| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Néstor F Díaz, Néstor E Díaz-Martínez, Ignacio Camacho-Arroyo, Iván Velasc. Estradiol promotes proliferation of dopaminergic precursors resulting in a higher proportion of dopamine neurons derived from mouse embryonic stem cells. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 27. issue 5. 2009-08-12. PMID:19379802. |
estradiol added at nm concentrations only during stage 4 increases the proliferation of dopaminergic precursors expressing lmx1a, inducing a higher proportion of dopamine neurons at stage 5. |
2009-08-12 |
2023-08-12 |
mouse |
| Shamol Saha, Maria D Guillily, Andrew Ferree, Joel Lanceta, Diane Chan, Joy Ghosh, Cindy H Hsu, Lilach Segal, Kesav Raghavan, Kunihiro Matsumoto, Naoki Hisamoto, Tomoki Kuwahara, Takeshi Iwatsubo, Landon Moore, Lee Goldstein, Mark Cookson, Benjamin Wolozi. LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 29. 2009-08-10. PMID:19625511. |
c. elegans expressing lrrk2 showed rapid loss of dopaminergic markers (dat::gfp fluorescence and dopamine levels) beginning in early adulthood. |
2009-08-10 |
2023-08-12 |
human |
| Shamol Saha, Maria D Guillily, Andrew Ferree, Joel Lanceta, Diane Chan, Joy Ghosh, Cindy H Hsu, Lilach Segal, Kesav Raghavan, Kunihiro Matsumoto, Naoki Hisamoto, Tomoki Kuwahara, Takeshi Iwatsubo, Landon Moore, Lee Goldstein, Mark Cookson, Benjamin Wolozi. LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 29. 2009-08-10. PMID:19625511. |
rotenone treatment induced a larger loss of dopamine markers in c. elegans expressing g2019s lrrk2 than in c. elegans expressing wild-type lrrk2; however, loss of dopaminergic markers in the g2019s lrrk2 nematode lines was not statistically different from that in the control line. |
2009-08-10 |
2023-08-12 |
human |
| Thaís Posser, Jeferson L Franco, Larisa Bobrovskaya, Rodrigo B Leal, Phillip W Dickson, Peter R Dunkle. Manganese induces sustained Ser40 phosphorylation and activation of tyrosine hydroxylase in PC12 cells. Journal of neurochemistry. vol 110. issue 3. 2009-08-07. PMID:19558449. |
the dopaminergic system is a particular target for mn2+ neurotoxicity.tyrosine hydroxylase (th) is the rate limiting enzyme for dopamine synthesis and is regulated acutely by phosphorylation at ser40 and chronically by protein synthesis. |
2009-08-07 |
2023-08-12 |
Not clear |
| C C Zai, A K Tiwari, V Basile, V De Luca, D J Müller, N King, A N Voineskos, G Remington, H Y Meltzer, J A Lieberman, S G Potkin, J L Kenned. Association study of tardive dyskinesia and five DRD4 polymorphisms in schizophrenia patients. The pharmacogenomics journal. vol 9. issue 3. 2009-08-05. PMID:19238168. |
abnormalities in dopaminergic activity in the nigro-striatal system have been most often suggested to be involved because the agents that cause td share in common potent antagonism of dopamine d(2) receptors (drd2). |
2009-08-05 |
2023-08-12 |
Not clear |
| Xenia Borue, Stephanie Cooper, Jay Hirsh, Barry Condron, B Jill Vento. Quantitative evaluation of serotonin release and clearance in Drosophila. Journal of neuroscience methods. vol 179. issue 2. 2009-08-04. PMID:19428541. |
when chr2 is targeted to dopaminergic neurons, dopamine release is measured demonstrating that this method is broadly applicable to other neurotransmitter systems. |
2009-08-04 |
2023-08-12 |
drosophila_melanogaster |
| Tonya N Taylor, W Michael Caudle, Kennie R Shepherd, AliReza Noorian, Chad R Jackson, P Michael Iuvone, David Weinshenker, James G Greene, Gary W Mille. Nonmotor symptoms of Parkinson's disease revealed in an animal model with reduced monoamine storage capacity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 25. 2009-08-04. PMID:19553450. |
