| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christina Krabbe, Elise Courtois, Pia Jensen, Jesper R Jørgensen, Jens Zimmer, Alberto Martínez-Serrano, Morten Meye. Enhanced dopaminergic differentiation of human neural stem cells by synergistic effect of Bcl-xL and reduced oxygen tension. Journal of neurochemistry. vol 110. issue 6. 2009-09-29. PMID:19627448. |
immunocytochemistry and q-pcr-analysis revealed expression of several dopaminergic markers besides of th just as dopamine was detected in the culture medium by hplc analysis. |
2009-09-29 |
2023-08-12 |
human |
| Quentin Barraud, Virginie Lambrecq, Claude Forni, Steve McGuire, Michael Hill, Bernard Bioulac, Emmanuel Balzamo, Erwan Bezard, François Tison, Imad Ghoraye. Sleep disorders in Parkinson's disease: the contribution of the MPTP non-human primate model. Experimental neurology. vol 219. issue 2. 2009-09-29. PMID:19635479. |
this was concomitant with a breakdown of dopaminergic homeostasis, as evidenced by decreased dopamine turnover measured after a single mptp injection. |
2009-09-29 |
2023-08-12 |
human |
| Martin Darvas, Richard D Palmite. Restriction of dopamine signaling to the dorsolateral striatum is sufficient for many cognitive behaviors. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 34. 2009-09-28. PMID:19667174. |
we therefore investigated the functional significance of dopaminergic signaling in cognitive tasks by studying dopamine-deficient (dd) mice and mice with dopamine signaling restored to only the dorsolateral (dl) striatum by viral rescue (vrdd-dl mice). |
2009-09-28 |
2023-08-12 |
mouse |
| Youren Tong, Antonio Pisani, Giuseppina Martella, Maha Karouani, Hiroo Yamaguchi, Emmanuel N Pothos, Jie She. R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 34. 2009-09-28. PMID:19667187. |
homozygous r1441c ki mice appear grossly normal and exhibit no dopaminergic (da) neurodegeneration or alterations in steady-state levels of striatal dopamine up to 2 years of age. |
2009-09-28 |
2023-08-12 |
mouse |
| Youren Tong, Antonio Pisani, Giuseppina Martella, Maha Karouani, Hiroo Yamaguchi, Emmanuel N Pothos, Jie She. R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 34. 2009-09-28. PMID:19667187. |
together, our data suggest that the r1441c mutation in lrrk2 impairs stimulated dopamine neurotransmission and d2 receptor function, which may represent pathogenic precursors preceding dopaminergic degeneration in pd brains. |
2009-09-28 |
2023-08-12 |
mouse |
| Christian J Fehske, Kristina Leuner, Walter E Mülle. Ginkgo biloba extract (EGb761) influences monoaminergic neurotransmission via inhibition of NE uptake, but not MAO activity after chronic treatment. Pharmacological research. vol 60. issue 1. 2009-09-25. PMID:19427589. |
as synaptic dopamine clearance in the frontal cortex is mediated by net, not dat, these findings may give an explanation for the enhancement of dopaminergic neurotransmission by egb761 seen in animal models, presumably linked to its positive effects on cognition and attention. |
2009-09-25 |
2023-08-12 |
mouse |
| Xuan V Nguyen, Mei Liu, Hyoung-Chun Kim, Guoying Bin. Effects of prodynorphin deletion on striatal dopamine in mice during normal aging and in response to MPTP. Experimental neurology. vol 219. issue 1. 2009-09-25. PMID:19500577. |
to test the hypothesis that dynorphin suppression mitigates effects of aging on the striatal dopaminergic system, hplc quantitation of dopamine and related amines was performed on striatal homogenates of wild-type (wt) mice and mice lacking the prodynorphin (pdyn) gene at varying ages. |
2009-09-25 |
2023-08-12 |
