| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Tilleman, O Kofman, L Nashelsky, U Livneh, N Roz, I Sillaber, A Biegon, M Rehavi, C Brodsk. Critical role of the embryonic mid-hindbrain organizer in the behavioral response to amphetamine and methylphenidate. Neuroscience. vol 163. issue 4. 2010-02-12. PMID:19635527. |
transmitter measurements, dopamine and serotonin transporter binding assays and autoradiography, indicated a subtle increase in striatal dopaminergic innervation and a marked general decrease of serotonergic innervation in mutants. |
2010-02-12 |
2023-08-12 |
mouse |
| P Witkovsky, J C Patel, C R Lee, M E Ric. Immunocytochemical identification of proteins involved in dopamine release from the somatodendritic compartment of nigral dopaminergic neurons. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19682556. |
immunocytochemical identification of proteins involved in dopamine release from the somatodendritic compartment of nigral dopaminergic neurons. |
2010-02-12 |
2023-08-12 |
Not clear |
| P Witkovsky, J C Patel, C R Lee, M E Ric. Immunocytochemical identification of proteins involved in dopamine release from the somatodendritic compartment of nigral dopaminergic neurons. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19682556. |
we examined the somatodendritic compartment of nigral dopaminergic neurons by immunocytochemistry and confocal microscopy, with the aim of identifying proteins that participate in dopamine packaging and release. |
2010-02-12 |
2023-08-12 |
Not clear |
| P Witkovsky, J C Patel, C R Lee, M E Ric. Immunocytochemical identification of proteins involved in dopamine release from the somatodendritic compartment of nigral dopaminergic neurons. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19682556. |
immunoreactive puncta of vesicular monoamine transporter type 2 and proton atpase, both involved in the packaging of dopamine for release, were located primarily in dopaminergic cell bodies, but were absent in distal dopaminergic dendrites. |
2010-02-12 |
2023-08-12 |
Not clear |
| P Witkovsky, J C Patel, C R Lee, M E Ric. Immunocytochemical identification of proteins involved in dopamine release from the somatodendritic compartment of nigral dopaminergic neurons. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19682556. |
on the other hand, syntaxin 3, synaptobrevin 2 (vamp 2) and snap-25-immunoreactivities were found in dopaminergic somata and dendrites our data imply that the storage and exocytosis of dopamine from the somatodendritic compartment of nigral dopaminergic neurons is mechanistically distinct from transmitter release at axon terminals utilizing amino acid neurotransmitters. |
2010-02-12 |
2023-08-12 |
Not clear |
| G A Prieto, A Perez-Burgos, T Fiordelisio, H Salgado, E Galarraga, R Drucker-Colin, J Barga. Dopamine D(2)-class receptor supersensitivity as reflected in Ca2+ current modulation in neostriatal neurons. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19699276. |
the loss of dopaminergic neurons followed by dopamine (da) depletion in the neostriatum is a hallmark of parkinson's disease. |
2010-02-12 |
2023-08-12 |
rat |
| R Cools, A Miyakawa, M Sheridan, M D'Esposit. Enhanced frontal function in Parkinson's disease. Brain : a journal of neurology. vol 133. issue Pt 1. 2010-02-12. PMID:19995871. |
we investigated the role of dopamine in working memory by examining effects of withdrawing dopaminergic medication in patients with parkinson's disease. |
2010-02-12 |
2023-08-12 |
Not clear |
| R Cools, A Miyakawa, M Sheridan, M D'Esposit. Enhanced frontal function in Parkinson's disease. Brain : a journal of neurology. vol 133. issue Pt 1. 2010-02-12. PMID:19995871. |
dopaminergic medication may reinstate distractibility by normalizing the balance between striatal and prefrontal dopamine transmission. |
2010-02-12 |
2023-08-12 |
Not clear |
| Yi-Fang Cui, Gunnar Hargus, Jin-Chong Xu, Janinne Sylvie Schmid, Yan-Qin Shen, Markus Glatzel, Melitta Schachner, Christian Bernreuthe. Embryonic stem cell-derived L1 overexpressing neural aggregates enhance recovery in Parkinsonian mice. Brain : a journal of neurology. vol 133. issue Pt 1. 2010-02-12. PMID:19995872. |
morphological analysis revealed increased numbers and migration of surviving transplanted cells, as well as increased numbers of dopaminergic neurons, leading to enhanced levels of dopamine in the striatum ipsilateral to the grafted side in l1 overexpressing stem cell-derived neural aggregates, when compared to wild-type stem cell-derived neural aggregates. |
2010-02-12 |
2023-08-12 |
mouse |
| Alexandra Doehring, Anja Kirchhof, Jörn Lötsc. Genetic diagnostics of functional variants of the human dopamine D2 receptor gene. Psychiatric genetics. vol 19. issue 5. 2010-02-09. PMID:19512960. |
the importance of dopamine d2 receptors (drd2) for central nervous dopaminergic signalling makes variants in the drd2 gene potential modulators of the risk or course of various behavioural, psychiatric or neurologic diseases (e.g. |
2010-02-09 |
2023-08-12 |
human |
| Q Bai, E A Burto. Cis-acting elements responsible for dopaminergic neuron-specific expression of zebrafish slc6a3 (dopamine transporter) in vivo are located remote from the transcriptional start site. Neuroscience. vol 164. issue 3. 2010-02-08. PMID:19755139. |
