| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M V Ugryumov, V I Mel'nikova, P V Ershov, I S Balan, A Kala. Non-dopaminergic neurons expressing dopamine synthesis enzymes: differentiation and functional significance. Neuroscience and behavioral physiology. vol 32. issue 3. 2002-08-19. PMID:12135344. |
thus, dopamine is probably synthesized in the arcuate nucleus not only by dopaminergic neurons, but also by neurons expressing only tyrosine hydroxylase or aromatic l-amino acid decarboxylase. |
2002-08-19 |
2023-08-12 |
rat |
| Toshio Obat. Nitric oxide and depolarization induce hydroxyl radical generation. Japanese journal of pharmacology. vol 88. issue 1. 2002-08-15. PMID:11855667. |
abnormal levels of extracellular free dopamine (da) and/or intraneuronal ca2+ triggered by 1-methyl-4-phenylpyridinium ion (mpp+) may be detrimental to the functioning of dopaminergic nerve terminals in the striatum. |
2002-08-15 |
2023-08-12 |
Not clear |
| J Jeanblanc, A Hoeltzel, A Louilo. Dissociation in the involvement of dopaminergic neurons innervating the core and shell subregions of the nucleus accumbens in latent inhibition and affective perception. Neuroscience. vol 111. issue 2. 2002-08-13. PMID:11983317. |
nonetheless dopamine in the ventromedial shell was found to be involved in affective perception of the stimulus.the present data suggest that dopaminergic neurons innervating the three nucleus accumbens subregions are functionally related to networks involved in parallel processing of the cognitive and affective values of environmental information, and that interaction between these systems, at some levels, may lead to a given behavioral output. |
2002-08-13 |
2023-08-12 |
rat |
| Francesco Fornai, Maria Teresa Carrì, Alberto Ferri, Egle Paolucci, Simona Prisco, Giorgio Bernardi, Giuseppe Rotilio, Nicola Biagio Mercur. Resistance to striatal dopamine depletion induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice expressing human mutant Cu,Zn superoxide dismutase. Neuroscience letters. vol 325. issue 2. 2002-08-06. PMID:12044637. |
in the present study we investigated whether a mutant form of sod1 (g93a), occurring in humans affected by amyotrophic lateral sclerosis, leads to a differential vulnerability of nigrostriatal dopaminergic neurons to the chronic dopamine depletion induced by the selective neurotoxin mptp. |
2002-08-06 |
2023-08-12 |
mouse |
| A Prikhojan, T Brannan, M D Yah. Intrastriatal iron perfusion releases dopamine: an in-vivo microdialysis study. Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 5-6. 2002-08-06. PMID:12111456. |
the implications of chronic release of dopamine as a cause of dopaminergic cell death are discussed. |
2002-08-06 |
2023-08-12 |
rat |
| A Nguyen, G Gille, R Moldzio, S-T Hung, W-D Rausc. Synthetic neuromelanin is toxic to dopaminergic cell cultures. Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 5-6. 2002-08-06. PMID:12111457. |
in the present study, primary cultures of mesencephalic dopaminergic cells were exposed to synthetic dopamine neuromelanin (nm) for 48 hrs at concentrations of 0, 1, 10, 20, 50 and 100 microg nm/ml medium. |
2002-08-06 |
2023-08-12 |
Not clear |
| Martine Barkats, Stéphanie Millecamps, Alicia Bilang-Bleuel, Jacques Malle. Neuronal transfer of the human Cu/Zn superoxide dismutase gene increases the resistance of dopaminergic neurons to 6-hydroxydopamine. Journal of neurochemistry. vol 82. issue 1. 2002-08-05. PMID:12091470. |
neurotoxin 6-hydroxydopamine (6-ohda), which induces parkinsonian symptoms in experimental animals, is thought to be formed endogenously in patients with pd through dopamine (da) oxidation and may cause dopaminergic cell death via a free radical mechanism. |
2002-08-05 |
2023-08-12 |
human |
| Syed Z Imam, Glenn D Newport, Helen M Duhart, Fakhrul Islam, William Slikker, Syed F Al. Methamphetamine-induced dopaminergic neurotoxicity and production of peroxynitrite are potentiated in nerve growth factor differentiated pheochromocytoma 12 cells. Annals of the New York Academy of Sciences. vol 965. 2002-08-02. PMID:12105096. |
meth administration selectively damages the dopaminergic nerve terminals, which is hypothesized to be due to release of dopamine from synaptic vesicles within the terminals. |
2002-08-02 |
2023-08-12 |
Not clear |
| K R Sidell, V Amamath, T J Montin. Dopamine thioethers in neurodegeneration. Current topics in medicinal chemistry. vol 1. issue 6. 2002-07-19. PMID:11895128. |
dopamine oxidation is proposed to be a significant contributor to mesostriatal dopaminergic neurodegeneration, although the mechanisms are not fully resolved. |
2002-07-19 |
2023-08-12 |
human |
| K R Sidell, V Amamath, T J Montin. Dopamine thioethers in neurodegeneration. Current topics in medicinal chemistry. vol 1. issue 6. 2002-07-19. PMID:11895128. |
recent results from in vitro and in vivo models have suggested that some products from mercapturic acid pathway (map) metabolism of oxidized dopamine (da) may contribute to dopaminergic neurodegeneration, and that at least one product of this pathway, 5-s-cysteinyldopamine (cys-da), is elevated in patients with advanced parkinson's disease (pd). |
2002-07-19 |
2023-08-12 |
human |