mouse |
| Rita C Carvalho, Daniela F Fukushiro, Daniel C Helfer, Donato Callegaro-Filho, Thaís F Trombin, Lineane H F Zanlorenci, Leandro Sanday, Regina H Silva, Roberto Frussa-Filh. Long-term haloperidol treatment (but not risperidone) enhances addiction-related behaviors in mice: role of dopamine D2 receptors. Addiction biology. vol 14. issue 3. 2009-09-24. PMID:19298320. |
the high prevalence of psychostimulant abuse observed in schizophrenic patients may be related to the development of mesolimbic dopaminergic supersensitivity (mds) or nigrostriatal dopaminergic supersensitivity (nds) in response to the chronic blockade of dopamine receptors produced by typical neuroleptic treatment. |
2009-09-24 |
2023-08-12 |
mouse |
| Steven C Cramer, Bruce H Dobkin, Elizabeth A Noser, Rachelle W Rodriguez, Lori A Enne. Randomized, placebo-controlled, double-blind study of ropinirole in chronic stroke. Stroke. vol 40. issue 9. 2009-09-22. PMID:19520987. |
the current study hypothesized that increased dopaminergic tone via the dopamine agonist ropinirole, when combined with physiotherapy (pt), would significantly and safely increase gait velocity. |
2009-09-22 |
2023-08-12 |
Not clear |
| Seema Singh, Kavita Singh, Devendra Kumar Patel, Chetna Singh, Chandishwar Nath, Vinod Kumar Singh, Raj Kumar Singh, Mahendra Pratap Sing. The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection. Rejuvenation research. vol 12. issue 3. 2009-09-22. PMID:19594327. |
mptp increased dopaminergic neuronal degeneration and the striatal mpp(+) level and reduced striatal dopamine content; it attenuated expression/activity of cyp2d22 and nachrs that were significantly restored in nicotine-treated animals. |
2009-09-22 |
2023-08-12 |
mouse |
| Maryka Quik, Luping Z Huang, Neeraja Parameswaran, Tanuja Bordia, Carla Campos, Xiomara A Pere. Multiple roles for nicotine in Parkinson's disease. Biochemical pharmacology. vol 78. issue 7. 2009-09-21. PMID:19433069. |
indeed, there is an extensive anatomical overlap between dopaminergic and cholinergic neurons, and acetylcholine is well known to modulate striatal dopamine release both in vitro and in vivo. |
2009-09-21 |
2023-08-12 |
Not clear |
| Anne-Sophie Rolland, Dominique Tandé, Maria-Trinidad Herrero, Maria-Rosario Luquin, Marianne Vazquez-Claverie, Carine Karachi, Etienne C Hirsch, Chantal Françoi. Evidence for a dopaminergic innervation of the pedunculopontine nucleus in monkeys, and its drastic reduction after MPTP intoxication. Journal of neurochemistry. vol 110. issue 4. 2009-09-21. PMID:19527435. |
taking into account the role of dopamine (da) in motor control and its degeneration in parkinson's disease, this neurotransmitter could induce dysfunction in the ppn and cun through a direct dopaminergic innervation of these brainstem structures. |
2009-09-21 |
2023-08-12 |
monkey |
| Anne-Sophie Rolland, Dominique Tandé, Maria-Trinidad Herrero, Maria-Rosario Luquin, Marianne Vazquez-Claverie, Carine Karachi, Etienne C Hirsch, Chantal Françoi. Evidence for a dopaminergic innervation of the pedunculopontine nucleus in monkeys, and its drastic reduction after MPTP intoxication. Journal of neurochemistry. vol 110. issue 4. 2009-09-21. PMID:19527435. |
this study provides the first demonstration that the ppn and cun are innervated by dopamine transporter-bearing fibres in normal monkeys, which points to a novel dopaminergic system that targets the lower brainstem. |
2009-09-21 |
2023-08-12 |
monkey |
| Lauren C Seeberger, Robert A Hause. Levodopa/carbidopa/entacapone in Parkinson's disease. Expert review of neurotherapeutics. vol 9. issue 7. 2009-09-21. PMID:19589043. |
