide and torasemide), and dopaminergic agents (dopamine, dopexamine). |
2002-12-20 |
2023-08-12 |
Not clear |
| Joanne Chu, Walter Wilczynsk. Androgen effects on tyrosine hydroxylase cells in the northern leopard frog, Rana pipiens. Neuroendocrinology. vol 76. issue 1. 2002-12-20. PMID:12097813. |
these results suggest that dopamine may be important in controlling the behavior or neuroendocrine mechanisms of reproduction in these animals and that dopaminergic activity in these areas is regulated by gonadal steroids. |
2002-12-20 |
2023-08-12 |
Not clear |
| Monica L Andersen, Sergio Tufi. Distinct effects of paradoxical sleep deprivation and cocaine administration on sexual behavior in male rats. Addiction biology. vol 7. issue 2. 2002-12-19. PMID:12006221. |
these findings are due probably to psd causing supersensitivity of dopamine (da) receptors exacerbating the cocaine actions on dopaminergic pathways inducing penile erection and ejaculation. |
2002-12-19 |
2023-08-12 |
rat |
| M F G Murphy, K Hey, E Johnstone, M Munafo, R Walton, B Willis, P J Harriso. Bromocriptine use is associated with decreased smoking rates. Addiction biology. vol 7. issue 3. 2002-12-19. PMID:12126493. |
one effective smoking cessation drug, bupropion, enhances dopaminergic transmission; conversely, antipsychotic drugs, which are dopamine antagonists, are associated with increased smoking. |
2002-12-19 |
2023-08-12 |
Not clear |
| Vural Ozdemir, Jeanne Fourie, Fatih Ozdene. Aripiprazole (Otsuka Pharmaceutical Co). Current opinion in investigational drugs (London, England : 2000). vol 3. issue 1. 2002-12-17. PMID:12054061. |
although presynaptic dopamine autoreceptor agonists may be efficacious in the treatment of schizophrenia, they may also potentially increase the risk for exacerbation of psychosis through stimulation of postsynaptic dopaminergic receptors [245791], [350478], [350479]. |
2002-12-17 |
2023-08-12 |
Not clear |
| Pippa S Loupe, Jonna D Bredemeier, Stephen R Schroeder, Richard E Tesse. Dopamine re-uptake inhibitor GBR-12909 induction of aberrant behaviors in animal models of dopamine dysfunction. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 20. issue 3-5. 2002-12-17. PMID:12175869. |
the three animal models included the neonatal 6-hydroxydopamine (6-ohda)-lesioned rat, a model of dopamine neuronal depletion, the prenatal methylazoxymethanol (mam)-exposed rat, a model of hyper-dopaminergic innervation and control rats, a model of normal dopaminergic function. |
2002-12-17 |
2023-08-12 |
rat |
| Pippa S Loupe, Jonna D Bredemeier, Stephen R Schroeder, Richard E Tesse. Dopamine re-uptake inhibitor GBR-12909 induction of aberrant behaviors in animal models of dopamine dysfunction. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 20. issue 3-5. 2002-12-17. PMID:12175869. |
these findings indicate the models of varying dopaminergic function interact differently with a dopamine re-uptake blocker than dopamine agonists and that the partially dopamine depleted model may model the behaviors seen in individuals with rett syndrome. |
2002-12-17 |
2023-08-12 |
rat |