| Lina Yao, Maria Pia Arolfo, Douglas P Dohrman, Zhan Jiang, Peidong Fan, Sara Fuchs, Patricia H Janak, Adrienne S Gordon, Ivan Diamon. betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption. Cell. vol 109. issue 6. 2002-07-19. PMID:12086672. |
dopamine release is activated by ethanol and addicting drugs, but molecular mechanisms linking dopaminergic signaling to neuronal responses and drinking behavior are poorly understood. |
2002-07-19 |
2023-08-12 |
Not clear |
| M Legault, P Congar, F J Michel, L-E Trudea. Presynaptic action of neurotensin on cultured ventral tegmental area dopaminergic neurones. Neuroscience. vol 111. issue 1. 2002-07-18. PMID:11955721. |
although indirect evidence suggests that some neurotensin receptors may be localised on the nerve terminals of dopaminergic neurones in the striatum and thus locally regulate dopamine release, a clear demonstration of such a mechanism is lacking and a number of indirect sites of action are possible. |
2002-07-18 |
2023-08-12 |
rat |
| M Legault, P Congar, F J Michel, L-E Trudea. Presynaptic action of neurotensin on cultured ventral tegmental area dopaminergic neurones. Neuroscience. vol 111. issue 1. 2002-07-18. PMID:11955721. |
however, nt(8-13) reduced the ability of terminal d2 dopamine receptors to inhibit action potential-evoked epscs in isolated dopaminergic neurones. |
2002-07-18 |
2023-08-12 |
rat |
| Shih-Jen Tsai, Younger W-Y Yu, Ching-Hua Lin, Tai-Jui Chen, Sheau-Ping Chen, Chen-Jee Hon. Dopamine D2 receptor and N-methyl-D-aspartate receptor 2B subunit genetic variants and intelligence. Neuropsychobiology. vol 45. issue 3. 2002-07-18. PMID:11979061. |
considering the major role played by the dopaminergic system in general cognitive function, genetic variants of the dopamine receptors and those involved in metabolism and modulation of reuptake should be tested to improve gene-based prediction of general cognitive function. |
2002-07-18 |
2023-08-12 |
human |
| Jonas Lindblom, Ants Kask, Erik Hägg, Linda Härmark, Lena Bergström, Jarl Wikber. Chronic infusion of a melanocortin receptor agonist modulates dopamine receptor binding in the rat brain. Pharmacological research. vol 45. issue 2. 2002-07-15. PMID:11846623. |
these data suggest that chronic infusion of a melanocortin receptor agonist alters the activity of dopaminergic neurons in the ventral tegmental area and substantia nigra, and support the hypothesis that melanocortin peptides may regulate the activity of central dopamine neurons. |
2002-07-15 |
2023-08-12 |
rat |
| Masashi Kitazawa, Jarrad R Wagner, Michael L Kirby, Vellareddy Anantharam, Anumantha G Kanthasam. Oxidative stress and mitochondrial-mediated apoptosis in dopaminergic cells exposed to methylcyclopentadienyl manganese tricarbonyl. The Journal of pharmacology and experimental therapeutics. vol 302. issue 1. 2002-07-12. PMID:12065696. |
mmt also potently depleted dopamine apparently by cytoplasmic vesicular release to the cytosol, a neurochemical change resembling other dopaminergic neurotoxicants. |
2002-07-12 |
2023-08-12 |
Not clear |
| R E Maldve, T A Zhang, K Ferrani-Kile, S S Schreiber, M J Lippmann, G L Snyder, A A Fienberg, S W Leslie, R A Gonzales, R A Morriset. DARPP-32 and regulation of the ethanol sensitivity of NMDA receptors in the nucleus accumbens. Nature neuroscience. vol 5. issue 7. 2002-07-12. PMID:12068305. |
here we investigate how dopaminergic inputs alter the ethanol sensitivity of nmda receptors in rats and mice and report that previous dopamine receptor-1 (d1) activation, culminating in dopamine and camp-regulated phosphoprotein-32 kd (darpp-32) and nmda receptor subunit-1 (nr1)-nmda receptor phosphorylation, strongly decreases ethanol inhibition of nmda responses. |
2002-07-12 |
2023-08-12 |
mouse |
| D M Wu, H Kawamura, Q Li, D G Pur. Dopamine activates ATP-sensitive K+ currents in rat retinal pericytes. Visual neuroscience. vol 18. issue 6. 2002-07-08. PMID:12020084. |
because dopaminergic neurites are closely associated with microvessels that express dopamine receptors, this molecule is a putative neuron-to-capillary signal, as well as neurotransmitter. |
2002-07-08 |
2023-08-12 |
rat |
| D M Wu, H Kawamura, Q Li, D G Pur. Dopamine activates ATP-sensitive K+ currents in rat retinal pericytes. Visual neuroscience. vol 18. issue 6. 2002-07-08. PMID:12020084. |
consistent with a signaling pathway involving d1 dopamine receptors, adenylate cyclase and protein kinase a (pka), the selective d1 antagonist, sch23390, inhibited the hyperpolarizing effect of dopamine; the activator of adenylate cyclase, forskolin, mimicked the dopaminergic effect, and h89, which inhibits pka, significantly reduced the hyperpolarization induced by dopamine. |
2002-07-08 |
2023-08-12 |
rat |
| Miriam A Hickey, Gavin P Reynolds, A Jennifer Morto. The role of dopamine in motor symptoms in the R6/2 transgenic mouse model of Huntington's disease. Journal of neurochemistry. vol 81. issue 1. 2002-07-05. PMID:12067237. |
in both huntington's disease (hd) patients and genetic mouse models of hd, there is a pre-symptomatic loss of dopamine (da) receptors, suggesting that dysfunctional dopaminergic neurotransmission may be involved in early hd presentation. |
2002-07-05 |
2023-08-12 |
mouse |