previously, we have shown that mice with a 95% genetic reduction in vesicular monoamine transporter expression (vmat2-deficient, vmat2 lo) display progressive loss of striatal dopamine, l-dopa-responsive motor deficits, alpha-synuclein accumulation, and nigral dopaminergic cell loss. |
2009-08-04 |
2023-08-12 |
mouse |
| Luna Abdallah, Stephen J Bonasera, F Woodward Hopf, Laura O'Dell, Marco Giorgetti, Minke Jongsma, Scott Carra, Massimo Pierucci, Giuseppe Di Giovanni, Ennio Esposito, Loren H Parsons, Antonello Bonci, Laurence H Tecot. Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 25. 2009-08-04. PMID:19553455. |
5-ht(2c)r mutant mice displayed increased activity of substantia nigra pars compacta (snc) dopaminergic neurons, elevated baseline extracellular dopamine concentrations in the dorsal striatum (dst), alterations in grooming behavior, and enhanced sensitivity to the stereotypic behavioral effects of d-amphetamine and gbr 12909. |
2009-08-04 |
2023-08-12 |
mouse |
| Fatuel Tecuapetla, Tibor Koós, James M Tepper, Nadine Kabbani, Mark F Yecke. Differential dopaminergic modulation of neostriatal synaptic connections of striatopallidal axon collaterals. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 28. 2009-08-03. PMID:19605635. |
in light of the cell type-specific expression of d(1a)r in striatonigral and d(2)r in striatopallidal neurons and the differential expression of the other d(1) and d(2) family dopamine receptors, we hypothesize that the nature of the dopaminergic modulation is specific to the types of spns that participate in the connection. |
2009-08-03 |
2023-08-12 |
Not clear |
| Zheng-xiong Xi, Krista Spiller, Eliot L Gardne. Mechanism-based medication development for the treatment of nicotine dependence. Acta pharmacologica Sinica. vol 30. issue 6. 2009-07-31. PMID:19434058. |
nicotine binds to alpha4beta2 and alpha7 nicotinic acetylcholine receptors (nachrs) located on dopaminergic, glutamatergic and gabaergic neurons in the mesolimbic dopamine (da) system, which causes an increase in extracellular da in the nucleus accumbens (nac). |
2009-07-31 |
2023-08-12 |
Not clear |
| Yasuhiko Izumi, Noriyuki Yamamoto, Takaaki Matsuo, Seiko Wakita, Hiroki Takeuchi, Toshiaki Kume, Hiroshi Katsuki, Hideyuki Sawada, Akinori Akaik. Vulnerability to glutamate toxicity of dopaminergic neurons is dependent on endogenous dopamine and MAPK activation. Journal of neurochemistry. vol 110. issue 2. 2009-07-31. PMID:19457068. |
vulnerability to glutamate toxicity of dopaminergic neurons is dependent on endogenous dopamine and mapk activation. |
2009-07-31 |
2023-08-12 |
rat |
| Yasuhiko Izumi, Noriyuki Yamamoto, Takaaki Matsuo, Seiko Wakita, Hiroki Takeuchi, Toshiaki Kume, Hiroshi Katsuki, Hideyuki Sawada, Akinori Akaik. Vulnerability to glutamate toxicity of dopaminergic neurons is dependent on endogenous dopamine and MAPK activation. Journal of neurochemistry. vol 110. issue 2. 2009-07-31. PMID:19457068. |
an increasing amount of evidence suggests that endogenous dopamine plays a role in the vulnerability of dopaminergic neurons. |
2009-07-31 |
2023-08-12 |
rat |
| Yasuhiko Izumi, Noriyuki Yamamoto, Takaaki Matsuo, Seiko Wakita, Hiroki Takeuchi, Toshiaki Kume, Hiroshi Katsuki, Hideyuki Sawada, Akinori Akaik. Vulnerability to glutamate toxicity of dopaminergic neurons is dependent on endogenous dopamine and MAPK activation. Journal of neurochemistry. vol 110. issue 2. 2009-07-31. PMID:19457068. |
furthermore, depletion of dopamine by alpha-methyl-dl-p-tyrosine methyl ester (alpha-mt), an inhibitor of tyrosine hydroxylase (th), protected dopaminergic neurons from the neurotoxicity. |
2009-07-31 |
2023-08-12 |
rat |