cis-acting elements responsible for dopaminergic neuron-specific expression of zebrafish slc6a3 (dopamine transporter) in vivo are located remote from the transcriptional start site. |
2010-02-08 |
2023-08-12 |
human |
| Q Bai, E A Burto. Cis-acting elements responsible for dopaminergic neuron-specific expression of zebrafish slc6a3 (dopamine transporter) in vivo are located remote from the transcriptional start site. Neuroscience. vol 164. issue 3. 2010-02-08. PMID:19755139. |
the purpose of this study was to analyze the transcriptional regulation of the zebrafish solute carrier family 6 member 3 gene (slc6a3, dopamine transporter, dat), as a first step towards isolating regulatory sequences useful for driving transgene expression within dopaminergic neurons of the zebrafish cns in vivo. |
2010-02-08 |
2023-08-12 |
human |
| Limin Liu, Yong Wang, Bo Li, Jun Jia, Zuoli Sun, Jinming Zhang, Jiahe Tian, Xiaomin Wan. Evaluation of nigrostriatal damage and its change over weeks in a rat model of Parkinson's disease: small animal positron emission tomography studies with [(11)C]beta-CFT. Nuclear medicine and biology. vol 36. issue 8. 2010-02-03. PMID:19875050. |
since dopamine transporter (dat) is a protein located presynaptically on dopaminergic nerve terminals, radioligands that bind to these sites are promising radiopharmaceuticals for evaluation of the integrity of the dopamine system. |
2010-02-03 |
2023-08-12 |
rat |
| Carl E Clarke, Paul Worth, Donald Grosset, David Stewar. Systematic review of apomorphine infusion, levodopa infusion and deep brain stimulation in advanced Parkinson's disease. Parkinsonism & related disorders. vol 15. issue 10. 2010-01-27. PMID:19805000. |
several treatments provide more continuous/less pulsatile dopaminergic stimulation by modifying the pharmacokinetics of levodopa or dopamine; however, patients with advanced disease can be refractory to these treatments. |
2010-01-27 |
2023-08-12 |
Not clear |
| Rodney W H Walker, Zuzana Walke. Dopamine transporter single photon emission computerized tomography in the diagnosis of dementia with Lewy bodies. Movement disorders : official journal of the Movement Disorder Society. vol 24 Suppl 2. 2010-01-26. PMID:19877236. |
visual and semiquantitative assessment of the nigrostriatal dopaminergic nerve terminals in the putamen and caudate nuclei can be obtained with single photon emission computerized tomography (spect) using ligands that bind to the dopamine transporter molecule in the membranes of the nigrostriatal nerve terminals. |
2010-01-26 |
2023-08-12 |
Not clear |
| Eva Andres-Mateos, Rebeca Mejias, Masayuki Sasaki, Xiaojie Li, Brian M Lin, Saskia Biskup, Li Zhang, Rebecca Banerjee, Bobby Thomas, Lichuan Yang, Guosheng Liu, M Flint Beal, David L Huso, Ted M Dawson, Valina L Dawso. Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 50. 2010-01-26. PMID:20016100. |
whether loss of lrrk2 function accounts for neurodegeneration of dopamine neurons in pd is not known, nor is it known whether lrrk2 kinase activity modulates the susceptibility of dopamine (da) neurons to the selective dopaminergic toxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
2010-01-26 |
2023-08-12 |
mouse |
| Irmgard Paris, Jorge Lozano, Carolina Perez-Pastene, Patricia Muñoz, Juan Segura-Aguila. Molecular and neurochemical mechanisms in PD pathogenesis. Neurotoxicity research. vol 16. issue 3. 2010-01-25. PMID:19526278. |
oxidation of dopamine to aminochrome seems to be a normal process leading to aminochrome polymerization to form neuromelanin, since normal individuals have this pigment in their dopaminergic neurons in the substantia nigra. |
2010-01-25 |
2023-08-12 |
Not clear |
| Howard J Federof. Nur(R1)turing a notion on the etiopathogenesis of Parkinson's disease. Neurotoxicity research. vol 16. issue 3. 2010-01-25. PMID:19526279. |
although the common sporadic/idiopathic form of pd most often presents clinically at around 60 years of age when the levels of striatal dopamine and numbers of ventral dopaminergic neurons are posited to have declined by 80 and 60%, respectively, the temporal pattern of injury to these vulnerable cells is unknown. |
2010-01-25 |
2023-08-12 |
Not clear |
| Sang Soo Cho, Antonio P Strafell. rTMS of the left dorsolateral prefrontal cortex modulates dopamine release in the ipsilateral anterior cingulate cortex and orbitofrontal cortex. PloS one. vol 4. issue 8. 2010-01-19. PMID:19696930. |
given the up-growing interest of non-invasive brain stimulation as potential tool for treatment of neurological and psychiatric disorders, it would be critical to investigate dopaminergic functional interactions in the prefrontal cortex and more in particular the effect of dorsolateral prefrontal cortex (dlpfc) (areas 9/46) stimulation on prefrontal dopamine (da). |
2010-01-19 |
2023-08-12 |
Not clear |
| Dardo Tomasi, Gene-Jack Wang, Ruiliang Wang, Walter Backus, Allan Geliebter, Frank Telang, Millar C Jayne, Christopher Wong, Joanna S Fowler, Nora D Volko. Association of body mass and brain activation during gastric distention: implications for obesity. PloS one. vol 4. issue 8. 2010-01-19. PMID:19718256. |
since obese subjects have dopaminergic deficits that correlate negatively with bmi and the amygdala is innervated by dopamine neurons, we hypothesized that bmi would correlate negatively with activation not just in the amygdala but also in other dopaminergic brain regions (midbrain and hypothalamus). |
2010-01-19 |
2023-08-12 |
human |