| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tino Dyhring, Elsebet Ø Nielsen, Clas Sonesson, Fredrik Pettersson, Jonas Karlsson, Peder Svensson, Palle Christophersen, Nicholas Water. The dopaminergic stabilizers pridopidine (ACR16) and (-)-OSU6162 display dopamine D(2) receptor antagonism and fast receptor dissociation properties. European journal of pharmacology. vol 628. issue 1-3. 2010-04-05. PMID:19919834. |
in contrast to the high-affinity typical antipsychotics haloperidol and raclopride, the dopaminergic stabilizers acr16 and (-)-osu6162 both displayed fast dopamine d(2) receptor dissociation properties, a feature that has previously been suggested as a contributing factor to antipsychotic atypicality and attributed mainly to low receptor affinity. |
2010-04-05 |
2023-08-12 |
Not clear |
| Tino Dyhring, Elsebet Ø Nielsen, Clas Sonesson, Fredrik Pettersson, Jonas Karlsson, Peder Svensson, Palle Christophersen, Nicholas Water. The dopaminergic stabilizers pridopidine (ACR16) and (-)-OSU6162 display dopamine D(2) receptor antagonism and fast receptor dissociation properties. European journal of pharmacology. vol 628. issue 1-3. 2010-04-05. PMID:19919834. |
the results demonstrate that dopaminergic stabilizers exhibit fast competitive dopamine d(2) receptor antagonism, possibly allowing for temporally variable and activity-dependent dopamine d(2) receptor occupancy that may partly account for their unique stabilization of dopamine dependent behaviors in vivo. |
2010-04-05 |
2023-08-12 |
Not clear |
| K Ohyama, C Sogawa, N Sogawa, K Morita, T Dohi, S Kitayam. Nicotine stimulates transcriptional activity of the human dopamine transporter gene. Neuroscience letters. vol 471. issue 1. 2010-04-05. PMID:20074615. |
nicotine modulates dopaminergic activity in the central nervous system by acting on the reuptake system, including the dopamine transporter (dat), although precisely remains unclear. |
2010-04-05 |
2023-08-12 |
human |
| Albert Gjedde, Yoshitaka Kumakura, Paul Cumming, Jakob Linnet, Arne Mølle. Inverted-U-shaped correlation between dopamine receptor availability in striatum and sensation seeking. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 8. 2010-04-05. PMID:20133675. |
the inverted-u shape is consistent with a negative correlation between sensation seeking and the reactivity ("gain") of dopaminergic neurotransmission to dopamine. |
2010-04-05 |
2023-08-12 |
Not clear |
| Fei Xu, Jian-hong Luo, Jing-hua Ji. [Alpha-synuclein interacted proteins: the relevance with the pathogenesis of Parkinson's disease]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 37. issue 5. 2010-04-02. PMID:18925724. |
parkinson's disease (pd) is characterized pathologically by the relatively preferential loss of dopaminergic neurons with resultant depletion of striatal dopamine and presence of lewy bodies mainly composed by alpha-synuclein (alpha-syn) in the remaining neurons in the substantia nigra. |
2010-04-02 |
2023-08-12 |
Not clear |
| Lee A Dawson, Paul W Smit. Therapeutic utility of NK3 receptor antagonists for the treatment of schizophrenia. Current pharmaceutical design. vol 16. issue 3. 2010-04-02. PMID:20109143. |
the dopamine hypothesis states that hyperactivity of the mesolimbic dopaminergic pathway is associated with positive symptoms of the disease, whereas hypoactivity of the mesocortical dopaminergic pathway is associated with the negative and cognitive symptoms. |
2010-04-02 |
2023-08-12 |
Not clear |
| Kyle C Schmitt, Maarten E A Reit. Regulation of the dopamine transporter: aspects relevant to psychostimulant drugs of abuse. Annals of the New York Academy of Sciences. vol 1187. 2010-04-02. PMID:20201860. |
dopaminergic signaling in the brain is primarily modulated by dopamine transporters (dats), which actively translocate extraneuronal dopamine back into dopaminergic neurons. |
2010-04-02 |
2023-08-12 |
Not clear |
| A Jon Stoess. Functional imaging studies of non-motoric manifestations of Parkinson's Disease. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20082973. |
this will depend upon the ability to investigate non dopaminergic mechanisms as well as extra-striatal release of dopamine and the capacity to assess the impact of behaviourally relevant stimuli on neurotransmitter release and on networks of brain activation. |
2010-03-31 |
2023-08-12 |
Not clear |
| Erik Ch Wolter. Non-motor extranigral signs and symptoms in Parkinson's disease. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20083010. |
during conventional, oral, dopaminomimetic treatment, the progressive loss of striatal dopaminergic nerve endings with the loss of cerebral dopamine storage capacity, renders the cerebral dopamine level fully dependent of the plasma levodopa levels, thus changing dopaminergic receptor stimulation from continuous to a more pulsatile pattern. |
2010-03-31 |
2023-08-12 |
Not clear |
| Fabrizio Stocch. The therapeutic concept of continuous dopaminergic stimulation (CDS) in the treatment of Parkinson's disease. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20083012. |
continuous dopaminergic stimulation is a therapeutic concept for the management of parkinson's disease (pd) that proposes that continuous, as opposed to discontinuous or pulsatile, stimulation of striatal dopamine receptors will delay or prevent the onset of levodopa-related motor complications. |