| Yasuhiko Izumi, Noriyuki Yamamoto, Takaaki Matsuo, Seiko Wakita, Hiroki Takeuchi, Toshiaki Kume, Hiroshi Katsuki, Hideyuki Sawada, Akinori Akaik. Vulnerability to glutamate toxicity of dopaminergic neurons is dependent on endogenous dopamine and MAPK activation. Journal of neurochemistry. vol 110. issue 2. 2009-07-31. PMID:19457068. |
these data suggest that endogenous dopamine is responsible for the vulnerability to glutamate toxicity of dopaminergic neurons and one of the mechanisms may be an enhancement of dopamine synthesis mediated by erk. |
2009-07-31 |
2023-08-12 |
rat |
| Randy L Hunter, Baohua Cheng, Dong-Young Choi, Mei Liu, Shuwei Liu, Wayne A Cass, Guoying Bin. Intrastriatal lipopolysaccharide injection induces parkinsonism in C57/B6 mice. Journal of neuroscience research. vol 87. issue 8. 2009-07-30. PMID:19224579. |
we showed progressive and specific dopaminergic neurodegeneration in the substantia nigra, which is accompanied by striatal dopamine depletion and progressive behavioral impairment, which was alleviated by the use of the pd drug l-dopa. |
2009-07-30 |
2023-08-12 |
mouse |
| Gero Falkenstein, Christoph Rosenthal, Torsten Reum, Rudolf Morgenstern, Máté Döbrössy, Guido Nikkha. Pattern of long-term sensorimotor recovery following intrastriatal and--accumbens DA micrografts in a rat model of Parkinson's disease. The Journal of comparative neurology. vol 515. issue 1. 2009-07-28. PMID:19399892. |
the data show that forelimb stepping, balancing behavior, and skilled forelimb reaching behavior was more restored in cpu-6-grafted animals as compared to cpu-2 animals, although the number surviving dopaminergic neurons and dopamine release were similar in the two groups. |
2009-07-28 |
2023-08-12 |
rat |
| Craig Blackston. Infantile parkinsonism-dystonia: a dopamine "transportopathy". The Journal of clinical investigation. vol 119. issue 6. 2009-07-24. PMID:19504720. |
the dopamine transporter (dat) retrieves the neurotransmitter dopamine from the synaptic cleft at dopaminergic synapses. |
2009-07-24 |
2023-08-12 |
human |
| Craig Blackston. Infantile parkinsonism-dystonia: a dopamine "transportopathy". The Journal of clinical investigation. vol 119. issue 6. 2009-07-24. PMID:19504720. |
though this might be predicted to result in dopamine excess in the synaptic cleft, it likely also causes depletion of presynaptic dopamine stores and possibly downregulation of postsynaptic dopamine receptor function, resulting in impairments in dopaminergic neurotransmission consistent with the clinical presentation. |
2009-07-24 |
2023-08-12 |
human |
| M L Persson, J Johansson, R Vumma, J Raita, L Bjerkenstedt, F-A Wiesel, N Venizelo. Aberrant amino acid transport in fibroblasts from patients with bipolar disorder. Neuroscience letters. vol 457. issue 1. 2009-07-22. PMID:19429160. |
the decreased tyrosine transport (low v(max)) found in this study may indicate less access of dopamine in the brain, resulting in disturbed dopaminergic and/or noradrenergic neurotransmission, that secondarily could lead to disturbances in other central neurotransmitter systems, such as the serotoninergic system. |
2009-07-22 |
2023-08-12 |
Not clear |
| Alfredo R Ramírez, Maite A Castro, Constanza Angulo, Laura Ramió, M Montserrat Rivera, Mauricio Torres, Teresa Rigau, Joan E Rodríguez-Gil, Ilona I Conch. The presence and function of dopamine type 2 receptors in boar sperm: a possible role for dopamine in viability, capacitation, and modulation of sperm motility. Biology of reproduction. vol 80. issue 4. 2009-07-16. PMID:19074002. |
we recently reported that dopamine type 2 receptors (drd2) are present in a wide range of mammalian sperm, suggesting a role for dopaminergic signaling in events such as fertilization, capacitation, and sperm motility. |
2009-07-16 |
2023-08-12 |
Not clear |