longer acting dopaminergic agents, such as dopamine agonists, are less likely to cause motor fluctuations and dyskinesias but are not as efficacious for control of motor symptoms. |
2009-09-21 |
2023-08-12 |
Not clear |
| Simon Sydserff, E J Sutton, Dekun Song, Michael C Quirk, Carla Maciag, Chaoying Li, Gerald Jonak, David Gurley, John C Gordon, Edward P Christian, James J Doherty, Tom Hudzik, Edwin Johnson, Ladislav Mrzljak, Tim Piser, Gennady N Smagin, Yi Wang, Dan Widzowski, Jeffrey S Smit. Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes. Biochemical pharmacology. vol 78. issue 7. 2009-09-21. PMID:19615981. |
together, these data indicate that selective interaction with alpha7 nnrs by azd0328 selectively enhances midbrain dopaminergic neuronal activity causing an enhancement of cortical dopamine levels; these neurochemical changes likely, underlie the positive behavioral responses observed in two different animal models. |
2009-09-21 |
2023-08-12 |
mouse |
| Miriam Schiff, Birgit Weinhold, Claudia Grothe, Herbert Hildebrand. NCAM and polysialyltransferase profiles match dopaminergic marker gene expression but polysialic acid is dispensable for development of the midbrain dopamine system. Journal of neurochemistry. vol 110. issue 5. 2009-09-21. PMID:19619134. |
as studied by quantitative real-time rt-pcr, mrna profiles of ncam and the polysialyltransferases, st8siaii and st8siaiv, matched the course of tyrosine hydroxylase, dopamine transporter, nur-related factor 1, and paired-like homeodomain transcription factor 3 expression, which were used as marker genes of dopaminergic development. |
2009-09-21 |
2023-08-12 |
mouse |
| V V Barishpolets, Iu O Fedotova, N S Saprono. [Structural and functional organization of the cerebral dopaminergic system]. Eksperimental'naia i klinicheskaia farmakologiia. vol 72. issue 3. 2009-09-17. PMID:19642593. |
the synthesis of dopamine, distribution of dopaminergic structures, structure and classification of dopamin receptors in the brain, and functions of dopamine are discussed. |
2009-09-17 |
2023-08-12 |
Not clear |
| Carmen S van der Zwaluw, Rutger C M E Engels, Jan Buitelaar, Robbert J Verkes, Barbara Franke, Ron H J Scholt. Polymorphisms in the dopamine transporter gene (SLC6A3/DAT1) and alcohol dependence in humans: a systematic review. Pharmacogenomics. vol 10. issue 5. 2009-09-16. PMID:19450132. |
the dopamine transporter terminates dopaminergic neurotransmission, making the gene encoding the transporter (slc6a3/dat1) an attractive candidate in clinical studies on alcohol dependence. |
2009-09-16 |
2023-08-12 |
Not clear |
| Satoshi Suo, Joseph G Culotti, Hubert H M Van To. Dopamine counteracts octopamine signalling in a neural circuit mediating food response in C. elegans. The EMBO journal. vol 28. issue 16. 2009-09-16. PMID:19609300. |
in contrast, dopamine is released from dopaminergic neurons only in the presence of food. |
2009-09-16 |
2023-08-12 |
caenorhabditis_elegans |
| Julien Dusonchet, Jean-Charles Bensadoun, Bernard L Schneider, Patrick Aebische. Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson's disease. Neurobiology of disease. vol 35. issue 1. 2009-09-14. PMID:19348945. |
gabaergic neurons of the globus pallidus were unaffected by pael-r overexpression, highlighting the selective vulnerability of nigral dopaminergic neurons to abnormal levels of pael-r. pael-r-induced degeneration also led to a depletion of striatal dopamine resulting in spontaneous motor impairments, as measured in the cylinder and stepping tests for forelimb akinesia. |
2009-09-14 |
2023-08-12 |
rat |