2010-03-31 |
2023-08-12 |
monkey |
| Fabrizio Stocch. The therapeutic concept of continuous dopaminergic stimulation (CDS) in the treatment of Parkinson's disease. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20083012. |
this hypothesis has arisen from studies of the normal basal ganglia demonstrating that nigral dopaminergic neurons normally fire continuously and striatal dopamine levels are relatively constant. |
2010-03-31 |
2023-08-12 |
monkey |
| Yasuhiro Tanaka, Tomoyuki Furuyashiki, Toshihiko Momiyama, Hisaaki Namba, Akira Mizoguchi, Tomoyuki Mitsumori, Tetsuro Kayahara, Hitoshi Shichi, Kazushi Kimura, Toshiyuki Matsuoka, Hiroyuki Nawa, Shuh Narumiy. Prostaglandin E receptor EP1 enhances GABA-mediated inhibition of dopaminergic neurons in the substantia nigra pars compacta and regulates dopamine level in the dorsal striatum. The European journal of neuroscience. vol 30. issue 12. 2010-03-30. PMID:20092576. |
prostaglandin e receptor ep1 enhances gaba-mediated inhibition of dopaminergic neurons in the substantia nigra pars compacta and regulates dopamine level in the dorsal striatum. |
2010-03-30 |
2023-08-12 |
mouse |
| Claudia Ganser, Anna Papazoglou, Lothar Just, Guido Nikkha. Neuroprotective effects of erythropoietin on 6-hydroxydopamine-treated ventral mesencephalic dopamine-rich cultures. Experimental cell research. vol 316. issue 5. 2010-03-25. PMID:20060824. |
parkinson's disease (pd) is a neurodegenerative disorder with motor symptoms caused by the loss of dopaminergic (da) cells and consequently dopamine release in the nigrostriatal system. |
2010-03-25 |
2023-08-12 |
rat |
| Yaping Chu, Jeffrey H Kordowe. Lewy body pathology in fetal grafts. Annals of the New York Academy of Sciences. vol 1184. 2010-03-25. PMID:20146690. |
these studies revealed robust neuronal survival with normal dopaminergic phenotypes in 18-month-old grafts and decreased dopamine transporter and increased cytoplasmic alpha-synuclein in 4-year-old grafts. |
2010-03-25 |
2023-08-12 |
Not clear |
| C Ardouin, I Chéreau, P-M Llorca, E Lhommée, F Durif, P Pollak, P Krac. [Assessment of hyper- and hypodopaminergic behaviors in Parkinson's disease]. Revue neurologique. vol 165. issue 11. 2010-03-24. PMID:19683776. |
the dopamine dysregulation syndrome includes hypersexuality, pathological gambling, and compulsive shopping; it is associated with addiction to dopaminergic medication. |
2010-03-24 |
2023-08-12 |
Not clear |
| Lawrence S Kegeles, Anissa Abi-Dargham, W Gordon Frankle, Roberto Gil, Thomas B Cooper, Mark Slifstein, Dah-Ren Hwang, Yiyun Huang, Suzanne N Haber, Marc Laruell. Increased synaptic dopamine function in associative regions of the striatum in schizophrenia. Archives of general psychiatry. vol 67. issue 3. 2010-03-17. PMID:20194823. |
a long-standing version of the dopamine hypothesis of schizophrenia postulates that hyperactivity of dopaminergic transmission at d(2) receptors in the limbic striatum is associated with the illness and that blockade of mesolimbic d(2) receptors is responsible for the antipsychotic action of d(2) receptor antagonists. |
2010-03-17 |
2023-08-12 |
Not clear |
| K Wu, M Politis, P Piccin. Parkinson disease and impulse control disorders: a review of clinical features, pathophysiology and management. Postgraduate medical journal. vol 85. issue 1009. 2010-03-12. PMID:19892894. |
the pathophysiology of underlying mechanisms is not fully understood, but recent evidence suggests that dopaminergic drugs, particularly dopamine agonists, coupled with changes in reward pathways involving the ventral striatal and related circuitry, may play a role. |
2010-03-12 |
2023-08-12 |
Not clear |
| Y T Cho, J L Fudg. Heterogeneous dopamine populations project to specific subregions of the primate amygdala. Neuroscience. vol 165. issue 4. 2010-03-12. PMID:19914353. |
to begin understanding how dopamine affects amygdala physiology and pathology in higher primates, we mapped the inputs from the midbrain dopaminergic neurons to various amygdala nuclei in the monkey using retrograde and anterograde tracing techniques, and single and double immunofluorescence histochemistry for tracer and tyrosine hydroxylase, a dopamine marker. |
2010-03-12 |
2023-08-12 |
rat |
| A Michaeli, R Yak. Dopamine inhibits GABA(A) currents in ventral tegmental area dopamine neurons via activation of presynaptic G-protein coupled inwardly-rectifying potassium channels. Neuroscience. vol 165. issue 4. 2010-03-12. PMID:19944748. |
dopamine (da) neurons in the ventral tegmental area (vta) constitute the origin of major dopaminergic neural pathways associated with essential functions including reward, motivation and cognition. |
2010-03-12 |
2023-08-12 |
rat |
| Yusuke Shibui, Xi Jun He, Kazuyuki Uchida, Hiroyuki Nakayam. MPTP-induced neuroblast apoptosis in the subventricular zone is not regulated by dopamine or other monoamine transporters. Neurotoxicology. vol 30. issue 6. 2010-03-09. PMID:19616025. |
for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) to exert neurotoxicity on dopaminergic neurons, 1-methyl-4-phenylpyridinium (mpp+), a metabolite of mptp, must be taken up into the dopaminergic neuron via the dopamine transporter (dat). |
2010-03-09 |
2023-08-12 |
mouse |